D-Nicotine (BioDeep_00000863221)

 

Secondary id: BioDeep_00001892919


代谢物信息卡片


InChI=1\C10H14N2\c1-12-7-3-5-10(12)9-4-2-6-11-8-9\h2,4,6,8,10H,3,5,7H2,1H

化学式: C10H14N2 (162.1156924)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 1.75%

分子结构信息

SMILES: CN1CCCC1C2=CN=CC=C2
InChI: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m1/s1

描述信息

同义名列表

20 个代谢物同义名

InChI=1\C10H14N2\c1-12-7-3-5-10(12)9-4-2-6-11-8-9\h2,4,6,8,10H,3,5,7H2,1H; NICOTINE (L) (PYRROLIDINE,N-METHYL,ALPHA-(D-BETA-PYRIDYL)); Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (R)- (9CI); 3-[(2R)-1-methylpyrrolidin-2-yl]pyridine; 3-[(2R)-1-methyl-2-pyrrolidinyl]pyridine; (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine; 3-(1-methylpyrrolidin-2-yl)pyridine; 2-beta-H-Nicotine; NCGC00163360-01; Pseudonicotine; PDSP1_000557; (R)-nicotine; PDSP2_000113; (+)-Nicotine; BRN 4666243; CHEBI:39162; 25162-00-9; D-Nicotine; 1596-94-7; (R)-Nicotine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wilbert S Aronow. Peripheral arterial disease of the lower extremities. Archives of medical science : AMS. 2012 May; 8(2):375-88. doi: 10.5114/aoms.2012.28568. [PMID: 22662015]
  • K Von Mulzer, S Dando, G Gustavsson, N Radley, G Sjöstedt, P Sydbom, A Waltermo. [Improved product characteristics of nicotine gums: an unexplored area for higher compliance with nicotine replacement therapy]. MMW Fortschritte der Medizin. 2011 Oct; 153 Suppl 3(?):75-82. doi: NULL. [PMID: 22184800]
  • Erik Lunell, Margareta Curvall. Nicotine delivery and subjective effects of Swedish portion snus compared with 4 mg nicotine polacrilex chewing gum. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2011 Jul; 13(7):573-8. doi: 10.1093/ntr/ntr044. [PMID: 21454913]
  • Takahiro Shimizu, Kenjiro Tanaka, Takashi Hasegawa, Kunihiko Yokotani. Brain α4β2 nicotinic acetylcholine receptors are involved in the secretion of noradrenaline and adrenaline from adrenal medulla in rats. European journal of pharmacology. 2011 Mar; 654(3):241-8. doi: 10.1016/j.ejphar.2010.12.034. [PMID: 21237150]
  • John T Bernert, Joseph R Alexander, Connie S Sosnoff, James E McGuffey. Time course of nicotine and cotinine incorporation into samples of nonsmokers' beard hair following a single dose of nicotine polacrilex. Journal of analytical toxicology. 2011 Jan; 35(1):1-7. doi: 10.1093/anatox/35.1.1. [PMID: 21219696]
  • Rabi Yacoub, Habib Habib, Ayham Lahdo, Radwan Al Ali, Leon Varjabedian, George Atalla, Nader Kassis Akl, Saleem Aldakheel, Saeed Alahdab, Sami Albitar. Association between smoking and chronic kidney disease: a case control study. BMC public health. 2010 Nov; 10(?):731. doi: 10.1186/1471-2458-10-731. [PMID: 21108832]
  • Hayden McRobbie, Simon Thornley, Chris Bullen, Ruey-Bin Lin, Hugh Senior, Murray Laugesen, Robyn Whittaker, Peter Hajek. A randomized trial of the effects of two novel nicotine replacement therapies on tobacco withdrawal symptoms and user satisfaction. Addiction (Abingdon, England). 2010 Jul; 105(7):1290-8. doi: 10.1111/j.1360-0443.2010.02950.x. [PMID: 20491724]
  • C Bullen, H McRobbie, S Thornley, M Glover, R Lin, M Laugesen. Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tobacco control. 2010 Apr; 19(2):98-103. doi: 10.1136/tc.2009.031567. [PMID: 20378585]
  • Saul Shiffman, Edward J Cone, August R Buchhalter, Jack E Henningfield, Jeffrey M Rohay, Joe G Gitchell, John M Pinney, Tommy Chau. Rapid absorption of nicotine from new nicotine gum formulations. Pharmacology, biochemistry, and behavior. 2009 Jan; 91(3):380-4. doi: 10.1016/j.pbb.2008.08.012. [PMID: 18762208]
  • Carme Puig, Oscar Garcia-Algar, Toni Monleon, Roberta Pacifici, Piergiorgio Zuccaro, Jordi Sunyer, Cecilia Figueroa, Simona Pichini, Oriol Vall. A longitudinal study of environmental tobacco smoke exposure in children: parental self reports versus age dependent biomarkers. BMC public health. 2008 Feb; 8(?):47. doi: 10.1186/1471-2458-8-47. [PMID: 18254964]
  • Wayne L Silver, Tod R Clapp, Leslie M Stone, Sue C Kinnamon. TRPV1 receptors and nasal trigeminal chemesthesis. Chemical senses. 2006 Nov; 31(9):807-12. doi: 10.1093/chemse/bjl022. [PMID: 16908491]
  • Erik Lunell, Marianne Lunell. Steady-state nicotine plasma levels following use of four different types of Swedish snus compared with 2-mg Nicorette chewing gum: a crossover study. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2005 Jun; 7(3):397-403. doi: 10.1080/14622200500125468. [PMID: 16085507]
  • Yingxian Xiao, Kenneth J Kellar. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. The Journal of pharmacology and experimental therapeutics. 2004 Jul; 310(1):98-107. doi: 10.1124/jpet.104.066787. [PMID: 15016836]
  • Jae H Choi, Carolyn M Dresler, Michele R Norton, Kenneth R Strahs. Pharmacokinetics of a nicotine polacrilex lozenge. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2003 Oct; 5(5):635-44. doi: 10.1080/1462220031000158690. [PMID: 14577980]
  • Shoshiro Okada, Takahiro Shimizu, Kunihiko Yokotani. Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats. European journal of pharmacology. 2003 Jul; 473(2-3):217-23. doi: 10.1016/s0014-2999(03)01966-6. [PMID: 12892841]
  • Nagaraju L Choragudi, Wilbert S Aronow, Albert J DeLuca. Nicotine gum-induced atrial fibrillation. Heart disease (Hagerstown, Md.). 2003 Mar; 5(2):100-1. doi: 10.1097/01.hdx.0000061700.11321.1a. [PMID: 12713677]
  • Omar Ghosheh, Edward M Hawes. Microsomal N-glucuronidation of nicotine and cotinine: human hepatic interindividual, human intertissue, and interspecies hepatic variation. Drug metabolism and disposition: the biological fate of chemicals. 2002 Dec; 30(12):1478-83. doi: 10.1124/dmd.30.12.1478. [PMID: 12433822]
  • Omar Ghosheh, Edward M Hawes. N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases. Drug metabolism and disposition: the biological fate of chemicals. 2002 Sep; 30(9):991-6. doi: 10.1124/dmd.30.9.991. [PMID: 12167564]
  • Ramón Soto-Otero, Estefanía Méndez-Alvarez, Alvaro Hermida-Ameijeiras, Ana María López-Real, José Luis Labandeira-García. Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease. Biochemical pharmacology. 2002 Jul; 64(1):125-35. doi: 10.1016/s0006-2952(02)01070-5. [PMID: 12106613]
  • M Kassiou, S Eberl, S R Meikle, A Birrell, C Constable, M J Fulham, D F Wong, J L Musachio. In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT. Nuclear medicine and biology. 2001 Feb; 28(2):165-75. doi: 10.1016/s0969-8051(00)00206-7. [PMID: 11295427]
  • C M Gaynor, S L Handley. Effects of nicotine on head-shakes and tryptophan metabolites. Psychopharmacology. 2001 Jan; 153(3):327-33. doi: 10.1007/s002130000558. [PMID: 11271405]
  • E H Herman, J A Vick, J M Strong, R J Parker, H M Geyer, E D Kramer, K M Higgins, F D Sistare. Cardiovascular effects of buccal exposure to dermal nicotine patches in the dog: a comparative evaluation. Journal of toxicology. Clinical toxicology. 2001; 39(2):135-42. doi: 10.1081/clt-100103829. [PMID: 11407499]