Alprostadil (BioDeep_00001867819)

Main id: BioDeep_00000001682

 

Chemicals and Drugs PANOMIX_OTCML-2023 natural product Volatile Flavor Compounds


代谢物信息卡片


Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11α,13E,15S)-

化学式: C20H34O5 (354.24061140000003)
中文名称: 前列腺素 E1, 前列地尔
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Alprostadil. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alprostadil (retrieved 2024-11-25) (BioDeep RN: BioDeep_00001867819). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
InChI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

描述信息

Prostaglandin E1. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=745-65-3 (retrieved 2024-07-09) (CAS RN: 745-65-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

同义名列表

4 个代谢物同义名

Prostaglandin E1; Alprostadil; PGE1; Alprostadil



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sebile Azırak. Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue. Prostaglandins & other lipid mediators. 2023 Feb; 164(?):106682. doi: 10.1016/j.prostaglandins.2022.106682. [PMID: 36349661]
  • Decai Zhu, Dawei Wang, Zhen Zhao, Qingqing Liu, Rongyuan Yang, Qing Liu. Application of Nanoliposome Alprostadil in the Perioperative Period of Percutaneous Coronary Intervention to Reduce In-Stent Restenosis: A Systematic Review and Meta-Analysis. Journal of interventional cardiology. 2023; 2023(?):4100197. doi: 10.1155/2023/4100197. [PMID: 37251365]
  • Yan-Xia Li, Kang-Di Zheng, Yu Duan, Hua-Juan Liu, Yu-Qun Tang, Jun Wu, Dong-Zi Lin, Zhao Zhang. Mass spectrometry-based identification of new serum biomarkers in patients with latent infection pulmonary tuberculosis. Medicine. 2022 Dec; 101(48):e32153. doi: 10.1097/md.0000000000032153. [PMID: 36482536]
  • Meliha Koldemir Gündüz. BGM, a Newly Synthesised Boron Compound, Induces Apoptosis and Reduces Oxidative Stress by Inhibiting Lipogenesis in 3T3-L1 Adipocytes via PPARγ and CTRP3. Biological trace element research. 2022 Nov; 200(11):4807-4816. doi: 10.1007/s12011-022-03261-z. [PMID: 35508889]
  • Yuling Luo, Qingze Fan, Yongqi Yu, Lunhui Zhang, Limei Dong, Hongli Luo. Efficacy of administrative intervention for neurosurgical patients with off-label use of alprostadil lipid microsphere. Scientific reports. 2022 Sep; 12(1):15363. doi: 10.1038/s41598-022-19717-0. [PMID: 36100635]
  • Nina Buchtele, Christian Schörgenhofer, Michael Schwameis, Bernd Jilma, Peter Schellongowski, Harald Herkner, Katharina Riss, Monika Schmid, Alexander Hermann, Oliver Robak, Bernhard Nagler, Ludwig Traby, Andja Bojic, Thomas Staudinger. Add-On Prostaglandin E1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-Blind, Placebo-controlled Pilot Trial. American journal of respiratory and critical care medicine. 2022 07; 206(2):170-177. doi: 10.1164/rccm.202110-2359oc. [PMID: 35426776]
  • Steven D Targum, Jeffrey Schappi, Athanasia Koutsouris, Runa Bhaumik, Mark H Rapaport, Natalie Rasgon, Mark M Rasenick. A novel peripheral biomarker for depression and antidepressant response. Molecular psychiatry. 2022 03; 27(3):1640-1646. doi: 10.1038/s41380-021-01399-1. [PMID: 34969978]
  • Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus. Frontiers in immunology. 2022; 13(?):964901. doi: 10.3389/fimmu.2022.964901. [PMID: 36275708]
  • Hongfang Fu, Weiwei Hou, Yang Zhang, Xiaoyu Hu. Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials. PloS one. 2022; 17(5):e0269111. doi: 10.1371/journal.pone.0269111. [PMID: 35617324]
  • Xiaogang Liu, Peng Zhang, Jing Zhang, Xue Zhang, Shicheng Yang, Naikuan Fu. The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score. Angiology. 2022 Jan; 73(1):33-41. doi: 10.1177/00033197211015540. [PMID: 34098771]
  • Tiphaine Belleville-Rolland, Alexandre Leuci, Alexandre Mansour, Benoit Decouture, Fanny Martin, Sonia Poirault-Chassac, Margot Rouaud, Hippolyte Guerineau, Blandine Dizier, Dominique Pidard, Pascale Gaussem, Christilla Bachelot-Loza. Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets. Thrombosis and haemostasis. 2021 12; 121(12):1628-1636. doi: 10.1055/a-1481-2663. [PMID: 33851387]
  • Sunny Z Hussain, Barrett Labrum, Shadreck Mareya, Stephen Stripling, Robert Clifford. Safety of Lubiprostone in Pediatric Patients With Functional Constipation: A Nonrandomized, Open-Label Trial. Journal of pediatric gastroenterology and nutrition. 2021 11; 73(5):572-578. doi: 10.1097/mpg.0000000000003280. [PMID: 34387619]
  • Hongling Xu, Hongye Wang, Chuang Zhang, Jun Xiao, Ning Hua, Xuezheng Tang, Jiaqi Xie, Zhengbin Zhang. Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis. Angiology. 2021 10; 72(9):878-888. doi: 10.1177/00033197211004412. [PMID: 33853365]
  • Heeju Lee, Bora Lee, Yeonhee Kim, Sohyun Min, Eunjoo Yang, Seungmin Lee. Effects of Sodium Selenite Injection on Serum Metabolic Profiles in Women Diagnosed with Breast Cancer-Related Lymphedema-Secondary Analysis of a Randomized Placebo-Controlled Trial Using Global Metabolomics. Nutrients. 2021 Sep; 13(9):. doi: 10.3390/nu13093253. [PMID: 34579131]
  • Jiaomei Li, Zhaohong Zheng, Min Liu, Yiping Ren, Yue Ruan, Duo Li. Relationship between the n-3 index, serum metabolites and breast cancer risk. Food & function. 2021 Sep; 12(17):7741-7748. doi: 10.1039/d1fo01245b. [PMID: 34296713]
  • Yosuke Ida, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro, Fumihito Hikage. Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids. Prostaglandins, leukotrienes, and essential fatty acids. 2021 08; 171(?):102315. doi: 10.1016/j.plefa.2021.102315. [PMID: 34246925]
  • Francisco H Velásquez-Forero, Pedro F Valencia-Mayoral. Histomorphometry evaluation of bone anabolism promoted by prostaglandin E1 and its relation to hypercalcemia. Boletin medico del Hospital Infantil de Mexico. 2021 06; 78(4):293-300. doi: 10.24875/bmhim.20000080. [PMID: 34077409]
  • Jenny T Mao, Bingye Xue, Sili Fan, Patricia Neis, Clifford Qualls, Larry Massie, Oliver Fiehn. Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study. Cancer prevention research (Philadelphia, Pa.). 2021 06; 14(6):619-626. doi: 10.1158/1940-6207.capr-20-0585. [PMID: 33707173]
  • Jing Cui, Kai Shan, Qin Yang, Yumin Qi, Hongyan Qu, Jiaqi Li, Rong Wang, Lingling Jia, Wei Chen, Ninghan Feng, Yong Q Chen. Prostaglandin E3 attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization. Journal of cellular and molecular medicine. 2021 06; 25(12):5586-5601. doi: 10.1111/jcmm.16570. [PMID: 33982835]
  • Wei Xi, Yaqing Zhou, Xiaojun Han, Xiaohua Yang. Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3(Special)):1187-1193. doi: . [PMID: 34602388]
  • Jianwen Wang, Shiqi Tang, Yang Xie, Jun Liu, Jishi Liu, Hong Wu, Hao Zhang. Lipid microsphere-coated PGE1 improves peritoneal transport and reduces inflammation in peritoneal dialysis: A randomized clinical pilot trial. Seminars in dialysis. 2021 05; 34(3):235-244. doi: 10.1111/sdi.12954. [PMID: 33592131]
  • Yosuke Ida, Megumi Watanabe, Hiroshi Ohguro, Fumihito Hikage. Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094648. [PMID: 33925005]
  • M Wang, X-F Cai, S-M Zhang, S-Y Xia, W-H Du, Y-L Ma. Alprostadil alleviates liver injury in septic rats via TLR4/NF-κB pathway. European review for medical and pharmacological sciences. 2021 02; 25(3):1592-1599. doi: 10.26355/eurrev_202102_24869. [PMID: 33629328]
  • Wade Muncey, Nicholas Sellke, Tyler Kim, Kirtishri Mishra, Nannan Thirumavalavan, Aram Loeb. Alternative Treatment for Erectile Dysfunction: a Growing Arsenal in Men's Health. Current urology reports. 2021 Jan; 22(2):11. doi: 10.1007/s11934-020-01023-9. [PMID: 33420972]
  • You Jeong Park, Jeffrey Farooq, Justin Cho, Blaise Cozene, Bella Gonzales-Portillo, Nadia Sadanandan, Madeline Saft, Jea Young Lee, Cesar V Borlongan. A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review. Advances in experimental medicine and biology. 2021; 1312(?):165-177. doi: 10.1007/5584_2020_596. [PMID: 33159307]
  • Ksenia M Shestakova, Natalia E Moskaleva, Natalia V Mesonzhnik, Alexey V Kukharenko, Igor V Serkov, Igor I Lyubimov, Elena V Fomina-Ageeva, Vladimir V Bezuglov, Mikhail G Akimov, Svetlana A Appolonova. In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245896. [PMID: 33322104]
  • Hailian Guan, Miaomiao Ye, Cao Fang, Limin Zhang, Pengding Han, Shiguang Qiu, Xiangyu Fang, Lanying Li. The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis. Medicine. 2020 Dec; 99(50):e23507. doi: 10.1097/md.0000000000023507. [PMID: 33327292]
  • Junko Tachi, Haruhiko Tokuda, Takashi Onuma, Shinobu Yamaguchi, Woo Kim, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Osamu Kozawa, Hiroki Iida. Duloxetine strengthens osteoblast activation by prostaglandin E1: Upregulation of p38 MAP kinase. Prostaglandins & other lipid mediators. 2020 12; 151(?):106481. doi: 10.1016/j.prostaglandins.2020.106481. [PMID: 33002595]
  • Liang Zhang, Pan Li, Bi-Li Zhang, Man-Li Yu, Rong-Liang Xu, Hong Wu, Shao-Ping Chen. Dysregulation of HULC promotes contrast-induced nephropathy (CIN) via regulating signaling pathway of miRNA-512 and prostaglandin E1 (PGE1). Scientific reports. 2020 07; 10(1):11691. doi: 10.1038/s41598-020-68634-7. [PMID: 32678165]
  • Pengyi Li, Lianbing Gu, Qingming Bian, Jing Tan, Dian Jiao, Fei Wu, Zeping Xu, Lijun Wang. Effects of prostaglandin E1 nebulization of ventilated lung under 60\%O2 one lung ventilation on patients' oxygenation and oxidative stress: a randomised controlled trial. Respiratory research. 2020 May; 21(1):113. doi: 10.1186/s12931-020-01380-6. [PMID: 32404117]
  • Aneta Ostróżka-Cieślik, Barbara Dolińska. The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature. Molecules (Basel, Switzerland). 2020 May; 25(9):. doi: 10.3390/molecules25092185. [PMID: 32392782]
  • X Cheng, J H Zhan, J H Luo, G Y Zheng. [Effect of alprostadil in early wound healing of rats with deep partial-thickness scald]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2020 Apr; 36(4):317-322. doi: 10.3760/cma.j.cn501120-20190125-00017. [PMID: 32340424]
  • Yu-Han Zhang, Ya-Qin Zhang, Cong-Cong Guo, Li-Kang Wang, Yu-Jiao Cui, Jian-Jun Dong, Lin Liao. Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway. Acta pharmacologica Sinica. 2020 Apr; 41(4):561-571. doi: 10.1038/s41401-019-0314-9. [PMID: 31685975]
  • Zhenbai Qin, Binghui Kong, Jing Zheng, Xiantao Wang, Lang Li. Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition. Drug design, development and therapy. 2020; 14(?):4407-4422. doi: 10.2147/dddt.s272877. [PMID: 33122886]
  • Jian Xie, Mingyang Jiang, Yunni Lin, Lang Li. Re: Effect of Alprostadil in the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials. Angiology. 2020 01; 71(1):97. doi: 10.1177/0003319719870398. [PMID: 31426651]
  • Verónica Palma-Barqueros, José Miguel Torregrosa, Eva Caparrós-Pérez, Nerea Mota-Pérez, Natalia Bohdan, María Del Carmen Llanos, Antonija Jurak Begonja, Martha Sola-Visner, Vicente Vicente, Raúl Teruel-Montoya, José Rivera, Francisca Ferrer-Marín. Developmental Differences in Platelet Inhibition Response to Prostaglandin E1. Neonatology. 2020; 117(1):15-23. doi: 10.1159/000504173. [PMID: 31786577]
  • J-H Tu, Y Xu, Y Dai, L Dang. Effect of alprostadil on myocardial fibrosis in rats with diabetes mellitus via TGF-β1/Smad signaling pathway. European review for medical and pharmacological sciences. 2019 Nov; 23(21):9633-9641. doi: 10.26355/eurrev_201911_19457. [PMID: 31773714]
  • Shuke Fei, Wei Li, Lei Xiang, Xuewen Xie, Liang Zhang. Protective Effect of Alprostadil on Acute Pancreatitis in Rats via Inhibiting Janus Kinase 2 (JAK2)/STAT3 Signal Transduction Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Oct; 25(?):7694-7701. doi: 10.12659/msm.919148. [PMID: 31606729]
  • Michael Schou Jensen, Henricus A M Mutsaers, Stine Julie Tingskov, Michael Christensen, Mia Gebauer Madsen, Peter Olinga, Tae-Hwan Kwon, Rikke Nørregaard. Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica (Oxford, England). 2019 09; 227(1):e13291. doi: 10.1111/apha.13291. [PMID: 31054202]
  • Jian Xie, Mingyang Jiang, Yunni Lin, Huachu Deng, Lang Li. Effect of Alprostadil on the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials. Angiology. 2019 Aug; 70(7):594-612. doi: 10.1177/0003319719825597. [PMID: 30669852]
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  • De-Qi Jiang, Shi-Hua Zhao, Ming-Xing Li, Li-Lin Jiang, Yong Wang, Yan Wang. Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials. Medicine. 2018 Nov; 97(44):e13020. doi: 10.1097/md.0000000000013020. [PMID: 30383660]
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  • Jing-Zhan Zhang, Xiao-Jing Kang, Ying Gao, Ying-Ying Zheng, Ting-Ting Wu, Long Li, Fen Liu, Yi-Ning Yang, Xiao-Mei Li, Yi-Tong Ma, Xiang Xie. Efficacy of alprostadil for preventing of contrast-induced nephropathy: A meta-analysis. Scientific reports. 2017 04; 7(1):1045. doi: 10.1038/s41598-017-01160-1. [PMID: 28432310]
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