Norepinephrine hydrochloride (BioDeep_00000858902)
Main id: BioDeep_00000395684
PANOMIX_OTCML-2023
代谢物信息卡片
dl-Norepinephrine hydrochloride
化学式: C8H12ClNO3 (205.0505672)
中文名称: DL-去甲肾上腺素 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1C(CN)O)O)O.Cl
InChI: 1H
描述信息
DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[1].
DL-Norepinephrine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine．DL-Norepinephrine hydrochloride is a neurotransmitter targets α1 and β1 adrenoceptors, has an increasing effect on subendocardial oxygen tension[1].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D09794
- PubChem: 5923
- ChEMBL: CHEMBL1734806
- MeSH: Norepinephrine
- CAS: 55-27-6
- medchemexpress: HY-N7142
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Xinyi Xiong, Jianwen Qiu, Shaofei Fu, Biaofeng Gu, Chunli Zhong, Lan Zhao, Yong Gao. A dual-response fluorescent probe for norepinephrine and viscosity and its application in depression research.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Jul; 315(?):124270. doi:
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Bioorganic chemistry.
2024 May; 146(?):107296. doi:
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Physiology & behavior.
2024 Mar; 275(?):114431. doi:
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Scientific reports.
2024 02; 14(1):4178. doi:
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Scientific reports.
2024 01; 14(1):1948. doi:
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Journal of animal science.
2024 Jan; 102(?):. doi:
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Zhonghua wei zhong bing ji jiu yi xue.
2024 Jan; 36(1):23-27. doi:
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Journal of intensive care medicine.
2024 Jan; 39(1):21-27. doi:
10.1177/08850666231187333. [PMID: 37431214] - Zack Blumenfeld, Kallol Bera, Eero Castrén, Henry A Lester. Antidepressants enter cells, organelles, and membranes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2024 Jan; 49(1):246-261. doi:
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2023 Dec; 888(?):147753. doi:
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Journal of medicinal food.
2023 Dec; 26(12):890-901. doi:
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Endocrinology.
2023 Nov; 165(1):. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2023 Nov; 57(6):426-451. doi:
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Shock (Augusta, Ga.).
2023 Oct; ?(?):. doi:
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2023 Aug; 45(4):533-540. doi:
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Acta biochimica et biophysica Sinica.
2023 Jul; ?(?):. doi:
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Neurobiology of disease.
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Neuromodulation : journal of the International Neuromodulation Society.
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BMC infectious diseases.
2023 Apr; 23(1):221. doi:
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Obesity (Silver Spring, Md.).
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Drug metabolism and personalized therapy.
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Cryobiology.
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Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
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Lipids.
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Scientific reports.
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Nutrients.
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Hormones and behavior.
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Journal of affective disorders.
2022 07; 308(?):229-235. doi:
10.1016/j.jad.2022.04.021. [PMID: 35413358] - Yingqi An, Zilin Liu, Shiya Wang, Qingxian Wang, Chaoyong Zhang, Limin Zhang, Ying Xu, Yuansen Ge, Meiyuan Zheng, Songming Zhang, Honggang Zheng, Qian Yu. Effect of Chaihu plus Longgu Muli decoction plus five-element music therapy in the treatment of cancer-related depression.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.
2022 Jun; ?(?):. doi:
10.1007/s00520-022-07172-6. [PMID: 35737144] - Jingjie Zhao, Wei Shi, Yujia Lu, Xuesong Gao, Anna Wang, Shan Zhang, Yi Du, Yongzhi Wang, Li Li. Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.
BMC psychiatry.
2022 06; 22(1):419. doi:
10.1186/s12888-022-04065-0. [PMID: 35733107] - Ling-Yun Pan, Yu Wang, Xin-Hua Liu, Yi-Qun Jia. [Simultaneous determination of 11 neurotransmitters in brain microdialysis samples from rats by UPLC-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2022 Mar; ?(?):1-7. doi:
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Molecular and cellular biochemistry.
2022 Mar; 477(3):663-672. doi:
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Pakistan journal of pharmaceutical sciences.
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The Journal of organic chemistry.
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Communications biology.
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Cells.
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Journal of ethnopharmacology.
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PloS one.
2022; 17(10):e0276236. doi:
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Neuroendocrinology.
2022; 112(11):1129-1142. doi:
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Oxidative medicine and cellular longevity.
2022; 2022(?):1984706. doi:
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International journal of medicinal mushrooms.
2022; 24(4):63-73. doi:
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Journal of healthcare engineering.
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International journal of nanomedicine.
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Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2021 Dec; 39(6):681-690. doi:
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Archives of toxicology.
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International journal of molecular sciences.
2021 Sep; 22(18):. doi:
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The Journal of endocrinology.
2021 09; 251(1):83-96. doi:
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In vitro cellular & developmental biology. Animal.
2021 Sep; 57(8):775-785. doi:
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Clinical toxicology (Philadelphia, Pa.).
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Behavioural brain research.
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Toxicon : official journal of the International Society on Toxinology.
2021 Aug; 199(?):127-138. doi:
10.1016/j.toxicon.2021.06.008. [PMID: 34139257] - Nashwa M Saied, Gehan S Georgy, Rokaya M Hussien, Wafaa A Hassan. Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats.
Clinical and experimental pharmacology & physiology.
2021 03; 48(3):337-346. doi:
10.1111/1440-1681.13427. [PMID: 33098686] - Xiaoyang Zhou, Jianneng Pan, Yang Wang, Hua Wang, Zhaojun Xu, Weibo Zhuo. Left ventricular-arterial coupling as a predictor of stroke volume response to norepinephrine in septic shock - a prospective cohort study.
BMC anesthesiology.
2021 02; 21(1):56. doi:
10.1186/s12871-021-01276-y. [PMID: 33596822] - Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo. 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Molecular brain.
2021 02; 14(1):28. doi:
10.1186/s13041-020-00724-z. [PMID: 33557888] - Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska. Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice.
Behavioural brain research.
2021 02; 399(?):112985. doi:
10.1016/j.bbr.2020.112985. [PMID: 33144177] - Kasparas Petkevicius, Guillaume Bidault, Sam Virtue, Benjamin Jenkins, Xanthe A M H van Dierendonck, Aurelien Dugourd, Julio Saez-Rodriguez, Rinke Stienstra, Albert Koulman, Antonio Vidal-Puig. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 02; 35(2):e21266. doi:
10.1096/fj.202001101r. [PMID: 33484195] - Hengli Tong, Jing Zhu, Feipeng Gong, Lingyun Zhong, Ting Xu. Relationship between cardiotonic activity of Fuzi (Radix Aconiti Lateralis Preparata) and its fingerprint determined by liquid chromatography-mass spectrometry.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2021 02; 41(1):140-149. doi:
10.19852/j.cnki.jtcm.2021.01.016. [PMID: 33522207] - Jie Ma, Ying-Da Zang, Jian-Jun Zhang, Chuang-Jun Li, Yan Li, Ya-Lun Su, Ai-Guo Wang, Dong-Ming Zhang. Nine prenylated acylphloroglucinols with potential anti-depressive and hepatoprotective activities from Hypericum scabrum.
Bioorganic chemistry.
2021 02; 107(?):104529. doi:
10.1016/j.bioorg.2020.104529. [PMID: 33339665] - Yihai Liu, Jiamin Xu, Mingyue Wu, Biao Xu, Lina Kang. Empagliflozin protects against atherosclerosis progression by modulating lipid profiles and sympathetic activity.
Lipids in health and disease.
2021 Jan; 20(1):5. doi:
10.1186/s12944-021-01430-y. [PMID: 33436015] - Garima Sharma, Naveen Sharma, Bao Trong Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Yukio Yoneda, Eun-Joo Shin, Hyoung-Chun Kim. Protective Potential of Ginkgo biloba Against an ADHD-like Condition.
Current molecular pharmacology.
2021; 14(2):200-209. doi:
10.2174/1874467213666200424152454. [PMID: 32329705] - Abdul Jalil Shah, Reyaz Hassan Mir, Roohi Mohi-Ud-Din, Faheem Hyder Pottoo, Mubashir Hussain Masoodi, Zulfiqar Ali Bhat. Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources.
Current neuropharmacology.
2021; 19(11):2020-2037. doi:
10.2174/1570159x19666210426115234. [PMID: 33902421] - Diogo A Fonseca, Mónica Ferreira, Maria Graça Campos, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim. Vascular effects of a polyphenolic fraction from Oxalis pes-caprae L.: role of α-adrenergic receptors Sub-types.
Natural product research.
2020 Dec; 34(23):3369-3372. doi:
10.1080/14786419.2018.1564291. [PMID: 30698035] - Jianning Guo, Yu Liu, Xiaoyao Guo, Yujiao Meng, Cong Qi, Jingxia Zhao, Tingting Di, Lu Zhang, Xinwei Guo, Yazhuo Wang, Yan Wang, Ping Li. Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
International immunopharmacology.
2020 Dec; 89(Pt B):107057. doi:
10.1016/j.intimp.2020.107057. [PMID: 33242707] - Fubo Tian, Wuzhong Cheng, Jianying Hu, Shaoqiang Huang, Shen Sun. Effects of botulinum toxin A on endometriosis‑associated pain and its related mechanism.
Molecular medicine reports.
2020 Nov; 22(5):4351-4359. doi:
10.3892/mmr.2020.11501. [PMID: 33000241] - Maghawry Hegazy, Mostafa El-Shafey, Ahmed Ibrahim Abulsoud, Bakheet E M Elsadek, Adel I Abd Elaziz, Salama Abdou Salama. Pioglitazone ameliorates high fat diet-induced hypertension and induces catechol o-methyl transferase expression in rats.
European journal of pharmacology.
2020 Oct; 885(?):173383. doi:
10.1016/j.ejphar.2020.173383. [PMID: 32750363] - Ashraf Al-Brakati, Alaa Jameel A Albarakati, Hamid M A Daabo, Roua S Baty, Fatma Elzahraa H Salem, Ola A Habotta, Ehab K Elmahallawy, Doaa M Abdel-Mohsen, Heba Taha, Ahmed M A Akabawy, Rami B Kassab, Ahmed E Abdel Moneim, Hatim K Amin. Neuromodulatory effects of green coffee bean extract against brain damage in male albino rats with experimentally induced diabetes.
Metabolic brain disease.
2020 10; 35(7):1175-1187. doi:
10.1007/s11011-020-00583-6. [PMID: 32548708] - Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Liu. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats.
Behavioural brain research.
2020 09; 393(?):112710. doi:
10.1016/j.bbr.2020.112710. [PMID: 32464121] - Michelle A Hieger, Nicole E Peters. Lipid Emulsion Therapy for Quetiapine Overdose.
American journal of therapeutics.
2020 Sep; 27(5):e518-e519. doi:
10.1097/mjt.0000000000000969. [PMID: 32769389] - Vandana Thakur, Sumit Jamwal, Mandeep Kumar, Vikrant Rahi, Puneet Kumar. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.
Neurotoxicity research.
2020 Aug; 38(2):359-369. doi:
10.1007/s12640-020-00231-y. [PMID: 32506340] - Yusei Fujioka, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki. Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels.
The Journal of veterinary medical science.
2020 Jul; 82(7):897-902. doi:
10.1292/jvms.20-0208. [PMID: 32418937] - Sujuan Zhang, Yi Liu, Shiying Li, Feng Ye, Robert D Foreman, Jiande D Z Chen. Effects of electroacupuncture on stress-induced gastric dysrhythmia and mechanisms involving autonomic and central nervous systems in functional dyspepsia.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 07; 319(1):R106-R113. doi:
10.1152/ajpregu.00256.2019. [PMID: 32493036] - Tuğçe Demirtaş Şahin, Semil Selcen Gocmez, Gökhan Duruksu, Yusufhan Yazir, Tijen Utkan. Infliximab prevents dysfunction of the vas deferens by suppressing inflammation and oxidative stress in rats with chronic stress.
Life sciences.
2020 Jun; 250(?):117545. doi:
10.1016/j.lfs.2020.117545. [PMID: 32173313] - Hongyan Dong, Shaoqiang Zhang, Wuxun Du, Hongliang Cong, Lihong Zhang. Pharmacodynamics and metabonomics study of Tianma Gouteng Decoction for treatment of spontaneously hypertensive rats with liver-yang hyperactivity syndrome.
Journal of ethnopharmacology.
2020 May; 253(?):112661. doi:
10.1016/j.jep.2020.112661. [PMID: 32058006] - Haitham S Mohammed, Eman N Hosny, Yasser A Khadrawy, Merna Magdy, Yasmen S Attia, Omnia A Sayed, Mahmoud AbdElaal. Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat.
Biochimica et biophysica acta. Molecular basis of disease.
2020 05; 1866(5):165665. doi:
10.1016/j.bbadis.2020.165665. [PMID: 31918005] - Lirong Hu, Bo Leng, Changxue Wu, Yuting Xue. A prospective observational study to explore the correlation of peripheral arterial pulse/resistance index, organ function, and inflammation in patients with septic shock.
Medicine.
2020 May; 99(20):e20235. doi:
10.1097/md.0000000000020235. [PMID: 32443357] - Paul J Fitzgerald. Neurodining: Common dietary factors may be substrates in novel biosynthetic pathways for monoaminergic neurotransmitters.
Medical hypotheses.
2020 May; 138(?):109618. doi:
10.1016/j.mehy.2020.109618. [PMID: 32070787] - Jelena Velebit, Anemari Horvat, Tina Smolič, Sonja Prpar Mihevc, Boris Rogelj, Robert Zorec, Nina Vardjan. Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism.
Scientific reports.
2020 04; 10(1):6003. doi:
10.1038/s41598-020-62864-5. [PMID: 32265469] - Domingo E Uceda, Xiang-Yang Zhu, John R Woollard, Christopher M Ferguson, Ioannis Patras, Daniel F Carlson, Samuel J Asirvatham, Amir Lerman, Lilach O Lerman. Accumulation of Pericardial Fat Is Associated With Alterations in Heart Rate Variability Patterns in Hypercholesterolemic Pigs.
Circulation. Arrhythmia and electrophysiology.
2020 04; 13(4):e007614. doi:
10.1161/circep.119.007614. [PMID: 32189516] - Qi Zhu, Jonathan Weng, Minqian Shen, Jace Fish, Zhujun Shen, Karen T Coschigano, W Sean Davidson, Patrick Tso, Haifei Shi, Chunmin C Lo. Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation.
Endocrinology.
2020 04; 161(4):. doi:
10.1210/endocr/bqaa042. [PMID: 32157301] - Andressa de Abreu Mello, Márcio Alberto Geihs, Thuany da Silva Nogueira, Silvana Allodi, Marcelo Alves Vargas, Cintia Monteiro de Barros. Oxidative stress: Noradrenaline as an integrator of responses in the neuroendocrine and immune systems of the ascidian Phallusia nigra.
Developmental and comparative immunology.
2020 04; 105(?):103573. doi:
10.1016/j.dci.2019.103573. [PMID: 31918205] - Wanyun Li, Jing Ma, Qian Jiang, Ting Zhang, Qingrong Qi, Yan Cheng. Fast Noninvasive Measurement of Brown Adipose Tissue in Living Mice by Near-Infrared Fluorescence and Photoacoustic Imaging.
Analytical chemistry.
2020 03; 92(5):3787-3794. doi:
10.1021/acs.analchem.9b05162. [PMID: 32066237] - J Song, T Wang, X Zhang, B Li, C Zhu, S Zhang. Upregulation of gastric norepinephrine with beta-adrenoceptors and gastric dysmotility in a rat model of functional dyspepsia.
Physiological research.
2020 02; 69(1):135-143. doi:
10.33549/physiolres.934169. [PMID: 31852208] - Xin Gui Peng, Zhen Zhao, Di Chang, Yingying Bai, Qiuzhen Xu, Shenghong Ju. Quantification of Fat Concentration and Vascular Response in Brown and White Adipose Tissue of Rats by Spectral CT Imaging.
Korean journal of radiology.
2020 02; 21(2):248-256. doi:
10.3348/kjr.2019.0111. [PMID: 31997600] - Xin Wu, Xiujiang Han, Lili Li, Simiao Fan, Pengwei Zhuang, Zhen Yang, Yanjun Zhang. iTRAQ-based quantitative proteomics and target-fishing strategies reveal molecular signatures on vasodilation of Compound Danshen Dripping Pills.
Chemico-biological interactions.
2020 Jan; 316(?):108923. doi:
10.1016/j.cbi.2019.108923. [PMID: 31838051] - Di Zhao, Yan Gao, Wei Wang, Hui Pei, Chunxiao Xu, Zhuo Zhao. PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte.
Experimental cell research.
2020 01; 386(2):111742. doi:
10.1016/j.yexcr.2019.111742. [PMID: 31759056] - Tatsuhiro Ayabe, Takafumi Fukuda, Yasuhisa Ano. Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation.
Biomolecules.
2020 01; 10(1):. doi:
10.3390/biom10010131. [PMID: 31940997] - Eugenia B Manukhina, Vadim E Tseilikman, Marina N Karpenko, Nina S Pestereva, Olga B Tseilikman, Maria V Komelkova, Marina V Kondashevskaya, Anna V Goryacheva, Maxim S Lapshin, Pavel O Platkovskii, Alexey P Sarapultsev, Anatoly V Alliluev, H Fred Downey. Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain.
International journal of molecular sciences.
2020 Jan; 21(1):. doi:
10.3390/ijms21010345. [PMID: 31948051] - Jordy F Botello, Pedro Corral, Tengfei Bian, Chengguo Xing. Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells.
Planta medica.
2020 Jan; 86(1):26-31. doi:
10.1055/a-1035-5183. [PMID: 31711251] - Ting-Wang Xiong, Qin Wu, Jie Liu, Bo Liu, Yun-Yan Xu, Li-Na Wang, Cheng-Chen Zhang, Wei Zhang, Jing-Shan Shi. [Research progress of effect of anxiolytic traditional Chinese medicines and formulas on neurotransmitters].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Jan; 45(1):14-19. doi:
10.19540/j.cnki.cjcmm.20190829.402. [PMID: 32237406] - Xianyong Liao, Lin Qian, Song Zhang, Xiang Chen, Jing Lei. Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock.
Journal of healthcare engineering.
2020; 2020(?):8862256. doi:
10.1155/2020/8862256. [PMID: 32802302] - Yangzhi Peng, Yue Su, Yong Jiang. Effect of the warming and tonifying kidney- yang recipe on monoamine neurotransmitters and pathological morphology of hippocampus tissue in depression model rats.
Technology and health care : official journal of the European Society for Engineering and Medicine.
2020; 28(S1):237-244. doi:
10.3233/thc-209024. [PMID: 32364156]