Sympamin (BioDeep_00000863187)

Main id: BioDeep_00000014673

 

Volatile Flavor Compounds


代谢物信息卡片


Benzeneethanamine, alpha-methyl-, (aS)- (9CI)

化学式: C9H13N (135.1047938)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC=CC=C1)N
InChI: InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3/t8-/m0/s1

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics > N06BA - Centrally acting sympathomimetics
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators

同义名列表

53 个代谢物同义名

Benzeneethanamine, alpha-methyl-, (aS)- (9CI); 4-12-00-02587 (Beilstein Handbook Reference); Benzeneethanamine, alpha-methyl-, (alphaS)-; Phenethylamine, alpha-methyl-, (+)- (8CI); Benzeneethanamine, alpha-methyl-, (S)-; (AlphaS)-alpha-methylbenzeneethanamine; [(1S)-1-methyl-2-phenyl-ethyl]amine; Phenethylamine, alpha-methyl-, (+)-; alpha-Methylphenethylamine, d-form; Phenethylamine, alpha-methyl-, d-; (S)-alpha-Methylbenzeneethanamine; (S)-(+)-beta-Phenylisopropylamine; d-1-Phenyl-2-aminopropan [German]; (+)-alpha-Methylphenylethylamine; (S)-alpha-Methylphenethylamine; (+)-alpha-Methylphenethylamine; d-alpha-Methylphenethylamine; Dexanfetamina [INN-Spanish]; Dexamfetamina [INN-Spanish]; Dexamphetaminum [INN-Latin]; (2S)-1-phenylpropan-2-amine; (S)-1-Phenyl-2-aminopropane; (S)-1-Phenyl-2-propylamine; (S)-alpha-Phenylethylamine; Dexamfetaminum [INN-Latin]; (S)-1-Phenyl-2-propanamine; Dextroamphetamine [USAN]; Dextroamphetamine (USAN); (2S)-(+)-Amphetamine; Desamfetamina [DCIT]; Dexamfetamine (INN); (+)-(S)-Amphetamine; Dextroamphetamine; D-(+)-Amphetamine; EINECS 200-112-1; (+)-Phenaminum; Desamfetamina; Dexamfetamine; DEA No. 1100; PDSP2_001495; PDSP1_001511; BRN 2205872; CHEBI:4469; Dexidrine; NSC 73713; Dexadrine; HSDB 3055; Sympamin; 51-64-9; C07884; D03740; Dextroamphetamine; Dextroamphetamine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maria D Chermá, Gunnel H Nilsson, Anna Johansson, Anna K Jönsson, Johan Ahlner. Use of Lisdexamfetamine or Amphetamine? Interpretation of Chiral Amphetamine Analyses. Journal of analytical toxicology. 2022 Feb; 46(1):10-16. doi: 10.1093/jat/bkaa170. [PMID: 33216112]
  • S S Negus, M L Banks. Confronting the challenge of failed translation in medications development for substance use disorders. Pharmacology, biochemistry, and behavior. 2021 11; 210(?):173264. doi: 10.1016/j.pbb.2021.173264. [PMID: 34461148]
  • Keke Ren, Haiying Liu, Baolin Guo, Rui Li, Honghui Mao, Qian Xue, Han Yao, Shengxi Wu, Zhantao Bai, Wenting Wang. Quercetin relieves D-amphetamine-induced manic-like behaviour through activating TREK-1 potassium channels in mice. British journal of pharmacology. 2021 09; 178(18):3682-3695. doi: 10.1111/bph.15510. [PMID: 33908633]
  • A M Berton, N Prencipe, R Giordano, E Ghigo, S Grottoli. Systemic steroids in patients with COVID-19: pros and contras, an endocrinological point of view. Journal of endocrinological investigation. 2021 Apr; 44(4):873-875. doi: 10.1007/s40618-020-01325-2. [PMID: 32514902]
  • Adriano José Maia Chaves Filho, Natássia Lopes Cunha, Patrícia de Araújo Rodrigues, Alana Gomes de Souza, Michele Verde-Ramo Soares, Paloma Marinho Jucá, Tatiana de Queiroz, Dino César da Silva Clemente, Melina Mottin, Carolina Horta Andrade, Christina Alves Peixoto, Danielle S Macedo. Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2021 01; 42(?):57-74. doi: 10.1016/j.euroneuro.2020.11.007. [PMID: 33191076]
  • Emily M Black, Rodrigo A España. D-amphetamine maintenance treatment goes a long way: lasting therapeutic effects on cocaine behavioral effects and cocaine potency at the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 01; 46(2):275-276. doi: 10.1038/s41386-020-00825-2. [PMID: 32859997]
  • Adriano José Maia Chaves Filho, Natássia Lopes Cunha, Alana Gomes de Souza, Michele Verde-Ramo Soares, Paloma Marinho Jucá, Tatiana de Queiroz, João Victor Souza Oliveira, Samira S Valvassori, Tatiana Barichello, Joao Quevedo, David de Lucena, Danielle S Macedo. The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry. 2020 04; 99(?):109872. doi: 10.1016/j.pnpbp.2020.109872. [PMID: 31954756]
  • Joshua A Lile, Amy R Johnson, Matthew L Banks, Kevin W Hatton, Lon R Hays, Katherine L Nicholson, Justin L Poklis, Abner O Rayapati, Craig R Rush, William W Stoops, S Stevens Negus. Pharmacological validation of a translational model of cocaine use disorder: Effects of d-amphetamine maintenance on choice between intravenous cocaine and a nondrug alternative in humans and rhesus monkeys. Experimental and clinical psychopharmacology. 2020 Apr; 28(2):169-180. doi: 10.1037/pha0000302. [PMID: 31259593]
  • Friederike Holze, Patrick Vizeli, Felix Müller, Laura Ley, Raoul Duerig, Nimmy Varghese, Anne Eckert, Stefan Borgwardt, Matthias E Liechti. Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2020 02; 45(3):462-471. doi: 10.1038/s41386-019-0569-3. [PMID: 31733631]
  • Predrag Kalaba, Marija Ilić, Nilima Y Aher, Vladimir Dragačević, Marcus Wieder, Martin Zehl, Judith Wackerlig, Stanislav Beyl, Simone B Sartori, Karl Ebner, Alexander Roller, Natalie Lukic, Tetyana Beryozkina, Eduardo Rene Perez Gonzalez, Philip Neill, Jawad Akbar Khan, Vasiliy Bakulev, Johann Jakob Leban, Steffen Hering, Christian Pifl, Nicolas Singewald, Jana Lubec, Ernst Urban, Harald H Sitte, Thierry Langer, Gert Lubec. Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. Journal of medicinal chemistry. 2020 01; 63(1):391-417. doi: 10.1021/acs.jmedchem.9b01938. [PMID: 31841637]
  • Samira S Valvassori, Paula T Tonin, Gustavo C Dal-Pont, Roger B Varela, José Henrique Cararo, Abel Freitas Garcia, Fernanda F Gava, Samira Menegas, Jair C Soares, João Quevedo. Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats. Translational psychiatry. 2019 11; 9(1):297. doi: 10.1038/s41398-019-0637-9. [PMID: 31723123]
  • Chloe J Jordan, Jianjing Cao, Amy Hauck Newman, Zheng-Xiong Xi. Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine. Neuropharmacology. 2019 11; 158(?):107609. doi: 10.1016/j.neuropharm.2019.04.015. [PMID: 31009632]
  • Samira S Valvassori, Gustavo C Dal-Pont, Paula T Tonin, Roger B Varela, Camila L Ferreira, Fernanda F Gava, Monica L Andersen, Jair C Soares, João Quevedo. Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania. Pharmacology, biochemistry, and behavior. 2019 08; 183(?):56-63. doi: 10.1016/j.pbb.2019.05.009. [PMID: 31158395]
  • Esteban A Fridman, Joseph R Osborne, Paul D Mozley, Jonathan D Victor, Nicholas D Schiff. Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury. Brain : a journal of neurology. 2019 07; 142(7):1887-1893. doi: 10.1093/brain/awz118. [PMID: 31505542]
  • Anna Rickli, Karolina Kolaczynska, Marius C Hoener, Matthias E Liechti. Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR. Neurotoxicology. 2019 05; 72(?):95-100. doi: 10.1016/j.neuro.2019.02.011. [PMID: 30776375]
  • Marcel M van Gaalen, Christina Schlumbohm, Joost H Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach, Robert E Stratford. Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine. The Journal of pharmacology and experimental therapeutics. 2019 04; 369(1):107-120. doi: 10.1124/jpet.118.254508. [PMID: 30733244]
  • Joost H Folgering, Minha Choi, Christina Schlumbohm, Marcel M van Gaalen, Robert E Stratford. Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response. Journal of neuroscience methods. 2019 04; 317(?):71-81. doi: 10.1016/j.jneumeth.2019.02.005. [PMID: 30768951]
  • Christopher T Smith, Linh C Dang, Leah L Burgess, Scott F Perkins, M Danica San Juan, Darcy K Smith, Ronald L Cowan, Nam T Le, Robert M Kessler, Gregory R Samanez-Larkin, David H Zald. Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET. Psychopharmacology. 2019 Feb; 236(2):581-590. doi: 10.1007/s00213-018-5083-5. [PMID: 30350220]
  • Petra Strajhar, Patrick Vizeli, Melanie Patt, Patrick C Dolder, Denise V Kratschmar, Matthias E Liechti, Alex Odermatt. Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study. The Journal of steroid biochemistry and molecular biology. 2019 02; 186(?):212-225. doi: 10.1016/j.jsbmb.2018.10.016. [PMID: 30381248]
  • Jonathan M Slezak, Melanie Mueller, George A Ricaurte, Jonathan L Katz. Pharmacokinetic and pharmacodynamic analysis of d-amphetamine in an attention task in rodents. Behavioural pharmacology. 2018 09; 29(6):551-556. doi: 10.1097/fbp.0000000000000409. [PMID: 29864032]
  • Ji Li, Lingli Zhang, Xianliang Cheng, Lei Zhang, Baochun Shen, Chen Qing, Guorong Fan. Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking. Journal of pharmaceutical and biomedical analysis. 2018 Jul; 156(?):263-271. doi: 10.1016/j.jpba.2018.04.040. [PMID: 29729640]
  • Maikel Herbrink, Masha Nuijten, Bastiaan Nuijen, Alwin D R Huitema, Jos H Beijnen, Vincent M Hendriks, Peter Blanken, Amin Janmohamed, Wim van den Brink. Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients. Journal of clinical psychopharmacology. 2018 Jun; 38(3):212-217. doi: 10.1097/jcp.0000000000000862. [PMID: 29620701]
  • Joseph A Frankl, Sudeshna Bose, Phillip H Kuo. False-Positive Findings on Dopamine Transporter SPECT Due to Therapeutic Dextroamphetamine and Amphetamine. Journal of nuclear medicine technology. 2018 Jun; 46(2):149-150. doi: 10.2967/jnmt.117.201558. [PMID: 29273699]
  • M Herbrink, B Thijssen, M J X Hillebrand, H Rosing, J H M Schellens, B Nuijen, J H Beijnen. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of Dexamphetamine in human plasma. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 148(?):259-264. doi: 10.1016/j.jpba.2017.10.009. [PMID: 29059615]
  • Predrag Kalaba, Nilima Y Aher, Marija Ilić, Vladimir Dragačević, Marcus Wieder, Andras G Miklosi, Martin Zehl, Judith Wackerlig, Alexander Roller, Tetyana Beryozkina, Bojana Radoman, Sivaprakasam R Saroja, Wolfgang Lindner, Eduardo Perez Gonzalez, Vasiliy Bakulev, Johann Jakob Leban, Harald H Sitte, Ernst Urban, Thierry Langer, Gert Lubec. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. Journal of medicinal chemistry. 2017 11; 60(22):9330-9348. doi: 10.1021/acs.jmedchem.7b01313. [PMID: 29091428]
  • Trisha M Kesar, Samir R Belagaje, Paola Pergami, Marc W Haut, Gerald Hobbs, Cathrin M Buetefisch. Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults. Brain research. 2017 Sep; 1670(?):106-117. doi: 10.1016/j.brainres.2017.06.015. [PMID: 28633996]
  • Shiqi Ma, Mary H Cheng, Daryl A Guthrie, Amy H Newman, Ivet Bahar, Alexander Sorkin. Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter. Scientific reports. 2017 07; 7(1):5399. doi: 10.1038/s41598-017-05637-x. [PMID: 28710426]
  • Matthew L Banks, Rodney W Snyder, Timothy R Fennell, S Stevens Negus. Role of d-amphetamine and d-methamphetamine as active metabolites of benzphetamine: Evidence from drug discrimination and pharmacokinetic studies in male rhesus monkeys. Pharmacology, biochemistry, and behavior. 2017 05; 156(?):30-38. doi: 10.1016/j.pbb.2017.03.008. [PMID: 28373066]
  • Lenard A Adler, Samuel Alperin, Terry Leon, Stephen V Faraone. Pharmacokinetic and Pharmacodynamic Properties of Lisdexamfetamine in Adults with Attention-Deficit/Hyperactivity Disorder. Journal of child and adolescent psychopharmacology. 2017 03; 27(2):196-199. doi: 10.1089/cap.2016.0121. [PMID: 27935735]
  • Anouk Schrantee, Jordi L Tremoleda, Marzena Wylezinska-Arridge, Valentine Bouet, Peter Hesseling, Gideon F Meerhoff, Kora M de Bruin, Jan Koeleman, Thomas Freret, Michel Boulouard, Emilie Desfosses, Laurent Galineau, Alessandro Gozzi, François Dauphin, Willy Gsell, Jan Booij, Paul J Lucassen, Liesbeth Reneman. Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PloS one. 2017; 12(2):e0172776. doi: 10.1371/journal.pone.0172776. [PMID: 28241065]
  • Patrick C Dolder, Petra Strajhar, Patrick Vizeli, Felix Hammann, Alex Odermatt, Matthias E Liechti. Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects. Frontiers in pharmacology. 2017; 8(?):617. doi: 10.3389/fphar.2017.00617. [PMID: 28936175]
  • James Ermer, Mary Corcoran, Kenneth Lasseter, Patrick T Martin. Relative Bioavailabilities of Lisdexamfetamine Dimesylate and D-Amphetamine in Healthy Adults in an Open-Label, Randomized, Crossover Study After Mixing Lisdexamfetamine Dimesylate With Food or Drink. Therapeutic drug monitoring. 2016 12; 38(6):769-776. doi: 10.1097/ftd.0000000000000343. [PMID: 27661399]
  • S V Trossbach, V Bader, L Hecher, M E Pum, S T Masoud, I Prikulis, S Schäble, M A de Souza Silva, P Su, B Boulat, C Chwiesko, G Poschmann, K Stühler, K M Lohr, K A Stout, A Oskamp, S F Godsave, A Müller-Schiffmann, T Bilzer, H Steiner, P J Peters, A Bauer, M Sauvage, A J Ramsey, G W Miller, F Liu, P Seeman, N J Brandon, J P Huston, C Korth. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular psychiatry. 2016 11; 21(11):1561-1572. doi: 10.1038/mp.2015.194. [PMID: 26754951]
  • Herbert M Himmel, Michael Hoffmann. The 'induced hyperactivity' test for the de-risking of potential off-target activity of antihypertensive drugs. Journal of pharmacological and toxicological methods. 2016 Sep; 81(?):313-22. doi: 10.1016/j.vascn.2016.05.004. [PMID: 27179911]
  • James Ermer, Mary Corcoran, Kenneth Lasseter, Thomas Marbury, Brian Yan, Patrick T Martin. A Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Lisdexamfetamine Dimesylate in Individuals With Normal and Impaired Renal Function. Therapeutic drug monitoring. 2016 08; 38(4):546-55. doi: 10.1097/ftd.0000000000000296. [PMID: 26926668]
  • Teri M Furlong, Lee S Leavitt, Kristen A Keefe, Jong-Hyun Son. Methamphetamine-, d-Amphetamine-, and p-Chloroamphetamine-Induced Neurotoxicity Differentially Effect Impulsive Responding on the Stop-Signal Task in Rats. Neurotoxicity research. 2016 May; 29(4):569-82. doi: 10.1007/s12640-016-9605-9. [PMID: 26846719]
  • Christopher T Smith, Jessica Weafer, Ronald L Cowan, Robert M Kessler, Abraham A Palmer, Harriet de Wit, David H Zald. Individual differences in timing of peak positive subjective responses to d-amphetamine: Relationship to pharmacokinetics and physiology. Journal of psychopharmacology (Oxford, England). 2016 Apr; 30(4):330-43. doi: 10.1177/0269881116631650. [PMID: 26880226]
  • Benedikt Stegmann, Anett Dörfelt, Ekkehard Haen. Quantification of Methylphenidate, Dexamphetamine, and Atomoxetine in Human Serum and Oral Fluid by HPLC With Fluorescence Detection. Therapeutic drug monitoring. 2016 Feb; 38(1):98-107. doi: 10.1097/ftd.0000000000000245. [PMID: 26349081]
  • Christine Saunders, Aurelio Galli. Insights in how amphetamine ROCKs (Rho-associated containing kinase) membrane protein trafficking. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec; 112(51):15538-9. doi: 10.1073/pnas.1520960112. [PMID: 26607447]
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  • Jessica K Roberts, Sarah F Cook, Chris Stockmann, Douglas E Rollins, Diana G Wilkins, Catherine M T Sherwin. A Population Pharmacokinetic Analysis of Dextroamphetamine in the Plasma and Hair of Healthy Adults. Clinical drug investigation. 2015 Oct; 35(10):633-43. doi: 10.1007/s40261-015-0323-5. [PMID: 26329917]
  • Samira S Valvassori, Paula T Tonin, Roger B Varela, André F Carvalho, Edemilson Mariot, Rafaela T Amboni, Guilherme Bianchini, Monica L Andersen, João Quevedo. Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine. Bipolar disorders. 2015 Aug; 17(5):507-17. doi: 10.1111/bdi.12299. [PMID: 25929806]
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  • Matthew L Banks, Blake A Hutsell, Bruce E Blough, Justin L Poklis, S Stevens Negus. Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure. The international journal of neuropsychopharmacology. 2015 Jan; 18(8):. doi: 10.1093/ijnp/pyv009. [PMID: 25618405]
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  • Patrick Martin, Bryan Dirks, Lev Gertsik, David Walling, Annette Stevenson, Mary Corcoran, Aparna Raychaudhuri, James Ermer. Safety and pharmacokinetics of lisdexamfetamine dimesylate in adults with clinically stable schizophrenia: a randomized, double-blind, placebo-controlled trial of ascending multiple doses. Journal of clinical psychopharmacology. 2014 Dec; 34(6):682-9. doi: 10.1097/jcp.0000000000000205. [PMID: 25310201]
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