Normangostin (BioDeep_00000620031)
Main id: BioDeep_00000017224
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
1,3,6,7-Tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one, 9CI
化学式: C23H24O6 (396.1572804)
中文名称: γ-倒捻子素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)O)CC=C(C)C)O)C
InChI: InChI=1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3
描述信息
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM) [1].
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes[1][2][3][4][5].
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer[2]. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM) [1].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:67548
- PubChem: 5464078
- Metlin: METLIN91029
- ChEMBL: CHEMBL260553
- CAS: 31271-07-5
- medchemexpress: HY-N1957
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
10 个相关的物种来源信息
- 271749 - Cratoxylum cochinchinense: 10.1021/NP200051J
- 198761 - Cratoxylum formosum: 10.1021/NP1001797
- 231904 - Garcinia costata: 10.3987/COM-10-12034
- 58228 - Garcinia mangostana:
- 58228 - Garcinia mangostana: -
- 1679256 - Garcinia xipshuanbannaensis:
- 140968 - Hypericum androsaemum:
- 212239 - Hypericum patulum: 10.1016/0031-9422(93)85286-Z
- 65561 - Hypericum perforatum: 10.1016/J.PHYTOCHEM.2005.10.017
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zi-Jie Long, Jun-Dan Wang, Sheng-Xiang Qiu, Yi Zhang, Si-Jin Wu, Xin-Xing Lei, Ze-Wei Huang, Jia-Jie Chen, Yong-Liang Yang, Xiang-Zhong Zhang, Quentin Liu. Dietary γ-mangostin triggers immunogenic cell death and activates cGAS signaling in acute myeloid leukemia.
Pharmacological research.
2023 Nov; 197(?):106973. doi:
10.1016/j.phrs.2023.106973. [PMID: 37898441] - Sandar Naing, Nichawadee Sandech, Arnatchai Maiuthed, Sumet Chongruchiroj, Jaturong Pratuangdejkul, Pattamapan Lomarat. Garcinia mangostana L. Pericarp Extract and Its Active Compound α-Mangostin as Potential Inhibitors of Immune Checkpoint Programmed Death Ligand-1.
Molecules (Basel, Switzerland).
2023 Oct; 28(19):. doi:
10.3390/molecules28196991. [PMID: 37836835] - Cecep Suhandi, Gofarana Wilar, Ronny Lesmana, Felix Zulhendri, Ine Suharyani, Nurhasni Hasan, Nasrul Wathoni. Propolis-Based Nanostructured Lipid Carriers for α-Mangostin Delivery: Formulation, Characterization, and In Vitro Antioxidant Activity Evaluation.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166057. [PMID: 37630309] - Mohamed Yousif Ibrahim, Najihah Mohd Hashim, Fatima Abdelmutaal Ahmed Omer, Muhammad Salisu Abubakar, Hoyam Adam Mohammed, Suzy Munir Salama, Soher Nagi Jayash. Potential Antitumor Effect of α-Mangostin against Rat Mammary Gland Tumors Induced by LA7 Cells.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms241210283. [PMID: 37373429] - Muchtaridi Muchtaridi, Dian Triwahyuningtyas, Taufik Muhammad Fakih, Sandra Megantara, Sy Bing Choi. Mechanistic insight of α-mangostin encapsulation in 2-hydroxypropyl-β-cyclodextrin for solubility enhancement.
Journal of biomolecular structure & dynamics.
2023 Jun; ?(?):1-10. doi:
10.1080/07391102.2023.2214237. [PMID: 37286382] - Heba M Eltahir, Hossein M Elbadawy, Ali Alalawi, Ahmed J Aldhafiri, Sabrin R M Ibrahim, Gamal A Mohamed, Abdel-Gawad S Shalkami, Mohannad A Almikhlafi, Muayad Albadrani, Yaser Alahmadi, Mekky M Abouzied, Maiiada H Nazmy. Alpha-Mangostin ameliorates acute kidney injury via modifying levels of circulating TNF-α and IL-6 in glycerol-induced rhabdomyolysis animal model.
Acta biochimica Polonica.
2023 04; ?(?):. doi:
10.18388/abp.2020_6509. [PMID: 37068203] - Maan T Khayat, Khadijah A Mohammad, Gamal A Mohamed, Dina S El-Agamy, Wael M Elsaed, Sabrin R M Ibrahim. γ-Mangostin abrogates AINT-induced cholestatic liver injury: Impact on Nrf2/NF-κB/NLRP3/Caspase-1/IL-1β/GSDMD signalling.
Life sciences.
2023 Apr; 322(?):121663. doi:
10.1016/j.lfs.2023.121663. [PMID: 37023956] - Yanfen Niu, Qiang Li, Caixia Tu, Na Li, Lihui Gao, Hua Lin, Zhenyu Wang, Zhihong Zhou, Ling Li. Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo.
Journal of natural products.
2023 01; 86(1):24-33. doi:
10.1021/acs.jnatprod.2c00531. [PMID: 36634312] - Yi-Jin Wu, Sa-Sa Zhang, Qin Yin, Ming Lei, Qi-Hai Wang, Wen-Gang Chen, Ting-Ting Luo, Peng Zhou, Cong-Lan Ji. α-Mangostin Inhibited M1 Polarization of Macrophages/Monocytes in Antigen-Induced Arthritis Mice by Up-Regulating Silent Information Regulator 1 and Peroxisome Proliferators-Activated Receptor γ Simultaneously.
Drug design, development and therapy.
2023; 17(?):563-577. doi:
10.2147/dddt.s397914. [PMID: 36860800] - Qirou Wang, Ruilin Li, Nannan Li, Yanan Jia, Yajie Wang, Yue Chen, Pharkphoom Panichayupakaranant, Haixia Chen. The antioxidant activities, inhibitory effects, kinetics, and mechanisms of artocarpin and α-mangostin on α-glucosidase and α-amylase.
International journal of biological macromolecules.
2022 Jul; 213(?):880-891. doi:
10.1016/j.ijbiomac.2022.06.017. [PMID: 35688278] - Romgase Sakamula, Teerapong Yata, Wachiryah Thong-Asa. Nanostructure lipid carriers enhance alpha-mangostin neuroprotective efficacy in mice with rotenone-induced neurodegeneration.
Metabolic brain disease.
2022 06; 37(5):1465-1476. doi:
10.1007/s11011-022-00967-w. [PMID: 35353275] - Rubén Estrada-Valencia, María Ester Hurtado-Díaz, Edgar Rangel-López, Socorro Retana-Márquez, Isaac Túnez, Alexey Tinkov, Cimen Karasu, Beatriz Ferrer, José Pedraza-Chaverri, Michael Aschner, Abel Santamaría. Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans.
Neurotoxicity research.
2022 Apr; 40(2):573-584. doi:
10.1007/s12640-022-00493-8. [PMID: 35380367] - Naroeporn Nopwinyoowong, Waranya Chatuphonprasert, Nitima Tatiya-Aphiradee, Kanokwan Jarukamjorn. Garcinia mangostana and α-Mangostin Revive Ulcerative Colitis-Modified Hepatic Cytochrome P450 Profiles in Mice.
Pakistan journal of biological sciences : PJBS.
2022 Jan; 25(9):843-851. doi:
10.3923/pjbs.2022.843.851. [PMID: 36098087] - Alexander Th Wu, Yuan-Chieh Yeh, Yan-Jiun Huang, Ntlotlang Mokgautsi, Bashir Lawal, Tse-Hung Huang. Gamma-mangostin isolated from garcinia mangostana suppresses colon carcinogenesis and stemness by downregulating the GSK3β/β-catenin/CDK6 cancer stem pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 95(?):153797. doi:
10.1016/j.phymed.2021.153797. [PMID: 34802869] - Intouch Sakpakdeejaroen, Patcharaporn Muanrit, Sumalee Panthong, Srisopa Ruangnoo. Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery.
TheScientificWorldJournal.
2022; 2022(?):9217268. doi:
10.1155/2022/9217268. [PMID: 36081606] - Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Wilawan Mahabusarakam, L Ravithej Singh, Ekachai Dumkliang, Kritamorn Jitrangsri, Alok K Paul, Sirirat Surinkaew, Polrat Wilairatana, Maria de Lourdes Pereira, Mohammed Rahmatullah, Christophe Wiart, Sonia Marlene Rodrigues Oliveira, Veeranoot Nissapatorn. Anti-Acanthamoeba activity of a semi-synthetic mangostin derivative and its ability in removal of Acanthamoeba triangularis WU19001 on contact lens.
PeerJ.
2022; 10(?):e14468. doi:
10.7717/peerj.14468. [PMID: 36523474] - Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K Leong, Ching-Feng Weng. Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Dec; 144(?):112333. doi:
10.1016/j.biopha.2021.112333. [PMID: 34678724] - Piyawat Tangsuksan, Jureeporn Chuerduangphui, Chutha Takahashi Yupanqui, Teerapol Srichana, Ekarat Hitakomate, Chamsai Pientong, Tipaya Ekalaksananan, Wipawee Nittayananta. Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment.
BMC oral health.
2021 10; 21(1):512. doi:
10.1186/s12903-021-01845-0. [PMID: 34629065] - Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi. α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175119. [PMID: 34500560] - Nargis Jamila, Naeem Khan, Nousheen Bibi, Muhammad Waqas, Sadiq Noor Khan, Amir Atlas, Farhat Amin, Faryal Khan, Malka Saba. Hg(II) sensing, catalytic, antioxidant, antimicrobial, and anticancer potential of Garcinia mangostana and α-mangostin mediated silver nanoparticles.
Chemosphere.
2021 Jun; 272(?):129794. doi:
10.1016/j.chemosphere.2021.129794. [PMID: 35534954] - Aihong Yang, Chang Liu, Jiarui Wu, Xiaodi Kou, Rui Shen. A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease.
European journal of pharmacology.
2021 Apr; 897(?):173950. doi:
10.1016/j.ejphar.2021.173950. [PMID: 33607107] - Tanpong Chaiwarit, Nutthapong Kantrong, Sarana Rose Sommano, Pornchai Rachtanapun, Taepin Junmahasathien, Mont Kumpugdee-Vollrath, Pensak Jantrawut. Extraction of Tropical Fruit Peels and Development of HPMC Film Containing the Extracts as an Active Antibacterial Packaging Material.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082265. [PMID: 33919710] - Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Baharrani Dwi Kurnia, Muhammad Faisal Rachman, Yana Maolana Syah. Calotetrapterins A-C, three new pyranoxanthones and their cytotoxicity from the stem bark of Calophyllum tetrapterum Miq.
Natural product research.
2021 Feb; 35(3):407-412. doi:
10.1080/14786419.2019.1634714. [PMID: 31305138] - Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn. Ethanolic Garcinia mangostana extract and α-mangostin improve dextran sulfate sodium-induced ulcerative colitis via the suppression of inflammatory and oxidative responses in ICR mice.
Journal of ethnopharmacology.
2021 Jan; 265(?):113384. doi:
10.1016/j.jep.2020.113384. [PMID: 32927006] - Oliver D John, Peter Mouatt, Sunil K Panchal, Lindsay Brown. Rind from Purple Mangosteen (Garcinia mangostana) Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020319. [PMID: 33499382] - Panudda Dechwongya, Songpol Limpisood, Nawong Boonnak, Supachoke Mangmool, Mariko Takeda-Morishita, Thitianan Kulsirirat, Pattarawit Rukthong, Korbtham Sathirakul. The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245877. [PMID: 33322620] - P Rukthong, N Sereesongsang, T Kulsirirat, N Boonnak, K Sathirakul. In vitro investigation of metabolic fate of α-mangostin and gartanin via skin permeation by LC-MS/MS and in silico evaluation of the metabolites by ADMET predictor™.
BMC complementary medicine and therapies.
2020 Nov; 20(1):359. doi:
10.1186/s12906-020-03144-7. [PMID: 33228689] - Huochun Ye, Qin Wang, Fadi Zhu, Gang Feng, Chao Yan, Jing Zhang. Antifungal Activity of Alpha-Mangostin against Colletotrichum gloeosporioides In Vitro and In Vivo.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225335. [PMID: 33207599] - Ning Tiang, Mohamad Anuar Ahad, Vikneswaran Murugaiyah, Zurina Hassan. Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats.
The Journal of pharmacy and pharmacology.
2020 Nov; 72(11):1629-1644. doi:
10.1111/jphp.13345. [PMID: 32743849] - M S Meah, M Lertcanawanichakul, P Pedpradab, W Lin, K Zhu, G Li, P Panichayupakaranant. Synergistic effect on anti-methicillin-resistant Staphylococcus aureus among combinations of α-mangostin-rich extract, lawsone methyl ether and ampicillin.
Letters in applied microbiology.
2020 Nov; 71(5):510-519. doi:
10.1111/lam.13369. [PMID: 32770753] - Huifeng Guan, Jiabing Li, Xiaofang Tan, Shenying Luo, Yangdan Liu, Yiwen Meng, Baichuan Wu, Yan Zhou, Yang Yang, Hongzhuan Chen, Lina Hou, Yu Qiu, Juan Li. Natural Xanthone α-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-κB Signaling Pathway.
Molecular nutrition & food research.
2020 07; 64(14):e2000096. doi:
10.1002/mnfr.202000096. [PMID: 32506806] - Wiparat Hotarat, Bodee Nutho, Peter Wolschann, Thanyada Rungrotmongkol, Supot Hannongbua. Delivery of Alpha-Mangostin Using Cyclodextrins through a Biological Membrane: Molecular Dynamics Simulation.
Molecules (Basel, Switzerland).
2020 May; 25(11):. doi:
10.3390/molecules25112532. [PMID: 32485931] - Xiao-Qian Chi, Bo Hou, Liu Yang, Cheng-Ting Zi, Yong-Feng Lv, Jin-Yu Li, Fu-Cai Ren, Ming-Yan Yuan, Jiang-Miao Hu, Jun Zhou. Design, synthesis and cholinesterase inhibitory activity of α-mangostin derivatives.
Natural product research.
2020 May; 34(10):1380-1388. doi:
10.1080/14786419.2018.1510925. [PMID: 30456989] - Jingxian Feng, Minjun Xu, Jiahao Wang, Songlei Zhou, Yipu Liu, Shanshan Liu, Yukun Huang, Yu Chen, Liang Chen, Qingxiang Song, Jingru Gong, Huiping Lu, Xiaoling Gao, Jun Chen. Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer.
Biomaterials.
2020 05; 241(?):119907. doi:
10.1016/j.biomaterials.2020.119907. [PMID: 32120315] - Yen-Shuo Chiu, Jia-Lin Wu, Chi-Tai Yeh, Vijesh Kumar Yadav, Hsu-Shan Huang, Liang-Shun Wang. γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling.
Aging.
2020 04; 12(8):6630-6643. doi:
10.18632/aging.103003. [PMID: 32302289] - Hai Zhang, Yu-Ping Tan, Lin Zhao, Lun Wang, Nai-Jie Fu, Song-Ping Zheng, Xiao-Fei Shen. Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1.
Cell death & disease.
2020 01; 11(1):63. doi:
10.1038/s41419-020-2227-4. [PMID: 31980595] - Abhijeet Parkhe, Pathik Parekh, Lakshmi Vineela Nalla, Nishant Sharma, Monika Sharma, Anagha Gadepalli, Abhijeet Kate, Amit Khairnar. Protective effect of alpha mangostin on rotenone induced toxicity in rat model of Parkinson's disease.
Neuroscience letters.
2020 01; 716(?):134652. doi:
10.1016/j.neulet.2019.134652. [PMID: 31778768] - Yu Shi, Yangwei Fan, Yuan Hu, Jiayu Jing, Chuying Wang, Yinying Wu, Qianqian Geng, Xuyuan Dong, Enxiao Li, Danfeng Dong. α-Mangostin suppresses the de novo lipogenesis and enhances the chemotherapeutic response to gemcitabine in gallbladder carcinoma cells via targeting the AMPK/SREBP1 cascades.
Journal of cellular and molecular medicine.
2020 01; 24(1):760-771. doi:
10.1111/jcmm.14785. [PMID: 31762191] - Zhe Yang, Qin Yin, Opeyemi Joshua Olatunji, Yan Li, Shu Pan, Dan-Dan Wang, Jian Zuo. Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats.
International journal of immunopathology and pharmacology.
2020 Jan; 34(?):2058738420954941. doi:
10.1177/2058738420954941. [PMID: 32886564] - Qin Yin, Yi-Jin Wu, Shu Pan, Dan-Dan Wang, Meng-Qing Tao, Wei-Ya Pei, Jian Zuo. Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats.
Drug design, development and therapy.
2020; 14(?):1983-1993. doi:
10.2147/dddt.s249865. [PMID: 32546965] - Keng Yoon Yeong, Kooi Yeong Khaw, Yukari Takahashi, Yukihiro Itoh, Vikneswaran Murugaiyah, Takayoshi Suzuki. Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor.
Bioorganic chemistry.
2020 01; 94(?):103403. doi:
10.1016/j.bioorg.2019.103403. [PMID: 31711765] - Chatchai Sungpud, Worawan Panpipat, Manat Chaijan, Attawadee Sae Yoon. Techno-biofunctionality of mangostin extract-loaded virgin coconut oil nanoemulsion and nanoemulgel.
PloS one.
2020; 15(1):e0227979. doi:
10.1371/journal.pone.0227979. [PMID: 31995599] - Kaiqiang Li, Lingling Wu, Yili Chen, Yuanyuan Li, Qianni Wang, Min Li, Ke Hao, Wei Zhang, Shanshan Jiang, Zhen Wang. Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition.
Drug design, development and therapy.
2020; 14(?):5315-5324. doi:
10.2147/dddt.s278414. [PMID: 33293793] - Liang Gu, Nan Cai, Yansi Lyu, Lijun Yao, Fei Wang, Hong Xu, Zhangli Hu, Hui Li, Xu Xu. γ-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells.
Journal of agricultural and food chemistry.
2019 Dec; 67(50):13929-13938. doi:
10.1021/acs.jafc.9b05632. [PMID: 31674780] - Dan Li, Qianyu Liu, Xiuqiang Lu, Zhengqiu Li, Chunming Wang, Chung-Hang Leung, Yitao Wang, Cheng Peng, Ligen Lin. α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice.
Aging.
2019 12; 11(23):11084-11110. doi:
10.18632/aging.102512. [PMID: 31806859] - Lawan Larsuprom, Nutchaphon Rungroj, Chalermpol Lekcharoensuk, Chantima Pruksakorn, Sumet Kongkiatpaiboon, Charles Chen, Udomlak Sukatta. In vitro antibacterial activity of mangosteen (Garcinia mangostana Linn.) crude extract against Staphylococcus pseudintermedius isolates from canine pyoderma.
Veterinary dermatology.
2019 Dec; 30(6):487-e145. doi:
10.1111/vde.12783. [PMID: 31441182] - Azazahemad A Kureshi, Chirag Dholakiya, Tabaruk Hussain, Amit Mirgal, Siddhesh P Salvi, Pritam C Barua, Madhumita Talukdar, Chekunnath Beena, Ashish Kar, Thondiath John Zachariah, Premlata Kumari, Tushar Dhanani, Raghuraj Singh, Ponnuchamy Manivel, Satyanshu Kumar. Simultaneous Identification and Quantification of Three Xanthones and Two Polyisoprenylated Benzophenones in Eight Indian Garcinia Species Using a Validated UHPLC-PDA Method.
Journal of AOAC International.
2019 Sep; 102(5):1423-1434. doi:
10.5740/jaoacint.18-0335. [PMID: 30808434] - Kui Yang, Qin Yin, Qingcheng Mao, Sheng Dai, Lin Wang, Jiyang Dong, Jian Zuo. Metabolomics Analysis Reveals Therapeutic Effects of α-Mangostin on Collagen-Induced Arthritis in Rats by Down-regulating Nicotinamide Phosphoribosyltransferase.
Inflammation.
2019 Apr; 42(2):741-753. doi:
10.1007/s10753-018-0932-2. [PMID: 30484004] - Julalak Chokpaisarn, Kanyatorn Yincharoen, Sineenart Sanpinit, Shunmugiah Thevar Karutha Pandian, Janarthanam Rathna Nandhini, Shanmugaraj Gowrishankar, Surasak Limsuwan, Nongluk Kunworarath, Supayang Piyawan Voravuthikunchai, Sasitorn Chusri. Effects of a traditional Thai polyherbal medicine 'Ya-Samarn-Phlae' as a natural anti-biofilm agent against Pseudomonas aeruginosa.
Microbial pathogenesis.
2019 Mar; 128(?):354-362. doi:
10.1016/j.micpath.2019.01.036. [PMID: 30684637] - Kamarza Mulia, Farah Fauzia, Elsa Anisa Krisanti. Polyalcohols as Hydrogen-Bonding Donors in Choline Chloride-Based Deep Eutectic Solvents for Extraction of Xanthones from the Pericarp of Garcinia mangostana L.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030636. [PMID: 30759720] - Diana Rocio Herrera-Aco, Omar Noel Medina-Campos, José Pedraza-Chaverri, Edda Sciutto-Conde, Gabriela Rosas-Salgado, Gladis Fragoso-González. Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Feb; 124(?):300-315. doi:
10.1016/j.fct.2018.12.018. [PMID: 30557668] - Anqi Wang, Fayang Zhou, Dan Li, Jin-Jian Lu, Yitao Wang, Ligen Lin. γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis.
Toxicology and applied pharmacology.
2019 01; 363(?):142-153. doi:
10.1016/j.taap.2018.11.011. [PMID: 30502394] - Youngmun Lee, Sunyoung Kim, Yeonsoo Oh, Young-Mi Kim, Young-Won Chin, Jungsook Cho. Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence.
Oxidative medicine and cellular longevity.
2019; 2019(?):3640753. doi:
10.1155/2019/3640753. [PMID: 31019651] - Neha Maharao, Jurgen Venitz, Phillip M Gerk. Use of generally recognized as safe or dietary compounds to inhibit buprenorphine metabolism: potential to improve buprenorphine oral bioavailability.
Biopharmaceutics & drug disposition.
2019 Jan; 40(1):18-31. doi:
10.1002/bdd.2166. [PMID: 30520057] - Panarat Arunrattiyakorn, Mayuso Kuno, Thammarat Aree, Surat Laphookhieo, Teerayut Sriyatep, Hiroshi Kanzaki, Miguel Angel Garcia Chavez, Yan Alexander Wang, Raymond J Andersen. Biotransformation of β-Mangostin by an Endophytic Fungus of Garcinia mangostana to Furnish Xanthenes with an Unprecedented Heterocyclic Skeleton.
Journal of natural products.
2018 10; 81(10):2244-2250. doi:
10.1021/acs.jnatprod.8b00519. [PMID: 30350994] - Hui-Suan Ng, Grace Yin Tze Tan, Ka-Heng Lee, Wolfgang Zimmermann, Hip Seng Yim, John Chi-Wei Lan. Direct recovery of mangostins from Garcinia mangostana pericarps using cellulase-assisted aqueous micellar biphasic system with recyclable surfactant.
Journal of bioscience and bioengineering.
2018 Oct; 126(4):507-513. doi:
10.1016/j.jbiosc.2018.04.008. [PMID: 29764763] - Lee Kar Wei, Nor Hisam Zamakshshari, Gwendoline Cheng Lian Ee, Siau Hui Mah, Siti Mariam Mohd Nor. Isolation and structural modifications of ananixanthone from Calophyllum teysmannii and their cytotoxic activities.
Natural product research.
2018 Sep; 32(18):2147-2151. doi:
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Molecules (Basel, Switzerland).
2018 Jul; 23(8):. doi:
10.3390/molecules23081852. [PMID: 30044450] - Syam Mohan, Suvitha Syam, Siddig Ibrahim Abdelwahab, Neelaveni Thangavel. An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach.
Food & function.
2018 Jul; 9(7):3860-3871. doi:
10.1039/c8fo00439k. [PMID: 29953154] - Wipawee Nittayananta, Surasak Limsuwan, Teerapol Srichana, Chutha Sae-Wong, Thanaporn Amnuaikit. Oral spray containing plant-derived compounds is effective against common oral pathogens.
Archives of oral biology.
2018 Jun; 90(?):80-85. doi:
10.1016/j.archoralbio.2018.03.002. [PMID: 29573647] - Tianhua Fu, Shijie Wang, Jinping Liu, Enbo Cai, Haijun Li, Pingya Li, Yan Zhao. Protective effects of α-mangostin against acetaminophen-induced acute liver injury in mice.
European journal of pharmacology.
2018 May; 827(?):173-180. doi:
10.1016/j.ejphar.2018.03.002. [PMID: 29563064] - Xiao-Tong Yan, Yin-Shi Sun, Shen Ren, Li-Chun Zhao, Wen-Cong Liu, Chen Chen, Zi Wang, Wei Li. Dietary α-Mangostin Provides Protective Effects against Acetaminophen-Induced Hepatotoxicity in Mice via Akt/mTOR-Mediated Inhibition of Autophagy and Apoptosis.
International journal of molecular sciences.
2018 May; 19(5):. doi:
10.3390/ijms19051335. [PMID: 29723988] - Zuo Peng Li, Yeong Hun Song, Zia Uddin, Yan Wang, Ki Hun Park. Inhibition of protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase by xanthones from Cratoxylum cochinchinense, and their kinetic characterization.
Bioorganic & medicinal chemistry.
2018 02; 26(3):737-746. doi:
10.1016/j.bmc.2017.12.043. [PMID: 29306546] - Edison Eukun Sage, Nashriq Jailani, Azney Zuhaily Md Taib, Normah Mohd Noor, Md Ikram Mohd Said, Muntaz Abu Bakar, Mukram Mohamed Mackeen. From the Front or Back Door? Quantitative analysis of direct and indirect extractions of α-mangostin from mangosteen (Garcinia mangostana).
PloS one.
2018; 13(10):e0205753. doi:
10.1371/journal.pone.0205753. [PMID: 30321238] - Ida Sriyanti, Dhewa Edikresnha, Annisa Rahma, Muhammad Miftahul Munir, Heni Rachmawati, Khairurrijal Khairurrijal. Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α-mangostin.
International journal of nanomedicine.
2018; 13(?):4927-4941. doi:
10.2147/ijn.s167670. [PMID: 30214198] - Masakatsu Fukuda, Hide Sakashita, Hiroyasu Hayashi, Junya Shiono, Genki Miyake, Yusuke Komine, Fuyoko Taira, Hideaki Sakashita. Synergism between α-mangostin and TRAIL induces apoptosis in squamous cell carcinoma of the oral cavity through the mitochondrial pathway.
Oncology reports.
2017 Dec; 38(6):3439-3446. doi:
10.3892/or.2017.6030. [PMID: 29039600] - A-Rang Im, Young-Mi Kim, Young-Won Chin, Sungwook Chae. Protective effects of compounds from Garcinia mangostana L. (mangosteen) against UVB damage in HaCaT cells and hairless mice.
International journal of molecular medicine.
2017 Dec; 40(6):1941-1949. doi:
10.3892/ijmm.2017.3188. [PMID: 29039482] - Jakarwan Yostawonkul, Suvimol Surassmo, Katawut Namdee, Mattaka Khongkow, Chatwalee Boonthum, Sasithon Pagseesing, Nattika Saengkrit, Uracha Rungsardthong Ruktanonchai, Kaywalee Chatdarong, Suppawiwat Ponglowhapan, Teerapong Yata. Nanocarrier-mediated delivery of α-mangostin for non-surgical castration of male animals.
Scientific reports.
2017 11; 7(1):16234. doi:
10.1038/s41598-017-16563-3. [PMID: 29176590] - Fatima Abdelmutaal Ahmed Omer, Najihah Binti Mohd Hashim, Mohamed Yousif Ibrahim, Firouzeh Dehghan, Maizatulakmal Yahayu, Hamed Karimian, Landa Zeenelabdin Ali Salim, Syam Mohan. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G0/G1 cell-cycle arrest.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2017 Nov; 39(11):1010428317731451. doi:
10.1177/1010428317731451. [PMID: 29110583] - Mayuri Tarasuk, Pucharee Songprakhon, Pattamawan Chimma, Panudda Sratongno, Kesara Na-Bangchang, Pa-Thai Yenchitsomanus. Alpha-mangostin inhibits both dengue virus production and cytokine/chemokine expression.
Virus research.
2017 08; 240(?):180-189. doi:
10.1016/j.virusres.2017.08.011. [PMID: 28864423] - Xin-Mei Hao, Lian-Da Li, Chang-Ling Duan, Yu-Juan Li. Neuroprotective effect of α-mangostin on mitochondrial dysfunction and α-synuclein aggregation in rotenone-induced model of Parkinson's disease in differentiated SH-SY5Y cells.
Journal of Asian natural products research.
2017 Aug; 19(8):833-845. doi:
10.1080/10286020.2017.1339349. [PMID: 28696167] - Hourieh Tousian Shandiz, Bibi Marjan Razavi, Hossein Hosseinzadeh. Review of Garcinia mangostana and its Xanthones in Metabolic Syndrome and Related Complications.
Phytotherapy research : PTR.
2017 Aug; 31(8):1173-1182. doi:
10.1002/ptr.5862. [PMID: 28656594] - Fatima Abdelmutaal Ahmed Omer, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Abdulmannan F Aldoubi, Pouya Hassandarvish, Firouzeh Dehghan, Noraziah Nordin, Hamed Karimian, Landa Zeenelabdin Ali Salim, Mahmood Ameen Abdulla, Karim Al-Jashamy, Syam Mohan. Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo.
BMC complementary and alternative medicine.
2017 Jul; 17(1):366. doi:
10.1186/s12906-017-1867-0. [PMID: 28716025] - Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy.
Experimental dermatology.
2017 07; 26(7):585-591. doi:
10.1111/exd.13233. [PMID: 27714857] - Ruchadaporn Kaomongkolgit, Kusuma Jamdee. Inhibitory effect of alpha-mangostin on Candida biofilms.
Odontology.
2017 Apr; 105(2):248-253. doi:
10.1007/s10266-016-0256-3. [PMID: 27368963] - Wen-Ke Xu, Hui Jiang, Kui Yang, Ya-Qin Wang, Qian Zhang, Jian Zuo. Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin.
The Kaohsiung journal of medical sciences.
2017 Mar; 33(3):116-123. doi:
10.1016/j.kjms.2016.12.003. [PMID: 28254113] - Ming-Hui Wang, Kuo-Jun Zhang, Qin-Lan Gu, Xiao-Ling Bi, Jin-Xin Wang. Pharmacology of mangostins and their derivatives: A comprehensive review.
Chinese journal of natural medicines.
2017 Feb; 15(2):81-93. doi:
10.1016/s1875-5364(17)30024-9. [PMID: 28284429] - J Zhang, Q Chen, S Wang, T Li, Z Xiao, W Lan, G Huang, X Cai. α-Mangostin, A Natural Xanthone, Induces Apoptosis and ROS Accumulation in Human Rheumatoid Fibroblast-Like Synoviocyte MH7A Cells.
Current molecular medicine.
2017; 17(5):375-380. doi:
10.2174/1566524018666171205123220. [PMID: 29210647] - Jakarwan Yostawonkul, Suvimol Surassmo, Tawin Iempridee, Wittaya Pimtong, Kunat Suktham, Warayuth Sajomsang, Pattarapond Gonil, Uracha Rungsardthong Ruktanonchai. Surface modification of nanostructure lipid carrier (NLC) by oleoyl-quaternized-chitosan as a mucoadhesive nanocarrier.
Colloids and surfaces. B, Biointerfaces.
2017 Jan; 149(?):301-311. doi:
10.1016/j.colsurfb.2016.09.049. [PMID: 27780087] - Sara Franceschelli, Mirko Pesce, Alessio Ferrone, Antonia Patruno, Livia Pasqualone, Giuseppe Carlucci, Vincenzo Ferrone, Maura Carlucci, Maria Anna de Lutiis, Alfredo Grilli, Mario Felaco, Lorenza Speranza. A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway.
Journal of cellular physiology.
2016 11; 231(11):2439-51. doi:
10.1002/jcp.25348. [PMID: 26895796] - Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn. In vivo antibacterial activity of Garcinia mangostana pericarp extract against methicillin-resistant Staphylococcus aureus in a mouse superficial skin infection model.
Pharmaceutical biology.
2016 Nov; 54(11):2606-2615. doi:
10.3109/13880209.2016.1172321. [PMID: 27180784] - Yan Zhao, Guosheng Tang, Qiang Tang, Jing Zhang, Yingying Hou, Enbo Cai, Shuangli Liu, Daihong Lei, Lianxue Zhang, Shijie Wang. A Method of Effectively Improved α-Mangostin Bioavailability.
European journal of drug metabolism and pharmacokinetics.
2016 Oct; 41(5):605-13. doi:
10.1007/s13318-015-0283-4. [PMID: 25990757] - Sineewan Phitaktim, Mullika Chomnawang, Kittipot Sirichaiwetchakoon, Benjawan Dunkhunthod, Glyn Hobbs, Griangsak Eumkeb. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus.
BMC microbiology.
2016 08; 16(1):195. doi:
10.1186/s12866-016-0814-4. [PMID: 27566110] - Hani Z Asfour. Antimicrobial and quorum sensing inhibitory activities of the pericarp of Garcinia mangostana.
Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4 Suppl):1353-7. doi:
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Drug design, development and therapy.
2016; 10(?):297-313. doi:
10.2147/dddt.s80625. [PMID: 26834460] - Yingqiu Liu, Jung-Min Park, Kyung-Hwa Chang, Young-Won Chin, Moo-Yeol Lee. α- and γ-mangostin cause shape changes, inhibit aggregation and induce cytolysis of rat platelets.
Chemico-biological interactions.
2015 Oct; 240(?):240-8. doi:
10.1016/j.cbi.2015.08.021. [PMID: 26343955] - Young Hee Choi, Jin Kyung Bae, Hee-Sung Chae, Young-Mi Kim, Yim Sreymom, Ling Han, Ha Young Jang, Young-Won Chin. α-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice.
Journal of agricultural and food chemistry.
2015 Sep; 63(38):8399-406. doi:
10.1021/acs.jafc.5b01637. [PMID: 26368128] - Ruthairat Benjakul, Lalana Kongkaneramit, Narong Sarisuta, Primchanien Moongkarndi, Christel C Müller-Goymann. Cytotoxic effect and mechanism inducing cell death of α-mangostin liposomes in various human carcinoma and normal cells.
Anti-cancer drugs.
2015 Sep; 26(8):824-34. doi:
10.1097/cad.0000000000000235. [PMID: 25811966] - Derek A Martin, Bradley W Bolling. A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases.
Food & function.
2015 Jun; 6(6):1773-86. doi:
10.1039/c5fo00202h. [PMID: 25986932] - Jomjai Peerapattana, Kuniko Otsuka, Yusuke Hattori, Makoto Otsuka. Quantitative analysis of α-mangostin in hydrophilic ointment using near-infrared spectroscopy.
Drug development and industrial pharmacy.
2015 Mar; 41(3):515-21. doi:
10.3109/03639045.2014.884115. [PMID: 24517571] - Wanna Chaijaroenkul, Murad A Mubaraki, Stephen A Ward, Kesara Na-Bangchang. Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.
Experimental parasitology.
2014 Oct; 145(?):80-6. doi:
10.1016/j.exppara.2014.07.013. [PMID: 25102435] - K Y Khaw, S B Choi, S C Tan, H A Wahab, K L Chan, V Murugaiyah. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Sep; 21(11):1303-9. doi:
10.1016/j.phymed.2014.06.017. [PMID: 25172794] - Primchanien Moongkarndi, Nattapon Jaisupa, Jutima Samer, Nuttavut Kosem, Julaporn Konlata, Ekkarat Rodpai, Narongchai Pongpan. Comparison of the biological activity of two different isolates from mangosteen.
The Journal of pharmacy and pharmacology.
2014 Aug; 66(8):1171-9. doi:
10.1111/jphp.12239. [PMID: 24641353] - Hong Zhang, Dan-Dan Zhang, Yuan-Zhi Lao, Wen-Wei Fu, Shuang Liang, Qing-Hong Yuan, Ling Yang, Hong-Xi Xu. Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
Journal of natural products.
2014 Jul; 77(7):1700-7. doi:
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Minerva stomatologica.
2014 Jul; 63(7-8):249-57. doi:
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Journal of ethnopharmacology.
2014 Apr; 153(2):435-45. doi:
10.1016/j.jep.2014.02.051. [PMID: 24607509] - Rathapon Asasutjarit, Papassara Larpmahawong, Asira Fuongfuchat, Vipaporn Sareedenchai, Sukitaya Veeranondha. Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract.
AAPS PharmSciTech.
2014 Apr; 15(2):306-16. doi:
10.1208/s12249-013-0057-8. [PMID: 24327275] - Young Hee Choi, Seung Yon Han, You-Jin Kim, Young-Mi Kim, Young-Won Chin. Absorption, tissue distribution, tissue metabolism and safety of α-mangostin in mangosteen extract using mouse models.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Apr; 66(?):140-6. doi:
10.1016/j.fct.2014.01.028. [PMID: 24472368] - Sakina M Petiwala, Gongbo Li, Atulkumar Ramaiya, Anoop Kumar, Ravinder K Gill, Seema Saksena, Jeremy J Johnson. Pharmacokinetic characterization of mangosteen (Garcinia mangostana) fruit extract standardized to α-mangostin in C57BL/6 mice.
Nutrition research (New York, N.Y.).
2014 Apr; 34(4):336-45. doi:
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