3D,7D,11D-Phytanic acid (BioDeep_00000871729)
Main id: BioDeep_00000019509
human metabolite Endogenous
代谢物信息卡片
3,7,11,15-Tetramethyl-[3R-(3R*,7R*,11R*)]-hexadecanoic acid
化学式: C20H40O2 (312.302814)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)O
InChI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/t17-,18-,19-/m1/s1
描述信息
3D,7D,11D-Phytanic acid is an isomer of Phytanic acid, an unusual 20-carbon branched-chain fatty acid; Phytanic acid accumulates in blood and tissues of patients with Refsum disease (RD, an inborn error of lipid metabolism inherited as an autosomal recessive trait (OMIM 266500)), and is a reliable identifier of RD from a large number of other neurological disorders. Phytanic acid also accumulates in a number of other disorders with a very different clinical course: disorders of peroxisome biogenesis (Zellweger syndrome (OMIM 214100), neonatal adrenoleukodystrophy (OMIM 202370), infantile Refsum disease (OMIM 266510)) and rhizomelic chondrodysplasia punctata, type 1 (OMIM 215100). Phytanic acid is a 3-methyl fatty acid that cannot be beta-oxidized directly, and first undergoes an alpha-oxidation a reaction catalyzed by the enzyme phytanoyl-CoA hydroxylase, which is deficient in RD, the only true disorder of phytanic acid alpha-oxidation. (The Metabolic and Molecular Bases of Inherited Disease).
Constituent of butter
同义名列表
14 个代谢物同义名
3,7,11,15-Tetramethyl-[3R-(3R*,7R*,11R*)]-hexadecanoic acid; 3,7,11,15-Tetramethyl-[3R-(3R*,7R*,11R*)]-hexadecanoate; ((3R,7R,11R)-)3,7,11,15-Tetramethylhexadecanoic acid; (3R,7R,11R)-3,7,11,15-tetramethylhexadecanoic acid; ((3R,7R,11R)-)3,7,11,15-Tetramethylhexadecanoate; 3,7,11,15-Tetramethyl-D,D,D-hexadecanoic acid; 3,7,11,15-Tetramethyl-D,D,D-hexadecanoate; (3R,7R,11R)-1-Phytanoic acid; (3R,7R,11R)-1-Phytanoate; 3D,7D,11D-Phytanic acid; D,D,D-Phytanic acid; 3D,7D,11D-Phytanate; D,D,D-Phytanate; Phytanoic acid
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:172542
- PubChem: 10380830
- HMDB: HMDB0000417
- foodb: FDB013514
- chemspider: 8556273
- CAS: 18654-64-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Mateus Grings, Anelise Miotti Tonin, Lisiane Aurélio Knebel, Angela Zanatta, Alana Pimentel Moura, Carlos Severo Dutra Filho, Moacir Wajner, Guilhian Leipnitz. Phytanic acid disturbs mitochondrial homeostasis in heart of young rats: a possible pathomechanism of cardiomyopathy in Refsum disease.
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