(2S)-5-amino-2-ammonio-5-oxopentanoate (BioDeep_00000898789)

Main id: BioDeep_00000398103

 


代谢物信息卡片


(2S)-5-amino-2-ammonio-5-oxopentanoate

化学式: C5H10N2O3 (146.069139)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(=O)N)C(C(=O)[O-])[NH3+]
InChI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

(2S)-5-amino-2-ammonio-5-oxopentanoate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(34)

BioCyc(52)

PlantCyc(16)

代谢反应

4314 个相关的代谢反应过程信息。

Reactome(431)

BioCyc(353)

WikiPathways(0)

Plant Reactome(1253)

INOH(0)

PlantCyc(2277)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Adam Skeens, Chathuranga Siriwardhana, Sophia E Massinople, Michelle M Wunder, Zachary L Ellis, Kaitlyn M Keith, Tyler Girman, Shelli L Frey, Justin Legleiter. The polyglutamine domain is the primary driver of seeding in huntingtin aggregation. PloS one. 2024; 19(3):e0298323. doi: 10.1371/journal.pone.0298323. [PMID: 38483973]
  • Ernesto Llamas, Seda Koyuncu, Hyun Ju Lee, Markus Wehrmann, Ricardo Gutierrez-Garcia, Nick Dunken, Nyasha Charura, Salvador Torres-Montilla, Elena Schlimgen, Amrei M Mandel, Erik Boelen Theile, Jan Grossbach, Prerana Wagle, Jan-Wilm Lackmann, Bernhard Schermer, Thomas Benzing, Andreas Beyer, Pablo Pulido, Manuel Rodriguez-Concepcion, Alga Zuccaro, David Vilchez. In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nature aging. 2023 Oct; ?(?):. doi: 10.1038/s43587-023-00502-1. [PMID: 37783816]
  • Bin Huang, Qiang Guo, Marie L Niedermeier, Jingdong Cheng, Tatjana Engler, Melanie Maurer, Alexander Pautsch, Wolfgang Baumeister, Florian Stengel, Stefan Kochanek, Rubén Fernández-Busnadiego. Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex. Structure (London, England : 1993). 2021 08; 29(8):804-809.e5. doi: 10.1016/j.str.2021.04.003. [PMID: 33909994]
  • Arnaud Marquette, Christopher Aisenbrey, Burkhard Bechinger. Membrane Interactions Accelerate the Self-Aggregation of Huntingtin Exon 1 Fragments in a Polyglutamine Length-Dependent Manner. International journal of molecular sciences. 2021 Jun; 22(13):. doi: 10.3390/ijms22136725. [PMID: 34201610]
  • Daniela Vilasboas-Campos, Marta Daniela Costa, Andreia Teixeira-Castro, Rejaine Rios, Fabiano Guimarães Silva, Carlos Bessa, Alberto C P Dias, Patrícia Maciel. Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free radical biology & medicine. 2021 01; 162(?):202-215. doi: 10.1016/j.freeradbiomed.2020.10.018. [PMID: 33096249]
  • Sharon E Groover, Maryssa Beasley, Visvanathan Ramamurthy, Justin Legleiter. Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems. Biochemistry. 2020 12; 59(49):4681-4693. doi: 10.1021/acs.biochem.0c00788. [PMID: 33256402]
  • Jae-Hoon Jung, Antonio D Barbosa, Stephanie Hutin, Janet R Kumita, Mingjun Gao, Dorothee Derwort, Catarina S Silva, Xuelei Lai, Elodie Pierre, Feng Geng, Sol-Bi Kim, Sujeong Baek, Chloe Zubieta, Katja E Jaeger, Philip A Wigge. A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature. 2020 09; 585(7824):256-260. doi: 10.1038/s41586-020-2644-7. [PMID: 32848244]
  • Lingyun Xiao, Haifeng Li, Jing Tian, Nanxiang Jin, Ju Zhang, Fan Yang, Ling Zhou, Qiangqiang Wang, Zebo Huang. The Traditional Formula Kai-Xin-San Alleviates Polyglutamine-Mediated Neurotoxicity by Modulating Proteostasis Network in Caenorhabditis elegans. Rejuvenation research. 2020 Jun; 23(3):207-216. doi: 10.1089/rej.2018.2149. [PMID: 31985332]
  • Sunyuan Zhang, Elizabeth Hinde, Molly Parkyn Schneider, David A Jans, Marie A Bogoyevitch. Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics. Scientific reports. 2020 01; 10(1):1557. doi: 10.1038/s41598-020-57994-9. [PMID: 32005838]
  • Xin-Yan Chen, De-Chun Liao, Meng-Lu Sun, Xiang-Huan Cui, Hong-Bing Wang. Essential Oil of Acorus tatarinowii Schott Ameliorates Aβ-Induced Toxicity in Caenorhabditis elegans through an Autophagy Pathway. Oxidative medicine and cellular longevity. 2020; 2020(?):3515609. doi: 10.1155/2020/3515609. [PMID: 33425207]
  • Chengfeng Xiao, Shuang Qiu, Xiao Li, Dan-Ju Luo, Gong-Ping Liu. EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. Neuroscience letters. 2019 07; 705(?):151-158. doi: 10.1016/j.neulet.2019.04.053. [PMID: 31029679]
  • Chengfeng Xiao, Shuang Qiu. Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster. Neuroscience letters. 2019 02; 694(?):168-175. doi: 10.1016/j.neulet.2018.12.009. [PMID: 30528881]
  • I-Cheng Chen, Chia-Ning Chang, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, Hsuan-Yuan Lin, Mei-Ling Cheng, Mu-Chun Chiang, Jung-Yaw Lin, Yih-Ru Wu, Guey-Jen Lee-Chen, Chiung-Mei Chen. Targeting Ubiquitin Proteasome Pathway with Traditional Chinese Medicine for Treatment of Spinocerebellar Ataxia Type 3. The American journal of Chinese medicine. 2019; 47(1):63-95. doi: 10.1142/s0192415x19500046. [PMID: 30612452]
  • Alberto Ceccon, G Marius Clore, Vitali Tugarinov. Decorrelating Kinetic and Relaxation Parameters in Exchange Saturation Transfer NMR: A Case Study of N-Terminal Huntingtin Peptides Binding to Unilamellar Lipid Vesicles. The journal of physical chemistry. B. 2018 12; 122(49):11271-11278. doi: 10.1021/acs.jpcb.8b07112. [PMID: 30156416]
  • Min Jee Kwon, Myeong Hoon Han, Joshua A Bagley, Do Young Hyeon, Byung Su Ko, Yun Mi Lee, In Jun Cha, Seung Yeol Kim, Dong Young Kim, Ho Min Kim, Daehee Hwang, Sung Bae Lee, Yuh Nung Jan. Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects. Proceedings of the National Academy of Sciences of the United States of America. 2018 11; 115(45):E10748-E10757. doi: 10.1073/pnas.1807206115. [PMID: 30348793]
  • Rajesh Mani, Manish Gupta, Anshu Malik, Ravi Tandon, Rajendra Prasad, Rakesh Bhatnagar, Nirupama Banerjee. Adjuvant Potential of Poly-α-l-Glutamine from the Cell Wall of Mycobacterium tuberculosis. Infection and immunity. 2018 10; 86(10):. doi: 10.1128/iai.00537-18. [PMID: 30104212]
  • Anthony C Bryan, Jin Zhang, Jianjun Guo, Priya Ranjan, Vasanth Singan, Kerrie Barry, Jeremy Schmutz, Deborah Weighill, Daniel Jacobson, Sara Jawdy, Gerald A Tuskan, Jin-Gui Chen, Wellington Muchero. A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein. G3 (Bethesda, Md.). 2018 07; 8(8):2631-2641. doi: 10.1534/g3.118.200188. [PMID: 29884614]
  • Alberto Ceccon, Thomas Schmidt, Vitali Tugarinov, Samuel A Kotler, Charles D Schwieters, G Marius Clore. Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR. Journal of the American Chemical Society. 2018 05; 140(20):6199-6202. doi: 10.1021/jacs.8b02619. [PMID: 29727175]
  • Anselm Gruber, Daniel Hornburg, Matthias Antonin, Natalie Krahmer, Javier Collado, Miroslava Schaffer, Greta Zubaite, Christian Lüchtenborg, Timo Sachsenheimer, Britta Brügger, Matthias Mann, Wolfgang Baumeister, F Ulrich Hartl, Mark S Hipp, Rubén Fernández-Busnadiego. Molecular and structural architecture of polyQ aggregates in yeast. Proceedings of the National Academy of Sciences of the United States of America. 2018 04; 115(15):E3446-E3453. doi: 10.1073/pnas.1717978115. [PMID: 29581260]
  • Jessica Brunquell, Stephanie Morris, Alana Snyder, Sandy D Westerheide. Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans. Cell stress & chaperones. 2018 01; 23(1):65-75. doi: 10.1007/s12192-017-0824-7. [PMID: 28674941]
  • Chang Geon Chung, Min Jee Kwon, Keun Hye Jeon, Do Young Hyeon, Myeong Hoon Han, Jeong Hyang Park, In Jun Cha, Jae Ho Cho, Kunhyung Kim, Sangchul Rho, Gyu Ree Kim, Hyobin Jeong, Jae Won Lee, TaeSoo Kim, Keetae Kim, Kwang Pyo Kim, Michael D Ehlers, Daehee Hwang, Sung Bae Lee. Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons. Cell reports. 2017 07; 20(2):356-369. doi: 10.1016/j.celrep.2017.06.059. [PMID: 28700938]
  • Adewale Adegbuyiro, Faezeh Sedighi, Albert W Pilkington, Sharon Groover, Justin Legleiter. Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease. Biochemistry. 2017 Mar; 56(9):1199-1217. doi: 10.1021/acs.biochem.6b00936. [PMID: 28170216]
  • Yanxia Xiang, Ju Zhang, Haifeng Li, Qiangqiang Wang, Lingyun Xiao, Huandi Weng, Xiaobin Zhou, Chung Wah Ma, Fangli Ma, Minghua Hu, Zebo Huang. Epimedium Polysaccharide Alleviates Polyglutamine-Induced Neurotoxicity in Caenorhabditis elegans by Reducing Oxidative Stress. Rejuvenation research. 2017 Feb; 20(1):32-41. doi: 10.1089/rej.2016.1830. [PMID: 27222166]
  • Vinod K Nelson, Asif Ali, Naibedya Dutta, Suvranil Ghosh, Manas Jana, Arnab Ganguli, Andrei Komarov, Soumyadip Paul, Vibha Dwivedi, Subhrangsu Chatterjee, Nihar R Jana, Subhash C Lakhotia, Gopal Chakrabarti, Anup K Misra, Subhash C Mandal, Mahadeb Pal. Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1. Oncotarget. 2016 Nov; 7(48):78281-78296. doi: 10.18632/oncotarget.12930. [PMID: 27835876]
  • Maxmore Chaibva, Sudi Jawahery, Albert W Pilkington, James R Arndt, Olivia Sarver, Stephen Valentine, Silvina Matysiak, Justin Legleiter. Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding. Biophysical journal. 2016 Jul; 111(2):349-362. doi: 10.1016/j.bpj.2016.06.018. [PMID: 27463137]
  • Masashi Ueda, Shimo Li, Masanori Itoh, Miao-Xing Wang, Miki Hayakawa, Saiful Islam, Tana, Kiyomi Nakagawa, Huayue Chen, Toshiyuki Nakagawa. Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion. Biochemical and biophysical research communications. 2016 05; 474(2):259-263. doi: 10.1016/j.bbrc.2016.04.034. [PMID: 27079237]
  • Chian Sing Ho, Nawal K Khadka, Fengyu She, Jianfeng Cai, Jianjun Pan. Polyglutamine aggregates impair lipid membrane integrity and enhance lipid membrane rigidity. Biochimica et biophysica acta. 2016 Apr; 1858(4):661-70. doi: 10.1016/j.bbamem.2016.01.016. [PMID: 26806158]
  • Nadine Schwierz, Stefanie Krysiak, Thorsten Hugel, Martin Zacharias. Mechanism of Reversible Peptide-Bilayer Attachment: Combined Simulation and Experimental Single-Molecule Study. Langmuir : the ACS journal of surfaces and colloids. 2016 Jan; 32(3):810-21. doi: 10.1021/acs.langmuir.5b03435. [PMID: 26717083]
  • Maximilian O Press, Amy Lanctot, Christine Queitsch. PIF4 and ELF3 Act Independently in Arabidopsis thaliana Thermoresponsive Flowering. PloS one. 2016; 11(8):e0161791. doi: 10.1371/journal.pone.0161791. [PMID: 27564448]
  • Protiti Maiti, Priyanka Ghorai, Sumit Ghosh, Mohan Kamthan, Rakesh Kumar Tyagi, Asis Datta. Mapping of functional domains and characterization of the transcription factor Cph1 that mediate morphogenesis in Candida albicans. Fungal genetics and biology : FG & B. 2015 Oct; 83(?):45-57. doi: 10.1016/j.fgb.2015.08.004. [PMID: 26291891]
  • Guobao Liu, Yueming Hu, Alan Tunnacliffe, Yizhi Zheng. A plant cell model of polyglutamine aggregation: Identification and characterisation of macromolecular and small-molecule anti-protein aggregation activity in vivo. Journal of biotechnology. 2015 Aug; 207(?):39-46. doi: 10.1016/j.jbiotec.2015.05.003. [PMID: 26003885]
  • Jessica Brunquell, Philip Bowers, Sandy D Westerheide. Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans. Mechanisms of ageing and development. 2014 Nov; 141-142(?):1-4. doi: 10.1016/j.mad.2014.08.002. [PMID: 25168631]
  • Anu Nagarajan, Sudi Jawahery, Silvina Matysiak. The effects of flanking sequences in the interaction of polyglutamine peptides with a membrane bilayer. The journal of physical chemistry. B. 2014 Jun; 118(24):6368-79. doi: 10.1021/jp407900c. [PMID: 24354677]
  • Lingyun Xiao, Haifeng Li, Ju Zhang, Fan Yang, Aizhen Huang, Jingjing Deng, Ming Liang, Fangli Ma, Minghua Hu, Zebo Huang. Salidroside protects Caenorhabditis elegans neurons from polyglutamine-mediated toxicity by reducing oxidative stress. Molecules (Basel, Switzerland). 2014 Jun; 19(6):7757-69. doi: 10.3390/molecules19067757. [PMID: 24918543]
  • Kuo-Hsuan Chang, Wan-Ling Chen, Yih-Ru Wu, Te-Hsien Lin, Yi-Ci Wu, Chih-Ying Chao, Jung-Yaw Lin, Li-Ching Lee, Yi-Chun Chen, Guey-Jen Lee-Chen, Chiung-Mei Chen. Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3. Neuropharmacology. 2014 Jun; 81(?):166-75. doi: 10.1016/j.neuropharm.2014.01.032. [PMID: 24486383]
  • Chiung-Mei Chen, Yu-Ting Weng, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, I-Cheng Chen, Li-Ching Lee, Hsuan-Yuan Lin, Yih-Ru Wu, Yi-Chun Chen, Kuo-Hsuan Chang, Hsiang-Yu Tang, Mei-Ling Cheng, Guey-Jen Lee-Chen, Jung-Yaw Lin. Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3. Free radical biology & medicine. 2014 Jun; 71(?):339-350. doi: 10.1016/j.freeradbiomed.2014.03.023. [PMID: 24675225]
  • Kathleen A Burke, Kaitlin M Hensal, C Samuel Umbaugh, Maxmore Chaibva, Justin Legleiter. Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner. Biochimica et biophysica acta. 2013 Aug; 1828(8):1953-61. doi: 10.1016/j.bbamem.2013.04.025. [PMID: 23643759]
  • Kathleen A Burke, Karlina J Kauffman, C Samuel Umbaugh, Shelli L Frey, Justin Legleiter. The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin. The Journal of biological chemistry. 2013 May; 288(21):14993-5005. doi: 10.1074/jbc.m112.446237. [PMID: 23572526]
  • Kathleen A Burke, Justin Legleiter. Atomic force microscopy assays for evaluating polyglutamine aggregation in solution and on surfaces. Methods in molecular biology (Clifton, N.J.). 2013; 1017(?):21-40. doi: 10.1007/978-1-62703-438-8_2. [PMID: 23719905]
  • Soledad Francisca Undurraga, Maximilian Oliver Press, Matthieu Legendre, Nora Bujdoso, Jacob Bale, Hui Wang, Seth J Davis, Kevin J Verstrepen, Christine Queitsch. Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov; 109(47):19363-7. doi: 10.1073/pnas.1211021109. [PMID: 23129635]
  • Young Mi Song, Sun-Ok Song, Yong-Keun Jung, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung-Wan Lee. Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction. Autophagy. 2012 Jul; 8(7):1085-97. doi: 10.4161/auto.20260. [PMID: 22722716]
  • Mathilde Schindler, Christine Fabre, Jan de Weille, Serge Carreau, Marcel Mersel, Norbert Bakalara. Disruption of nongenomic testosterone signaling in a model of spinal and bulbar muscular atrophy. Molecular endocrinology (Baltimore, Md.). 2012 Jul; 26(7):1102-16. doi: 10.1210/me.2011-1367. [PMID: 22570336]
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  • Yun Liu, Sohini Chakrabortee, Ranhui Li, Yizhi Zheng, Alan Tunnacliffe. Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation. FEBS letters. 2011 Feb; 585(4):630-4. doi: 10.1016/j.febslet.2011.01.020. [PMID: 21251910]
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