polythiazide (BioDeep_00001867977)

Main id: BioDeep_00000006597

 


代谢物信息卡片


polythiazide (200 mg)

化学式: C11H13ClF3N3O4S3 (438.97088040000006)
中文名称: 聚噻嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(CSCC(F)(F)F)Nc2cc(c(cc2S1(=O)=O)S(=O)(=O)N)Cl
InChI: InChI=1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)

描述信息

D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

2 个代谢物同义名

polythiazide (200 mg); polythiazide



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Gustavo Frindt, Tiffany McNair, Anke Dahlmann, Emily Jacobs-Palmer, Lawrence G Palmer. Epithelial Na channels and short-term renal response to salt deprivation. American journal of physiology. Renal physiology. 2002 Oct; 283(4):F717-26. doi: 10.1152/ajprenal.00379.2001. [PMID: 12217863]
  • A Gregoric, K Bracic, N Marcun-Varda. Familial hypomagnesemia--hypercalciuria and pseudotumor cerebri. Wiener klinische Wochenschrift. 2001; 113 Suppl 3(?):59-61. doi: NULL. [PMID: 15503623]
  • K Cakalaroski, N Ivanovski, R Grozdanovski, V Ristovska, M Polenakovic. Long-term diuretic therapy in patients with chronic renal failure. Clinical nephrology. 1997 Jul; 48(1):56-8. doi: NULL. [PMID: 9247782]
  • M Schöneshöfer, P Heilmann, R Rejaibi. Automated column liquid chromatographic determination of polythiazide in human serum. Journal of chromatography. 1987 Jul; 417(2):434-8. doi: 10.1016/0378-4347(87)80141-x. [PMID: 3654894]
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  • B F Johnson, L Romero, J Johnson, R Marwaha. Comparative effects of propranolol and prazosin upon serum lipids in thiazide- treated hypertensive patients. The American journal of medicine. 1984 Feb; 76(2A):109-12. doi: 10.1016/0002-9343(84)90967-7. [PMID: 6367445]
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  • V Janata, L Lege. Metabolic investigations of the rat kidney after chronic administration of polythiazide, furosemide and ethacrynic acid. I. Changes of the carbohydrate metabolism in the cytoplasmatic fraction or renal cortex and medulla. International journal of clinical pharmacology, therapy and toxicology. 1972 Jun; 6(2):125-9. doi: NULL. [PMID: 4638971]
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  • A F Lant, G M Wilson. Long-term therapy of diabetes insipidus with oral benzothiadiazine and phthalimidine diuretics. Clinical science. 1971 Jun; 40(6):497-511. doi: 10.1042/cs0400497. [PMID: 5557958]
  • T Ishino, S Fujimatsu, H Fujita, N Oe, K Otsuka. [Treatment of diabetes insipidus with chlorpropamide and thiazide group diuretics with special reference to the combined administration]. Horumon to rinsho. Clinical endocrinology. 1971 May; 19(5):381-5. doi: NULL. [PMID: 5165074]
  • V Janata, O Schück. Metabolic investigations of the rat kidney after administration of polythiazide, furosemide, and ethacrynic acid. I. Changes of the carbohydrate metabolism in the cytoplasmatic fraction of the renal cortex and medulla. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology. 1971 Feb; 4(2):196-9. doi: NULL. [PMID: 5550414]
  • V Janata, O Schück. Metabolic inestigations of the rat kidney after administration of polythiazide, furosemide, and ethacrynic acid. II. Changes of some enzyme activities in mitochondria ofthe renal cortex and medulla. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology. 1971 Feb; 4(2):200-3. doi: NULL. [PMID: 4323777]
  • O Schück, J Stríbná. Localization of the action of diuretics on renal tubular potassium transport in man. Physiologia Bohemoslovaca. 1971; 20(4):297-305. doi: NULL. [PMID: 4258985]
  • V Janata, J Turek, P Radikovský. [Metabolic studies on rat kidney after administration of polythiazide, furosemide and ethacrynic acid. II. Changes in some enzymatic activities in mitochondria of the renal cortex and medulla]. Ceskoslovenska farmacie. 1970 Mar; 19(2):53-6. doi: NULL. [PMID: 4315791]
  • V Janata, J Turek, P Radikovský. [Metabolic studies in rat kidney after administration of polythiazide, furosemide and ethacrinic acid. I. Changes in glycide metabolism in cytoplasmic fraction of renal cortex and medulla]. Ceskoslovenska farmacie. 1970 Feb; 19(1):17-20. doi: NULL. [PMID: 5443422]
  • B S Lindblad. The venous plasma free amino acid levels during the first hours of life. I. After normal and short gestation and gestation complicated by hypertension, with special reference to the 'small for dates' syndrome. Acta paediatrica Scandinavica. 1970 Jan; 59(1):13-20. doi: NULL. [PMID: 5448482]
  • L Wojdylo, I Zatónska. [Observations on the action of polythiazide in congestive heart failure. I. The influence of polythiazide on the diuresis, glomerular filtration, excretion of some electrolytes in urine and their levels in serum, and on the general condition of patients]. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina. 1970; 25(?):259-64. doi: NULL. [PMID: 5525324]
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  • J Turek, V Janata, O Schück, E Konopásek. Change in the ATPase activity of rat kidney ater the administration of polythiazide. Physiologia Bohemoslovaca. 1969; 18(2):157-9. doi: NULL. [PMID: 4243166]
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