Cholenate (BioDeep_00000603189)

Main id: BioDeep_00000025012

 

PANOMIX_OTCML-2023


代谢物信息卡片


(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]pentanoic acid

化学式: C24H38O3 (374.2820798)
中文名称: 3β-羟基-Δ5-胆烯酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h5,15,17-21,25H,4,6-14H2,1-3H3,(H,26,27)/t15-,17+,18+,19-,20+,21+,23+,24-/m1/s1

描述信息

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin and could be found in children with the syndrome of hepatic ductular hypoplasia.

同义名列表

25 个代谢物同义名

(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]pentanoic acid; 3beta-Hydroxy-chol-5-en-24-oic Acid; 3beta-Hydroxychol-5-en-24-Oic acid; 3beta-Hydroxy-delta5-cholenic acid; 3b-Hydroxy-chol-5-en-24-Oic acid; 3beta-Hydroxy-chol-5-en-24-Oate; 3b-Hydroxychol-5-en-24-Oic acid; 3b-Hydroxychol-5-en-24-ic acid; 3beta-Hydroxychol-5-en-24-Oate; 3beta-Hydroxy-5-cholenoic acid; 3beta-Hydroxy-5-cholenic acid; 3b-Hydroxy-chol-5-en-24-Oate; 3b-Hydroxy-5-cholenoic acid; 3b-Hydroxychol-5-en-24-Oate; 3b-Hydroxychol-5-enoic acid; 3b-Hydroxychol-5-en-24-ate; 3beta-Hydroxy-5-cholenoate; 3b-Hydroxycholenoic acid; 3b-Hydroxy-5-cholenoate; 3b-Hydroxychol-5-enoate; 3b-Hydroxycholenoate; D5-Cholenic acid; Cholenic acid; D5-Cholenate; Cholenate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nagaraju Akula, Andrew Midzak, Laurent Lecanu, Vassilios Papadopoulos. Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design. Bioorganic & medicinal chemistry letters. 2012 Jun; 22(12):4139-43. doi: 10.1016/j.bmcl.2012.04.058. [PMID: 22575868]
  • Tatsuki Mizuochi, Akihiko Kimura, Isao Ueki, Tomoyuki Takahashi, Takuji Hashimoto, Akira Takao, Yoshitaka Seki, Hajime Takei, Hiroshi Nittono, Takao Kurosawa, Toyojiro Matsuishi. Molecular genetic and bile acid profiles in two Japanese patients with 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase deficiency. Pediatric research. 2010 Sep; 68(3):258-63. doi: 10.1203/pdr.0b013e3181eb0188. [PMID: 20531254]
  • L Riello, L D'Antiga, M Guido, R Alaggio, G Giordano, L Zancan. Titration of bile acid supplements in 3beta-hydroxy-Delta 5-C27-steroid dehydrogenase/isomerase deficiency. Journal of pediatric gastroenterology and nutrition. 2010 Jun; 50(6):655-60. doi: 10.1097/mpg.0b013e3181b97bd2. [PMID: 20400917]
  • Anna N Bukiya, Jacob McMillan, Abby L Parrill, Alejandro M Dopico. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels. Journal of lipid research. 2008 Nov; 49(11):2441-51. doi: 10.1194/jlr.m800286-jlr200. [PMID: 18650555]
  • Nariyasu Mano, Yoshiaki Sato, Masanori Nagata, Takaaki Goto, Junichi Goto. Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems. Journal of lipid research. 2004 Sep; 45(9):1741-8. doi: 10.1194/jlr.m400157-jlr200. [PMID: 15175361]
  • Y Yamato, A Kimura, T Inoue, T Kurosawa, H Kato. Fetal bile acid metabolism: analysis of urinary 3beta-monohydroxy-delta(5) bile acid in preterm infants. Biology of the neonate. 2001 Jul; 80(1):19-25. doi: 10.1159/000047114. [PMID: 11474144]
  • A B Reiss, K O Martin, N B Javitt, D W Martin, E A Grossi, A C Galloway. Sterol 27-hydroxylase: high levels of activity in vascular endothelium. Journal of lipid research. 1994 Jun; 35(6):1026-30. doi: 10.1016/s0022-2275(20)40099-9. [PMID: 8077842]
  • J Shoda, T Osuga, K Matsuura, R Mahara, M Tohma, N Tanaka, Y Matsuzaki, H Miyazaki. Concurrent occurrence of 3 beta,12 alpha-dihydroxy-5-cholenoic acid associated with 3 beta-hydroxy-5-cholenoic acid and their preferential urinary excretion in liver diseases. Journal of lipid research. 1989 Aug; 30(8):1233-42. doi: 10.1016/s0022-2275(20)38280-8. [PMID: 2769075]
  • K Sugiyama, S Okuyama, M Imoto, K Okumura, K Takagi, T Satake. Clinical evaluation of serum 3 beta-hydroxy-5-cholenoic acid in hepatobiliary diseases. Gastroenterologia Japonica. 1986 Dec; 21(6):608-16. doi: 10.1007/bf02774489. [PMID: 3471620]
  • S K Krisans, S L Thompson, L A Pena, E Kok, N B Javitt. Bile acid synthesis in rat liver peroxisomes: metabolism of 26-hydroxycholesterol to 3 beta-hydroxy-5-cholenoic acid. Journal of lipid research. 1985 Nov; 26(11):1324-32. doi: 10.1016/s0022-2275(20)34258-9. [PMID: 4067421]
  • A Hernanz, R Codoceo, P Jara, C Diaz. Unusual serum bile acid pattern in children with the syndrome of hepatic ductular hypoplasia. Clinica chimica acta; international journal of clinical chemistry. 1985 Feb; 145(3):289-96. doi: 10.1016/0009-8981(85)90036-1. [PMID: 3987031]
  • M Tohma, H Wajima, R Mahara, T Kurosawa, I Makino. Determination of 3 beta-hydroxy-5-cholen-24-oic acid and its sulfate in human serum by gas chromatography-mass spectrometry. Steroids. 1984 Jul; 44(1):47-55. doi: 10.1016/s0039-128x(84)80015-x. [PMID: 6537044]
  • S Yamauchi, M Kojima, F Nakayama. Preparation and antigenic property of methyl 3 beta-hydroxy-19-oxo-5-cholen-24-oate 19-(O-carboxymethyl) oxime-bovine serum albumin conjugate. Steroids. 1983 Feb; 41(2):155-64. doi: 10.1016/0039-128x(83)90004-1. [PMID: 6197781]
  • Y Tazawa, T Konno. Urinary monohydroxy bile acids in young infants with obstructive jaundice. Acta paediatrica Scandinavica. 1982 Jan; 71(1):91-5. doi: 10.1111/j.1651-2227.1982.tb09377.x. [PMID: 7136622]
  • E I Minder, G Karlaganis, G Paumgartner. Radioimmunological determination of serum 3 beta-hydroxy-5-cholenoic acid in normal subjects and patients with liver disease. Journal of lipid research. 1979 Nov; 20(8):986-93. doi: NULL. [PMID: 93138]