γ-Oryzanol (BioDeep_00000858497)
Main id: BioDeep_00000395619
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
Cycloartenyl ferulate
化学式: C40H58O4 (602.4334868)
中文名称: 环木菠萝烯醇阿魏酸酯, 谷维素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC=C(C)C)C1CCC2(C1(CCC34C2CCC5C3(C4)CCC(C5(C)C)OC(=O)C=CC6=CC(=C(C=C6)O)OC)C)C
InChI: InChI=1S/C40H58O4/c1-26(2)10-9-11-27(3)29-18-20-38(7)33-16-15-32-36(4,5)34(19-21-39(32)25-40(33,39)23-22-37(29,38)6)44-35(42)17-13-28-12-14-30(41)31(24-28)43-8/h10,12-14,17,24,27,29,32-34,41H,9,11,15-16,18-23,25H2,1-8H3/b17-13+/t27-,29-,32+,33+,34+,37-,38+,39-,40+/m1/s1
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities[1].
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:32345
- KEGGdrug: D01221
- PubChem: 5282164
- ChEMBL: CHEMBL388595
- CAS: 286011-27-6
- CAS: 11042-64-1
- CAS: 21238-33-5
- medchemexpress: HY-125938
- medchemexpress: HY-B2194
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sisi Yan, Jihong Chen, Lingfeng Zhu, Tianyi Guo, Dandan Qin, Zuomin Hu, Shuai Han, Yaping Zhou, Otobang Donald Akan, Ji Wang, Feijun Luo, Qinlu Lin. Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Journal of agricultural and food chemistry.
2022 Jun; 70(21):6429-6443. doi:
10.1021/acs.jafc.2c00885. [PMID: 35587527] - Sisi Yan, Jihong Chen, Lingfeng Zhu, Tianyi Guo, Dandan Qin, Zuomin Hu, Shuai Han, Ji Wang, Froilan Bernard Matias, Lixin Wen, Feijun Luo, Qinlu Lin. Oryzanol alleviates high fat and cholesterol diet-induced hypercholesterolemia associated with the modulation of the gut microbiota in hamsters.
Food & function.
2022 Apr; 13(8):4486-4501. doi:
10.1039/d1fo03464b. [PMID: 35348138] - Abouzar Najafi, Hossein Daghigh-Kia, Mahdieh Mehdipour, Hossein Mohammadi, Hamed Hamishehkar. Comparing the effect of rooster semen extender supplemented with gamma-oryzanol and its nano form on post-thaw sperm quality and fertility.
Poultry science.
2022 Mar; 101(3):101637. doi:
10.1016/j.psj.2021.101637. [PMID: 35038650] - Somaiyeh Maleki, AmirAhmad Arabzadeh, Kazem Nejati, Farzaneh Fathi. Exploring The Interactions of a Natural Gamma-Oryzanol with Human Serum Albumin: Surface Plasmon Resonance, Fluorescence, and Molecular Modeling Studies.
Drug research.
2021 Nov; 71(9):520-527. doi:
10.1055/a-1533-2941. [PMID: 34331299] - Fabiane Valentini Francisqueti-Ferron, Artur Junio Togneri Ferron, Alessandra Altomare, Jéssica Leite Garcia, Fernando Moreto, Ana Lúcia A Ferreira, Igor Otávio Minatel, Giancarlo Aldini, Camila Renata Corrêa. Gamma-oryzanol reduces renal inflammation and oxidative stress by modulating AGEs/RAGE axis in animals submitted to high sugar-fat diet.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2021 Oct; 43(4):460-469. doi:
10.1590/2175-8239-jbn-2021-0002. [PMID: 34174064] - Ewa Młodzińska-Michta, Weronika Korzeniowska. Gamma-oryzanol as an example of a complex of phytosterol esters and ferulic acid with broad biological activity.
Postepy biochemii.
2021 09; 67(3):205-211. doi:
10.18388/pb.2021_391. [PMID: 34894391] - Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Junio Togneri Ferron, Erika Tiemi Nakandakare-Maia, Cristina Schmitt Gregolin, Janaina Paixão das Chagas Silva, Klinsmann Carolo Dos Santos, Ângelo Thompson Colombo Lo, Juliana Silva Siqueira, Letícia de Mattei, Bruno Henrique de Paula, Felipe Sarzi, Carol Cristina Vágula de Almeida Silva, Fernando Moreto, Mariane Róvero Costa, Ana Lucia A Ferreira, Igor Otávio Minatel, Camila Renata Corrêa. Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?.
Molecular and cellular endocrinology.
2021 01; 520(?):111095. doi:
10.1016/j.mce.2020.111095. [PMID: 33253762] - Elham Ramazani, Maryam Akaberi, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms.
Current pharmaceutical design.
2021; 27(19):2299-2316. doi:
10.2174/1381612826666201102101428. [PMID: 33138751] - S Singh, C Kothari, M Patel, S Panchal. Novel bio-analytical technique for estimation of gamma oryzanol in rat plasma and brain homogenate using HPLC.
Annales pharmaceutiques francaises.
2020 Nov; 78(6):515-524. doi:
10.1016/j.pharma.2020.07.003. [PMID: 32681901] - Hui-Li Lin, Shih-Hsiung Lin, Kuo-Ping Shen, Hua-Chen Chan, Yu-Hsiu Tseng, Hsueh-Wei Yen, Shi-Hui Law, Liang-Yin Ke. Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome.
Journal of food biochemistry.
2020 02; 44(2):e13129. doi:
10.1111/jfbc.13129. [PMID: 31846084] - Laura A Calvo-Castro, Nadine Sus, Christina Schiborr, Anja Bosy-Westphal, Maria Luisa Duran, Doris Fesenmeyer, Gerhard Fesenmeyer, Jan Frank. Pharmacokinetics of vitamin E, γ-oryzanol, and ferulic acid in healthy humans after the ingestion of a rice bran-enriched porridge prepared with water or with milk.
European journal of nutrition.
2019 Aug; 58(5):2099-2110. doi:
10.1007/s00394-018-1770-6. [PMID: 29978378] - Eduarda Escobar, Sabrina Lopes, Cristiano Malavolta, Juliana Bernera Ramalho, Daniele Missio, Hirya Fernandes Pinto, Melina Bucco Soares, Fábio Gallas Leivas, Daniela Dos Santos Brum, Francielli Weber Santos Cibin. Effect of γ-oryzanol on testicular degeneration induced by scrotal insulation in rams.
Theriogenology.
2019 Apr; 128(?):167-175. doi:
10.1016/j.theriogenology.2019.01.041. [PMID: 30772660] - Eri Kobayashi, Junya Ito, Naoki Shimizu, Takumi Kokumai, Shunji Kato, Kazue Sawada, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa. Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol.
Nutrients.
2019 Jan; 11(1):. doi:
10.3390/nu11010104. [PMID: 30621350] - Salina Akter, Hiroyuki Sasaki, Kazi Rasel Uddin, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata. Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain.
Life sciences.
2019 Jan; 216(?):119-128. doi:
10.1016/j.lfs.2018.11.042. [PMID: 30468832] - Phumon Sookwong, Sugunya Mahatheeranont. Some Strategies for Utilization of Rice Bran Functional Lipids and Phytochemicals.
Journal of oleo science.
2018 Jun; 67(6):669-678. doi:
10.5650/jos.ess17257. [PMID: 29760331] - Bhaskaragoud G, Geetha V, Sharanappa T, Mohan Kumar A S, Hema Kumar C, Suresh Kumar G. Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than β-Oxidation.
Molecular nutrition & food research.
2018 04; 62(8):e1700511. doi:
10.1002/mnfr.201700511. [PMID: 29469229] - W Rungratanawanich, G Abate, M M Serafini, M Guarienti, M Catanzaro, M Marziano, M Memo, C Lanni, D Uberti. Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway.
Oxidative medicine and cellular longevity.
2018; 2018(?):2987249. doi:
10.1155/2018/2987249. [PMID: 29725495] - Fabiane Valentini Francisqueti, Artur Junio Togneri Ferron, Fabiana Kurokawa Hasimoto, Pedro Henrique Rizzi Alves, Jéssica Leite Garcia, Klinsmann Carolo Dos Santos, Fernando Moreto, Vanessa Dos Santos Silva, Ana Lúcia A Ferreira, Igor Otávio Minatel, Camila Renata Corrêa. Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis.
Oxidative medicine and cellular longevity.
2018; 2018(?):1278392. doi:
10.1155/2018/1278392. [PMID: 30271526] - Fabiane Valentini Francisqueti, Igor Otávio Minatel, Artur Junio Togneri Ferron, Silméia Garcia Zanati Bazan, Vanessa Dos Santos Silva, Jéssica Leite Garcia, Dijon Henrique Salomé de Campos, Ana Lúcia Ferreira, Fernando Moreto, Antonio Carlos Cicogna, Camila Renata Corrêa. Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet.
Nutrients.
2017 Nov; 9(12):. doi:
10.3390/nu9121299. [PMID: 29186059] - Long Wang, Qinlu Lin, Tao Yang, Ying Liang, Ying Nie, Yi Luo, Junjun Shen, Xiangjin Fu, Yiping Tang, Feijun Luo. Oryzanol Modifies High Fat Diet-Induced Obesity, Liver Gene Expression Profile, and Inflammation Response in Mice.
Journal of agricultural and food chemistry.
2017 Sep; 65(38):8374-8385. doi:
10.1021/acs.jafc.7b03230. [PMID: 28853872] - Xinmei Jin, Lijun Ding, Depeng Xia, Peifang Chen. [Effects of acupoint catgut embedding combined with auricular point pressure on menopausal syndrome of liver-kidney deficiency type and estradiol].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Aug; 37(8):836-839. doi:
10.13703/j.0255-2930.2017.08.010. [PMID: 29231343] - Saman Heydari, Saeed Ghanbarzadeh, Behzad Anoush, Mohammadreza Ranjkesh, Yousef Javadzadeh, Maryam Kouhsoltani, Hamed Hamishehkar. Nanoethosomal formulation of gammaoryzanol for skin-aging protection and wrinkle improvement: a histopathological study.
Drug development and industrial pharmacy.
2017 Jul; 43(7):1154-1162. doi:
10.1080/03639045.2017.1300169. [PMID: 28277843] - Cristina Perez-Ternero, Carmen Claro, Juan Parrado, Maria Dolores Herrera, Maria Alvarez de Sotomayor. Rice bran enzymatic extract reduces atherosclerotic plaque development and steatosis in high-fat fed ApoE-/- mice.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 May; 37(?):22-29. doi:
10.1016/j.nut.2016.12.005. [PMID: 28359358] - Eri Kobayashi, Junya Ito, Shunji Kato, Kazue Sawada, Midori Matsuki, Hiroyuki Hashimoto, Teruo Miyazawa, Kiyotaka Nakagawa. Presence of orally administered rice bran oil γ-oryzanol in its intact form in mouse plasma.
Food & function.
2016 Dec; 7(12):4816-4822. doi:
10.1039/c6fo01552b. [PMID: 27878202] - G Bhaskaragoud, S Rajath, V P Mahendra, G Sunil Kumar, A G Gopala Krishna, G Suresh Kumar. Hypolipidemic mechanism of oryzanol components- ferulic acid and phytosterols.
Biochemical and biophysical research communications.
2016 07; 476(2):82-9. doi:
10.1016/j.bbrc.2016.05.053. [PMID: 27179780] - Guang-Liang Hong, Jia-Ming Liu, Guang-Ju Zhao, Jia-Ping Tan, Bin Wu, Meng-Fang Li, Guang Liang, Qiao-Meng Qiu, Zhong-Qiu Lu. Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1.
Journal of cellular biochemistry.
2016 Apr; 117(4):872-80. doi:
10.1002/jcb.25370. [PMID: 26358524] - Stephanie Hagl, Dirk Berressem, Rehka Grewal, Nadine Sus, Jan Frank, Gunter P Eckert. Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice.
Nutritional neuroscience.
2016; 19(1):1-10. doi:
10.1179/1476830515y.0000000040. [PMID: 26241203] - Ou Wang, Jia Liu, Qian Cheng, Xiaoxuan Guo, Yong Wang, Liang Zhao, Feng Zhou, Baoping Ji. Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats.
PloS one.
2015; 10(2):e0118135. doi:
10.1371/journal.pone.0118135. [PMID: 25646799] - Daichi Ijiri, Tsutomu Nojima, Mana Kawaguchi, Yoko Yamauchi, Yoshikazu Fujita, Satoru Ijiri, Akira Ohtsuka. Effects of feeding outer bran fraction of rice on lipid accumulation and fecal excretion in rats.
Bioscience, biotechnology, and biochemistry.
2015; 79(8):1337-41. doi:
10.1080/09168451.2015.1032883. [PMID: 25867004] - Yu-Xin Wang, Yang Li, An-Min Sun, Feng-Jiao Wang, Guo-Ping Yu. Hypolipidemic and antioxidative effects of aqueous enzymatic extract from rice bran in rats fed a high-fat and -cholesterol diet.
Nutrients.
2014 Sep; 6(9):3696-710. doi:
10.3390/nu6093696. [PMID: 25230211] - Cristiano C Spiazzi, Vanusa Manfredini, Fabiana E Barcellos da Silva, Erico M M Flores, Aryele P Izaguirry, Laura M Vargas, Melina B Soares, Francielli W Santos. γ-Oryzanol protects against acute cadmium-induced oxidative damage in mice testes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 May; 55(?):526-32. doi:
10.1016/j.fct.2013.01.048. [PMID: 23395783] - Mustapha Umar Imam, Maznah Ismail. Nutrigenomic effects of germinated brown rice and its bioactives on hepatic gluconeogenic genes in type 2 diabetic rats and HEPG2 cells.
Molecular nutrition & food research.
2013 Mar; 57(3):401-11. doi:
10.1002/mnfr.201200429. [PMID: 23307605] - Maria L Justo, Rosalia Rodriguez-Rodriguez, Carmen M Claro, Maria Alvarez de Sotomayor, Juan Parrado, Maria D Herrera. Water-soluble rice bran enzymatic extract attenuates dyslipidemia, hypertension and insulin resistance in obese Zucker rats.
European journal of nutrition.
2013 Mar; 52(2):789-97. doi:
10.1007/s00394-012-0385-6. [PMID: 22661284] - Rebecca M Kaup, Mohamed T Khayyal, Eugen J Verspohl. Antidiabetic effects of a standardized Egyptian rice bran extract.
Phytotherapy research : PTR.
2013 Feb; 27(2):264-71. doi:
10.1002/ptr.4705. [PMID: 22566008] - Makoto Nakaya, Aiko Shojo, Hiroaki Hirai, Kenji Matsumoto, Shinichi Kitamura. Hypolipidemic effects of starch and γ-oryzanol from wx/ae double-mutant rice on BALB/c.KOR-Apoe(shl) mice.
Bioscience, biotechnology, and biochemistry.
2013; 77(7):1435-40. doi:
10.1271/bbb.130087. [PMID: 23832334] - Sani Ismaila Muhammad, Ismail Maznah, Rozi Mahmud, Abu Bakar Zakaria Zuki, Mustapha Umar Imam. Upregulation of genes related to bone formation by γ-amino butyric acid and γ-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats.
Clinical interventions in aging.
2013; 8(?):1259-71. doi:
10.2147/cia.s45943. [PMID: 24098073] - Chisayo Kozuka, Kouichi Yabiku, Sumito Sunagawa, Rei Ueda, Shin-Ichiro Taira, Hiroyuki Ohshiro, Tomomi Ikema, Ken Yamakawa, Moritake Higa, Hideaki Tanaka, Chitoshi Takayama, Masayuki Matsushita, Seiichi Oyadomari, Michio Shimabukuro, Hiroaki Masuzaki. Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice.
Diabetes.
2012 Dec; 61(12):3084-93. doi:
10.2337/db11-1767. [PMID: 22826028] - Kazuyuki Ohara, Yuka Kiyotani, Asako Uchida, Reiko Nagasaka, Hiroyuki Maehara, Shigeharu Kanemoto, Masatoshi Hori, Hideki Ushio. Oral administration of γ-aminobutyric acid and γ-oryzanol prevents stress-induced hypoadiponectinemia.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Jun; 18(8-9):655-60. doi:
10.1016/j.phymed.2011.01.003. [PMID: 21316207] - Reiko Nagasaka, Tomoteru Yamsaki, Asako Uchida, Kazuyuki Ohara, Hideki Ushio. γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Jun; 18(8-9):669-71. doi:
10.1016/j.phymed.2011.01.004. [PMID: 21310601] - Hsing-Hsien Cheng, Chien-Ya Ma, Tsui-Wei Chou, Ya-Yen Chen, Ming-Hoang Lai. Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2010 Jan; 80(1):45-53. doi:
10.1024/0300-9831/a000005. [PMID: 20533244] - Kazuyuki Ohara, Asako Uchida, Reiko Nagasaka, Hideki Ushio, Toshiaki Ohshima. The effects of hydroxycinnamic acid derivatives on adiponectin secretion.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2009 Mar; 16(2-3):130-7. doi:
10.1016/j.phymed.2008.09.012. [PMID: 19013780] - Chatchawan Chotimarkorn, Hideki Ushio. The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2008 Nov; 15(11):951-8. doi:
10.1016/j.phymed.2008.02.014. [PMID: 18424018] - Thomas A Wilson, Robert J Nicolosi, Benjamin Woolfrey, David Kritchevsky. Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent than ferulic acid in hypercholesterolemic hamsters.
The Journal of nutritional biochemistry.
2007 Feb; 18(2):105-12. doi:
10.1016/j.jnutbio.2006.03.006. [PMID: 16713234] - R Accinni, M Rosina, F Bamonti, C Della Noce, A Tonini, F Bernacchi, J Campolo, R Caruso, C Novembrino, L Ghersi, S Lonati, S Grossi, S Ippolito, E Lorenzano, A Ciani, M Gorini. Effects of combined dietary supplementation on oxidative and inflammatory status in dyslipidemic subjects.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2006 Mar; 16(2):121-7. doi:
10.1016/j.numecd.2005.05.006. [PMID: 16487912] - Mun-Hee Suh, Sang-Ho Yoo, Pahn-Shick Chang, Hyeon Gyu Lee. Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats.
Journal of agricultural and food chemistry.
2005 Dec; 53(25):9747-50. doi:
10.1021/jf051912t. [PMID: 16332125] - Saleta Sierra, Federico Lara-Villoslada, Mónica Olivares, Jesús Jiménez, Julio Boza, Jordi Xaus. Increased immune response in mice consuming rice bran oil.
European journal of nutrition.
2005 Dec; 44(8):509-16. doi:
10.1007/s00394-005-0554-y. [PMID: 15719157] - Alvin Berger, Dietrich Rein, Angela Schäfer, Irina Monnard, Gérard Gremaud, Pierre Lambelet, Constantin Bertoli. Similar cholesterol-lowering properties of rice bran oil, with varied gamma-oryzanol, in mildly hypercholesterolemic men.
European journal of nutrition.
2005 Mar; 44(3):163-73. doi:
10.1007/s00394-004-0508-9. [PMID: 15309429] - A F Cicero, A Gaddi. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions.
Phytotherapy research : PTR.
2001 Jun; 15(4):277-89. doi:
10.1002/ptr.907. [PMID: 11406848] - M Hirose, S Fukushima, K Imaida, N Ito, T Shirai. Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research.
1999 Sep; 19(5A):3665-70. doi:
NULL. [PMID: 10625936] - A C Fry, E Bonner, D L Lewis, R L Johnson, M H Stone, W J Kraemer. The effects of gamma-oryzanol supplementation during resistance exercise training.
International journal of sport nutrition.
1997 Dec; 7(4):318-29. doi:
10.1123/ijsn.7.4.318. [PMID: 9407258] - N Rong, L M Ausman, R J Nicolosi. Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters.
Lipids.
1997 Mar; 32(3):303-9. doi:
10.1007/s11745-997-0037-9. [PMID: 9076667] - M Hirose, K Ozaki, K Takaba, S Fukushima, T Shirai, N Ito. Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis.
1991 Oct; 12(10):1917-21. doi:
10.1093/carcin/12.10.1917. [PMID: 1657429] - K B Wheeler, K A Garleb. Gamma oryzanol-plant sterol supplementation: metabolic, endocrine, and physiologic effects.
International journal of sport nutrition.
1991 Jun; 1(2):170-7. doi:
10.1123/ijsn.1.2.170. [PMID: 1844993] - G S Seetharamaiah, N Chandrasekhara. Effect of oryzanol on cholesterol absorption & biliary & fecal bile acids in rats.
The Indian journal of medical research.
1990 Dec; 92(?):471-5. doi:
NULL. [PMID: 2079365] - K Hiramatsu, T Tani, Y Kimura, S Izumi, P K Nakane. Effect of gamma-oryzanol on atheroma formation in hypercholesterolemic rabbits.
The Tokai journal of experimental and clinical medicine.
1990 Jul; 15(4):299-305. doi:
NULL. [PMID: 2130537] - G S Seetharamaiah, T P Krishnakantha, N Chandrasekhara. Influence of oryzanol on platelet aggregation in rats.
Journal of nutritional science and vitaminology.
1990 Jun; 36(3):291-7. doi:
10.3177/jnsv.36.291. [PMID: 2292731] - J Sasaki, Y Takada, K Handa, M Kusuda, Y Tanabe, A Matsunaga, K Arakawa. Effects of gamma-oryzanol on serum lipids and apolipoproteins in dyslipidemic schizophrenics receiving major tranquilizers.
Clinical therapeutics.
1990 May; 12(3):263-8. doi:
NULL. [PMID: 1974170] - G S Seetharamaiah, N Chandrasekhara. Studies on hypocholesterolemic activity of rice bran oil.
Atherosclerosis.
1989 Aug; 78(2-3):219-23. doi:
10.1016/0021-9150(89)90226-8. [PMID: 2783204] - K Sakamoto, T Tabata, K Shirasaki, T Inagaki, S Nakayama. Effects of gamma-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats.
Japanese journal of pharmacology.
1987 Dec; 45(4):559-65. doi:
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Japanese journal of pharmacology.
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