Levalbuterol (BioDeep_00000837588)

Main id: BioDeep_00000001514

 

Volatile Flavor Compounds


代谢物信息卡片


(-)-Salbutamol

化学式: C13H21NO3 (239.1521356)
中文名称: 左旋沙丁胺醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O
InChI: InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/m0/s1

描述信息

C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
Same as: D08124

同义名列表

4 个代谢物同义名

(-)-Salbutamol; Levalbuterol; R-Salbutamol; R-Salbutamol



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Dujuan Zhang, Yanni Teng, Keguang Chen, Sha Liu, Chunmin Wei, Benjie Wang, Guiyan Yuan, Rui Zhang, Xiaoyan Liu, Ruichen Guo. Determination of salbutamol in human plasma and urine using liquid chromatography coupled to tandem mass spectrometry and its pharmacokinetic study. Biomedical chromatography : BMC. 2012 Oct; 26(10):1176-82. doi: 10.1002/bmc.2675. [PMID: 22213268]
  • Zhi-Gang Shen, Wen-Hao Chen, Nital Jugade, Ling-Yan Gao, William Glover, Jin-Ye Shen, Jimmy Yun, Jian-Feng Chen. Fabrication of inhalable spore like pharmaceutical particles for deep lung deposition. International journal of pharmaceutics. 2012 Jul; 430(1-2):98-103. doi: 10.1016/j.ijpharm.2012.03.044. [PMID: 22486960]
  • Marvin A Soriano-Ursúa, Daniel A McNaught-Flores, Gustavo Nieto-Alamilla, Aldo Segura-Cabrera, José Correa-Basurto, José A Arias-Montaño, José G Trujillo-Ferrara. Cell-based and in-silico studies on the high intrinsic activity of two boron-containing salbutamol derivatives at the human β₂-adrenoceptor. Bioorganic & medicinal chemistry. 2012 Jan; 20(2):933-41. doi: 10.1016/j.bmc.2011.11.054. [PMID: 22182578]
  • Sabeeh Mohsin, Nisar-Ur Rahman, Muneeb Ahmad Idrees, Mohammad Khan Sarfraz, Muhammad Khalid Khan, Ghulam Mustafa. Suitability of Gelucire 50/13 for controlled release formulation of salbutamol sulphate. Pakistan journal of pharmaceutical sciences. 2012 Jan; 25(1):35-41. doi: ". [PMID: 22186307]
  • Hulya Uzkeser, Elif Cadirci, Zekai Halici, Fehmi Odabasoglu, Beyzagul Polat, Tugba Nurcan Yuksel, Seda Ozaltin, Fadime Atalay. Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism. Mediators of inflammation. 2012; 2012(?):438912. doi: 10.1155/2012/438912. [PMID: 22665951]
  • Santo Scalia, Rania Salama, Paul Young, Daniela Traini. Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. Journal of microencapsulation. 2012; 29(3):225-33. doi: 10.3109/02652048.2011.646326. [PMID: 22208706]
  • Khalid P Akhter, Mahmood Ahmad, Shujaat Ali Khan, Munazza Ramzan, Ishrat Shafi, Burhana Muryam, Zafar Javed, Ghulam Murtaza. Application of the piecewise rational quadratic interpolant to the AUC calculation in the bioavailability study. Acta poloniae pharmaceutica. 2012 Jan; 69(1):81-5. doi: NULL. [PMID: 22574510]
  • Jingwen Wu, Cungang Ding, Qinghua Ge, Zhou Li, Zhen Zhou, Xiaojin Zhi. Simultaneous determination of ipratropium and salbutamol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3475-83. doi: 10.1016/j.jchromb.2011.09.027. [PMID: 21983198]
  • Eric M Snyder, Eric C Wong, William T Foxx-Lupo, Courtney M Wheatley, Nicholas A Cassuto, Asad E Patanwala. Effects of an inhaled β2-agonist on cardiovascular function and sympathetic activity in healthy subjects. Pharmacotherapy. 2011 Aug; 31(8):748-56. doi: 10.1592/phco.31.8.748. [PMID: 21923601]
  • J Hinkle, J Hinson, E Kerwin, E Goodwin, K Sciarappa, L Curry, J P Hanrahan. A cumulative dose, safety and tolerability study of arformoterol in pediatric subjects with stable asthma. Pediatric pulmonology. 2011 Aug; 46(8):761-9. doi: 10.1002/ppul.21446. [PMID: 21584948]
  • Kwang Choon Yee, Glenn A Jacobson, Richard Wood-Baker, E Haydn Walters. Albuterol enantiomer levels, lung function and QTc interval in patients with acute severe asthma and COPD in the emergency department. International journal of emergency medicine. 2011 Jun; 4(1):30. doi: 10.1186/1865-1380-4-30. [PMID: 21676212]
  • Nicola Scichilone, Chiara Minaldi, Roberta Santagata, Salvatore Battaglia, Gaetana Camarda, Vincenzo Bellia. Anti-inflammatory effects of pre-seasonal Th1-adjuvant vaccine to Parietaria judaica in asthmatics. Journal of asthma and allergy. 2011; 4(?):19-25. doi: 10.2147/jaa.s17784. [PMID: 21660177]
  • Mark Jackson. 'Divine stramonium': the rise and fall of smoking for asthma. Medical history. 2010 Apr; 54(2):171-94. doi: 10.1017/s0025727300000235. [PMID: 20357985]
  • Ajay Punj, Ashish Prakash, Ashu Bhasin. Levosalbutamol vs racemic salbutamol in the treatment of acute exacerbation of asthma. Indian journal of pediatrics. 2009 Nov; 76(11):1131-5. doi: 10.1007/s12098-009-0245-4. [PMID: 20012785]
  • Li Ding, Jun-Shou Zhang. [Isobutane driven salbutamol sulfate metered dose inhaler: formulation selection and respiratory tract absorption in guinea pigs]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Sep; 44(9):1040-5. doi: NULL. [PMID: 20055182]
  • Timothy Andrews, Erin McGintee, Manoj K Mittal, Lisa Tyler, Amber Chew, Xuemei Zhang, Nicholas Pawlowski, Joseph J Zorc. High-dose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. The Journal of pediatrics. 2009 Aug; 155(2):205-10.e1. doi: 10.1016/j.jpeds.2009.01.073. [PMID: 19464028]
  • Z Chik, R C Basu, R Pendek, T C Lee, Z Mohamed. Comparative bioavailability study of two salbutamol tablets in healthy adult volunteers. International journal of clinical pharmacology and therapeutics. 2009 Jun; 47(6):413-8. doi: 10.5414/cpp47413. [PMID: 19473604]
  • Yoshiaki Omura, Avraham Henoch, Yasuhira Shimotsuura, Harsha Duvvi, Hiroshi Kawashima, Motomu Ohki. Severe asthma with markedly increased asbestos of 2 types & TXB2, and markedly reduced acetylcholine, DHEA & drug uptake in parts of upper lungs, & similar abnormalities at respiratory & cardiac center of medulla oblongata: complete elimination of this asthma within 15 days using one optimal dose of astragalus & application of strong red light & EMF neutralizer on respiratory centers of abnormal medulla oblongata. Acupuncture & electro-therapeutics research. 2009; 34(1-2):41-73. doi: 10.3727/036012909803861059. [PMID: 19711774]
  • Kenneth Tripp, William K McVicar, Parameswaran Nair, Jonathan Corren, Warren W Pleskow, Elizabeth Goodwin, Rudolf A Baumgartner, John P Hanrahan. A cumulative dose study of levalbuterol and racemic albuterol administered by hydrofluoroalkane-134a metered-dose inhaler in asthmatic subjects. The Journal of allergy and clinical immunology. 2008 Sep; 122(3):544-9. doi: 10.1016/j.jaci.2008.06.015. [PMID: 18692886]
  • Basil O Ibe, May F Abdallah, J Usha Raj. Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. International archives of allergy and immunology. 2008; 146(4):321-33. doi: 10.1159/000121466. [PMID: 18362475]
  • Mukesh Kumar Gupta, Meenu Singh. Evidence based review on levosalbutamol. Indian journal of pediatrics. 2007 Feb; 74(2):161-7. doi: 10.1007/s12098-007-0010-5. [PMID: 17337829]
  • Teerapol Srichana, Roongnapa Suedee, Niwan Tanmanee, Det Muanpanarai, Christopher Marriott. The correlation of urinary levels of albuterol and its metabolites isomers following inhalation from a dry powder inhaler and in vitro particle size characterisation. Pulmonary pharmacology & therapeutics. 2007; 20(1):36-45. doi: 10.1016/j.pupt.2005.10.004. [PMID: 16325440]
  • Patrick H Conway, Sarah Edwards, Erin R Stucky, Vincent W Chiang, Mary C Ottolini, Christopher P Landrigan. Variations in management of common inpatient pediatric illnesses: hospitalists and community pediatricians. Pediatrics. 2006 Aug; 118(2):441-7. doi: 10.1542/peds.2006-0484. [PMID: 16882793]
  • Richard Nowak, Charles Emerman, John P Hanrahan, Merdad V Parsey, Nicola A Hanania, Raymond Claus, Kendyl Schaefer, Rudolf A Baumgartner. A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adults. The American journal of emergency medicine. 2006 May; 24(3):259-67. doi: 10.1016/j.ajem.2006.01.027. [PMID: 16635694]
  • Y Hong, F Q Hu, H Yuan. Effect of PEG2000 on drug delivery characterization from solid lipid nanoparticles. Die Pharmazie. 2006 Apr; 61(4):312-5. doi: ". [PMID: 16649544]
  • William R Henderson, Ena Ray Banerjee, Emil Y Chi. Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. The Journal of allergy and clinical immunology. 2005 Aug; 116(2):332-40. doi: 10.1016/j.jaci.2005.04.013. [PMID: 16083788]
  • Herald Ostovar, Jeffrey Jones, Michael Brown. Best evidence topic report. Nebulised levalbuterol or albuterol for lowering serum potassium. Emergency medicine journal : EMJ. 2005 May; 22(5):366-7. doi: 10.1136/emj.2005.024414. [PMID: 15843710]
  • Jun-liang Weng, Yi-shan Zheng, Qiong-feng Ma. [The long term effect of small dose budesonide turbuhaler on mild bronchial asthma]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2005 Feb; 28(2):88-92. doi: NULL. [PMID: 15854388]
  • Nora Y K Chew, Patricia Tang, Hak-Kim Chan, Judy A Raper. How much particle surface corrugation is sufficient to improve aerosol performance of powders?. Pharmaceutical research. 2005 Jan; 22(1):148-52. doi: 10.1007/s11095-004-9020-4. [PMID: 15771241]
  • S Narasimha Murthy, Shobharani R Hiremath. Clinical pharmacokinetic and pharmacodynamic evaluation of transdermal drug delivery systems of salbutamol sulfate. International journal of pharmaceutics. 2004 Dec; 287(1-2):47-53. doi: 10.1016/j.ijpharm.2004.08.018. [PMID: 15541911]
  • Kerstin Naidu Sjöswärd, Mounira Hmani, Anette Davidsson, Peter Söderkvist, Birgitta Schmekel. Single-isomer R-salbutamol is not superior to racemate regarding protection for bronchial hyperresponsiveness. Respiratory medicine. 2004 Oct; 98(10):990-9. doi: 10.1016/j.rmed.2004.03.005. [PMID: 15481276]
  • Shrenik P Shah, Ambikanandan Misra. Liposomal amikacin dry powder inhaler: effect of fines on in vitro performance. AAPS PharmSciTech. 2004 Aug; 5(4):e65. doi: 10.1208/pt050465. [PMID: 15760062]
  • Satoru Tanaka, Yasunori Momose, Masaru Tsutsui, Tomoyuki Kishida, Junji Kuroda, Nobuo Shibata, Takemi Yoshida, Ryoichi Yamagishi. Quantitative estimation of myocardial fibrosis based on receptor occupancy for beta2-adrenergic receptor agonists in rats. The Journal of toxicological sciences. 2004 Aug; 29(3):179-86. doi: 10.2131/jts.29.179. [PMID: 15467267]
  • Hartwig Steckel, Heike G Brandes. A novel spray-drying technique to produce low density particles for pulmonary delivery. International journal of pharmaceutics. 2004 Jun; 278(1):187-95. doi: 10.1016/j.ijpharm.2004.03.010. [PMID: 15158961]
  • Richard M Nowak, Charles L Emerman, Kendyl Schaefer, Rachel L Disantostefano, Louis Vaickus, James M Roach. Levalbuterol compared with racemic albuterol in the treatment of acute asthma: results of a pilot study. The American journal of emergency medicine. 2004 Jan; 22(1):29-36. doi: 10.1016/j.ajem.2003.11.001. [PMID: 14724875]
  • Diana Pancu, Michelle LaFlamme, Elizabeth Evans, James Reed. Levalbuterol is as effective as racemic albuterol in lowering serum potassium. The Journal of emergency medicine. 2003 Jul; 25(1):13-6. doi: 10.1016/s0736-4679(03)00133-1. [PMID: 12865102]
  • G A Jacobson, F V Chong, R Wood-Baker. (R,S)-salbutamol plasma concentrations in severe asthma. Journal of clinical pharmacy and therapeutics. 2003 Jun; 28(3):235-8. doi: 10.1046/j.1365-2710.2003.00483.x. [PMID: 12795782]
  • Kerstin Naidu Sjöswärd, Martin Josefsson, Johan Ahlner, Rolf G G Andersson, Birgitta Schmekel. Metabolism of salbutamol differs between asthmatic patients and healthy volunteers. Pharmacology & toxicology. 2003 Jan; 92(1):27-32. doi: 10.1034/j.1600-0773.2003.920105.x. [PMID: 12710594]
  • Mohammed Nasser Ali Chisty, Robert A Bellantone, David R Taft, Fotios M Plakogiannis. In vitro evaluation of the release of albuterol sulfate from polymer gels: effect of fatty acids on drug transport across biological membranes. Drug development and industrial pharmacy. 2002 Nov; 28(10):1221-9. doi: 10.1081/ddc-120015355. [PMID: 12476868]
  • Qian He, Jinyan Sha, Qing Gu, Hang Gu, Xiong Chen, Zhouhui Yang, Hongyan Ning. [Clinical effect and mechanism of nitroglycerin patch on arresting preterm labor]. Zhonghua fu chan ke za zhi. 2002 Mar; 37(3):134-5. doi: NULL. [PMID: 11953077]
  • Tejas R Desai, Jonathan P Wong, Robert E W Hancock, Warren H Finlay. A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effects of milling. Journal of pharmaceutical sciences. 2002 Feb; 91(2):482-91. doi: 10.1002/jps.10021. [PMID: 11835207]
  • A A Punin, R S Bogachev, S K Zubkov, O A Kozyrev, Iu A Khokhlova. [Cardiovascular and metabolic effects in nebulizer therapy of bronchial asthma]. Klinicheskaia meditsina. 2002; 80(1):40-3. doi: NULL. [PMID: 11855317]
  • Levent Dirikolu, Brad A Mollett, Amy Troppmann, William E Woods, Calvert Bratton, Conor P Cashman, Dwight Schroedter, Brent Mayer, Andreas F Lehner, Wojciech Karpiesiuk, Charlie Hughes, Jeff Boyles, John D Harkins, Thomas Tobin. Apparent ELISA detection times for albuterol after administration with the torpex equine inhaler device. Veterinary therapeutics : research in applied veterinary medicine. 2002; 3(3):297-307. doi: NULL. [PMID: 12447838]
  • H Milgrom, D P Skoner, G Bensch, K T Kim, R Claus, R A Baumgartner. Low-dose levalbuterol in children with asthma: safety and efficacy in comparison with placebo and racemic albuterol. The Journal of allergy and clinical immunology. 2001 Dec; 108(6):938-45. doi: 10.1067/mai.2001.120134. [PMID: 11742271]
  • N Y Chew, H K Chan. Use of solid corrugated particles to enhance powder aerosol performance. Pharmaceutical research. 2001 Nov; 18(11):1570-7. doi: 10.1023/a:1013082531394. [PMID: 11758765]
  • S N Murthy, S Rani, R Hiremath. Formulation and evaluation of controlled-release transdermal patches of theophylline-salbutamol sulfate. Drug development and industrial pharmacy. 2001 Nov; 27(10):1057-62. doi: 10.1081/ddc-100108368. [PMID: 11794808]
  • J Lötvall, M Palmqvist, P Arvidsson, A Maloney, G P Ventresca, J Ward. The therapeutic ratio of R-albuterol is comparable with that of RS-albuterol in asthmatic patients. The Journal of allergy and clinical immunology. 2001 Nov; 108(5):726-31. doi: 10.1067/mai.2001.119152. [PMID: 11692096]
  • F S Ram, J Wright, D Brocklebank, J E White. Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering beta (2 )agonists bronchodilators in asthma. BMJ (Clinical research ed.). 2001 Oct; 323(7318):901-5. doi: 10.1136/bmj.323.7318.901. [PMID: 11668134]
  • D W Boulton, J P Fawcett. The pharmacokinetics of levosalbutamol: what are the clinical implications?. Clinical pharmacokinetics. 2001 Jan; 40(1):23-40. doi: 10.2165/00003088-200140010-00003. [PMID: 11236808]