2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine (BioDeep_00000896080)

 

Secondary id: BioDeep_00000032143

human metabolite Endogenous Toxin


代谢物信息卡片


[3-[[4-(2-amino-2-Carboxy-ethyl)-1H-imidazol-2-yl]]-1-carboxy- propyl]-methyl-ammonium

化学式: C11H19N4O4+ (271.1406234)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[NH2+]C(CCC1=NC=C(C[C@H](N)C(O)=O)N1)C(O)=O
InChI: InChI=1S/C11H18N4O4/c1-13-8(11(18)19)2-3-9-14-5-6(15-9)4-7(12)10(16)17/h5,7-8,13H,2-4,12H2,1H3,(H,14,15)(H,16,17)(H,18,19)/p+1/t7-,8?/m0/s1

描述信息

2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine is an unusual amino acid that results from the post-translational modification of histidine in certain proteins. In particular, it is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 (EF2) at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2. It is a precursor for diphthamide. This compound is a substrate for the enzyme diphthine synthase (EC 2.1.1.98). This enzyme catalyzes the chemical reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine [HMDB]
2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine is an unusual amino acid that results from the post-translational modification of histidine in certain proteins. In particular, it is a post-translational derivative of histidine that exists in protein synthesis elongation factor 2 (EF2) at the site of diphtheria toxin-catalyzed ADP-ribosylation of elongation factor 2. It is a precursor for diphthamide. This compound is a substrate for the enzyme diphthine synthase (EC 2.1.1.98). This enzyme catalyzes the chemical reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine.

同义名列表

10 个代谢物同义名

[3-[[4-(2-amino-2-Carboxy-ethyl)-1H-imidazol-2-yl]]-1-carboxy- propyl]-methyl-ammonium; (3-{4-[(2S)-2-amino-2-carboxyethyl]-3H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium; (3-{5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl}-1-carboxypropyl)(methyl)azanium; Elongation factor 2 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine; 1-Carboxy-3-(L-histidin-2-yl)-N-methylpropan-1-aminium; EF-2 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine; 2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine; 2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine; 2-[3-Carboxy-3-(methylammonio)propyl]-histidine; 2-[3-Carboxy-3-(methylammonio)propyl]-his



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1 个相关的物种来源信息

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