&alpha (BioDeep_00000614854)

Main id: BioDeep_00000003157

 

PANOMIX_OTCML-2023


代谢物信息卡片


DL-alpha-Amino-N-valenic acid

化学式: C5H11NO2 (117.0789746)
中文名称: DL-正缬氨酸, D-正缬氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(C(=O)O)N
InChI: InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1

描述信息

DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

同义名列表

28 个代谢物同义名

DL-alpha-Amino-N-valenic acid; alpha-DL-Aminopentanoic acid; (2R)-2-aminopentanoic acid; DL-alpha-Aminovaleric acid; alpha-Aminopentanoic acid; Norvaline (acd/name 4.0); DL-2-Aminopentanoic acid; alpha-Aminovaleric acid; -DL-Aminopentanoic acid; D-2-Aminopentanoic acid; 2-Amino-DL-valeric acid; 2-Aminopentanoic acids; D-2-Aminovaleric acid; 2-Aminovaleric acids; 2-Aminovaleric acid; -Aminovaleric acid; (.+/-.)-norvaline; (.+-.)-norvaline; D(-)-Norvaline; DL-NORVALINE; D-Norvaline; Norvalines; DL-α Norvaline; α 2-Aminopentanoic acid; D-Norvaline; DL-Norvaline



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hayarpi Javrushyan, Edita Nadiryan, Anna Grigoryan, Nikolay Avtandilyan, Alina Maloyan. Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Experimental and molecular pathology. 2022 06; 126(?):104763. doi: 10.1016/j.yexmp.2022.104763. [PMID: 35398371]
  • Michael A Gilinsky, Yulia K Polityko, Arkady L Markel, Tatyana V Latysheva, Abraham O Samson, Baruh Polis, Sergey E Naumenko. Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension. BioMed research international. 2020; 2020(?):4935386. doi: 10.1155/2020/4935386. [PMID: 32149110]
  • Abhijit De, Mamta F Singh, Vinod Singh, Veerma Ram, Shradha Bisht. Treatment effect of l-Norvaline on the sexual performance of male rats with streptozotocin induced diabetes. European journal of pharmacology. 2016 Jan; 771(?):247-54. doi: 10.1016/j.ejphar.2015.12.008. [PMID: 26671005]
  • A P Lytvynenko, T Yu Voznesenska, R I Yanchiy. [THE ROLE OF NO AND MEXIDOL IN CONTRACTILITY OF OVARIAN AND CERVICAL PARTS OF UTERUS UNDER THE CONDITION OF IMMUNE-MEDIATED INJURY IN MICE]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). 2015; 61(5):52-6. doi: 10.15407/fz61.05.052. [PMID: 26845844]
  • Hany M El-Bassossy, Rania El-Fawal, Ahmed Fahmy, Malcolm L Watson. Arginase inhibition alleviates hypertension in the metabolic syndrome. British journal of pharmacology. 2013 Jun; 169(3):693-703. doi: 10.1111/bph.12144. [PMID: 23441715]
  • Hany M El-Bassossy, Rania El-Fawal, Ahmed Fahmy. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascular pharmacology. 2012 Nov; 57(5-6):194-200. doi: 10.1016/j.vph.2012.01.001. [PMID: 22281732]
  • Naohito Ishii, Hideki Ikenaga, Pamela K Carmines, Yoshikazu Aoki, Zensuke Ogawa, Takao Saruta, Tetsuya Suga. High glucose augments arginase activity and nitric oxide production in the renal cortex. Metabolism: clinical and experimental. 2004 Jul; 53(7):868-74. doi: 10.1016/j.metabol.2004.02.011. [PMID: 15254879]
  • Y Abe, S Fukui, Y Koshiji, M Kobayashi, T Shoji, S Sugata, H Nishizawa, H Suzuki, K Iwata. Enantioselective binding sites on bovine serum albumin to dansyl amino acids. Biochimica et biophysica acta. 1999 Aug; 1433(1-2):188-97. doi: 10.1016/s0167-4838(99)00135-1. [PMID: 10446371]
  • E Peyrin, Y C Guillaume, N Morin, C Guinchard. Retention behavior of D,L-dansyl-amino acids on a human serum albumin chiral stationary phase: effect of a mobile phase modifier. Journal of chromatography. A. 1998 May; 808(1-2):113-20. doi: 10.1016/s0021-9673(98)00117-4. [PMID: 9652113]
  • B Picur, M Lisowski, H Taniuchi, E Poerio. Comparison of thermodynamic and kinetic effects between the Leu32-->norvaline and Leu35-->norvaline substitutions of the three-fragment complex of cytochrome c. Archives of biochemistry and biophysics. 1994 Dec; 315(2):533-47. doi: 10.1006/abbi.1994.1534. [PMID: 7986101]
  • M Arslan, C R Pohl, M S Smith, T M Plant. Studies of the role of the N-methyl-D-aspartate (NMDA) receptor in the hypothalamic control of prolactin secretion. Life sciences. 1992; 50(4):295-300. doi: 10.1016/0024-3205(92)90337-o. [PMID: 1531081]
  • H Angliker, P Wikström, E Shaw. Pseudoarginine: synthesis and properties of derivatives of delta-(1-imidazolyl)norvaline. The Biochemical journal. 1990 Mar; 266(3):829-34. doi: . [PMID: 2327968]
  • J K Tews, A E Harper. Tissue amino acids in rats fed norleucine, norvaline, homoarginine or other amino acid analogues. The Journal of nutrition. 1986 Aug; 116(8):1464-72. doi: 10.1093/jn/116.8.1464. [PMID: 2428957]
  • M E Fico, T Motyl, J A Milner. Species comparison of the influence of ammonia on orotic acid and urea biosynthesis in liver. The Journal of nutrition. 1984 Mar; 114(3):613-21. doi: 10.1093/jn/114.3.613. [PMID: 6699742]
  • K Aoyagi, S Ohba, M Narita, S Tojo. Regulation of biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes and in vivo. Kidney international. Supplement. 1983 Dec; 16(?):S224-8. doi: . [PMID: 6588254]