Deoxycorticosterone acetate (BioDeep_00000416072)
Secondary id: BioDeep_00000001943, BioDeep_00000419036
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
Desoxycorticosterone Acetate
化学式: C23H32O4 (372.2300472)
中文名称: 醋酸去氧皮质酮
谱图信息:
最多检出来源 Viridiplantae(plant) 1.57%
分子结构信息
SMILES: CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI: InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D008901 - Mineralocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria[1][2].
同义名列表
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:34671
- KEGGdrug: D81855
- KEGGdrug: D03698
- PubChem: 5952
- DrugBank: DB06780
- ChEMBL: CHEMBL1200542
- MeSH: Desoxycorticosterone Acetate
- CAS: 56-47-3
- MoNA: CCMSLIB00005463881
- MoNA: CCMSLIB00005463882
- MoNA: CCMSLIB00005463883
- MoNA: CCMSLIB00005463884
- MoNA: MoNA038690
- MoNA: MoNA037350
- MoNA: MoNA036399
- MoNA: MoNA036398
- MoNA: MoNA036395
- RefMet: Deoxycorticosterone acetate
- medchemexpress: HY-B1472
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-626
- KEGG: C14554
- PubChem: 17395554
- KNApSAcK: 34671
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Camila Rodrigues Moro, Edina da Luz Abreu, Samia Hassan Husein Kanaan, Antonio Márquez, Jose Antonio Uranga-Ocio, Luciana Venturini Rossoni, Dalton Valentim Vassallo, Marta Miguel-Castro, Giulia Alessandra Wiggers. Egg white hydrolysate protects white adipose tissue against metabolic insult in deoxycorticosterone acetate-salt rats.
The British journal of nutrition.
2024 Jun; 131(11):1827-1840. doi:
10.1017/s0007114524000552. [PMID: 38410884] - Henglai Sun, Jijuan Nai, Biqi Deng, Zhen Zheng, Xuemei Chen, Chao Zhang, Huagang Sheng, Liqiao Zhu. Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin.
Molecules (Basel, Switzerland).
2024 Feb; 29(3):. doi:
10.3390/molecules29030731. [PMID: 38338476] - Qiao Liu, Qingman Luo, Bin Zhong, Kecheng Tang, Xueling Chen, Shengqian Yang, Xiaohui Li. Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways.
European journal of pharmacology.
2024 Jan; 962(?):176236. doi:
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Journal of cardiovascular translational research.
2023 02; 16(1):127-140. doi:
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Circulation research.
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Cardiovascular research.
2019 03; 115(4):776-787. doi:
10.1093/cvr/cvy252. [PMID: 30357309] - Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Merve Matilda Tuglu, Mecit Orhan Uludag, Emine Demirel-Yilmaz. Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction.
Vascular pharmacology.
2019 02; 113(?):38-46. doi:
10.1016/j.vph.2018.11.004. [PMID: 30458302] - Izabela Dobrzyńska, Barbara Szachowicz-Petelska, Jolanta Weresa, Zbigniew A Figaszewski, Elżbieta Skrzydlewska. Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor.
Chemico-biological interactions.
2019 Feb; 299(?):52-58. doi:
10.1016/j.cbi.2018.11.024. [PMID: 30502333] - Eun Hui Bae, In Jin Kim, Ji Hong Song, Hong Sang Choi, Chang Seong Kim, Gwang Hyeon Eom, Inkyeom Kim, Hyunju Cha, Joong Myung Cho, Seong Kwon Ma, Soo Wan Kim. Renoprotective Effect of the Histone Deacetylase Inhibitor CG200745 in DOCA-Salt Hypertensive Rats.
International journal of molecular sciences.
2019 Jan; 20(3):. doi:
10.3390/ijms20030508. [PMID: 30691015] - Venkateswara Rao Amara, Sunil Kumar Surapaneni, Kulbhushan Tikoo. Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection.
Toxicology and applied pharmacology.
2019 01; 362(?):95-104. doi:
10.1016/j.taap.2018.10.004. [PMID: 30290168] - Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Mecit Orhan Uludag, Emine Demirel-Yilmaz. The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta.
Life sciences.
2018 Nov; 213(?):287-293. doi:
10.1016/j.lfs.2018.10.042. [PMID: 30366037] - Fatima Trebak, Wencheng Li, Yumei Feng. Neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake.
Physiological genomics.
2018 10; 50(10):904-912. doi:
10.1152/physiolgenomics.00065.2018. [PMID: 30142028] - Michał Biernacki, Wojciech Łuczaj, Iwona Jarocka-Karpowicz, Ewa Ambrożewicz, Marek Toczek, Elżbieta Skrzydlewska. The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
10.3390/molecules23092350. [PMID: 30223427] - Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewska. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
Prostaglandins & other lipid mediators.
2018 09; 138(?):54-63. doi:
10.1016/j.prostaglandins.2018.09.001. [PMID: 30201316] - Mi Tian, Li Tang, Yuanyuan Wu, Srinivasan Beddhu, Yufeng Huang. Adiponectin attenuates kidney injury and fibrosis in deoxycorticosterone acetate-salt and angiotensin II-induced CKD mice.
American journal of physiology. Renal physiology.
2018 09; 315(3):F558-F571. doi:
10.1152/ajprenal.00137.2018. [PMID: 29873514] - Yoshitaka Iwazu, Shigeaki Muto, Takashi Ioka, Yuko Watanabe, Kana Iwazu, Eiji Kusano, Daisuke Nagata. Multiple Sclerosis Drug Fingolimod Induces Thrombotic Microangiopathy in Deoxycorticosterone Acetate/Salt Hypertension.
Hypertension (Dallas, Tex. : 1979).
2018 09; 72(3):776-784. doi:
10.1161/hypertensionaha.117.10655. [PMID: 30354753] - Douglas Jackson, Kylie Connolly, Romeo Batacan, Kimberly Ryan, Rebecca Vella, Andrew Fenning. (-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats.
Molecules (Basel, Switzerland).
2018 06; 23(7):. doi:
10.3390/molecules23071511. [PMID: 29932135] - Lauren G Douma, Meaghan R Holzworth, Kristen Solocinski, Sarah H Masten, Amber H Miller, Kit-Yan Cheng, I Jeanette Lynch, Brian D Cain, Charles S Wingo, Michelle L Gumz. Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology.
2018 06; 314(6):F1138-F1144. doi:
10.1152/ajprenal.00546.2017. [PMID: 29357420] - Christopher T Banek, Madeline M Gauthier, Daniel C Baumann, Dusty Van Helden, Ninitha Asirvatham-Jeyaraj, Angela Panoskaltsis-Mortari, Gregory D Fink, John W Osborn. Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat.
American journal of physiology. Regulatory, integrative and comparative physiology.
2018 06; 314(6):R883-R891. doi:
10.1152/ajpregu.00416.2017. [PMID: 29513561] - Leila Safaeian, Reyhaneh Emami, Valiollah Hajhashemi, Zahra Haghighatian. Antihypertensive and antioxidant effects of protocatechuic acid in deoxycorticosterone acetate-salt hypertensive rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Apr; 100(?):147-155. doi:
10.1016/j.biopha.2018.01.107. [PMID: 29428662] - Ryan K Mui, Roxanne N Fernandes, Hannah G Garver, Nico Van Rooijen, James J Galligan. Macrophage-dependent impairment of α2-adrenergic autoreceptor inhibition of Ca2+ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats.
American journal of physiology. Heart and circulatory physiology.
2018 04; 314(4):H863-H877. doi:
10.1152/ajpheart.00536.2017. [PMID: 29351460] - Yannick Marc, Reda Hmazzou, Fabrice Balavoine, Adrien Flahault, Catherine Llorens-Cortes. Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.
Journal of hypertension.
2018 03; 36(3):641-650. doi:
10.1097/hjh.0000000000001563. [PMID: 28968260] - Uttam Kumar Maji, Pradipta Jana, Mitali Chatterjee, Sanmay Karmakar, Arup Saha, Tamal Kanti Ghosh. Role of Acetyl Salicylic Acid in Controlling the DOCA-Salt Induced Hypertension in Rats by Stimulating the Synthesis of r-Cortexin in the Kidney.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2018 Mar; 25(1):79-88. doi:
10.1007/s40292-017-0241-0. [PMID: 29307050] - Marialuisa Perrotta, Andrea Lori, Lorenzo Carnevale, Stefania Fardella, Giuseppe Cifelli, Roberta Iacobucci, Francesco Mastroiacovo, Daniele Iodice, Fabio Pallante, Marianna Storto, Giuseppe Lembo, Daniela Carnevale. Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation.
Cardiovascular research.
2018 Mar; 114(3):456-467. doi:
10.1093/cvr/cvy001. [PMID: 29324984] - Kensei Taguchi, Sho-Ichi Yamagishi, Miyuki Yokoro, Sakuya Ito, Goh Kodama, Yusuke Kaida, Yosuke Nakayama, Ryotaro Ando, Nana Yamada-Obara, Katsuhiko Asanuma, Takanori Matsui, Yuichiro Higashimoto, Craig R Brooks, Seiji Ueda, Seiya Okuda, Kei Fukami. RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice.
Scientific reports.
2018 02; 8(1):2686. doi:
10.1038/s41598-018-21176-5. [PMID: 29422652] - Agnieszka Polak, Ewa Harasim-Symbor, Barbara Malinowska, Irena Kasacka, Alicja Lewandowska, Adrian Chabowski. The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(2):727-739. doi:
10.1159/000488730. [PMID: 29621749] - Meng-Chun Cheng, Tzu-Ming Pan. Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products.
Pharmaceutical biology.
2017 Dec; 55(1):487-496. doi:
10.1080/13880209.2016.1253109. [PMID: 27937042] - Dong Wang, Yuhuan Luo, Komuraiah Myakala, David J Orlicky, Evgenia Dobrinskikh, Xiaoxin Wang, Moshe Levi. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats.
Scientific reports.
2017 08; 7(1):9793. doi:
10.1038/s41598-017-09470-0. [PMID: 28851937] - Agnieszka Polak, Ewa Harasim-Symbor, Barbara Malinowska, Irena Kasacka, Anna Pędzińska-Betiuk, Jolanta Weresa, Adrian Chabowski. The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats.
Life sciences.
2017 Aug; 183(?):1-10. doi:
10.1016/j.lfs.2017.06.019. [PMID: 28633967] - Patrick Slattery, Stefanie Frölich, Itamar Goren, Rolf M Nüsing. Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice.
American journal of physiology. Renal physiology.
2017 06; 312(6):F1044-F1055. doi:
10.1152/ajprenal.00565.2016. [PMID: 28274925] - Bibi S van Thiel, Alexandre Góes Martini, Luuk Te Riet, David Severs, Estrellita Uijl, Ingrid M Garrelds, Frank P J Leijten, Ingrid van der Pluijm, Jeroen Essers, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Ludovit Paulis, Romana Rajkovicova, Oliver Domenig, Marko Poglitsch, A H Jan Danser. Brain Renin-Angiotensin System: Does It Exist?.
Hypertension (Dallas, Tex. : 1979).
2017 06; 69(6):1136-1144. doi:
10.1161/hypertensionaha.116.08922. [PMID: 28396529] - Xing Wei, Peng Gao, Yunfei Pu, Qiang Li, Tao Yang, Hexuan Zhang, Shiqiang Xiong, Yuanting Cui, Li Li, Xin Ma, Daoyan Liu, Zhiming Zhu. Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorticosterone acetate (DOCA)-salt-induced hypertension.
Clinical science (London, England : 1979).
2017 Apr; 131(7):567-581. doi:
10.1042/cs20160780. [PMID: 28143892] - Tyler Basting, Eric Lazartigues. DOCA-Salt Hypertension: an Update.
Current hypertension reports.
2017 Apr; 19(4):32. doi:
10.1007/s11906-017-0731-4. [PMID: 28353076] - Francine Z Marques, Erin Nelson, Po-Yin Chu, Duncan Horlock, April Fiedler, Mark Ziemann, Jian K Tan, Sanjaya Kuruppu, Niwanthi W Rajapakse, Assam El-Osta, Charles R Mackay, David M Kaye. High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.
Circulation.
2017 Mar; 135(10):964-977. doi:
10.1161/circulationaha.116.024545. [PMID: 27927713] - Yeong Hann Ling, Shalini M Krishnan, Christopher T Chan, Henry Diep, Dorota Ferens, Jaye Chin-Dusting, Barbara K Kemp-Harper, Chrishan S Samuel, Timothy D Hewitson, Eicke Latz, Ashley Mansell, Christopher G Sobey, Grant R Drummond. Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.
Pharmacological research.
2017 02; 116(?):77-86. doi:
10.1016/j.phrs.2016.12.015. [PMID: 27986554] - Anees A Syed, Shibani Lahiri, Divya Mohan, Guru R Valicherla, Anand P Gupta, Mohammed Riyazuddin, Sudhir Kumar, Rakesh Maurya, Kashif Hanif, Jiaur R Gayen. Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats.
Journal of ethnopharmacology.
2016 Dec; 193(?):555-565. doi:
10.1016/j.jep.2016.10.008. [PMID: 27720848] - Christopher T Banek, Mark M Knuepfer, Jason D Foss, Jessica K Fiege, Ninitha Asirvatham-Jeyaraj, Dusty Van Helden, Yoji Shimizu, John W Osborn. Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension.
Hypertension (Dallas, Tex. : 1979).
2016 12; 68(6):1415-1423. doi:
10.1161/hypertensionaha.116.07850. [PMID: 27698066] - Kiyoshi Arai, Yuka Morikawa, Naoko Ubukata, Hiroyuki Tsuruoka, Tsuyoshi Homma. CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats.
The Journal of pharmacology and experimental therapeutics.
2016 09; 358(3):548-57. doi:
10.1124/jpet.116.234765. [PMID: 27384074] - Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats.
Toxicology and applied pharmacology.
2016 06; 301(?):31-41. doi:
10.1016/j.taap.2016.04.006. [PMID: 27086176] - Xuexiang Wang, Ashley C Johnson, Jennifer M Sasser, Jan M Williams, Leah C Solberg Woods, Michael R Garrett. Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats.
American journal of physiology. Renal physiology.
2016 05; 310(10):F1054-64. doi:
10.1152/ajprenal.00555.2015. [PMID: 26936874] - Marek Toczek, Marta Baranowska-Kuczko, Emilia Grzęda, Anna Pędzińska-Betiuk, Jolanta Weresa, Barbara Malinowska. Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats.
Pharmacological reports : PR.
2016 Apr; 68(2):363-9. doi:
10.1016/j.pharep.2015.10.004. [PMID: 26922540] - Jitesh S Rathee, Birija S Patro, Lindsay Brown, Subrata Chattopadhyay. Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats.
Free radical research.
2016; 50(1):111-21. doi:
10.3109/10715762.2015.1112005. [PMID: 26503350] - Kai Song, Deborah Stuart, Nikita Abraham, Fei Wang, Shuping Wang, Tianxin Yang, Curt D Sigmund, Donald E Kohan, Nirupama Ramkumar. Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury.
PloS one.
2016; 11(7):e0159872. doi:
10.1371/journal.pone.0159872. [PMID: 27467376] - Sameer H Sawant, Subhash L Bodhankar. Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats.
Renal failure.
2016; 38(3):411-23. doi:
10.3109/0886022x.2015.1136895. [PMID: 26795298] - Achim Lother, David Fürst, Stella Bergemann, Ralf Gilsbach, Florian Grahammer, Tobias B Huber, Ingo Hilgendorf, Christoph Bode, Martin Moser, Lutz Hein. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure.
Hypertension (Dallas, Tex. : 1979).
2016 Jan; 67(1):130-8. doi:
10.1161/hypertensionaha.115.06530. [PMID: 26553231] - Chuan-Teng Liu, Se-Ping Chien, Dur-Zong Hsu, Srinivasan Periasamy, Ming-Yie Liu. Curative effect of sesame oil in a rat model of chronic kidney disease.
Nephrology (Carlton, Vic.).
2015 Dec; 20(12):922-30. doi:
10.1111/nep.12524. [PMID: 26016645] - S Sugin Lal Jabaris, Haridass Sumathy, Ramesh Girish, Shridhar Narayanan, Mani Sugumar, Chidambaram Saravana Babu, Sadagopan Thanikachalam, Mohan Thanikachalam. Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Brain research.
2015 Oct; 1622(?):279-91. doi:
10.1016/j.brainres.2015.07.003. [PMID: 26168894] - Youping Wang, Mingjun Zhu, Hui Xu, Lin Cui, Weihong Liu, Xiaoxiao Wang, Si Shen, Donna H Wang. Role of the monocyte chemoattractant protein-1/C-C chemokine receptor 2 signaling pathway in transient receptor potential vanilloid type 1 ablation-induced renal injury in salt-sensitive hypertension.
Experimental biology and medicine (Maywood, N.J.).
2015 Sep; 240(9):1223-34. doi:
10.1177/1535370214565970. [PMID: 25585624] - Kiyoshi Arai, Tsuyoshi Homma, Yuka Morikawa, Naoko Ubukata, Hiyoyuki Tsuruoka, Kazumasa Aoki, Hirokazu Ishikawa, Makoto Mizuno, Toshio Sada. Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
European journal of pharmacology.
2015 Aug; 761(?):226-34. doi:
10.1016/j.ejphar.2015.06.015. [PMID: 26073023] - Chao-Zong Lan, Ling Ding, Yi-Lin Su, Kun Guo, Li Wang, Hong-Wei Kan, Yu-Rong Ou, Shan Gao. Grape seed proanthocyanidins prevent DOCA-salt hypertension-induced renal injury and its mechanisms in rats.
Food & function.
2015 Jul; 6(7):2179-86. doi:
10.1039/c5fo00253b. [PMID: 26011796] - Tamara Abramoff, María J Guil, Vanina P Morales, Sandra I Hope, Christian Höcht, Liliana G Bianciotti, Marcelo S Vatta. Involvement of endothelins in deoxycorticosterone acetate-salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus.
Experimental physiology.
2015 Jun; 100(6):617-27. doi:
10.1113/ep085230. [PMID: 25809871] - K M Appleton, A J Grippo, T G Beltz, A K Johnson. Consumption of a high n-3 polyunsaturated fatty acid diet during gradual mild physiological stress in rats.
Prostaglandins, leukotrienes, and essential fatty acids.
2015 Apr; 95(?):11-8. doi:
10.1016/j.plefa.2014.11.010. [PMID: 25534694] - Shu-Yan Dai, Wei Peng, Yu-Ping Zhang, Jian-Dong Li, Ying Shen, Xiao-Fei Sun. Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats.
Journal of neuroinflammation.
2015 Mar; 12(?):47. doi:
10.1186/s12974-015-0261-4. [PMID: 25885968] - R Akcilar, C Ayada, G Turgut, S Turgut. Supplementation of apelin increase plasma levels of nesfatin-1 in normal and DOCA-salt hypertensive rats.
Bratislavske lekarske listy.
2015; 116(2):104-8. doi:
10.4149/bll_2015_020. [PMID: 25665476] - Sevtap Han, Mecit Orhan Uludag, Suzan Emel Usanmaz, Fatma Ayaloglu-Butun, Kamil Can Akcali, Emine Demirel-Yilmaz. Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
Molecular biology reports.
2015 Jan; 42(1):35-42. doi:
10.1007/s11033-014-3737-x. [PMID: 25234650]