Nikomet (BioDeep_00000615895)

Main id: BioDeep_00000018401

 

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


Methyl ester OF pyridine-3-carboxylic acid

化学式: C7H7NO2 (137.0476762)
中文名称: 烟酸甲酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)C1=CN=CC=C1
InChI: InChI=1S/C7H7NO2/c1-10-7(9)6-3-2-4-8-5-6/h2-5H,1H3

描述信息

Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[1].
Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain[1].

同义名列表

20 个代谢物同义名

Methyl ester OF pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, methyl ester; methyl pyridine-3-carboxylate; Nicotinic acid, methyl ester; Methyl 3-pyridinecarboxylate; Nicotinic acid methyl ester; m-(Methoxycarbonyl)pyridine; 3-(Methoxycarbonyl)pyridine; 3-(Carbomethoxy)pyridine; Methyl nicotinate (usan); 3-Carbomethoxypyridine; Methyl Nicotinate; Methyl-nicotinate; Heat spray (TN); Heat spray; FEMA 3709; 3PyrCOOMe; Nicometh; Nikomet; Methyl nicotinate



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gerald B Kasting, Matthew A Miller, Lijing Xu, Fang Yu, Joanna Jaworska. In Vitro Human Skin Absorption of Solvent-deposited Solids: Niacinamide and Methyl Nicotinate. Journal of pharmaceutical sciences. 2022 03; 111(3):727-733. doi: 10.1016/j.xphs.2021.09.040. [PMID: 34600943]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Antonella Barone, Maria Chiara Cristiano, Felisa Cilurzo, Marcello Locatelli, Dalila Iannotta, Luisa Di Marzio, Christian Celia, Donatella Paolino. Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids and surfaces. B, Biointerfaces. 2020 Sep; 193(?):111152. doi: 10.1016/j.colsurfb.2020.111152. [PMID: 32535351]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ranran Wu, Fengxia Zhang, Lingyun Liu, Wei Li, Eran Pichersky, Guodong Wang. MeNA, Controlled by Reversible Methylation of Nicotinate, Is an NAD Precursor that Undergoes Long-Distance Transport in Arabidopsis. Molecular plant. 2018 10; 11(10):1264-1277. doi: 10.1016/j.molp.2018.07.003. [PMID: 30055263]
  • Brian M Ross. Methylnicotinate stimulated prostaglandin synthesis in patients with schizophrenia: A preliminary investigation. Prostaglandins, leukotrienes, and essential fatty acids. 2018 09; 136(?):99-102. doi: 10.1016/j.plefa.2017.05.002. [PMID: 28552466]
  • Vegard Lysne, Elin Strand, Gard F T Svingen, Bodil Bjørndal, Eva R Pedersen, Øivind Midttun, Thomas Olsen, Per M Ueland, Rolf K Berge, Ottar Nygård. Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. Nutrients. 2016 Jan; 8(1):. doi: 10.3390/nu8010026. [PMID: 26742069]
  • Alessia Offerta, Francesco Bonina, Franco Gasparri, Andrea Zanardi, Lucia Micicche, Carmelo Puglia. In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery. Current drug delivery. 2016; 13(1):111-20. doi: 10.2174/1567201812666150722123218. [PMID: 26201345]
  • Penny N Newson, Maarten van den Buuse, Sally Martin, Ann Lynch-Frame, Loris A Chahl. Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour. Behavioural brain research. 2014 Oct; 272(?):55-65. doi: 10.1016/j.bbr.2014.06.036. [PMID: 24975423]
  • Helmut Pabst, Axel Schaefer, Christiane Staiger, Marc Junker-Samek, Hans-Georg Predel. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. Phytotherapy research : PTR. 2013 Jun; 27(6):811-7. doi: 10.1002/ptr.4790. [PMID: 22887778]
  • Christiane Staiger. Comfrey root: from tradition to modern clinical trials. Wiener medizinische Wochenschrift (1946). 2013 Feb; 163(3-4):58-64. doi: 10.1007/s10354-012-0162-4. [PMID: 23224633]
  • Iti Som, Kashish Bhatia, Mohd Yasir. Status of surfactants as penetration enhancers in transdermal drug delivery. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):2-9. doi: 10.4103/0975-7406.92724. [PMID: 22368393]
  • David M Suckling, Rachael L Sagar. Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 2011 Jul; 91(4):327-8. doi: 10.1016/j.tube.2011.04.008. [PMID: 21546308]
  • Wen-Fei Chiou, Han-Chieh Ko, Bai-Luh Wei. Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):750513. doi: 10.1093/ecam/nep238. [PMID: 21799692]
  • Jurij J Hostynek, Frank Dreher, Howard I Maibach. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2011 Jan; 60(1):79-86. doi: 10.1007/s00011-010-0238-9. [PMID: 20721598]
  • Pengjun Zhang, Xiaoyun Zhu, Fang Huang, Yong Liu, Jinming Zhang, Yaobin Lu, Yongming Ruan. Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis. PloS one. 2011; 6(7):e22378. doi: 10.1371/journal.pone.0022378. [PMID: 21818315]
  • Mojgan Moddaresi, Slobodanka Tamburic, Stefanie Williams, Stuart A Jones, Yanjun Zhao, Marc B Brown. Effects of lipid nanocarriers on the performance of topical vehicles in vivo. Journal of cosmetic dermatology. 2009 Jun; 8(2):136-43. doi: 10.1111/j.1473-2165.2009.00440.x. [PMID: 19527338]
  • Carmelo Puglia, Francesco Bonina. In vivo spectrophotometric evaluation of skin barrier recovery after topical application of soybean phytosterols. Journal of cosmetic science. 2008 May; 59(3):217-24. doi: NULL. [PMID: 18528589]
  • Stefan Smesny, Timm Rosburg, Kati Baur, Nicole Rudolph, Heinrich Sauer. Cannabinoids influence lipid-arachidonic acid pathways in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2007 Oct; 32(10):2067-73. doi: 10.1038/sj.npp.1301343. [PMID: 17314920]
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  • Daniel B Yarosh, Jason W Galvin, Stephanie L Nay, Arely V Peña, Matthew T Canning, David A Brown. Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine. Journal of dermatological science. 2006 Apr; 42(1):13-21. doi: 10.1016/j.jdermsci.2005.12.009. [PMID: 16423507]
  • Y Remane, C S Leopold. Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents. Skin pharmacology and physiology. 2006; 19(6):303-10. doi: 10.1159/000095250. [PMID: 16931897]
  • Masako Fujiwara, Kazunori Arifuku, Itiro Ando, Tadashi Nemoto. Pattern recognition analysis for classification of hypertensive model rats and diurnal variation using 1H-NMR spectroscopy of urine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Nov; 21(11):1259-62. doi: 10.2116/analsci.21.1259. [PMID: 16317890]
  • Carmelo Puglia, Elisabetta Esposito, Enea Menegatti, Claudio Nastruzzi, Luisa Rizza, Rita Cortesi, Francesco Bonina. Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles. The Journal of pharmacy and pharmacology. 2005 Sep; 57(9):1169-76. doi: 10.1211/jpp.57.9.0011. [PMID: 16105237]
  • Brian M Ross, Pauline Ward, Iain Glen. Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder. Journal of affective disorders. 2004 Oct; 82(2):285-90. doi: 10.1016/j.jad.2003.11.005. [PMID: 15488259]
  • J Hibatallah, C Carduner, M C Poelman. In-vivo and in-vitro assessment of the free-radical-scavenger activity of Ginkgo flavone glycosides at high concentration. The Journal of pharmacy and pharmacology. 1999 Dec; 51(12):1435-40. doi: 10.1211/0022357991777083. [PMID: 10678500]
  • C S Leopold, B C Lippold. Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo. Journal of pharmaceutical sciences. 1995 Feb; 84(2):195-8. doi: 10.1002/jps.2600840214. [PMID: 7738800]
  • J D Morrow, J A Awad, J A Oates, L J Roberts. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. The Journal of investigative dermatology. 1992 May; 98(5):812-5. doi: 10.1111/1523-1747.ep12499963. [PMID: 1373750]
  • K A Walters, M Walker, O Olejnik. Non-ionic surfactant effects on hairless mouse skin permeability characteristics. The Journal of pharmacy and pharmacology. 1988 Aug; 40(8):525-9. doi: 10.1111/j.2042-7158.1988.tb05295.x. [PMID: 2907003]