prochlorperazine (BioDeep_00000405999)

Main id: BioDeep_00000002062

 


代谢物信息卡片


prochlorperazine

化学式: C20H24ClN3S (373.13793740000006)
中文名称: 奋乃静
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: ClC1=CC=C2SC=3C=CC=CC3N(C2=C1)CCCN4CCN(C)CC4
InChI: InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AB - Phenothiazines with piperazine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D005765 - Gastrointestinal Agents > D000932 - Antiemetics

同义名列表

2 个代谢物同义名

prochlorperazine; Prochlorperazine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kirti Sad, Palak Parashar, Pragya Tripathi, Hungharla Hungyo, Ramesh Sistla, Ravi Soni, Vibha Tandon. Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation. Free radical biology & medicine. 2021 12; 177(?):299-312. doi: 10.1016/j.freeradbiomed.2021.11.001. [PMID: 34742922]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • C S Kow, S S Hasan. Prochlorperazine for nausea and vomiting accompanied COVID-19. Journal of gastroenterology and hepatology. 2021 Feb; 36(2):524-525. doi: 10.1111/jgh.15301. [PMID: 33068035]
  • Michał Otręba, Leon Kośmider, Anna Rzepecka-Stojko. Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. European journal of pharmacology. 2020 Nov; 887(?):173553. doi: 10.1016/j.ejphar.2020.173553. [PMID: 32949606]
  • Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami. Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients. Annals of clinical biochemistry. 2018 May; 55(3):385-393. doi: 10.1177/0004563217731432. [PMID: 28853295]
  • M Otręba, E Buszman. Perphenazine and prochlorperazine induce concentration-dependent loss in human glioblastoma cells viability. Die Pharmazie. 2018 Jan; 73(1):19-21. doi: 10.1691/ph.2018.7806. [PMID: 29441946]
  • Masaki Tashiro, Takafumi Naito, Kazunori Ohnishi, Yoshiyuki Kagawa, Junichi Kawakami. Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients. Clinica chimica acta; international journal of clinical chemistry. 2014 Feb; 429(?):175-80. doi: 10.1016/j.cca.2013.12.011. [PMID: 24360851]
  • Ana M Chamoun-Emanuelli, Eve-Isabelle Pecheur, Rudo L Simeon, Da Huang, Paul S Cremer, Zhilei Chen. Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes. Antimicrobial agents and chemotherapy. 2013 Jun; 57(6):2571-81. doi: 10.1128/aac.02593-12. [PMID: 23529728]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami. Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2012 Jun; 26(6):754-60. doi: 10.1002/bmc.1725. [PMID: 21990013]
  • Ann R Holmes, Mikhail V Keniya, Irena Ivnitski-Steele, Brian C Monk, Erwin Lamping, Larry A Sklar, Richard D Cannon. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial agents and chemotherapy. 2012 Mar; 56(3):1508-15. doi: 10.1128/aac.05706-11. [PMID: 22203607]
  • J N Cheng, A Lee, J Jannes, R J Heddle, S A Koblar. A patient with anaphylaxis after alteplase infusion. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2012 Feb; 19(2):314-5. doi: 10.1016/j.jocn.2011.07.018. [PMID: 22099072]
  • Shuhao Yu, Zhizhong Guo, Yan Guan, Yi-Yu Lu, Pei Hao, Yixue Li, Shi-Bing Su. Combining ZHENG Theory and High-Throughput Expression Data to Predict New Effects of Chinese Herbal Formulae. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):986427. doi: 10.1155/2012/986427. [PMID: 22666299]
  • Megan E Musselman, Linda A Browning, Dennis Parker, Suprat Saely. Neuroleptic malignant syndrome associated with the use of prochlorperazine in a patient with a recent history of antipsychotic-induced neuroleptic malignant syndrome. The Annals of pharmacotherapy. 2011 Nov; 45(11):e61. doi: 10.1345/aph.1q325. [PMID: 21972252]
  • Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase. Basic & clinical pharmacology & toxicology. 2011 Jan; 108(1):46-54. doi: 10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390]
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  • Miao Yan, Yun-Gui Zhu, Huan-De Li, Ben-Mei Chen, Ning Ma, Yan-Qing Lei, Yi-Ping Liu. Quantification of prochlorperazine maleate in human plasma by liquid chromatography-mass spectrometry: Application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):3243-7. doi: 10.1016/j.jchromb.2009.07.038. [PMID: 19682959]
  • Kristy Dolan, Sara Montgomery, Bradley Buchheit, Louis Didone, Melanie Wellington, Damian J Krysan. Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization. Antimicrobial agents and chemotherapy. 2009 Aug; 53(8):3337-46. doi: 10.1128/aac.01564-08. [PMID: 19487443]
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  • M J Avram, D A Spyker, T K Henthorn, J V Cassella. The pharmacokinetics and bioavailability of prochlorperazine delivered as a thermally generated aerosol in a single breath to volunteers. Clinical pharmacology and therapeutics. 2009 Jan; 85(1):71-7. doi: 10.1038/clpt.2008.184. [PMID: 18830225]
  • M Cruz-Vera, R Lucena, S Cárdenas, M Valcárcel. Determination of phenothiazine derivatives in human urine by using ionic liquid-based dynamic liquid-phase microextraction coupled with liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jan; 877(1-2):37-42. doi: 10.1016/j.jchromb.2008.11.017. [PMID: 19042163]
  • Ramadhan Oruch, Erlend Hodneland, Ian F Pryme, Holm Holmsen. Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?. Biochimica et biophysica acta. 2008 Oct; 1778(10):2165-76. doi: 10.1016/j.bbamem.2008.04.007. [PMID: 18503745]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Ian N Olver. Prevention of chemotherapy-induced nausea and vomiting: focus on fosaprepitant. Therapeutics and clinical risk management. 2008 Apr; 4(2):501-6. doi: 10.2147/tcrm.s2345. [PMID: 18728837]
  • Jie Cao, Shi-min Luo, Li-jian Liang, Wen-jie Hu. [Effect of branched-chain amino acid-rich parenteral nutrition on protein metabolism after partial hepatectomy in rats with liver cirrhosis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2007 Nov; 27(11):1721-3. doi: NULL. [PMID: 18024299]
  • Einosuke Tanaka, Takako Nakamura, Masaru Terada, Tatsuo Shinozuka, Chikako Hashimoto, Katsuyoshi Kurihara, Katsuya Honda. Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jul; 854(1-2):116-20. doi: 10.1016/j.jchromb.2007.04.004. [PMID: 17459789]
  • Michael J Avram, Thomas K Henthorn, Daniel A Spyker, Tom C Krejcie, Peter M Lloyd, James V Cassella, Joshua D Rabinowitz. Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug metabolism and disposition: the biological fate of chemicals. 2007 Feb; 35(2):262-7. doi: 10.1124/dmd.106.010652. [PMID: 17079359]
  • Mayowa O Owolabi, Okechukwu S Ogah, Adesola Ogunniyi. Episodic vertigo resulting from vascular risk factors, cervical spondylosis and head rotation: Two case reports. Neuropsychiatric disease and treatment. 2007; 3(5):675-8. doi: ". [PMID: 19300597]
  • Anna Ferrari, Gustavo Savino, Daniela Gallesi, Diego Pinetti, Alfio Bertolini, Grazia Sances, Ciro Pio Rosario Coccia, Gabriella Pasciullo, Sheila Leone, Marianna Loi, Emilio Sternieri. Effect of overuse of the antimigraine combination of indomethacin, prochlorperazine and caffeine (IPC) on the disposition of its components in chronic headache patients. Pharmacological research. 2006 Aug; 54(2):142-9. doi: 10.1016/j.phrs.2006.03.022. [PMID: 16697657]
  • Hope E Uronis, David C Currow, Amy P Abernethy. Palliative management of refractory dyspnea in COPD. International journal of chronic obstructive pulmonary disease. 2006; 1(3):289-304. doi: 10.2147/copd.2006.1.3.289. [PMID: 18046866]
  • Andrew Finn, Jason Collins, Robert Voyksner, Celeste Lindley. Bioavailability and metabolism of prochlorperazine administered via the buccal and oral delivery route. Journal of clinical pharmacology. 2005 Dec; 45(12):1383-90. doi: 10.1177/0091270005281044. [PMID: 16291713]
  • Akemi Marumo, Takeshi Kumazawa, Xiao-Pen Lee, Koichiro Fujimaki, Ayako Kuriki, Chika Hasegawa, Keizo Sato, Hiroshi Seno, Osamu Suzuki. Analysis of phenothiazines in human body fluids using disk solid-phase extraction and liquid chromatography. Journal of AOAC International. 2005 Nov; 88(6):1655-60. doi: . [PMID: 16526447]
  • Li-jian Liang, Shi-min Luo, Wen-jie Hu. [Effects of amino acid solution and recombinant human growth hormone on growth hormone/insulin like growth factor-1 axis in rats with liver cirrhosis]. Zhonghua wai ke za zhi [Chinese journal of surgery]. 2005 Jun; 43(11):697-701. doi: NULL. [PMID: 16008955]
  • Yoshioki Satoh, Atsushi Sugiyama, Akira Takahara, Kentaro Ando, Kai Wang, Sachiko Honsho, Keitaro Hashimoto. The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart. Journal of pharmacological sciences. 2005 Jan; 97(1):101-6. doi: 10.1254/jphs.fpj04038x. [PMID: 15655290]
  • Stacey L Berg, Alexander Aleksic, Leticia McGuffey, Robert Dauser, Jed Nuchtern, Bruce Bernacky, Susan M Blaney. Plasma and cerebrospinal fluid pharmacokinetics of rebeccamycin (NSC 655649) in nonhuman primates. Cancer chemotherapy and pharmacology. 2004 Aug; 54(2):127-30. doi: 10.1007/s00280-004-0787-0. [PMID: 15150671]
  • Ayse L Mindikoglu, Abhinandana Anantharaju, Grace G Hartman, Shilun D Li, Jaime Villanueva, David H Van Thiel. Prochlorperazine-induced cholestasis in a patient with alpha-1 antitrypsin deficiency. Hepato-gastroenterology. 2003 Sep; 50(53):1338-40. doi: NULL. [PMID: 14571732]
  • Aron D Mosnaim, Javier Puente, Rolando Saavedra, Seymour Diamond, Marion E Wolf. In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure. Pharmacology. 2003 Jan; 67(1):6-13. doi: 10.1159/000066781. [PMID: 12444298]
  • Yasushi Mizuno, Keizo Sato, Toshiyuki Sano, Rina Kurihara, Takashi Kojima, Yoshinori Yamakawa, Akira Ishii, Yoshinao Katsumata. Identification and characterization of 17 phenothiazine compounds by capillary high-performance liquid chromatography/fast atom bombardment mass spectrometry. Legal medicine (Tokyo, Japan). 2002 Dec; 4(4):207-16. doi: 10.1016/s1344-6223(02)00051-2. [PMID: 12935655]
  • A Krishan, K S Sridhar, C Mou, W D Stein, E Lyubimov, Y P Hu, H Fernandez. Synergistic effect of prochlorperazine and dipyridamole on the cellular retention and cytotoxicity of doxorubicin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2000 Apr; 6(4):1508-17. doi: . [PMID: 10778983]
  • S Ginder, B Oatman, M Pollack. A prospective study of i.v. magnesium and i.v. prochlorperazine in the treatment of headaches. The Journal of emergency medicine. 2000 Apr; 18(3):311-5. doi: 10.1016/s0736-4679(99)00220-6. [PMID: 10729668]
  • J W Raschko, T W Synold, W Chow, P Coluzzi, V Hamasaki, L A Leong, K A Margolin, R J Morgan, S I Shibata, G Somlo, M L Tetef, Y Yen, A ter Veer, J H Doroshow. A phase I study of carboplatin and etoposide administered in conjunction with dipyridamole, prochlorperazine and cyclosporine A. Cancer chemotherapy and pharmacology. 2000; 46(5):403-10. doi: 10.1007/s002800000142. [PMID: 11127945]
  • S Singh, D R Sharma, A Chaudhary. Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis. Journal of the Indian Medical Association. 1999 Aug; 97(8):346-7. doi: NULL. [PMID: 10643185]
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