AM251 (BioDeep_00000600006)
Main id: BioDeep_00000002560
代谢物信息卡片
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
化学式: C22H21Cl2IN4O (554.0137106)
中文名称: 1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-(哌啶-1-基)-1H-吡唑-3-甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I
InChI: InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:90724
- KEGG: C20220
- PubChem: 2125
- Metlin: METLIN43422
- ChEMBL: CHEMBL285932
- CAS: 183232-66-8
- PubChem: 163311963
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- X Qi, W Lin, Y Wu, Q Li, X Zhou, H Li, Q Xiao, Y Wang, B Shao, Q Yuan. CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome.
Journal of dental research.
2022 02; 101(2):206-215. doi:
10.1177/00220345211024528. [PMID: 34269108] - Xiaotao Xu, Kaixuan Wu, Xiaqing Ma, Wenying Wang, Haiyan Wang, Min Huang, Limin Luo, Chen Su, Tifei Yuan, Haibo Shi, Ji Han, Aizhong Wang, Tao Xu. mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress.
Molecular neurobiology.
2021 Oct; 58(10):4944-4958. doi:
10.1007/s12035-021-02469-9. [PMID: 34227060] - Mohammad-Mahdi Ghanbari, Ali Gharibi Loron, Mohammad Sayyah. The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
Brain research bulletin.
2021 05; 170(?):74-80. doi:
10.1016/j.brainresbull.2021.02.011. [PMID: 33581310] - Lindsey Shapiro, Francesca Gado, Clementina Manera, Andrew Escayg. Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.
Neuropharmacology.
2021 05; 188(?):108448. doi:
10.1016/j.neuropharm.2021.108448. [PMID: 33450277] - Zhizhen Wang, Peng Zheng, Yuanyi Xie, Xi Chen, Nadia Solowij, Katrina Green, Yee Lian Chew, Xu-Feng Huang. Cannabidiol regulates CB1-pSTAT3 signaling for neurite outgrowth, prolongs lifespan, and improves health span in Caenorhabditis elegans of Aβ pathology models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 05; 35(5):e21537. doi:
10.1096/fj.202002724r. [PMID: 33817834] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Inmaculada Ruz-Maldonado, Bo Liu, Patricio Atanes, Attilio Pingitore, Guo Cai Huang, Pratik Choudhary, Shanta J Persaud. The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Cellular and molecular life sciences : CMLS.
2020 Nov; 77(22):4709-4723. doi:
10.1007/s00018-019-03433-6. [PMID: 31925452] - R J Newsom, R J Garcia, J Stafford, C Osterlund, C E O'Neill, H E W Day, S Campeau. Remote CB1 receptor antagonist administration reveals multiple sites of tonic and phasic endocannabinoid neuroendocrine regulation.
Psychoneuroendocrinology.
2020 03; 113(?):104549. doi:
10.1016/j.psyneuen.2019.104549. [PMID: 31884322] - Ruisan Zhang, Yongcai Zheng, Fengrui Hu, Xin Meng, Bosen Lv, Kejing Lao, Xingchun Gao, Xiaohua Zhang, Xingchun Gou. Effect of (m)VD-hemopressin against Aβ1-42-induced oxidative stress and apoptosis in mouse hippocampal neurons.
Peptides.
2020 02; 124(?):170185. doi:
10.1016/j.peptides.2019.170185. [PMID: 31730791] - Sofia B Gustafsson, Stig O P Jacobsson. Effects of cannabinoids on the development of chick embryos in ovo.
Scientific reports.
2019 09; 9(1):13486. doi:
10.1038/s41598-019-50004-7. [PMID: 31530885] - Jonathan J Simone, Jennet L Baumbach, Cheryl M McCormick. Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2018 Oct; 69(?):119-131. doi:
10.1016/j.ijdevneu.2018.07.011. [PMID: 30063953] - Weisheng Wang, Yousheng Jia, Danielle T Pham, Linda C Palmer, Kwang-Mook Jung, Conor D Cox, Gavin Rumbaugh, Daniele Piomelli, Christine M Gall, Gary Lynch. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.
Cerebral cortex (New York, N.Y. : 1991).
2018 07; 28(7):2253-2266. doi:
10.1093/cercor/bhx126. [PMID: 28520937] - Manoela V Fogaça, Alline C Campos, Ludmila D Coelho, Ronald S Duman, Francisco S Guimarães. The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.
Neuropharmacology.
2018 06; 135(?):22-33. doi:
10.1016/j.neuropharm.2018.03.001. [PMID: 29510186] - Zul Merali, Christian Cayer, Pamela Kent, Rui Liu, Victor Cal, Cory S Harris, John T Arnason. Sacred Maya incense, copal (Protium copal - Burseraceae), has antianxiety effects in animal models.
Journal of ethnopharmacology.
2018 Apr; 216(?):63-70. doi:
10.1016/j.jep.2018.01.027. [PMID: 29414121] - Guo-Qi Li, Zhe Wang, Tong Zhao, Shi-Xuan Dai, Jia-Ming Liu, Bo-Zhi Jia, Yi Zhang, Qian Li. Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats.
Journal of hypertension.
2018 04; 36(4):801-808. doi:
10.1097/hjh.0000000000001621. [PMID: 29493561] - Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompres. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain.
Neuropharmacology.
2018 Feb; 129(?):1-15. doi:
10.1016/j.neuropharm.2017.11.005. [PMID: 29113897] - Ellen Lüder, Robert Ramer, Kirsten Peters, Burkhard Hinz. Decisive role of P42/44 mitogen-activated protein kinase in Δ9-tetrahydrocannabinol-induced migration of human mesenchymal stem cells.
Oncotarget.
2017 Dec; 8(62):105984-105994. doi:
10.18632/oncotarget.22517. [PMID: 29285308] - Duy-Khanh Dang, Eun-Joo Shin, Anh-Thu Mai, Choon-Gon Jang, Seung-Yeol Nah, Ji Hoon Jeong, Catherine Ledent, Tsuneyuki Yamamoto, Toshitaka Nabeshima, Emmanuel S Onaivi, Hyoung-Chun Kim. Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Free radical biology & medicine.
2017 07; 108(?):204-224. doi:
10.1016/j.freeradbiomed.2017.03.033. [PMID: 28363605] - Yue Hu, Kai-Yi Zhou, Ze-Jian Wang, Yang Lu, Ming Yin. N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H2O2 in HEK293/Tau cells via the CB2 receptor.
Chemico-biological interactions.
2017 Jun; 272(?):135-144. doi:
10.1016/j.cbi.2017.05.009. [PMID: 28526263] - Olga A Sergeeva, Roberto De Luca, Karolina Mazur, Aissa N Chepkova, Helmut L Haas, Andreas Bauer. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms.
Neuropharmacology.
2017 06; 119(?):111-122. doi:
10.1016/j.neuropharm.2017.04.011. [PMID: 28400256] - Cherno O Sidibeh, Maria J Pereira, Joey Lau Börjesson, Prasad G Kamble, Stanko Skrtic, Petros Katsogiannos, Magnus Sundbom, Maria K Svensson, Jan W Eriksson. Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.
Endocrine.
2017 Mar; 55(3):839-852. doi:
10.1007/s12020-016-1172-6. [PMID: 27858284] - Tao Wang, Guo-Qi Li, Hui-Ping Zhang, Yi Zhang, Qian Li. Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats.
Journal of hypertension.
2017 03; 35(3):538-545. doi:
10.1097/hjh.0000000000001179. [PMID: 27861247] - Cristina da Costa Oliveira, Clarice de Carvalho Veloso, Renata Cristina Mendes Ferreira, Gisele Avelar Lage, Lúcia Pinheiro Santos Pimenta, Igor Dimitri Gama Duarte, Thiago Roberto Lima Romero, Andrea de Castro Perez. Peltatoside Isolated from Annona crassiflora Induces Peripheral Antinociception by Activation of the Cannabinoid System.
Planta medica.
2017 Feb; 83(3-04):261-267. doi:
10.1055/s-0042-113386. [PMID: 27574895] - Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Using proteomics to discover novel biomarkers for fatty liver development and response to CB1R antagonist treatment in an obese mouse model.
Proteomics.
2017 01; 17(1-2):. doi:
10.1002/pmic.201600292. [PMID: 27928909] - Helen de Morais, Camila P de Souza, Luisa M da Silva, Daniele M Ferreira, Cristiane Hatsuko Baggio, Ana Carolina Vanvossen, Milene Cristina de Carvalho, José Eduardo da Silva-Santos, Leandro José Bertoglio, Joice M Cunha, Janaina M Zanoveli. Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2016 10; 26(10):1590-600. doi:
10.1016/j.euroneuro.2016.08.007. [PMID: 27544303] - Berhanu Geresu, Emmanuel Onaivi, Ephrem Engidawork. Behavioral evidence for the interaction between cannabinoids and Catha edulis F. (Khat) in mice.
Brain research.
2016 10; 1648(Pt A):333-338. doi:
10.1016/j.brainres.2016.08.006. [PMID: 27502029] - Evangelia Bakali, Yvonne Mbaki, David G Lambert, Ruth A Elliott, Robert Mason, Douglas G Tincello. Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.
International urogynecology journal.
2016 Sep; 27(9):1393-400. doi:
10.1007/s00192-016-2984-x. [PMID: 26942594] - Elisabetta Esposito, Markus Drechsler, Rita Cortesi, Claudio Nastruzzi. Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 May; 102(?):87-91. doi:
10.1016/j.ejpb.2016.03.005. [PMID: 26952905] - Giovanna Morello, Roberta Imperatore, Letizia Palomba, Carmine Finelli, Giuseppe Labruna, Fabrizio Pasanisi, Lucia Sacchetti, Lorena Buono, Fabiana Piscitelli, Pierangelo Orlando, Vincenzo Di Marzo, Luigia Cristino. Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2016 Apr; 113(17):4759-64. doi:
10.1073/pnas.1521304113. [PMID: 27071101] - Isabel González-Mariscal, Susan M Krzysik-Walker, Wook Kim, Michael Rouse, Josephine M Egan. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.
Molecular and cellular endocrinology.
2016 Mar; 423(?):1-10. doi:
10.1016/j.mce.2015.12.015. [PMID: 26724516] - Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.
International journal of molecular medicine.
2016 Mar; 37(3):743-54. doi:
10.3892/ijmm.2016.2475. [PMID: 26847930] - Tomoyo Yoshinaga, Kenichiro Uwabe, Shoichi Naito, Kenichi Higashino, Toru Nakano, Yoshito Numata, Akio Kihara. AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells.
PloS one.
2016; 11(12):e0167848. doi:
10.1371/journal.pone.0167848. [PMID: 27936102] - Lawrence M Carey, Richard A Slivicki, Emma Leishman, Ben Cornett, Ken Mackie, Heather Bradshaw, Andrea G Hohmann. A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Molecular pain.
2016; 12(?):. doi:
10.1177/1744806916649192. [PMID: 27178246] - Sofia A Omari, Murray J Adams, Dale A Kunde, Dominic P Geraghty. Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation.
Pharmacology.
2016; 98(1-2):79-86. doi:
10.1159/000445437. [PMID: 27160991] - Silvia G Ruginsk, Fernanda M V Vechiato, Ernane T Uchoa, Lucila L K Elias, Jose Antunes-Rodrigues. Type 1 cannabinoid receptor modulates water deprivation-induced homeostatic responses.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 Dec; 309(11):R1358-68. doi:
10.1152/ajpregu.00536.2014. [PMID: 26468265] - J J Simone, B L Malivoire, C M McCormick. Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats.
Neuroscience.
2015 Oct; 306(?):123-37. doi:
10.1016/j.neuroscience.2015.08.032. [PMID: 26311003] - Antonio Ortega-Álvaro, Francisco Navarrete, Auxiliadora Aracil-Fernández, Daniela Navarro, Pere Berbel, Jorge Manzanares. Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Oct; 40(11):2639-47. doi:
10.1038/npp.2015.113. [PMID: 25895455] - L S Sampaio, R Taveira Da Silva, D Lima, C L C Sampaio, F A Iannotti, E Mazzarella, V Di Marzo, A Vieyra, R A M Reis, M Einicker-Lamas. The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways.
British journal of pharmacology.
2015 Oct; 172(19):4615-25. doi:
10.1111/bph.13050. [PMID: 25537261] - Takahiro Shimizu, Kenjiro Tanaka, Shogo Shimizu, Youichirou Higashi, Toshio Yawata, Kumiko Nakamura, Keisuke Taniuchi, Tetsuya Ueba, Kazunari Yuri, Motoaki Saito. Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat.
Neuropharmacology.
2015 Aug; 95(?):278-89. doi:
10.1016/j.neuropharm.2015.03.034. [PMID: 25882827] - A Vigolo, A Ossato, C Trapella, F Vincenzi, C Rimondo, C Seri, K Varani, G Serpelloni, M Marti. Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice.
Neuropharmacology.
2015 Aug; 95(?):68-82. doi:
10.1016/j.neuropharm.2015.02.008. [PMID: 25769232] - Sang-Hun Lee, Marco Ledri, Blanka Tóth, Ivan Marchionni, Christopher M Henstridge, Barna Dudok, Kata Kenesei, László Barna, Szilárd I Szabó, Tibor Renkecz, Michelle Oberoi, Masahiko Watanabe, Charles L Limoli, George Horvai, Ivan Soltesz, István Katona. Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Jul; 35(27):10039-57. doi:
10.1523/jneurosci.4112-14.2015. [PMID: 26157003] - Chin-Chang Chen, Tzung-Yan Lee, Ching-Fai Kwok, Yung-Pei Hsu, Kuang-Chung Shih, Yan-Jie Lin, Low-Tone Ho. Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.
Biochemical and biophysical research communications.
2015 May; 460(4):1063-8. doi:
10.1016/j.bbrc.2015.03.155. [PMID: 25843798] - Kayte A Jenkin, Lannie O'Keefe, Anna C Simcocks, Esther Grinfeld, Michael L Mathai, Andrew J McAinch, Deanne H Hryciw. Chronic administration of AM251 improves albuminuria and renal tubular structure in obese rats.
The Journal of endocrinology.
2015 May; 225(2):113-24. doi:
10.1530/joe-15-0004. [PMID: 25804605] - Peng Zhong, Yong Liu, Ying Hu, Tong Wang, Yong-ping Zhao, Qing-song Liu. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Mar; 35(10):4469-81. doi:
10.1523/jneurosci.2924-14.2015. [PMID: 25762688] - Zdeněk Fišar, Namrata Singh, Jana Hroudová. Cannabinoid-induced changes in respiration of brain mitochondria.
Toxicology letters.
2014 Nov; 231(1):62-71. doi:
10.1016/j.toxlet.2014.09.002. [PMID: 25195527] - Mahsa Shahidi, Enoch S E Tay, Scott A Read, Mehdi Ramezani-Moghadam, Kazuaki Chayama, Jacob George, Mark W Douglas. Endocannabinoid CB1 antagonists inhibit hepatitis C virus production, providing a novel class of antiviral host-targeting agents.
The Journal of general virology.
2014 Nov; 95(Pt 11):2468-2479. doi:
10.1099/vir.0.067231-0. [PMID: 25053565] - Gaurav Bedse, Roberto Colangeli, Angelo M Lavecchia, Adele Romano, Fabio Altieri, Carlo Cifani, Tommaso Cassano, Silvana Gaetani. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2014 Sep; 24(9):1511-23. doi:
10.1016/j.euroneuro.2014.07.005. [PMID: 25106694] - M Sałaga, A Mokrowiecka, P K Zakrzewski, A Cygankiewicz, E Leishman, M Sobczak, H Zatorski, E Małecka-Panas, R Kordek, M Storr, W M Krajewska, H B Bradshaw, J Fichna. Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
Journal of Crohn's & colitis.
2014 Sep; 8(9):998-1009. doi:
10.1016/j.crohns.2014.01.025. [PMID: 24530133] - M Wierucka-Rybak, M Wolak, E Bojanowska. The effects of leptin in combination with a cannabinoid receptor 1 antagonist, AM 251, or cannabidiol on food intake and body weight in rats fed a high-fat or a free-choice high sugar diet.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2014 Aug; 65(4):487-96. doi:
". [PMID: 25179081] - Jessica A Fawley, Mackenzie E Hofmann, Michael C Andresen. Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Jun; 34(24):8324-32. doi:
10.1523/jneurosci.0315-14.2014. [PMID: 24920635] - Rajib K Paul, Artur Wnorowski, Isabel Gonzalez-Mariscal, Surendra K Nayak, Karolina Pajak, Ruin Moaddel, Fred E Indig, Michel Bernier, Irving W Wainer. (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility.
Biochemical pharmacology.
2014 Feb; 87(4):547-61. doi:
10.1016/j.bcp.2013.11.020. [PMID: 24355564] - Himiko Suzuki, Yuki Ito, Yuki Noro, Mamoru Koketsu, Michihiro Kamijima, Motohiro Tomizawa. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s).
Toxicology letters.
2014 Feb; 225(1):153-7. doi:
10.1016/j.toxlet.2013.12.004. [PMID: 24361246] - Giovane Galdino, Thiago R L Romero, José Felipe P Silva, Daniele C Aguiar, Ana Maria de Paula, Jader S Cruz, Cosimo Parrella, Fabiana Piscitelli, Igor D Duarte, Vincenzo Di Marzo, Andrea C Perez. The endocannabinoid system mediates aerobic exercise-induced antinociception in rats.
Neuropharmacology.
2014 Feb; 77(?):313-24. doi:
10.1016/j.neuropharm.2013.09.022. [PMID: 24148812] - Yann Ravussin, Cuiying Xiao, Oksana Gavrilova, Marc L Reitman. Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
PloS one.
2014; 9(1):e85876. doi:
10.1371/journal.pone.0085876. [PMID: 24465761] - Margarita Vida, Patricia Rivera, Ana Luisa Gavito, Juan Suárez, Francisco Javier Pavón, Sergio Arrabal, Miguel Romero-Cuevas, Dolores Bautista, Ana Martínez, Fernando Rodríguez de Fonseca, Antonia Serrano, Elena Baixeras. CB1 blockade potentiates down-regulation of lipogenic gene expression in perirenal adipose tissue in high carbohydrate diet-induced obesity.
PloS one.
2014; 9(2):e90016. doi:
10.1371/journal.pone.0090016. [PMID: 24587189] - A M McKillop, B M Moran, Y H A Abdel-Wahab, P R Flatt. Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.
British journal of pharmacology.
2013 Nov; 170(5):978-90. doi:
10.1111/bph.12356. [PMID: 23992544] - Ikram Merroun, Cristina Sánchez-González, Rosario Martínez, Carlos López-Chaves, Jesús M Porres, Pilar Aranda, Juan Llopis, Milagros Galisteo, Antonio Zarzuelo, Mohammed Errami, María López-Jurado. Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Metabolism: clinical and experimental.
2013 Nov; 62(11):1641-50. doi:
10.1016/j.metabol.2013.06.011. [PMID: 23932644] - Silvia G Ruginsk, Ernane T Uchoa, Lucila Lk Elias, Jose Antunes-Rodrigues. Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion.
Clinical and experimental pharmacology & physiology.
2013 Oct; 40(10):698-705. doi:
10.1111/1440-1681.12155. [PMID: 23875874] - J P Prestifilippo, V A Medina, C E Mohn, P A Rodriguez, J C Elverdin, J Fernandez-Solari. Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus.
Archives of oral biology.
2013 Sep; 58(9):1251-9. doi:
10.1016/j.archoralbio.2013.04.003. [PMID: 23684250] - Muhammad T Akhtar, Shaukat Ali, Hassan Rashidi, Frank van der Kooy, Robert Verpoorte, Michael K Richardson. Developmental effects of cannabinoids on zebrafish larvae.
Zebrafish.
2013 Sep; 10(3):283-93. doi:
10.1089/zeb.2012.0785. [PMID: 23789728] - Thomas J Younts, Vivien Chevaleyre, Pablo E Castillo. CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Aug; 33(34):13743-57. doi:
10.1523/jneurosci.0817-13.2013. [PMID: 23966696] - Alline C Campos, Zaira Ortega, Javier Palazuelos, Manoela V Fogaça, Daniele C Aguiar, Javier Díaz-Alonso, Silvia Ortega-Gutiérrez, Henar Vázquez-Villa, Fabricio A Moreira, Manuel Guzmán, Ismael Galve-Roperh, Francisco S Guimarães. The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
The international journal of neuropsychopharmacology.
2013 Jul; 16(6):1407-19. doi:
10.1017/s1461145712001502. [PMID: 23298518] - J L Wallace, K L Flannigan, W McKnight, L Wang, J G P Ferraz, D Tuitt. Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2013 Apr; 64(2):167-75. doi:
. [PMID: 23756391] - András Iring, Éva Ruisanchez, Miriam Leszl-Ishiguro, Béla Horváth, Rita Benkő, Zsombor Lacza, Zoltán Járai, Péter Sándor, Vincenzo Di Marzo, Pál Pacher, Zoltán Benyó. Role of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.
PloS one.
2013; 8(1):e53390. doi:
10.1371/journal.pone.0053390. [PMID: 23308211] - Douglas McHugh, Jeremy Page, Emily Dunn, Heather B Bradshaw. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
British journal of pharmacology.
2012 Apr; 165(8):2414-24. doi:
10.1111/j.1476-5381.2011.01497.x. [PMID: 21595653] - R J Newsom, C Osterlund, C V Masini, H E Day, R L Spencer, S Campeau. Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats.
Neuroscience.
2012 Mar; 204(?):64-73. doi:
10.1016/j.neuroscience.2011.11.043. [PMID: 22138156] - D A Kupferschmidt, A E Newman, R Boonstra, S Erb. Antagonism of cannabinoid 1 receptors reverses the anxiety-like behavior induced by central injections of corticotropin-releasing factor and cocaine withdrawal.
Neuroscience.
2012 Mar; 204(?):125-33. doi:
10.1016/j.neuroscience.2011.07.022. [PMID: 21784132] - Elisa Rettori, Andrea De Laurentiis, María Zorrilla Zubilete, Valeria Rettori, Juan Carlos Elverdin. Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat.
Neuroimmunomodulation.
2012; 19(5):293-303. doi:
10.1159/000339113. [PMID: 22777139] - Ming-hua Cao, Yong-yu Li, Jing Xu, Ya-jing Feng, Xu-hong Lin, Kun Li, Tong Han, Chang-jie Chen. Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
PloS one.
2012; 7(12):e52921. doi:
10.1371/journal.pone.0052921. [PMID: 23285225] - Tanya L Daigle, William C Wetsel, Marc G Caron. Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
The European journal of neuroscience.
2011 Nov; 34(9):1378-89. doi:
10.1111/j.1460-9568.2011.07874.x. [PMID: 22034973] - Badr Mostafa Ibrahim, Abdel A Abdel-Rahman. Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor responses in conscious rats.
Brain research.
2011 Sep; 1414(?):1-9. doi:
10.1016/j.brainres.2011.07.046. [PMID: 21840505] - Mako Toyoda, Akira Kitaoka, Kazuyuki Machida, Takuya Nishinakagawa, Ryoko Yada, Motoyuki Kohjima, Masaki Kato, Kazuhiro Kotoh, Naoya Sakamoto, Goshi Shiota, Makoto Nakamuta, Manabu Nakashima, Munechika Enjoji. Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes.
International journal of molecular medicine.
2011 May; 27(5):619-24. doi:
10.3892/ijmm.2011.622. [PMID: 21331443] - Patricia Rivera, Yanina Romero-Zerbo, Francisco J Pavón, Antonia Serrano, María-Dolores López-Ávalos, Manuel Cifuentes, Jesús-Mateos Grondona, Francisco-Javier Bermúdez-Silva, Pedro Fernández-Llebrez, Fernando R de Fonseca, Juan Suárez, Margarita Pérez-Martín. Obesity-dependent cannabinoid modulation of proliferation in adult neurogenic regions.
The European journal of neuroscience.
2011 May; 33(9):1577-86. doi:
10.1111/j.1460-9568.2011.07650.x. [PMID: 21395869] - Ana Crespillo, Juan Suárez, Francisco J Bermúdez-Silva, Patricia Rivera, Margarita Vida, Monica Alonso, Ana Palomino, Miguel A Lucena, Antonia Serrano, Margarita Pérez-Martín, Manuel Macias, Pedro Fernández-Llébrez, Fernando Rodríguez de Fonseca. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade.
The Biochemical journal.
2011 Jan; 433(1):175-85. doi:
10.1042/bj20100751. [PMID: 20955176] - A Alhamoruni, A C Lee, K L Wright, M Larvin, S E O'Sullivan. Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability.
The Journal of pharmacology and experimental therapeutics.
2010 Oct; 335(1):92-102. doi:
10.1124/jpet.110.168237. [PMID: 20592049] - Takahiro Shimizu, Lianyi Lu, Kunihiko Yokotani. Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.
European journal of pharmacology.
2010 Sep; 641(1):54-60. doi:
10.1016/j.ejphar.2010.05.007. [PMID: 20519139] - Ying-Ying Yang, Hongqun Liu, Soon Woo Nam, George Kunos, Samuel S Lee. Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids.
Journal of hepatology.
2010 Aug; 53(2):298-306. doi:
10.1016/j.jhep.2010.03.011. [PMID: 20626112] - M A Storr, M Bashashati, C Hirota, V K Vemuri, C M Keenan, M Duncan, B Lutz, K Mackie, A Makriyannis, W K Macnaughton, K A Sharkey. Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2010 Jul; 22(7):787-96, e223. doi:
10.1111/j.1365-2982.2010.01478.x. [PMID: 20180825] - Valentina De Chiara, Francesco Angelucci, Silvia Rossi, Alessandra Musella, Francesca Cavasinni, Cristina Cantarella, Giorgia Mataluni, Lucia Sacchetti, Francesco Napolitano, Maura Castelli, Carlo Caltagirone, Giorgio Bernardi, Mauro Maccarrone, Alessandro Usiello, Diego Centonze. Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Jun; 30(24):8127-37. doi:
10.1523/jneurosci.1683-10.2010. [PMID: 20554863] - M D Gutierrez-Lopez, N Llopis, S Feng, D A Barrett, E O'Shea, M I Colado. Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine.
British journal of pharmacology.
2010 Jun; 160(3):772-83. doi:
10.1111/j.1476-5381.2010.00720.x. [PMID: 20590579] - Brian D Hudson, Terence E Hébert, Melanie E M Kelly. Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors.
British journal of pharmacology.
2010 Jun; 160(3):627-42. doi:
10.1111/j.1476-5381.2010.00681.x. [PMID: 20590567] - Sarah A Eisenstein, Jason R Clapper, Philip V Holmes, Daniele Piomelli, Andrea G Hohmann. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Pharmacological research.
2010 May; 61(5):419-29. doi:
10.1016/j.phrs.2009.12.013. [PMID: 20044005] - Sayaka Kozono, Takashi Matsuyama, Kamal Krishna Biwasa, Ko-ichi Kawahara, Yumiko Nakajima, Takehiko Yoshimoto, Yutaka Yonamine, Hideshi Kadomatsu, Salunya Tancharoen, Teruto Hashiguchi, Kazuyuki Noguchi, Ikuro Maruyama. Involvement of the endocannabinoid system in periodontal healing.
Biochemical and biophysical research communications.
2010 Apr; 394(4):928-33. doi:
10.1016/j.bbrc.2010.03.080. [PMID: 20233580] - Esterina D'Asti, Hong Long, Jennifer Tremblay-Mercier, Magdalena Grajzer, Stephen C Cunnane, Vincenzo Di Marzo, Claire-Dominique Walker. Maternal dietary fat determines metabolic profile and the magnitude of endocannabinoid inhibition of the stress response in neonatal rat offspring.
Endocrinology.
2010 Apr; 151(4):1685-94. doi:
10.1210/en.2009-1092. [PMID: 20160134] - Kayte A Jenkin, Andrew J McAinch, Esther Grinfeld, Deanne H Hryciw. Role for cannabinoid receptors in human proximal tubular hypertrophy.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(6):879-86. doi:
10.1159/000323997. [PMID: 21220919] - Y S Weems, A W Lewis, D A Neuendorff, R D Randel, C W Weems. Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro.
Prostaglandins & other lipid mediators.
2009 Dec; 90(3-4):89-93. doi:
10.1016/j.prostaglandins.2009.09.003. [PMID: 19765667] - M K Judge, Y Zhang, P J Scarpace. Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
The Journal of endocrinology.
2009 Nov; 203(2):281-90. doi:
10.1677/joe-09-0210. [PMID: 19679649] - Ankur Kapur, Pingwei Zhao, Haleli Sharir, Yushi Bai, Marc G Caron, Larry S Barak, Mary E Abood. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
The Journal of biological chemistry.
2009 Oct; 284(43):29817-27. doi:
10.1074/jbc.m109.050187. [PMID: 19723626] - M Rutkowska, H Gliniak. The influence of ACEA--a selective cannabinoid CB1 receptor agonist on whole blood and platelet-poor plasma serotonin concentrations.
Die Pharmazie.
2009 Sep; 64(9):598-601. doi:
NULL. [PMID: 19827303] - B M Fonseca, G Correia-da-Silva, N A Teixeira. Anandamide-induced cell death: dual effects in primary rat decidual cell cultures.
Placenta.
2009 Aug; 30(8):686-92. doi:
10.1016/j.placenta.2009.05.012. [PMID: 19560819] - Gernot Riedel, Paola Fadda, Susan McKillop-Smith, Roger G Pertwee, Bettina Platt, Lianne Robinson. Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
British journal of pharmacology.
2009 Apr; 156(7):1154-66. doi:
10.1111/j.1476-5381.2008.00107.x. [PMID: 19378378] - Li-sheng Jiang, Jun Pu, Zhi-hua Han, Liu-hua Hu, Ben He. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.
Cardiovascular research.
2009 Mar; 81(4):805-13. doi:
10.1093/cvr/cvn344. [PMID: 19074161] - Beatriz Fioravanti, Milena De Felice, Cheryl L Stucky, Karen A Medler, Miaw-Chyi Luo, Luis R Gardell, Mohab Ibrahim, T Phil Malan, Henry I Yamamura, Michael H Ossipov, Tamara King, Josephine Lai, Frank Porreca, Todd W Vanderah. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Nov; 28(45):11593-602. doi:
10.1523/jneurosci.3322-08.2008. [PMID: 18987195] - Marco Aurélio Liberato Costa da Veiga, Flávia Fonseca Bloise, Ricardo Henrique Costa-E-Sousa, Luana Lopes Souza, Norma Aparecida Dos Santos Almeida, Karen Jesus Oliveira, Carmen Cabanelas Pazos-Moura. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion.
The Journal of endocrinology.
2008 Nov; 199(2):235-42. doi:
10.1677/joe-08-0380. [PMID: 18755884] - Michelle Roche, John P Kelly, Maeve O'Driscoll, David P Finn. Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
Immunology.
2008 Oct; 125(2):263-71. doi:
10.1111/j.1365-2567.2008.02838.x. [PMID: 18393970] - Yin Duan, Chengyong Liao, Saurabh Jain, Russell A Nicholson. The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [(3)H]batrachotoxinin A 20 alpha-benzoate binding to sodium channels and inhibit sodium channel function.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2008 Sep; 148(3):244-9. doi:
10.1016/j.cbpc.2008.06.002. [PMID: 18599378] - Alline Cristina Campos, Francisco Silveira Guimarães. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.
Psychopharmacology.
2008 Aug; 199(2):223-30. doi:
10.1007/s00213-008-1168-x. [PMID: 18446323] - Boris B Gorzalka, Anna C Morrish, Matthew N Hill. Endocannabinoid modulation of male rat sexual behavior.
Psychopharmacology.
2008 Jul; 198(4):479-86. doi:
10.1007/s00213-007-0901-1. [PMID: 17694389] - Nigel Irwin, Kerry Hunter, Peter R Flatt. Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Peptides.
2008 Jun; 29(6):1036-41. doi:
10.1016/j.peptides.2008.01.006. [PMID: 18291559]
