Tigecycline (BioDeep_00000858439)
Main id: BioDeep_00000014658
代谢物信息卡片
WAY-gar-936
化学式: C29H39N5O8 (585.2798494)
中文名称: 替加环素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(=O)NC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C
InChI: InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1
描述信息
Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Same as: D01079
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:149836
- KEGG: C12012
- KEGGdrug: D01079
- PubChem: 54686904
- DrugBank: DB00560
- ChEMBL: CHEMBL376140
- MeSH: Tigecycline
- CAS: 220620-09-7
- MetaboLights: MTBLC149836
- PubChem: 14170
- PDB-CCD: T1C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- ChunYan Wu, Dongmei Li, Zhu Zeng, Youjian Yang, Yunling Huang, Xiaoyan Yao. Investigation of the Clinical Studies of Traditional Chinese Medicine and Western Medicine in the Treatment of Disorders Related to Ventilators.
Alternative therapies in health and medicine.
2023 Nov; 29(8):286-291. doi:
". [PMID: 37573602] - Suyeon Park, Jihyun Choi, Dongwoo Shin, Ki Tae Kwon, Si-Ho Kim, Yu Mi Wi, Kwan Soo Ko. Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy.
International journal of antimicrobial agents.
2023 Oct; ?(?):107017. doi:
10.1016/j.ijantimicag.2023.107017. [PMID: 37884228] - Donghong Gao, Chongmei Tian, Delian Huang, Siwei Wang, Yongfeng Bai, Tianhong Ma, Xueyu Fan. Genome sequence of a tigecycline-resistant Acinetobacter seifertii recovered in human bloodstream infection in China.
Journal of global antimicrobial resistance.
2023 09; 34(?):39-42. doi:
10.1016/j.jgar.2023.06.007. [PMID: 37364734] - Qin Wang, Guiyi Liao, Quan Xia, Chaoliang Ge, Handong Ding. Safety and effectiveness of tigecycline combination therapy in renal transplant patients with infection due to carbapenem-resistant gram-negative bacteria.
Frontiers in cellular and infection microbiology.
2023; 13(?):1215288. doi:
10.3389/fcimb.2023.1215288. [PMID: 38035333] - B-G Liu, M Xie, Y-T Gong, Y Dong, G-M Zheng, H Wu, G-Z Hu, M Bai, E-P Xu. Prevalence, resistance phenotypes, and fluoroquinolone resistance genes of Salmonella isolates from raw milk of healthy dairy cows in Henan province, China.
European review for medical and pharmacological sciences.
2022 09; 26(18):6837-6844. doi:
10.26355/eurrev_202209_29786. [PMID: 36196732] - Jiangang Ma, Wei Zhou, Jing Wu, Xiaofeng Liu, Jiahui Lin, Xiaofeng Ji, Hui Lin, Jianmei Wang, Han Jiang, Qianjin Zhou, Guoping Zhao, Hua Yang, Biao Tang. Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China.
Microbiology spectrum.
2022 08; 10(4):e0201522. doi:
10.1128/spectrum.02015-22. [PMID: 35950758] - Samiah Hamad S Al-Mijalli, Ashwag Y Shami, Rasha A Al-Salem, Nawaf M Alnafisi. Development of Diagnostic Capabilities for Complications of Bacterial Infection in Diabetic Patients.
The review of diabetic studies : RDS.
2022 Jun; 18(2):135-139. doi:
10.1900/rds.2022.18.135. [PMID: 35831935] - Carla Bastida, María Hernández-Tejero, Marcial Cariqueo, Fátima Aziz, Virginia Fortuna, Miquel Sanz, Mercè Brunet, Javier Fernández, Dolors Soy. Tigecycline population pharmacokinetics in critically ill patients with decompensated cirrhosis and severe infections.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1365-1371. doi:
10.1093/jac/dkac036. [PMID: 35178567] - Jiangang Zhang, Jinru Xie, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, Hui Wang. Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.
Microbiology spectrum.
2022 02; 10(1):e0159321. doi:
10.1128/spectrum.01593-21. [PMID: 35044218] - Francesca Martelli, Manal AbuOun, Shaun Cawthraw, Nathaniel Storey, Olivia Turner, Matthew Ellington, Satheesh Nair, Anais Painset, Christopher Teale, Muna F Anjum. Detection of the transferable tigecycline resistance gene tet(X4) in Escherichia coli from pigs in the United Kingdom.
The Journal of antimicrobial chemotherapy.
2022 02; 77(3):846-848. doi:
10.1093/jac/dkab439. [PMID: 34897485] - Cuihong Tong, Danyu Xiao, Longfei Xie, Jintao Yang, Ruonan Zhao, Jie Hao, Zhipeng Huo, Zhenling Zeng, Wenguang Xiong. Swine manure facilitates the spread of antibiotic resistome including tigecycline-resistant tet(X) variants to farm workers and receiving environment.
The Science of the total environment.
2022 Feb; 808(?):152157. doi:
10.1016/j.scitotenv.2021.152157. [PMID: 34871697] - Tian Wei, Chengyun Zou, Jie Qin, Jianmin Tao, Li Yan, Jiangjun Wang, Hong Du, Fang Shen, Yanqin Zhao, Haiying Wang. Emergence of Hypervirulent ST11-K64 Klebsiella pneumoniae Poses a Serious Clinical Threat in Older Patients.
Frontiers in public health.
2022; 10(?):765624. doi:
10.3389/fpubh.2022.765624. [PMID: 35309213] - G Dimopoulos, M P Almyroudi, I Kapralos, O Apostolopoulou, A Flevari, D P Nicolau, A Dokoumetzidis. Intrapulmonary pharmacokinetics of high doses of tigecycline in patients with ventilator-associated pneumonia.
International journal of antimicrobial agents.
2022 Jan; 59(1):106487. doi:
10.1016/j.ijantimicag.2021.106487. [PMID: 34843925] - Yanyan Xu, Yajun Ren, Yanyan Zhu, Xiayan Zhang, Zhenbo Wu, Ziwei Mei, Jieru Hu, Yuhe Li, Xiaoyu Chen, Ni Huang, Xi Xu, Haixiang Wang, Jilai Tian. Preparation, characterization, and antibacterial activity of tigecycline-loaded, ultrasound-activated microbubbles.
Pharmaceutical development and technology.
2022 Jan; 27(1):1-8. doi:
10.1080/10837450.2021.2017967. [PMID: 34895029] - Rong-Min Zhang, Jian Sun, Ruan-Yang Sun, Min-Ge Wang, Chao-Yue Cui, Liang-Xing Fang, Mei-Na Liao, Xiao-Qing Lu, Yong-Xin Liu, Xiao-Ping Liao, Ya-Hong Liu. Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X).
Microbiology spectrum.
2021 12; 9(3):e0116421. doi:
10.1128/spectrum.01164-21. [PMID: 34935428] - Yongchang Xu, Lizhang Liu, Huimin Zhang, Youjun Feng. Co-production of Tet(X) and MCR-1, two resistance enzymes by a single plasmid.
Environmental microbiology.
2021 12; 23(12):7445-7464. doi:
10.1111/1462-2920.15425. [PMID: 33559156] - Sara Akalay, Thomas Vanassche, Paul De Munter. Tigecycline-induced life-threatening coagulopathy in a patient with a Mycobacterium abscess: a case report and step-by-step diagnostic approach.
Acta clinica Belgica.
2021 Oct; 76(5):410-414. doi:
10.1080/17843286.2020.1747197. [PMID: 32255411] - Aman Bajpai, Nakshi Nayan Desai, Shalini Pandey, Chinmayee Shukla, Bhaskar Datta, Sudipta Basu. Nanoparticle-Mediated Routing of Antibiotics into Mitochondria in Cancer Cells.
ACS applied bio materials.
2021 09; 4(9):6799-6806. doi:
10.1021/acsabm.1c00527. [PMID: 35006980] - Liang Cai, Lingti Kong, Chenchen Wu, Desheng Wu, Xiaofei Wu. Pharmacokinetics of tigecycline in both plasma and sputum in patients with severe pneumonia.
Journal of global antimicrobial resistance.
2021 09; 26(?):1-3. doi:
10.1016/j.jgar.2021.04.023. [PMID: 34020074] - Bercemhan Yazirli, Emre Kara, Ahmet Cagkan Inkaya, Sarpcan Maden, Ugur Ozberk, Tolga Yildirim, Erkan Parlak, Omrum Uzun, Seref Rahmi Yilmaz, Mustafa Arici. A case report of tigecycline induced acute pancreatitis in a renal transplant patient and review of the literature: Should we avoid tigecycline in patients on calcineurin inhibitors?.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13593. doi:
10.1111/tid.13593. [PMID: 33655683] - Zhi-Qiang Wang, Zhi-Liang Guo, Hao Feng, Cheng Fu, Guang-Yuan Zhao, Ke Ma, Lan Zhu, Gang Chen. Treatment of Donor-derived Carbapenem-resistant Klebsiella pneumoniae Infection after Renal Transplantation with Tigecycline and Extended-infusion Meropenem.
Current medical science.
2021 Aug; 41(4):770-776. doi:
10.1007/s11596-021-2397-z. [PMID: 34403102] - Yangang Zhou, Ping Xu, Huande Li, Feng Wang, Han Yan, Wu Liang, Daxiong Xiang, Bikui Zhang, Hoan Linh Banh. Population pharmacokinetics and exposure-response analysis of tigecycline in patients with hospital-acquired pneumonia.
British journal of clinical pharmacology.
2021 07; 87(7):2838-2846. doi:
10.1111/bcp.14692. [PMID: 33283892] - Yulin Fu, Yiqiang Chen, Dejun Liu, Dawei Yang, Zhihai Liu, Yingyu Wang, Jiayi Wang, Xueyang Wang, Xiangyue Xu, Xing Li, Junjia He, Junyao Jiang, Weishuai Zhai, Lingli Huang, Tao He, Xi Xia, Chang Cai, Yang Wang, Haiyang Jiang. Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms.
Journal of hazardous materials.
2021 05; 409(?):124921. doi:
10.1016/j.jhazmat.2020.124921. [PMID: 33421874] - Javad Yasbolaghi Sharahi, Ali Hashemi, Abdollah Ardebili, Sara Davoudabadi. Molecular characteristics of antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains isolated from hospitalized patients in Tehran, Iran.
Annals of clinical microbiology and antimicrobials.
2021 Apr; 20(1):32. doi:
10.1186/s12941-021-00437-8. [PMID: 33906654] - Guoan Wang, Wei Yu, Yushan Cui, Qingyi Shi, Chen Huang, Yonghong Xiao. Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation.
BMC infectious diseases.
2021 Mar; 21(1):307. doi:
10.1186/s12879-021-06000-2. [PMID: 33771113] - Wen Juan Yan, Nan Jing, Shan Mei Wang, Jun Hong Xu, You Hua Yuan, Qi Zhang, A Li Li, Li Hao Chen, Jiang Feng Zhang, Bing Ma, Qiong Ma, Yi Li. Molecular characterization of carbapenem-resistant Enterobacteriaceae and emergence of tigecycline non-susceptible strains in the Henan province in China: a multicentrer study.
Journal of medical microbiology.
2021 Mar; 70(3):. doi:
10.1099/jmm.0.001325. [PMID: 33587030] - Qianqian Lu, Xinxin Xu, Shanshan Song, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu. Development of a monoclonal antibody-based immunochromatographic strip for the rapid detection of tigecycline in human serum.
Analytical methods : advancing methods and applications.
2021 02; 13(6):817-824. doi:
10.1039/d0ay02182b. [PMID: 33502396] - Brianna Kispal, Sandra A N Walker. Monte Carlo simulation evaluation of tigecycline dosing for bacteria with raised minimum inhibitory concentrations in non-critically ill adults.
European journal of clinical pharmacology.
2021 Feb; 77(2):197-205. doi:
10.1007/s00228-020-02998-7. [PMID: 32975650] - Kaihang Yu, Weiliang Zeng, Ye Xu, Wenli Liao, Wenya Xu, Tieli Zhou, Jianming Cao, Lijiang Chen. Bloodstream infections caused by ST2 Acinetobacter baumannii: risk factors, antibiotic regimens, and virulence over 6 years period in China.
Antimicrobial resistance and infection control.
2021 01; 10(1):16. doi:
10.1186/s13756-020-00876-6. [PMID: 33461617] - Guangjun Fan, Liu Jin, Hansheng Bai, Kang Jiang, Jiao Xie, Yalin Dong. Safety and Efficacy of Tigecycline in Intensive Care Unit Patients Based on Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2020 12; 42(6):835-840. doi:
10.1097/ftd.0000000000000784. [PMID: 32858577] - Yingying Cheng, Yong Chen, Yang Liu, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou. Identification of novel tetracycline resistance gene tet(X14) and its co-occurrence with tet(X2) in a tigecycline-resistant and colistin-resistant Empedobacter stercoris.
Emerging microbes & infections.
2020 Dec; 9(1):1843-1852. doi:
10.1080/22221751.2020.1803769. [PMID: 32731802] - D Chen, H Li, Y Zhao, Y Qiu, L Xiao, H He, D Zheng, X Li, L Huang, X Yu, N Xu, X Hu, Y Chen, F Chen. Characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital in Fuzhou, China.
Journal of applied microbiology.
2020 Nov; 129(5):1220-1226. doi:
10.1111/jam.14700. [PMID: 32396222] - Hubert Ziółkowski, Agnieszka Jasiecka-Mikołajczyk, Hanna Madej-Śmiechowska, Joanna Janiuk, Aleksandra Zygmuntowicz, Michał Dąbrowski. Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens.
Poultry science.
2020 Oct; 99(10):4750-4757. doi:
10.1016/j.psj.2020.06.038. [PMID: 32988509] - Hong-Huan Zhao, Wai-Jiao Tang, Yuan-Xia Yang, Zhong-Ran Cen, Li-Qing Wang. PK/PD study of tigecycline in severely infected patients with continuous renal replacement therapy.
International journal of clinical pharmacology and therapeutics.
2020 Oct; 58(10):531-538. doi:
10.5414/cp203669. [PMID: 32716292] - Yawei Zhang, Chunjiang Zhao, Qi Wang, Xiaojuan Wang, Hongbin Chen, Henan Li, Feifei Zhang, Hui Wang. Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli.
The Journal of antimicrobial chemotherapy.
2020 09; 75(9):2609-2615. doi:
10.1093/jac/dkaa217. [PMID: 32591806] - David Campany-Herrero, Maria Larrosa-Garcia, Pilar Lalueza-Broto, Lucas Rivera-Sánchez, Juan Espinosa-Pereiro, Jaume Mestre-Torres, Carles Pigrau-Serrallach. Tigecycline-associated hypofibrinogenemia in a real-world setting.
International journal of clinical pharmacy.
2020 Aug; 42(4):1184-1189. doi:
10.1007/s11096-020-01072-7. [PMID: 32504166] - Maryn McKenna. The antibiotic paradox: why companies can't afford to create life-saving drugs.
Nature.
2020 08; 584(7821):338-341. doi:
10.1038/d41586-020-02418-x. [PMID: 32814891] - Avik Ray, Swati Sharma, Shubham Atal, Balakrishnan Sadasivam, Ratinder Jhaj. Tigecycline-Induced Severe Hypoglycemia in a Non-Diabetic Individual: A Case Report and Brief Review of Tigecycline-Induced Severe Hypoglycemia.
The American journal of case reports.
2020 Jul; 21(?):e924556. doi:
10.12659/ajcr.924556. [PMID: 32667905] - Yiming Li, Zhangqi Shen, Shuangyang Ding, Shaolin Wang. A TaqMan-based multiplex real-time PCR assay for the rapid detection of tigecycline resistance genes from bacteria, faeces and environmental samples.
BMC microbiology.
2020 06; 20(1):174. doi:
10.1186/s12866-020-01813-8. [PMID: 32571294] - Yulin Fu, Dejun Liu, Huangwei Song, Zhihai Liu, Haiyang Jiang, Yang Wang. Development of a Multiplex Real-Time PCR Assay for Rapid Detection of Tigecycline Resistance Gene tet(X) Variants from Bacterial, Fecal, and Environmental Samples.
Antimicrobial agents and chemotherapy.
2020 03; 64(4):. doi:
10.1128/aac.02292-19. [PMID: 32041710] - Kairav J Shah, Kartikeya Cherabuddi, Kalynn B Pressly, Kaitlyn L Wright, Ashutosh Shukla. Clostridioides difficile associated peritonitis in peritoneal dialysis patients - a case series based review of an under-recognized entity with therapeutic challenges.
BMC nephrology.
2020 03; 21(1):76. doi:
10.1186/s12882-020-01734-8. [PMID: 32131755] - Guolian Xia, Ronglin Jiang. Clinical study on the safety and efficacy of high-dose tigecycline in the elderly patients with multidrug-resistant bacterial infections: A retrospective analysis.
Medicine.
2020 Mar; 99(10):e19466. doi:
10.1097/md.0000000000019466. [PMID: 32150105] - Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem, Vincent O Rotimi. Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.
BMC microbiology.
2020 01; 20(1):14. doi:
10.1186/s12866-020-1703-4. [PMID: 31941446] - Kai Ming Chow, Wing Fai Pang, Gordon Chun Kau Chan, Chi Bon Leung, Cheuk Chun Szeto, Philip Kam Tao Li. Beware of drug interaction between tigecycline and tacrolimus.
Nephrology (Carlton, Vic.).
2020 01; 25(1):99-100. doi:
10.1111/nep.13594. [PMID: 31099103] - Paolo Gaibani, Donatella Lombardo, Michele Bartoletti, Simone Ambretti, Caterina Campoli, Maddalena Giannella, Sara Tedeschi, Matteo Conti, Rita Mancini, Maria Paola Landini, Maria Carla Re, Pierluigi Viale, Russell E Lewis. Comparative serum bactericidal activity of meropenem-based combination regimens against extended-spectrum beta-lactamase and KPC-producing Klebsiella pneumoniae.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2019 Oct; 38(10):1925-1931. doi:
10.1007/s10096-019-03628-6. [PMID: 31278562] - Rong Zhang, Yan-Yan Hu, Hong-Wei Zhou, Shao-Lin Wang, Ling-Bin Shu, Gong-Xiang Chen. Emergence of mcr-1 and the tet(A) variant in a Klebsiella pneumoniae isolate from the faeces of a healthy person.
Journal of medical microbiology.
2019 09; 68(9):1267-1268. doi:
10.1099/jmm.0.000932. [PMID: 31329094] - Wejdene Mansour, Raoudha Grami, Nadia Jaidane, Aziza Messaoudi, Karama Charfi, Lotfi Ben Romdhane, Anis Bel Haj Khalifa, Mohamed Khedher, Noureddine Boujaafar, Olfa Bouallègue, Hedi Mammeri. Epidemiology and Whole-Genome Analysis of NDM-1-Producing Klebsiella pneumoniae KP3771 from Tunisia.
Microbial drug resistance (Larchmont, N.Y.).
2019 Jun; 25(5):644-651. doi:
10.1089/mdr.2018.0204. [PMID: 30614778] - Yangang Zhou, Xumin Chen, Ping Xu, Yan Zhu, Kuangguo Wang, Daxiong Xiang, Feng Wang, Hoan Linh Banh. Clinical experience with tigecycline in the treatment of hospital-acquired pneumonia caused by multidrug resistant Acinetobacter baumannii.
BMC pharmacology & toxicology.
2019 04; 20(1):19. doi:
10.1186/s40360-019-0300-3. [PMID: 31023357] - Baher I Salman, Marwa F B Ali, Mostafa A Marzouq, Samiha A Hussein. Utility of the fluorogenic characters of benzofurazan for analysis of tigecycline using spectrometric technique; application to pharmacokinetic study, urine and pharmaceutical formulations.
Luminescence : the journal of biological and chemical luminescence.
2019 Mar; 34(2):175-182. doi:
10.1002/bio.3590. [PMID: 30637925] - Stelios F Assimakopoulos, Vassilis Karamouzos, Aikaterini Lefkaditi, Christina Sklavou, Fevronia Kolonitsiou, Mirto Christofidou, Fotini Fligou, Charalambos Gogos, Markos Marangos. Triple combination therapy with high-dose ampicillin/sulbactam, high-dose tigecycline and colistin in the treatment of ventilator-associated pneumonia caused by pan-drug resistant Acinetobacter baumannii: a case series study.
Le infezioni in medicina.
2019 Mar; 27(1):11-16. doi:
NULL. [PMID: 30882373] - Bing Leng, Yuan Chao Xue, Wen Zhang, Tian Tian Gao, Gen Quan Yan, Hui Tang. A Retrospective Analysis of the Effect of Tigecycline on Coagulation Function.
Chemical & pharmaceutical bulletin.
2019; 67(3):258-264. doi:
10.1248/cpb.c18-00844. [PMID: 30828002] - Ming-Jen Kuo, Chou-Pin Kuo, Szu-Ying Chu, Der-Cherng Tarng, Wei-Cheng Tseng. The Case A 71-year-old man with fever, acute kidney injury, and a black crustaceous lesion.
Kidney international.
2019 01; 95(1):239-240. doi:
10.1016/j.kint.2018.09.008. [PMID: 30606424] - A Broeker, S G Wicha, C Dorn, A Kratzer, M Schleibinger, F Kees, A Heininger, M G Kees, H Häberle. Tigecycline in critically ill patients on continuous renal replacement therapy: a population pharmacokinetic study.
Critical care (London, England).
2018 12; 22(1):341. doi:
10.1186/s13054-018-2278-4. [PMID: 30558639] - A Jasiecka-Mikołajczyk, J J Jaroszewski, T Maślanka. Effect of tigecycline on the production of selected cytokines and counts of murine CD4+ and CD8+ T cells - an in vitro study.
Polish journal of veterinary sciences.
2018 Dec; 21(4):819-822. doi:
10.24425/pjvs.2018.125994. [PMID: 30605291] - Xin-Ping Zhou, Xiu-Jin Ye, Jian-Ping Shen, Jian-Ping Lan, Hui-Fang Jiang, Jin Zhang, Xue-Jin Zhang, Li Li, Shen-Xian Qian, Hong-Yan Tong. Salvage tigecycline in high risk febrile neutropenic patients with hematological malignancies: a prospective multicenter study.
Leukemia & lymphoma.
2018 11; 59(11):2679-2685. doi:
10.1080/10428194.2018.1436173. [PMID: 29448851] - Huixian Tong, Juxiang Liu, Xiaohui Yao, Haiyan Jia, Jianchao Wei, Donghua Shao, Ke Liu, Yafeng Qiu, Zhiyong Ma, Beibei Li. High carriage rate of mcr-1 and antimicrobial resistance profiles of mcr-1-positive Escherichia coli isolates in swine faecal samples collected from eighteen provinces in China.
Veterinary microbiology.
2018 Nov; 225(?):53-57. doi:
10.1016/j.vetmic.2018.09.018. [PMID: 30322533] - Ona Rogiers, Michelle Holtappels, Wafi Siala, Mohamed Lamkanfi, Françoise Van Bambeke, Katrien Lagrou, Patrick Van Dijck, Sona Kucharíková. Anidulafungin increases the antibacterial activity of tigecycline in polymicrobial Candida albicans/Staphylococcus aureus biofilms on intraperitoneally implanted foreign bodies.
The Journal of antimicrobial chemotherapy.
2018 10; 73(10):2806-2814. doi:
10.1093/jac/dky246. [PMID: 30010876] - Jennifer K Bender, Vincent Cattoir, Kristin Hegstad, Ewa Sadowy, Teresa M Coque, Henrik Westh, Anette M Hammerum, Kirsten Schaffer, Karen Burns, Stephen Murchan, Carla Novais, Ana R Freitas, Luísa Peixe, Maria Del Grosso, Annalisa Pantosti, Guido Werner. Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
2018 09; 40(?):25-39. doi:
10.1016/j.drup.2018.10.002. [PMID: 30447411] - Haejeong Lee, Jin Yang Baek, So Yeon Kim, HyunJi Jo, KyeongJin Kang, Jae-Hoon Ko, Sun Young Cho, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko. Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.
Journal of microbiology (Seoul, Korea).
2018 Sep; 56(9):665-672. doi:
10.1007/s12275-018-8130-3. [PMID: 30141159] - Eleni Mylona, Vasilios Papastamopoulos, Myrto Giannopoulou, Efstathia Perivolioti, Zoi Psaroudaki, Athanasios Skoutelis. Lymphocutaneous nocardiosis in a kidney transplant patient successfully treated with tigecycline.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2018 Sep; 29(5):1207-1210. doi:
10.4103/1319-2442.243954. [PMID: 30381521] - Danxia Gu, Huoyang Lv, Qiaoling Sun, Lingbin Shu, Rong Zhang. Emergence of tet(A) and blaKPC-2 co-carrying plasmid from a ST11 hypervirulent Klebsiella pneumoniae isolate in patient's gut.
International journal of antimicrobial agents.
2018 08; 52(2):307-308. doi:
10.1016/j.ijantimicag.2018.06.003. [PMID: 29898411] - Rong Zhang, Ning Dong, Yonglu Huang, Hongwei Zhou, Miaomiao Xie, Edward Wai-Chi Chan, Yanyan Hu, Jiachang Cai, Sheng Chen. Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract.
Emerging microbes & infections.
2018 Jul; 7(1):127. doi:
10.1038/s41426-018-0129-7. [PMID: 29985412] - Toyotaka Sato, Kazuki Harada, Masaru Usui, Yuzo Tsuyuki, Tsukasa Shiraishi, Yutaka Tamura, Shin-Ichi Yokota. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages.
Microbial drug resistance (Larchmont, N.Y.).
2018 Jul; 24(6):860-867. doi:
10.1089/mdr.2017.0184. [PMID: 29232167] - Hao-Yuan Lee, Shih-Yun Hsu, Jen-Fu Hsu, Chyi-Liang Chen, Yi-Hsin Wang, Cheng-Hsun Chiu. Risk factors and molecular epidemiology of Acinetobacter baumannii bacteremia in neonates.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2018 Jun; 51(3):367-376. doi:
10.1016/j.jmii.2017.07.013. [PMID: 28830746] - Jinwen Lin, Rending Wang, Jianghua Chen. Tigecycline-induced acute pancreatitis in a renal transplant patient: a case report and literature review.
BMC infectious diseases.
2018 05; 18(1):201. doi:
10.1186/s12879-018-3103-z. [PMID: 29720098] - Christoph Dorn, Alexander Kratzer, Uwe Liebchen, Michael Schleibinger, Alexandra Murschhauser, Jens Schlossmann, Frieder Kees, Philipp Simon, Martin G Kees. Impact of Experimental Variables on the Protein Binding of Tigecycline in Human Plasma as Determined by Ultrafiltration.
Journal of pharmaceutical sciences.
2018 02; 107(2):739-744. doi:
10.1016/j.xphs.2017.09.006. [PMID: 28927988] - Rong Shao, Xingang Li, Yangmin Hu, Jinliang Chen, Honggang Lou, Haibin Dai. Determination of tigecycline in human plasma by LC-MS/MS and its application to population pharmacokinetics study in Chinese patients with hospital-acquired pneumonia.
Biomedical chromatography : BMC.
2018 Feb; 32(2):. doi:
10.1002/bmc.4045. [PMID: 28677837] - A Jasiecka-Mikołajczyk, H Ziółkowski, J J Jaroszewski. Pharmacokinetics of tigecycline in turkeys following different routes of administration.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):e22-e29. doi:
10.1111/jvp.12447. [PMID: 28833289] - Jian Li, Xianghai Yang, Lidan Chen, Xinran Duan, Zhihui Jiang. In Vitro Activity of Various Antibiotics in Combination with Tigecycline Against Acinetobacter baumannii: A Systematic Review and Meta-Analysis.
Microbial drug resistance (Larchmont, N.Y.).
2017 Dec; 23(8):982-993. doi:
10.1089/mdr.2016.0279. [PMID: 28437233] - Lorika S Beukes, Tracy L B King, Stefan Schmidt. Assessment of pit latrines in a peri-urban community in KwaZulu-Natal (South Africa) as a source of antibiotic resistant E. coli strains.
International journal of hygiene and environmental health.
2017 11; 220(8):1279-1284. doi:
10.1016/j.ijheh.2017.08.002. [PMID: 28867170] - Meiping Ye, Baixing Ding, Hongliang Qian, Qingqing Xu, Jianping Jiang, Jinwei Huang, Hongyu Ou, Fupin Hu, Minggui Wang. In vivo development of tigecycline resistance in Klebsiella pneumoniae owing to deletion of the ramR ribosomal binding site.
International journal of antimicrobial agents.
2017 Oct; 50(4):523-528. doi:
10.1016/j.ijantimicag.2017.04.024. [PMID: 28668690] - Linda Tkhawkho, Orna Nitzan, Nina Pastukh, Diana Brodsky, Karen Jackson, Avi Peretz. Antimicrobial susceptibility of Clostridium difficile isolates in Israel.
Journal of global antimicrobial resistance.
2017 09; 10(?):161-164. doi:
10.1016/j.jgar.2017.04.005. [PMID: 28729205] - Mark H Gotfried, Karolyn Horn, Lynne Garrity-Ryan, Stephen Villano, Evan Tzanis, Surya Chitra, Amy Manley, S Ken Tanaka, Keith A Rodvold. Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.01135-17. [PMID: 28696233] - Bo Wang, Jinsong Ao, Dan Yu, Ting Rao, Yuan Ruan, Xiaobin Yao. Inhibition of mitochondrial translation effectively sensitizes renal cell carcinoma to chemotherapy.
Biochemical and biophysical research communications.
2017 08; 490(3):767-773. doi:
10.1016/j.bbrc.2017.06.115. [PMID: 28645610] - Beatrix Wulkersdorfer, David Jaros, Sabine Eberl, Stefan Poschner, Walter Jäger, Enrico Cosentini, Markus Zeitlinger, Richard Schwameis. Human Bile Reduces Antimicrobial Activity of Selected Antibiotics against Enterococcus faecalis and Escherichia coli In Vitro.
Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
10.1128/aac.00527-17. [PMID: 28559254] - Cristina M Ovejero, Jose Antonio Escudero, Daniel Thomas-Lopez, Andreas Hoefer, Gabriel Moyano, Natalia Montero, Carmen Martin-Espada, Bruno Gonzalez-Zorn. Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals.
Antimicrobial agents and chemotherapy.
2017 06; 61(6):. doi:
10.1128/aac.02640-16. [PMID: 28396550] - Adhi Kristianto Sugianli, Franciscus Ginting, R Lia Kusumawati, Emmy Hermiyati Pranggono, Ayodhia Pitaloka Pasaribu, Firza Gronthoud, Suzanne Geerlings, Ida Parwati, Menno D De Jong, Frank Van Leth, Constance Schultsz. Antimicrobial resistance in uropathogens and appropriateness of empirical treatment: a population-based surveillance study in Indonesia.
The Journal of antimicrobial chemotherapy.
2017 05; 72(5):1469-1477. doi:
10.1093/jac/dkw578. [PMID: 28137940] - Ravi Shankar Prasad Singh, Jatinder Kaur Mukker, Stefanie K Drescher, Amelia N Deitchman, Hartmut Derendorf. A need to revisit clinical breakpoints of tigecycline: effect of atypical non-linear plasma protein binding.
International journal of antimicrobial agents.
2017 Apr; 49(4):449-455. doi:
10.1016/j.ijantimicag.2016.12.008. [PMID: 28237830] - A Jasiecka-Mikołajczyk, J J Jaroszewski. Determination of tigecycline in turkey plasma by LC-MS/MS: validation and application in a pharmacokinetic study.
Polish journal of veterinary sciences.
2017 Mar; 20(2):241-249. doi:
10.1515/pjvs-2017-0029. [PMID: 28865218] - Jonathan McMahan, Ryan P Moenster. Tigecycline-induced coagulopathy.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2017 02; 74(3):130-134. doi:
10.2146/ajhp150894. [PMID: 28122754] - Tyler Liebenstein, Lucas T Schulz, Chris Viesselmann, Emma Bingen, Jackson Musuuza, Nasia Safdar, Warren E Rose. Effectiveness and Safety of Tigecycline Compared with Other Broad-Spectrum Antimicrobials in Abdominal Solid Organ Transplant Recipients with Polymicrobial Intraabdominal Infections.
Pharmacotherapy.
2017 02; 37(2):151-158. doi:
10.1002/phar.1883. [PMID: 27983753] - Jun Tan, Meijun Song, Mi Zhou, Yaoren Hu. Antibiotic tigecycline enhances cisplatin activity against human hepatocellular carcinoma through inducing mitochondrial dysfunction and oxidative damage.
Biochemical and biophysical research communications.
2017 01; 483(1):17-23. doi:
10.1016/j.bbrc.2017.01.021. [PMID: 28069382] - Valerio Del Bono, Daniele Roberto Giacobbe, Anna Marchese, Andrea Parisini, Carmen Fucile, Erika Coppo, Valeria Marini, Antonio Arena, Alexandre Molin, Antonietta Martelli, Angelo Gratarola, Claudio Viscoli, Paolo Pelosi, Francesca Mattioli. Meropenem for treating KPC-producing Klebsiella pneumoniae bloodstream infections: Should we get to the PK/PD root of the paradox?.
Virulence.
2017 01; 8(1):66-73. doi:
10.1080/21505594.2016.1213476. [PMID: 27430122] - Marilena Tsala, Sophia Vourli, George L Daikos, Athanassios Tsakris, Loukia Zerva, Johan W Mouton, Joseph Meletiadis. Impact of bacterial load on pharmacodynamics and susceptibility breakpoints for tigecycline and Klebsiella pneumoniae.
The Journal of antimicrobial chemotherapy.
2017 01; 72(1):172-180. doi:
10.1093/jac/dkw354. [PMID: 27650184] - Huale Chen, Jianming Cao, Cui Zhou, Haiyang Liu, Xiaoxiao Zhang, Tieli Zhou. Biofilm Formation Restrained by Subinhibitory Concentrations of Tigecyclin in Acinetobacter baumannii Is Associated with Downregulation of Efflux Pumps.
Chemotherapy.
2017; 62(2):128-133. doi:
10.1159/000450537. [PMID: 27816975] - Hong Jiang, Luxi Cao, Qixia Shen, Lihui Qu, Yan Jiang, Tingting Qu, Jian Zhang, Yingying Lu, Bingjue Li, Chaohong Zhu, Guangjun Liu, Rending Wang, Miao Chen, Yucheng Wang, Yanfei Wang, Shi Feng, Junwen Wang, Yunsong Yu, Jianyong Wu, Jianghua Chen. Whole-Genome Analysis of an Extensive Drug-Resistant Acinetobacter Baumannii ST195 Isolate from a Recipient After DCD Renal Transplantation in China.
Kidney & blood pressure research.
2017; 42(6):1247-1257. doi:
10.1159/000485928. [PMID: 29248914] - Zhijie Pan, Rong Liu, Pei Zhang, Hua Zhou, Yiqi Fu, Jianying Zhou. Combination of Tigecycline and Levofloxacin for Successful Treatment of Nosocomial Pneumonia Caused by New Delhi Metallo-β-Lactamase-1-Producing Raoultella planticola.
Microbial drug resistance (Larchmont, N.Y.).
2017 Jan; 23(1):127-131. doi:
10.1089/mdr.2015.0346. [PMID: 27754764] - Shenghui Mei, Xuying Luo, Xingang Li, Qian Li, Jiping Huo, Li Yang, Leting Zhu, Weixing Feng, Jianxin Zhou, Guangzhi Shi, Zhigang Zhao. Development and validation of an LC-MS/MS method for the determination of tigecycline in human plasma and cerebrospinal fluid and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2016 Dec; 30(12):1992-2002. doi:
10.1002/bmc.3776. [PMID: 27245381] - Ravi Shankar Prasad Singh, Jatinder Kaur Mukker, Amelia N Deitchman, Stephanie K Drescher, Hartmut Derendorf. Role of Divalent Metal Ions in Atypical Nonlinear Plasma Protein Binding Behavior of Tigecycline.
Journal of pharmaceutical sciences.
2016 11; 105(11):3409-3414. doi:
10.1016/j.xphs.2016.07.013. [PMID: 27616672] - J Osei Sekyere, U Govinden, L A Bester, S Y Essack. Colistin and tigecycline resistance in carbapenemase-producing Gram-negative bacteria: emerging resistance mechanisms and detection methods.
Journal of applied microbiology.
2016 Sep; 121(3):601-17. doi:
10.1111/jam.13169. [PMID: 27153928] - T R Nimal, Gaurav Baranwal, M C Bavya, Raja Biswas, R Jayakumar. Anti-staphylococcal Activity of Injectable Nano Tigecycline/Chitosan-PRP Composite Hydrogel Using Drosophila melanogaster Model for Infectious Wounds.
ACS applied materials & interfaces.
2016 Aug; 8(34):22074-83. doi:
10.1021/acsami.6b07463. [PMID: 27508491] - Meritxell García-Quintanilla, José M Caro-Vega, Marina R Pulido, Patricia Moreno-Martínez, Jerónimo Pachón, Michael J McConnell. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):5076-9. doi:
10.1128/aac.00407-16. [PMID: 27270288] - Maria Lina Mezzatesta, Carla Caio, Floriana Gona, Tiziana Zingali, Iasmine Salerno, Stefania Stefani. Colistin Increases the Cidal Activity of Antibiotic Combinations Against Multidrug-Resistant Klebsiella pneumoniae: An In Vitro Model Comparing Multiple Combination Bactericidal Testing at One Peak Serum Concentration and Time-Kill Method.
Microbial drug resistance (Larchmont, N.Y.).
2016 Jul; 22(5):360-3. doi:
10.1089/mdr.2015.0160. [PMID: 26909754] - Marius Linkevicius, Jytte Mark Anderssen, Linus Sandegren, Dan I Andersson. Fitness of Escherichia coli mutants with reduced susceptibility to tigecycline.
The Journal of antimicrobial chemotherapy.
2016 May; 71(5):1307-13. doi:
10.1093/jac/dkv486. [PMID: 26851608] - George G Zhanel, Doris Cheung, Heather Adam, Sheryl Zelenitsky, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew Walkty, Alfred S Gin, Daryl J Hoban, James A Karlowsky. Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent.
Drugs.
2016 Apr; 76(5):567-88. doi:
10.1007/s40265-016-0545-8. [PMID: 26863149] - Pallavi Thakur, Raman Chawla, Ankita Singh Chakotiya, Ankit Tanwar, Rajeev Goel, Alka Narula, Rajesh Arora, Rakesh Kumar Sharma. Camellia sinensis Ameliorates the Efficacy of Last Line Antibiotics Against Carbapenem Resistant Escherichia coli.
Phytotherapy research : PTR.
2016 Feb; 30(2):314-22. doi:
10.1002/ptr.5535. [PMID: 26620305] - Magnus von Seth, Jan Sjölin, Anders Larsson, Mats Eriksson, Lars Hillered, Miklós Lipcsey. Effects of tigecycline and doxycycline on inflammation and hemodynamics in porcine endotoxemia: a prospective, randomized, and placebo-controlled trial.
Shock (Augusta, Ga.).
2015 Jun; 43(6):604-11. doi:
10.1097/shk.0000000000000351. [PMID: 25664982] - Sirisha Kundrapu, Kelly Hurless, Venkata C K Sunkesula, Myreen Tomas, Curtis J Donskey. Tigecycline exhibits inhibitory activity against Clostridium difficile in the intestinal tract of hospitalised patients.
International journal of antimicrobial agents.
2015 Apr; 45(4):424-6. doi:
10.1016/j.ijantimicag.2014.11.016. [PMID: 25623897] - Casey M Theriot, Cassie A Schumacher, Christine M Bassis, Anna M Seekatz, Vincent B Young. Effects of tigecycline and vancomycin administration on established Clostridium difficile infection.
Antimicrobial agents and chemotherapy.
2015 Mar; 59(3):1596-604. doi:
10.1128/aac.04296-14. [PMID: 25547352]