gomisin A (BioDeep_00000859142)
Main id: BioDeep_00000230166
PANOMIX_OTCML-2023
代谢物信息卡片
Schizandrol B
化学式: C23H28O7 (416.1834938)
中文名称: 五味子醇乙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4CC1(C)O)OC)OC)OC)OC)OCO3
InChI: InChI=1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3
描述信息
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities[1][2][3].
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities[1][2][3].
同义名列表
7 个代谢物同义名
gomisin A; Schizandrol B; Gomisin-A; TJN-101; Wuweizi alcohol-B; Schisandrol B; Gomisin A
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31272
- KEGGdrug: D01752
- PubChem: 634470
- PubChem: 68781
- ChEMBL: CHEMBL1834755
- CAS: 58546-54-6
- medchemexpress: HY-N0692
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Di He, Xinyi Pei, Bo Liu, Jiajing Li, Juane Dong, Thomas Efferth, Pengda Ma. Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155361. doi:
10.1016/j.phymed.2024.155361. [PMID: 38552434] - Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154273. doi:
10.1016/j.phymed.2022.154273. [PMID: 36044818] - Ying-Yuan Zhao, Xin-Peng Yao, Ting-Ying Jiao, Jia-Ning Tian, Yue Gao, Shi-Cheng Fan, Pan-Pan Chen, Yi-Ming Jiang, Yan-Ying Zhou, Yi-Xin Chen, Xiao Yang, Min Huang, Hui-Chang Bi. Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Apr; 84(?):153520. doi:
10.1016/j.phymed.2021.153520. [PMID: 33662920] - Minsun Park, Kwang-Geun Lee. Effect of roasting temperature and time on volatile compounds, total polyphenols, total flavonoids, and lignan of omija (Schisandra chinensis Baillon) fruit extract.
Food chemistry.
2021 Feb; 338(?):127836. doi:
10.1016/j.foodchem.2020.127836. [PMID: 32827900] - Yo-Han Han, Ji-Ye Kee, Seung-Heon Hong. Gomisin A Alleviates Obesity by Regulating the Phenotypic Switch between White and Brown Adipocytes.
The American journal of Chinese medicine.
2021; 49(8):1929-1948. doi:
10.1142/s0192415x21500919. [PMID: 34961413] - Zhenyue Wang, Yongtao Liu, Xiaohui Ai, Liqiao Zhong, Gang Han, Jinlong Song, Qiuhong Yang, Jing Dong. Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1043-1051. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2020 Sep; 37(9):1437-1448. doi:
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Journal of clinical pharmacy and therapeutics.
2019 Aug; 44(4):611-617. doi:
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Journal of natural medicines.
2019 Mar; 73(2):381-387. doi:
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Journal of pharmaceutical and biomedical analysis.
2018 Sep; 159(?):186-191. doi:
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Journal of dietary supplements.
2017 Nov; 14(6):640-652. doi:
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Journal of separation science.
2017 Sep; 40(17):3430-3439. doi:
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Molecules (Basel, Switzerland).
2017 Aug; 22(8):. doi:
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Acta pharmacologica Sinica.
2016 Mar; 37(3):382-9. doi:
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Phytotherapy research : PTR.
2015 Oct; 29(10):1658-64. doi:
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Journal of ethnopharmacology.
2015 May; 166(?):305-12. doi:
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Die Pharmazie.
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Chemico-biological interactions.
2015 Apr; 231(?):83-9. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2015 Mar; 38(3):169-77. doi:
10.1038/hr.2014.162. [PMID: 25427681] - Yiming Jiang, Xiaomei Fan, Ying Wang, Pan Chen, Hang Zeng, Huasen Tan, Frank J Gonzalez, Min Huang, Huichang Bi. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Jan; 143(1):107-15. doi:
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Food & function.
2014 Nov; 5(11):3018-25. doi:
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. [PMID: 25095364] - Xiaoxiao Wang, Di Hu, Lijia Zhang, Guoning Lian, Siqi Zhao, Chunming Wang, Jun Yin, Chunfu Wu, Jingyu Yang. Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Jan; 63(?):119-27. doi:
10.1016/j.fct.2013.10.048. [PMID: 24211520] - Haitao Liu, Hongwu Lai, Xinyue Jia, Jiushi Liu, Zhao Zhang, Yaodong Qi, Jin Zhang, Junbin Song, Chongming Wu, Bengang Zhang, Peigen Xiao. Comprehensive chemical analysis of Schisandra chinensis by HPLC-DAD-MS combined with chemometrics.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Sep; 20(12):1135-43. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Apr; 77(?):120-7. doi:
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International journal of molecular medicine.
2013 Apr; 31(4):888-98. doi:
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Journal of separation science.
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Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Sep; 35(9):928-34. doi:
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Journal of natural medicines.
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Biological & pharmaceutical bulletin.
2012; 35(2):171-7. doi:
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Phytotherapy research : PTR.
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Die Pharmazie.
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Phytochemical analysis : PCA.
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Journal of ethnopharmacology.
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The Journal of pharmacy and pharmacology.
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Journal of pharmacological sciences.
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Planta medica.
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European journal of pharmacology.
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