Angiotensin (1-7) (BioDeep_00000837829)

 

Secondary id: BioDeep_00000010942


代谢物信息卡片


Angiotensin I/II (1-7) trifluoroacetate salt

化学式: C41H62N12O11 (898.4660782)
中文名称: 血管紧张素 (1-7)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

描述信息

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C307 - Biological Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].

同义名列表

5 个代谢物同义名

Angiotensin I/II (1-7) trifluoroacetate salt; Angiotensin (1-7); TXA127; Ang-(1-7); Talfirastide



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(2)

PathBank(0)

PharmGKB(1)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Na Li, Qiongyu Zhang, Shiyu Dai, Wenzhuo Rao, Haitao Shi, Li Ding, Meiling Hong. Angiotensin-(1-7) plays an important role in regulating spermatogenesis in Trachemys scripta elegans under salinity stress. The Journal of experimental biology. 2024 Jan; 227(2):. doi: 10.1242/jeb.246742. [PMID: 38149682]
  • Dan Ye, Jiamin Liu, Long Lin, Pengwei Hou, Tianshun Feng, Shousen Wang. The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia. PloS one. 2024; 19(5):e0303150. doi: 10.1371/journal.pone.0303150. [PMID: 38728304]
  • Jose A Godoy-Lugo, Dora A Mendez, Ruben Rodriguez, Akira Nishiyama, Daisuke Nakano, Jose G Soñanez-Organis, Rudy M Ortiz. Improved lipogenesis gene expression in liver is associated with elevated plasma angiotensin 1-7 after AT1 receptor blockade in insulin-resistant OLETF rats. Molecular and cellular endocrinology. 2022 09; 555(?):111729. doi: 10.1016/j.mce.2022.111729. [PMID: 35921918]
  • Xin-Yue Liu, Jing-Chao Su, Xin-Fang Zhang, Shui-Ying Xiang, Chun-Mei Yi, Yu-Wen Wang, Cai-Yun Wang, Zi-Bing Liu. [Electroacupuncture preconditioning improves pulmonary function via inhibiting inflammatory response and up-regulating expression of ACE2 and Ang (1-7) in lipopolysaccharide-induced acute lung injury rats]. Zhen ci yan jiu = Acupuncture research. 2022 Aug; 47(8):684-9. doi: 10.13702/j.1000-0607.20210979. [PMID: 36036101]
  • Elshymaa A Abdel-Hakeem, Sara Mohamed Naguib Abdel Hafez, Bothina A Kamel, Heba A Abdel-Hamid. Angiotensin 1-7 mitigates rhabdomyolysis induced renal injury in rats via modulation of TLR-4/NF-kB/iNOS and Nrf-2/heme‑oxygenase-1 signaling pathways. Life sciences. 2022 Aug; 303(?):120678. doi: 10.1016/j.lfs.2022.120678. [PMID: 35654118]
  • Andrzej K Ciechanowicz, Wen Xin Lay, Jefte Prado Paulino, Erika Suchocki, Susanne Leszczak, Christian Leszczak, Magdalena Kucia. Angiotensin 1-7 Stimulates Proliferation of Lung Bronchoalveolar Progenitors-Implications for SARS-CoV-2 Infection. Cells. 2022 Jul; 11(13):. doi: 10.3390/cells11132102. [PMID: 35805187]
  • Asif Zaman, Anees A Banday. Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats. American journal of physiology. Renal physiology. 2022 07; 323(1):F33-F47. doi: 10.1152/ajprenal.00283.2021. [PMID: 35532070]
  • Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukla. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022 05; 13(10):1491-1504. doi: 10.1021/acschemneuro.1c00797. [PMID: 35533351]
  • Yi Xu, Fang Zhang, Chunhui Li, Huiyao Hao, Yongmei Hao. Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels. Peptides. 2022 05; 151(?):170765. doi: 10.1016/j.peptides.2022.170765. [PMID: 35181349]
  • Mauro G Silva, Nora L Falcoff, Gerardo R Corradi, José Alfie, Rolando F Seguel, Gabriela C Tabaj, Laura I Iglesias, Myriam Nuñez, Gabriela R Guman, Mariela M Gironacci. Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes. Life sciences. 2022 Mar; 293(?):120324. doi: 10.1016/j.lfs.2022.120324. [PMID: 35032553]
  • Che Mohd Nasril Che Mohd Nassir, Mohd K I Zolkefley, Muhammad Danial Ramli, Haziq Hazman Norman, Hafizah Abdul Hamid, Muzaimi Mustapha. Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063085. [PMID: 35328506]
  • Marta Kuczeriszka, Leszek Dobrowolski, Agnieszka Walkowska, Iwona Baranowska, Joanna D Sitek, Elżbieta Kompanowska-Jezierska. Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats. Clinical and experimental pharmacology & physiology. 2022 03; 49(3):432-441. doi: 10.1111/1440-1681.13618. [PMID: 34870864]
  • Kaiming Wang, Mahmoud Gheblawi, Anish Nikhanj, Matt Munan, Erika MacIntyre, Conar O'Neil, Marko Poglitsch, Daniele Colombo, Franca Del Nonno, Zamaneh Kassiri, Wendy Sligl, Gavin Y Oudit. Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):365-378. doi: 10.1161/hypertensionaha.121.18295. [PMID: 34844421]
  • Hala Attia, Norah Albekairi, Layal Albdeirat, Arwa Soliman, Reem Rajab, Hend Alotaibi, Rehab Ali, Amira Badr. Chrysin Attenuates Fructose-Induced Nonalcoholic Fatty Liver in Rats via Antioxidant and Anti-Inflammatory Effects: The Role of Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis. Oxidative medicine and cellular longevity. 2022; 2022(?):9479456. doi: 10.1155/2022/9479456. [PMID: 35720181]
  • Santoshi Sahu, C R Patil, Sachin Kumar, Subbu Apparsundaram, Ramesh K Goyal. Role of ACE2-Ang (1-7)-Mas axis in post-COVID-19 complications and its dietary modulation. Molecular and cellular biochemistry. 2022 Jan; 477(1):225-240. doi: 10.1007/s11010-021-04275-2. [PMID: 34655418]
  • Flavia L Martins, Caio A M Tavares, Pamella A Malagrino, Thiago Rentz, Acaris Benetti, Thiago M S Rios, Gabriel M D Pereira, Bruno Caramelli, Samantha K Teixeira, José E Krieger, Adriana C C Girardi. Sex differences in the lung ACE/ACE2 balance in hypertensive rats. Bioscience reports. 2021 12; 41(12):. doi: 10.1042/bsr20211201. [PMID: 34751382]
  • Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragão, Rodolfo de Paula Vieira, Nádia Bertoncello, Nestor Schor, Flávio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha. Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1-7 axis and reduces inflammation in the kidney of diabetic rats. Life sciences. 2021 Dec; 287(?):120058. doi: 10.1016/j.lfs.2021.120058. [PMID: 34673118]
  • Wei Hu, Wenchuang Gao, Jiayi Miao, Ziheng Xu, Lei Sun. Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways. Peptides. 2021 12; 146(?):170627. doi: 10.1016/j.peptides.2021.170627. [PMID: 34400214]
  • Elaine F Barry, Julie O'Neill, Mohammed H Abdulla, Edward J Johns. The renal excretory responses to acute renal interstitial angiotensin (1-7) infusion in anaesthetised spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. 2021 12; 48(12):1674-1684. doi: 10.1111/1440-1681.13570. [PMID: 34375480]
  • Omar Echeverría-Rodríguez, Beatriz Godínez-Chaparro, María V Gómez-García, Alfonso Mata-Bermúdez, Leonardo Del Valle-Mondragón, Itzell A Gallardo-Ortíz, Rafael Villalobos-Molina. Participation of angiotensin-(1-7) in exercise-induced analgesia in rats with neuropathic pain. Peptides. 2021 12; 146(?):170670. doi: 10.1016/j.peptides.2021.170670. [PMID: 34634392]
  • Taylor Morganstein, Zahraa Haidar, Joshua Trivlidis, Ilan Azuelos, Megan Jiaxin Huang, David H Eidelman, Carolyn J Baglole. Involvement of the ACE2/Ang-(1-7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312955. [PMID: 34884756]
  • Tomas Rajtik, Peter Galis, Linda Bartosova, Ludovit Paulis, Eva Goncalvesova, Jan Klimas. Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312800. [PMID: 34884604]
  • Oliver von Bohlen Und Halbach. The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid. Histology and histopathology. 2021 Nov; 36(11):1125-1131. doi: 10.14670/hh-18-356. [PMID: 34142714]
  • Christina Hoyer-Kimura, John P Konhilas, Heidi M Mansour, Robin Polt, Kristian P Doyle, Dean Billheimer, Meredith Hay. Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia. Journal of neuroinflammation. 2021 Oct; 18(1):236. doi: 10.1186/s12974-021-02281-1. [PMID: 34654436]
  • Juliana Fabiana Gregório, Giselle Santos Magalhães, Maria Glória Rodrigues-Machado, Kézia Emanoeli Ramos Gonzaga, Daisy Motta-Santos, Puebla Cassini-Vieira, Lucíola Silva Barcelos, Maria Aparecida Ribeiro Vieira, Robson Augusto Souza Santos, Maria Jose Campagnole-Santos. Angiotensin-(1-7)/Mas receptor modulates anti-inflammatory effects of exercise training in a model of chronic allergic lung inflammation. Life sciences. 2021 Oct; 282(?):119792. doi: 10.1016/j.lfs.2021.119792. [PMID: 34229006]
  • Daniele T Alves, Luiz Felipe Mendes, Walkyria O Sampaio, Leda M C Coimbra-Campos, Maria Aparecida R Vieira, Anderson J Ferreira, Almir S Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A S Santos, Maria Jose Campagnole-Santos. Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein. Clinical science (London, England : 1979). 2021 09; 135(18):2197-2216. doi: 10.1042/cs20210599. [PMID: 34494083]
  • Xuming Sun, Hao Wang, Hunter Hodge, Kendra N Wright, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats. Translational research : the journal of laboratory and clinical medicine. 2021 09; 235(?):62-76. doi: 10.1016/j.trsl.2021.04.004. [PMID: 33915312]
  • Mohammad Mahmudur Rahman, Maruf Hasan, Asif Ahmed. Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients. Reviews in medical virology. 2021 09; 31(5):1-12. doi: 10.1002/rmv.2213. [PMID: 33426683]
  • Fernanda Ribeiro Marins, Aline Cristina Oliveira, Fatimunnisa Qadri, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Marco Antonio Peliky Fontes, Robson Augusto Souza Santos. Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex. American journal of physiology. Regulatory, integrative and comparative physiology. 2021 09; 321(3):R513-R521. doi: 10.1152/ajpregu.00308.2020. [PMID: 34346721]
  • Mariele Montanari, Barbara Canonico, Evelyn Nordi, Daniela Vandini, Simone Barocci, Serena Benedetti, Eugenio Carlotti, Loris Zamai. Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?. Advances in biological regulation. 2021 08; 81(?):100820. doi: 10.1016/j.jbior.2021.100820. [PMID: 34419773]
  • D Clark Files, Kevin W Gibbs, Christopher L Schaich, Sean P Collins, TanYa M Gwathmey, Jonathan D Casey, Wesley H Self, Mark C Chappell. A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure. American journal of physiology. Lung cellular and molecular physiology. 2021 07; 321(1):L213-L218. doi: 10.1152/ajplung.00129.2021. [PMID: 34009036]
  • Li Zhu, Zhen Liu, Li-Ping Huang, Hou-Rong Zhou, Yu Cao, Xue-Ping Yang, Bing-Jin Wang, Zi-Li Yang, Jing Chen. Angiotensin (1-7) Alleviates Postresuscitation Myocardial Dysfunction by Suppressing Oxidative Stress Through the Phosphoinositide 3-Kinase, Protein Kinase B, and Endothelial Nitric Oxide Synthase Signaling Pathway. Journal of cardiovascular pharmacology. 2021 07; 78(1):e65-e76. doi: 10.1097/fjc.0000000000001037. [PMID: 33929390]
  • Chengliang Wang, Liying Ren, Shankang Chen, Huihui Zheng, Yifan Yang, Tieguang Gu, Yuhao Li, Chunxia Wang. Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats. Journal of ethnopharmacology. 2021 Jun; 274(?):114072. doi: 10.1016/j.jep.2021.114072. [PMID: 33781876]
  • Maha M Abdel-Fattah, Abdel Nasser A M Elgendy, Wafaa R Mohamed. Xanthenone, ACE2 activator, counteracted gentamicin-induced nephrotoxicity in rats: Impact on oxidative stress and ACE2/Ang-(1-7) signaling. Life sciences. 2021 Jun; 275(?):119387. doi: 10.1016/j.lfs.2021.119387. [PMID: 33774027]
  • Elena Cantero-Navarro, Beatriz Fernández-Fernández, Adrian M Ramos, Sandra Rayego-Mateos, Raúl R Rodrigues-Diez, María Dolores Sánchez-Niño, Ana B Sanz, Marta Ruiz-Ortega, Alberto Ortiz. Renin-angiotensin system and inflammation update. Molecular and cellular endocrinology. 2021 06; 529(?):111254. doi: 10.1016/j.mce.2021.111254. [PMID: 33798633]
  • Jorge F Giani, Luciana C Veiras, Justin Z Y Shen, Ellen A Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A Gonzalez-Villalobos, Kenneth E Bernstein. Novel roles of the renal angiotensin-converting enzyme. Molecular and cellular endocrinology. 2021 06; 529(?):111257. doi: 10.1016/j.mce.2021.111257. [PMID: 33781839]
  • Fitra Rianto, Thien Hoang, Ritika Revoori, Matthew A Sparks. Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Molecular and cellular endocrinology. 2021 06; 529(?):111259. doi: 10.1016/j.mce.2021.111259. [PMID: 33781840]
  • Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Magdalena Białas, Magdalena Łomnicka, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Giżycka, Jacek Jawień, Rafał Olszanecki. Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115861. [PMID: 34070749]
  • Ali Aghazadeh-Habashi, Sana Khajehpour. Improved pharmacokinetics and bone tissue accumulation of Angiotensin-(1-7) peptide through bisphosphonate conjugation. Amino acids. 2021 May; 53(5):653-664. doi: 10.1007/s00726-021-02972-2. [PMID: 33791863]
  • Veselina V Uzunova, Angel Todev, Jacqueline Zarkos, Daniel Addai, Julian Ananiev, Pavel Rashev, Radostina Alexandrova, Anna Tolekova. Strengthening CoViD-19 therapy via combinations of RAS modulators. Medical hypotheses. 2021 May; 150(?):110571. doi: 10.1016/j.mehy.2021.110571. [PMID: 33799164]
  • Hiroki Nakano, Kazuki Shiina, Hirofumi Tomiyama. Cardiovascular Outcomes in the Acute Phase of COVID-19. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084071. [PMID: 33920790]
  • Ranjana Tripathi, Ryan D Sullivan, Tai-Hwang M Fan, Radhika M Mehta, Inna P Gladysheva, Guy L Reed. A Low-Sodium Diet Boosts Ang (1-7) Production and NO-cGMP Bioavailability to Reduce Edema and Enhance Survival in Experimental Heart Failure. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084035. [PMID: 33919841]
  • Alexander Kutz, Anna Conen, Claudia Gregoriano, Sebastian Haubitz, Daniel Koch, Oliver Domenig, Luca Bernasconi, Beat Mueller, Philipp Schuetz. Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19. European journal of endocrinology. 2021 Apr; 184(4):543-552. doi: 10.1530/eje-20-1445. [PMID: 33539316]
  • Mark C Chappell, Nancy T Pirro, Andrew M South, TanYa M Gwathmey. Concerns on the Specificity of Commercial ELISAs for the Measurement of Angiotensin (1-7) and Angiotensin II in Human Plasma. Hypertension (Dallas, Tex. : 1979). 2021 03; 77(3):e29-e31. doi: 10.1161/hypertensionaha.120.16724. [PMID: 33399002]
  • Hugo Luca Corrêa, Rodrigo Vanerson Passos Neves, Lysleine Alves Deus, Beatriz Carneiro Habbema Maia, Athila Teles Maya, Carmen Tzanno-Martins, Michel Kendy Souza, José Adeirton Bezerra Silva, Anderson Sola Haro, Fernando Costa, Milton Rocha Moraes, Herbert Gustavo Simões, Jonato Prestes, Whitley Stone, Thiago Santos Rosa. Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1-7 and vasopressin✰,✰✰. Physiology & behavior. 2021 03; 230(?):113295. doi: 10.1016/j.physbeh.2020.113295. [PMID: 33340514]
  • Pawel Namsolleck, Alan Richardson, Gert N Moll, Axel Mescheder. LP2, the first lanthipeptide GPCR agonist in a human pharmacokinetics and safety study. Peptides. 2021 02; 136(?):170468. doi: 10.1016/j.peptides.2020.170468. [PMID: 33253776]
  • Juan Liu, Yan Liu, Wenyou Pan, Yongsheng Li. Angiotensin-(1-7) attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Amino acids. 2021 Feb; 53(2):171-181. doi: 10.1007/s00726-020-02935-z. [PMID: 33398523]
  • Brandon M Henry, Justin L Benoit, Brandon A Berger, Christina Pulvino, Carl J Lavie, Giuseppe Lippi, Stefanie W Benoit. Coronavirus disease 2019 is associated with low circulating plasma levels of angiotensin 1 and angiotensin 1,7. Journal of medical virology. 2021 02; 93(2):678-680. doi: 10.1002/jmv.26479. [PMID: 32880990]
  • Jithin Kuriakose, Augusto C Montezano, Rhian M Touyz. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical science (London, England : 1979). 2021 01; 135(2):387-407. doi: 10.1042/cs20200480. [PMID: 33511992]
  • Prateek Khanna, Hong Jie Soh, Chun-Hau Chen, Ruchi Saxena, Seema Amin, Maura Naughton, Patrick Neset Joslin, Andrew Moore, Ziad Bakouny, Carol O'Callaghan, Paul Catalano, Sabina Signoretti, Rana McKay, Toni K Choueiri, Manoj Bhasin, Thomas Walther, Rupal S Bhatt. ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma. Science translational medicine. 2021 01; 13(577):. doi: 10.1126/scitranslmed.abc0170. [PMID: 33472951]
  • Hsin-Jung Tsai, Chih-Chin Shih, Kuang-Yi Chang, Mei-Hui Liao, Wen-Jinn Liaw, Chin-Chen Wu, Cheng-Ming Tsao. Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats. Scientific reports. 2021 01; 11(1):610. doi: 10.1038/s41598-020-79902-x. [PMID: 33436885]
  • Jingjing Li, Ruifang Zhu, Yalin Liu, Jinhui Yang, Xiaoyan Wang, Lisha Geng, Tingting Xu, Junhua He. Angiotensin-(1-7) Improves Islet Function in a Rat Model of Streptozotocin- Induced Diabetes Mellitus by Up-Regulating the Expression of Pdx1/Glut2. Endocrine, metabolic & immune disorders drug targets. 2021; 21(1):156-162. doi: 10.2174/1871530320666200717161538. [PMID: 32679026]
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