Pregnanetriolone (BioDeep_00000637587)
Main id: BioDeep_00000010652
Volatile Flavor Compounds
代谢物信息卡片
(3alpha,5beta,20S)-3,17,20-Trihydroxypregnan-11-one
化学式: C21H34O4 (350.24569640000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1(CCC2C1(CC(=O)C3C2CCC4C3(CCC(C4)O)C)C)O)O
InChI: InChI=1S/C21H34O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h12-16,18,22-23,25H,4-11H2,1-3H3/t12-,13+,14+,15-,16-,18+,19-,20-,21-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:79870
- KEGG: C15368
- PubChem: 254631
- LipidMAPS: LMST02030290
- CAS: 603-99-6
- PubChem: 17396365
- NIKKAJI: J39.481E
- KNApSAcK: 79870
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt. Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.
The Journal of clinical endocrinology and metabolism.
2017 06; 102(6):1797-1806. doi:
10.1210/jc.2016-2855. [PMID: 27845856] - Clemens Kamrath, Michaela F Hartmann, Claudia Boettcher, Klaus-Peter Zimmer, Stefan A Wudy. Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infants.
The Journal of steroid biochemistry and molecular biology.
2016 Feb; 156(?):10-6. doi:
10.1016/j.jsbmb.2015.10.013. [PMID: 26493852] - Clemens Kamrath, Michaela F Hartmann, Claudia Boettcher, Stefan A Wudy. Reduced activity of 11β-hydroxylase accounts for elevated 17α-hydroxyprogesterone in preterms.
The Journal of pediatrics.
2014 Aug; 165(2):280-4. doi:
10.1016/j.jpeds.2014.04.011. [PMID: 24862381] - Masayuki Hayashi, Yuko Kataoka, Yoshihisa Sugimura, Fumiko Kato, Maki Fukami, Tsutomu Ogata, Keiko Homma, Tomonobu Hasegawa, Yutaka Oiso, Hironobu Sasano, Hiroshi Tanaka. A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol.
The Tohoku journal of experimental medicine.
2013 10; 231(2):75-84. doi:
10.1620/tjem.231.75. [PMID: 24077358] - Yuhei Koyama, Keiko Homma, Maki Fukami, Masayuki Miwa, Kazushige Ikeda, Tsutomu Ogata, Tomonobu Hasegawa, Mitsuru Murata. Two-step biochemical differential diagnosis of classic 21-hydroxylase deficiency and cytochrome P450 oxidoreductase deficiency in Japanese infants by GC-MS measurement of urinary pregnanetriolone/ tetrahydroxycortisone ratio and 11β-hydroxyandrosterone.
Clinical chemistry.
2012 Apr; 58(4):741-7. doi:
10.1373/clinchem.2011.173286. [PMID: 22273564] - Keiko Homma, Tomonobu Hasegawa, Eiko Takeshita, Kiyoaki Watanabe, Makoto Anzo, Takio Toyoura, Kazuhiko Jinno, Toya Ohashi, Takashi Hamajima, Yukihiro Takahashi, Takao Takahashi, Nobutake Matsuo. Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates.
The Journal of clinical endocrinology and metabolism.
2004 Dec; 89(12):6087-91. doi:
10.1210/jc.2004-0473. [PMID: 15579762] - Haruo Mizuno, Yoichiro Ohro, Yukari Sugiyama, Tetsuya Ito, Tomonobu Hasegawa, Keiko Homma, Hajime Ueshiba, Makoto Ono, Hajime Togari. Transient hyper-17-OHPnemia unrelated to cross-reactions with residual fetal adrenal cortex products.
Hormone research.
2004; 61(5):242-5. doi:
10.1159/000076961. [PMID: 14988602] - A B Yong, J J Pitt, J Montalto, H E Davies, G L Warne, J F Connelly. Diagnosis of 21-hydroxylase deficiency in newborn infants by GC-MS of urinary steroids.
Australian paediatric journal.
1988 Oct; 24(5):280-5. doi:
10.1111/j.1440-1754.1988.tb01363.x. [PMID: 3265870] - J Homoki, J Solyom, W M Teller. Detection of late onset steroid 21-hydroxylase deficiency by capillary gas chromatographic profiling of urinary steroids in children and adolescents.
European journal of pediatrics.
1988 Apr; 147(3):257-62. doi:
10.1007/bf00442691. [PMID: 3260557] - C H Shackleton, J Irias, C McDonald, J Imperato-McGinley. Late-onset 21-hydroxylase deficiency: reliable diagnosis by steroid analysis of random urine collections.
Steroids.
1986 Sep; 48(3-4):239-50. doi:
10.1016/0039-128x(86)90007-3. [PMID: 3502202] - T Kawasaki, M Maeda, A Tsuji. Fluorescence high performance liquid chromatographic determination of 3 alpha-hydroxysteroids in urine of 21-hydroxylase deficiency.
Biomedical chromatography : BMC.
1986 Feb; 1(1):1-6. doi:
10.1002/bmc.1130010102. [PMID: 3506812] - Y Hikita. [Reevaluation of recalled infants by neonatal mass screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Diagnostic value of pregnanetriolone in a single urine specimen using glass capillary gas chromatography].
Nihon Naibunpi Gakkai zasshi.
1985 Mar; 61(3):197-219. doi:
10.1507/endocrine1927.61.3_197. [PMID: 3874793] - M Zachmann, D Tassinari, A Prader. Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
The Journal of clinical endocrinology and metabolism.
1983 Feb; 56(2):222-9. doi:
10.1210/jcem-56-2-222. [PMID: 6296182] - Y Igarashi, H Ogawa, Y Hikita. [Abnormal steroid hormone production (in children)--special reference to microanalysis of urinary steroids by glass capillary gas chromatography and its application].
Rinsho byori. The Japanese journal of clinical pathology.
1982 Nov; Suppl 52(?):143-55. doi:
NULL. [PMID: 6762451] - M Zachmann, E A Werder, A Prader. Two types of male pseudohermaphroditism due to 17, 20-desmolase deficiency.
The Journal of clinical endocrinology and metabolism.
1982 Sep; 55(3):487-90. doi:
10.1210/jcem-55-3-487. [PMID: 6212590] - K R van der Ploeg, B G Wolthers, G T Nagel, M Volmer, N M Drayer. The diagnosis of 21-hydroxylase deficiency in a prematurely born infant on the basis of the urinary steroid excretion pattern.
Clinica chimica acta; international journal of clinical chemistry.
1982 Apr; 120(3):341-53. doi:
10.1016/0009-8981(82)90375-8. [PMID: 6978779] - C Firmin. [Estimations of pregnanetriolone, pregnanetetrol, delta 5-pregnenetriol by spectrophotometry and by gas liquid chromatography (author's transl)].
Annales de biologie clinique.
1980; 38(6):365-73. doi:
NULL. [PMID: 7212393] - H J Lahoud, B M Luttrell, A W Steinbeck. Pregnanetriolone, a normal steroid metabolite: its excretion by normal, Cushing's syndrome and congenital adrenal hyperplasia subjects.
Steroids.
1976 Feb; 27(2):211-23. doi:
10.1016/0039-128x(76)90098-2. [PMID: 1273887] - K KINOSHITA, K ISURUGI. [A METHOD FOR ESTIMATION OF URINARY PREGNANEDIOL, PREGNANETRIOL, PREGNANETRIOLONE AND PREGNANETETROL BY GAS CHROMATOGRAPHY].
Nihon Naibunpi Gakkai zasshi.
1964 Oct; 40(?):978-81. doi:
10.1507/endocrine1927.40.7_978. [PMID: 14220986] - R I COX, R P SHEARMAN. Abnormal excretion of pregnanetriolone and Delta 5-pregnenetriol in the Stein-Leventhal syndrome.
The Journal of clinical endocrinology and metabolism.
1961 May; 21(?):586-90. doi:
10.1210/jcem-21-5-586. [PMID: 13696138]