3-HYDROXYGLUTARIC ACID (BioDeep_00000406088)
Main id: BioDeep_00000018489
PANOMIX_OTCML-2023
代谢物信息卡片
3-HYDROXYGLUTARIC ACID
化学式: C5H8O5 (148.0371718)
中文名称: 3-羟基戊二酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(CC(=O)O)O)C(=O)O
InChI: InChI=1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
描述信息
A 3 hydroxy carboxylic acid that is glutaric acid which is substituted by a hydroxy group at position 3. It is a diagnostic marker for glutaric aciduria type I.
3-Hydroxyglutaric acid is a glutaric acid derivative.
同义名列表
1 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:39980
- PubChem: 181976
- Metlin: METLIN5417
- DrugBank: DB04594
- ChEMBL: CHEMBL556937
- CAS: 638-18-6
- MoNA: MoNA037730
- MoNA: MoNA034878
- MoNA: MoNA034877
- MoNA: MoNA034876
- MoNA: FiehnHILIC000959
- MetaboLights: MTBLC39980
- RefMet: 3-Hydroxyglutaric acid
- medchemexpress: HY-113411
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Joshua A Dubland, Graham Sinclair, Hilary Vallance, Bojana Rakić. A simple method modification to increase separation of 2- and 3-hydroxyglutaric acid by GC-MS for clinical urine organic acids analysis.
Clinical biochemistry.
2022 Jul; 105-106(?):81-86. doi:
10.1016/j.clinbiochem.2022.04.016. [PMID: 35500672] - Muntaj Shaik, Kruthika-Vinod T P, Mahesh Kamate, Vedamurthy A B. Is Expanded Newborn Screening Adequate to Detect Indian Biochemical Low Excretor Phenotype Patients of Glutaric Aciduria Type I?.
Indian journal of pediatrics.
2019 11; 86(11):995-1001. doi:
10.1007/s12098-019-03017-z. [PMID: 31302874] - Anais Melin, Charles Brossard, Mireille Castanet, Soumeya Bekri, Abdellah Tebani. Hyperinsulinemic Hypoglycemia in a Neonate.
Clinical chemistry.
2019 02; 65(2):351-353. doi:
10.1373/clinchem.2018.292326. [PMID: 30692138] - Garfield A Simon, Andrea Wierenga. Quantitation of plasma and urine 3-hydroxyglutaric acid, after separation from 2-hydroxyglutaric acid and other compounds of similar ion transition, by liquid chromatography-tandem mass spectrometry for the confirmation of glutaric aciduria type 1.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Oct; 1097-1098(?):101-110. doi:
10.1016/j.jchromb.2018.09.007. [PMID: 30218917] - Roy W A Peake. Seizures, Dystonia, and Spasms in a 14-Year-Old Child.
Clinical chemistry.
2016 08; 62(8):1159-60. doi:
10.1373/clinchem.2016.257865. [PMID: 27471246] - A L Colín-González, A L Paz-Loyola, I N Serratos, B Seminotti, C A J Ribeiro, G Leipnitz, D O Souza, M Wajner, A Santamaría. The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes.
Neuroscience.
2015 Dec; 310(?):578-88. doi:
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Neuroscience.
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Neurology.
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PloS one.
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Cellular and molecular neurobiology.
2007 Sep; 27(6):805-18. doi:
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2007 Jul; 85(7):763-70. doi:
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2007 Jun; 48(5):557-9. doi:
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Cellular and molecular neurobiology.
2007 Jun; 27(4):423-38. doi:
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Retina (Philadelphia, Pa.).
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