Phenelzine (BioDeep_00000405985)
Main id: BioDeep_00000003165
Volatile Flavor Compounds
代谢物信息卡片
Phenelzine
化学式: C8H12N2 (136.1000432)
中文名称: 苯乙基肼, 苯乙肼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CCNN
InChI: InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AF - Monoamine oxidase inhibitors, non-selective
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:8060
- KEGG: C07430
- KEGGdrug: D08349
- PubChem: 3675
- DrugBank: DB00780
- ChEMBL: CHEMBL1089
- MeSH: Phenelzine
- CAS: 14847-47-3
- CAS: 51-71-8
- MoNA: FiehnHILIC002239
- MoNA: FiehnHILIC000670
- PubChem: 9634
- NIKKAJI: J4.125D
- KNApSAcK: 8060
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Rachel L Hill, Indrapal N Singh, Juan A Wang, Jacqueline R Kulbe, Edward D Hall. Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats.
Experimental neurology.
2020 08; 330(?):113322. doi:
10.1016/j.expneurol.2020.113322. [PMID: 32325157] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Josep Mercader, Agustín G Sabater, Sophie Le Gonidec, Pauline Decaunes, Alice Chaplin, Saioa Gómez-Zorita, Fermín I Milagro, Christian Carpéné. Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet.
The Journal of pharmacology and experimental therapeutics.
2019 11; 371(2):555-566. doi:
10.1124/jpet.119.259895. [PMID: 31270215] - Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov. Prediction of Severity of Drug-Drug Interactions Caused by Enzyme Inhibition and Activation.
Molecules (Basel, Switzerland).
2019 Oct; 24(21):. doi:
10.3390/molecules24213955. [PMID: 31683720] - Glen Baker, Dmitriy Matveychuk, Erin M MacKenzie, Andrew Holt, Yanlin Wang, Satyabrata Kar. Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.
Chemico-biological interactions.
2019 May; 304(?):139-147. doi:
10.1016/j.cbi.2019.03.003. [PMID: 30857888] - Rachel L Hill, Indrapal N Singh, Juan A Wang, Edward D Hall. Effects of Phenelzine Administration on Mitochondrial Function, Calcium Handling, and Cytoskeletal Degradation after Experimental Traumatic Brain Injury.
Journal of neurotrauma.
2019 04; 36(8):1231-1251. doi:
10.1089/neu.2018.5946. [PMID: 30358485] - Ayman G Mustafa, Othman Al-Shboul, Mahmoud A Alfaqih, Mohammad A Al-Qudah, Ahmed N Al-Dwairi. Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins.
Archives of physiology and biochemistry.
2018 Dec; 124(5):418-423. doi:
10.1080/13813455.2017.1415939. [PMID: 29256275] - Christian Carpéné, Saioa Gómez-Zorita, Alice Chaplin, Josep Mercader. Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice.
International journal of molecular sciences.
2018 Sep; 19(10):. doi:
10.3390/ijms19102904. [PMID: 30257452] - Christian Carpéné, Josep Mercader, Sophie Le Gonidec, Stéphane Schaak, Jeanne Mialet-Perez, Alexia Zakaroff-Girard, Jean Galitzky. Body fat reduction without cardiovascular changes in mice after oral treatment with the MAO inhibitor phenelzine.
British journal of pharmacology.
2018 06; 175(12):2428-2440. doi:
10.1111/bph.14211. [PMID: 29582416] - Jacqueline R Kulbe, Indrapal N Singh, Juan A Wang, John E Cebak, Edward D Hall. Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats.
Journal of neurotrauma.
2018 06; 35(11):1280-1293. doi:
10.1089/neu.2017.5353. [PMID: 29336204] - John E Cebak, Indrapal N Singh, Rachel L Hill, Juan A Wang, Edward D Hall. Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection.
Journal of neurotrauma.
2017 04; 34(7):1302-1317. doi:
10.1089/neu.2016.4624. [PMID: 27750484] - M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Psychopharmacology.
2016 Aug; 233(15-16):2955-71. doi:
10.1007/s00213-016-4342-6. [PMID: 27259485] - Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega-Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao, Riyi Shi. Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury.
Journal of neurochemistry.
2016 07; 138(2):328-38. doi:
10.1111/jnc.13639. [PMID: 27060873] - Liam E Potter, John W Paylor, Jee Su Suh, Gustavo Tenorio, Jayalakshmi Caliaperumal, Fred Colbourne, Glen Baker, Ian Winship, Bradley J Kerr. Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis.
Journal of neuroinflammation.
2016 06; 13(1):142. doi:
10.1186/s12974-016-0609-4. [PMID: 27282914] - Raja Reddy Kallem, Bhupathi Jillela, Arun Reddy Ravula, Ramakrishna Samala, Adinarayana Andy, Mullangi Ramesh, Jvln Seshagiri Rao. Highly sensitive LC-MS/MS-ESI method for determination of phenelzine in human plasma and its application to a human pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):126-132. doi:
10.1016/j.jchromb.2016.04.006. [PMID: 27085800] - C Carpéné, S Gomez-Zorita, R Gupta, S Grès, C Rancoule, T Cadoudal, J Mercader, A Gomez, C Bertrand, Z Iffiu-Soltész. Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice.
European journal of nutrition.
2014 Dec; 53(8):1625-35. doi:
10.1007/s00394-014-0668-1. [PMID: 24531732] - Shagufta Khan, Ghulam Abbas, Fahad Shabbir Ahmed, Attaur Rahman, Ahsana Dar. Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents.
Pakistan journal of pharmaceutical sciences.
2014 Mar; 27(2):303-7. doi:
. [PMID: 24577919] - Christian Carpéné, Sandra Grès, Simon Rascalou. The amine oxidase inhibitor phenelzine limits lipogenesis in adipocytes without inhibiting insulin action on glucose uptake.
Journal of neural transmission (Vienna, Austria : 1996).
2013 Jun; 120(6):997-1003. doi:
10.1007/s00702-012-0951-3. [PMID: 23242743] - Indrapal N Singh, Lesley K Gilmer, Darren M Miller, John E Cebak, Juan A Wang, Edward D Hall. Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2013 Apr; 33(4):593-9. doi:
10.1038/jcbfm.2012.211. [PMID: 23321786] - Ghulam Abbas, Sabira Naqvi, Shaista Erum, Shakil Ahmed, Atta-ur-Rahman, Ahsana Dar. Potential antidepressant activity of Areca catechu nut via elevation of serotonin and noradrenaline in the hippocampus of rats.
Phytotherapy research : PTR.
2013 Jan; 27(1):39-45. doi:
10.1002/ptr.4674. [PMID: 22447641] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Dinesh Dhingra, Parul Joshi, Arun Gupta, Ritu Chhillar. Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice.
CNS neuroscience & therapeutics.
2012 May; 18(5):419-25. doi:
10.1111/j.1755-5949.2011.00256.x. [PMID: 22070517] - Ki-Chan Ha, Min-Gul Kim, Mi-Ra Oh, Eun-Kyung Choi, Hyang-Im Back, Sun-Young Kim, Eun-Ok Park, Dae-Young Kwon, Hye-Jeong Yang, Min-Jeong Kim, Hee-Joo Kang, Ju-Hyung Lee, Kyung-Min Choi, Soo-Wan Chae, Chang-Seop Lee. A placebo-controlled trial of Korean red ginseng extract for preventing influenza-like illness in healthy adults.
BMC complementary and alternative medicine.
2012 Feb; 12(?):10. doi:
10.1186/1472-6882-12-10. [PMID: 22314101] - Marco Antonioli, Joanna Rybka, Livia A Carvalho. Neuroimmune endocrine effects of antidepressants.
Neuropsychiatric disease and treatment.
2012; 8(?):65-83. doi:
10.2147/ndt.s16409. [PMID: 22347798] - H-J Kim, K-H Yoon, M-J Kang, H-W Yim, K-S Lee, V Vuksan, M-K Sung. A six-month supplementation of mulberry, korean red ginseng, and banaba decreases biomarkers of systemic low-grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):735191. doi:
10.1155/2012/735191. [PMID: 22474520] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Zhang-Jin Zhang, Qing-Rong Tan, Yao Tong, Xue-Yi Wang, Huai-Hai Wang, Lai-Ming Ho, Hei Kiu Wong, Yi-Bin Feng, Di Wang, Roger Ng, Grainne M McAlonan, Chuan-Yue Wang, Vivian Taam Wong. An epidemiological study of concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction.
PloS one.
2011 Feb; 6(2):e17239. doi:
10.1371/journal.pone.0017239. [PMID: 21359185] - X-W Chen, E S Serag, K B Sneed, J Liang, H Chew, S-Y Pan, S-F Zhou. Clinical herbal interactions with conventional drugs: from molecules to maladies.
Current medicinal chemistry.
2011; 18(31):4836-50. doi:
10.2174/092986711797535317. [PMID: 21919844] - Tomi Rantamäki, Liisa Vesa, Hanna Antila, Antonio Di Lieto, Päivi Tammela, Angelika Schmitt, Klaus-Peter Lesch, Maribel Rios, Eero Castrén. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade.
PloS one.
2011; 6(6):e20567. doi:
10.1371/journal.pone.0020567. [PMID: 21666748] - Tamar Goren, Liat Adar, Nissim Sasson, Yoni M Weiss. Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Journal of clinical pharmacology.
2010 Dec; 50(12):1420-8. doi:
10.1177/0091270010369674. [PMID: 20445015] - Naropa J Mike Craske, Warren Turner, Joseph Zammit-Maempe, Myeong Soo Lee. Qigong ameliorates symptoms of chronic fatigue: a pilot uncontrolled study.
Evidence-based complementary and alternative medicine : eCAM.
2009 Jun; 6(2):265-70. doi:
10.1093/ecam/nem088. [PMID: 18955297] - Françoise Chiche, Morwenna Le Guillou, Gérard Chétrite, Françoise Lasnier, Isabelle Dugail, Christian Carpéné, Marthe Moldes, Bruno Fève. Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes.
Molecular pharmacology.
2009 May; 75(5):1052-61. doi:
10.1124/mol.108.052563. [PMID: 19201819] - Zaorui Zhao, Han-Ting Zhang, Elianna Bootzin, Mark J Millan, James M O'Donnell. Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 May; 34(6):1467-81. doi:
10.1038/npp.2008.183. [PMID: 18923402] - Angelo A Izzo, Edzard Ernst. Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Drugs.
2009; 69(13):1777-98. doi:
10.2165/11317010-000000000-00000. [PMID: 19719333] - Gillian W Reierson, Claudio A Mastronardi, Julio Licinio, Ma-Li Wong. Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent.
Clinical pharmacology : advances and applications.
2009; 1(?):1-6. doi:
10.2147/cpaa.s7157. [PMID: 22291481] - Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang. Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.
PloS one.
2008 Jul; 3(7):e2697. doi:
10.1371/journal.pone.0002697. [PMID: 18628990] - Ashwin A Patkar, C-U Pae, Prakash S Masand. Transdermal selegiline: the new generation of monoamine oxidase inhibitors.
CNS spectrums.
2006 May; 11(5):363-75. doi:
10.1017/s1092852900014498. [PMID: 16641841] - Alison Kier, Jie Han, Lauren Jacobson. Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression.
Endocrinology.
2005 Mar; 146(3):1338-47. doi:
10.1210/en.2004-0650. [PMID: 15564336] - Zeping Hu, Xiaoxia Yang, Paul Chi Lui Ho, Sui Yung Chan, Paul Wan Sia Heng, Eli Chan, Wei Duan, Hwee Ling Koh, Shufeng Zhou. Herb-drug interactions: a literature review.
Drugs.
2005; 65(9):1239-82. doi:
10.2165/00003495-200565090-00005. [PMID: 15916450] - Tom K Birkenhäger, Walter W van den Broek, Paul G Mulder, Jan A Bruijn, Peter Moleman. Efficacy and tolerability of tranylcypromine versus phenelzine: a double-blind study in antidepressant-refractory depressed inpatients.
The Journal of clinical psychiatry.
2004 Nov; 65(11):1505-10. doi:
10.4088/jcp.v65n1110. [PMID: 15554763] - Takashi Yoshitake, Ryuji Iizuka, Shimako Yoshitake, Pia Weikop, Walter E Müller, Sven Ove Ogren, Jan Kehr. Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
British journal of pharmacology.
2004 Jun; 142(3):414-8. doi:
10.1038/sj.bjp.0705822. [PMID: 15148244] - C C Will, F Aird, E E Redei. Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants.
Molecular psychiatry.
2003 Nov; 8(11):925-32. doi:
10.1038/sj.mp.4001345. [PMID: 14593430] - David Kiefer, Traci Pantuso. Panax ginseng.
American family physician.
2003 Oct; 68(8):1539-42. doi:
". [PMID: 14596440] - Hans-Peter Landolt, John R Kelsoe, Marc H Rapaport, J Christian Gillin. Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep.
Journal of sleep research.
2003 Mar; 12(1):13-8. doi:
10.1046/j.1365-2869.2003.00336.x. [PMID: 12603782] - T Boniel, P Dannon. [The safety of herbal medicines in the psychiatric practice].
Harefuah.
2001 Aug; 140(8):780-3, 805. doi:
". [PMID: 11547487] - C Odlind, I Reenilä, P T Männistö, J Ekblom, P Hansell. The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat.
Pflugers Archiv : European journal of physiology.
2001 Jul; 442(4):505-10. doi:
10.1007/s004240100545. [PMID: 11510881] - A A Izzo, E Ernst. Interactions between herbal medicines and prescribed drugs: a systematic review.
Drugs.
2001; 61(15):2163-75. doi:
10.2165/00003495-200161150-00002. [PMID: 11772128] - L J Urichuk, K Allison, A Holt, A J Greenshaw, G B Baker. Comparison of neurochemical effects of the monoamine oxidase inhibitors phenelzine, moclobemide and brofaromine in the rat after short- and long-term administration.
Journal of affective disorders.
2000 May; 58(2):135-44. doi:
10.1016/s0165-0327(99)00105-6. [PMID: 10781703] - S Benmansour, M Cecchi, D A Morilak, G A Gerhardt, M A Javors, G G Gould, A Frazer. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1999 Dec; 19(23):10494-501. doi:
. [PMID: 10575045] - F Gómez, P Graugés, M Martín, A Armario. The effect of chronic administration of antidepressants on the circadian pattern of corticosterone in the rat.
Psychopharmacology.
1998 Nov; 140(2):127-34. doi:
10.1007/s002130050749. [PMID: 9860102] - G E Duncan, D J Knapp, S W Carson, G R Breese. Differential effects of chronic antidepressant treatment on swim stress- and fluoxetine-induced secretion of corticosterone and progesterone.
The Journal of pharmacology and experimental therapeutics.
1998 May; 285(2):579-87. doi:
NULL. [PMID: 9580601] - C T Lai, V A Tanay, G J Charrois, G B Baker, A N Bateson. Effects of phenelzine and imipramine on the steady-state levels of mRNAs that encode glutamic acid decarboxylase (GAD67 and GAD65), the GABA transporter GAT-1 and GABA transaminase in rat cortex.
Naunyn-Schmiedeberg's archives of pharmacology.
1998 Jan; 357(1):32-8. doi:
10.1007/pl00005135. [PMID: 9459570] - M Tatsumi, K Groshan, R D Blakely, E Richelson. Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
European journal of pharmacology.
1997 Dec; 340(2-3):249-58. doi:
10.1016/s0014-2999(97)01393-9. [PMID: 9537821] - M R Anari, S Khan, S D Jatoe, P J O'Brien. Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes.
European journal of drug metabolism and pharmacokinetics.
1997 Oct; 22(4):305-10. doi:
10.1007/bf03190961. [PMID: 9512925] - M Runge-Morris, Y Feng, R C Zangar, R F Novak. Effects of hydrazine, phenelzine, and hydralazine treatment on rat hepatic and renal drug-metabolizing enzyme expression.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jul; 24(7):734-7. doi:
. [PMID: 8818569] - R E Poland, P Lutchmansingh, S McGeoy, D Au, M Que, S Acosta, M Edelstein, J T McCracken. Prenatal stress prevents the desensitization of the corticosterone response to TFMPP by desmethylimipramine, but not by phenelzine, in adult male offspring.
Life sciences.
1995; 57(23):2163-70. doi:
10.1016/0024-3205(95)02208-z. [PMID: 7475968] - D E Malcolm, P H Yu, R C Bowen, C O'Donovan, J Hawkes, M Hussein. Phenelzine reduces plasma vitamin B6.
Journal of psychiatry & neuroscience : JPN.
1994 Nov; 19(5):332-4. doi:
NULL. [PMID: 7803366] - R Weizman, R Burgin, M Gavish. Modulatory effect of antidepressants on peripheral-type benzodiazepine receptors.
European journal of pharmacology.
1993 Dec; 250(2):289-94. doi:
10.1016/0014-2999(93)90393-v. [PMID: 8112386] - K F McKenna, G B Baker, R T Coutts. Urinary excretion of bioactive amines and their metabolites in psychiatric patients receiving phenelzine.
Neurochemical research.
1993 Sep; 18(9):1023-7. doi:
10.1007/bf00966763. [PMID: 8232718] - P H Soloff, J Cornelius, A George, S Nathan, J M Perel, R F Ulrich. Efficacy of phenelzine and haloperidol in borderline personality disorder.
Archives of general psychiatry.
1993 May; 50(5):377-85. doi:
10.1001/archpsyc.1993.01820170055007. [PMID: 8489326] - P Celada, J Pérez, E Alvarez, F Artigas. Monoamine oxidase inhibitors phenelzine and brofaromine increase plasma serotonin and decrease 5-hydroxyindoleacetic acid in patients with major depression: relationship to clinical improvement.
Journal of clinical psychopharmacology.
1992 Oct; 12(5):309-15. doi:
. [PMID: 1282522] - R Mongeau, S A Welner, R Quirion, B E Suranyi-Cadotte. Further evidence for differential affinity states of the serotonin1A receptor in rat hippocampus.
Brain research.
1992 Sep; 590(1-2):229-38. doi:
10.1016/0006-8993(92)91100-s. [PMID: 1358403] - C P Coyne, J E Smith, R M DeBowes. Pharmacologic evaluation of factor XIIIa*-like enzyme activity in equine plasma as a potential therapeutic avenue for the inhibition of fibrinous tissue.
American journal of veterinary research.
1992 May; 53(5):695-705. doi:
NULL. [PMID: 1355954] - L S Brady, P W Gold, M Herkenham, A B Lynn, H J Whitfield. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications.
Brain research.
1992 Feb; 572(1-2):117-25. doi:
10.1016/0006-8993(92)90459-m. [PMID: 1351783] - R P Sharma, P G Janicak, J I Javaid, G N Pandey, B Gierl, J M Davis. Platelet MAO inhibition, urinary MHPG, and leukocyte beta-adrenergic receptors in depressed patients treated with phenelzine.
The American journal of psychiatry.
1990 Oct; 147(10):1318-21. doi:
10.1176/ajp.147.10.1318. [PMID: 2169208] - J F Patterson. Myoclonus caused by a tricyclic antidepressant.
Southern medical journal.
1990 Apr; 83(4):463-5. doi:
10.1097/00007611-199004000-00026. [PMID: 2181694] - B Bertocci, G Garotta, G Zürcher, V Miggiano, M Da Prada. Monoclonal antibodies recognizing both soluble and membrane bound catechol-O-methyltransferase.
Journal of neural transmission. Supplementum.
1990; 32(?):369-74. doi:
10.1007/978-3-7091-9113-2_50. [PMID: 2089101] - R B Lydiard, M T Laraia, E F Howell, M D Fossey, R D Reynolds, J C Ballenger. Phenelzine treatment of panic disorder: lack of effect on pyridoxal phosphate levels.
Journal of clinical psychopharmacology.
1989 Dec; 9(6):428-31. doi:
. [PMID: 2687338] - N Koshikawa, Y Maruyama, M Kobayashi, I C Campbell. Rapid development of brain beta-adrenoceptor down-regulation induced by phenelzine: subcellular studies.
European journal of pharmacology.
1989 Oct; 170(1-2):101-4. doi:
10.1016/0014-2999(89)90141-6. [PMID: 2558891] - T Obata, T Egashira, Y Yamanaka. Amine oxidase released into plasma of rats treated with hepatotoxin allyl formate.
Research communications in chemical pathology and pharmacology.
1989 Oct; 66(1):69-85. doi:
. [PMID: 2515565] - P H Yu. Determination of plasma pyridoxal 5'-phosphate by an enzymatic-high-performance liquid chromatographic procedure.
Analytical biochemistry.
1989 Sep; 181(2):267-70. doi:
10.1016/0003-2697(89)90241-8. [PMID: 2817390] - A Georgotas, R E McCue, T B Cooper, N Nagachandran, A Friedhoff. Factors affecting the delay of antidepressant effect in responders to nortriptyline and phenelzine.
Psychiatry research.
1989 Apr; 28(1):1-9. doi:
10.1016/0165-1781(89)90192-3. [PMID: 2662234] - M B Youdim, D K Banerjee, K Kelner, L Offutt, H B Pollard. Steroid regulation of monoamine oxidase activity in the adrenal medulla.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1989 Apr; 3(6):1753-9. doi:
10.1096/fasebj.3.6.2495232. [PMID: 2495232] - P R Bieck, L Firkusny, C Schick, K H Antonin, E Nilsson, R Schulz, M Schwenk, H Wollmann. Monoamine oxidase inhibition by phenelzine and brofaromine in healthy volunteers.
Clinical pharmacology and therapeutics.
1989 Mar; 45(3):260-9. doi:
10.1038/clpt.1989.26. [PMID: 2920501] - R E McCue, A Georgotas, R F Suckow, T B Cooper. 10-Hydroxynortriptyline and treatment effects in elderly depressed patients.
The Journal of neuropsychiatry and clinical neurosciences.
1989; 1(2):176-80. doi:
10.1176/jnp.1.2.176. [PMID: 2521060] - J W Stewart, U Halbreich. Plasma melatonin levels in depressed patients before and after treatment with antidepressant medication.
Biological psychiatry.
1989 Jan; 25(1):33-8. doi:
10.1016/0006-3223(89)90144-3. [PMID: 2643443] - P J McGrath, T B Cooper, F M Quitkin, D F Klein. Effects of imipramine and phenelzine on plasma PEA levels.
Psychiatry research.
1988 Nov; 26(2):239. doi:
10.1016/0165-1781(88)90077-7. [PMID: 3237916] - J W Stewart, W Harrison, T B Cooper, F M Quitkin. Tyramine sulfate excretion may be a better predictor of antidepressant response than monoamine oxidase activity.
Psychiatry research.
1988 Aug; 25(2):195-201. doi:
10.1016/0165-1781(88)90051-0. [PMID: 3051071] - M Lichtenwalner, M McMullin, D Hardy, F Rieders. Quantitative determination of phenelzine in human fluids by gas chromatography with nitrogen specific detection.
Journal of analytical toxicology.
1988 Mar; 12(2):98-101. doi:
10.1093/jat/12.2.98. [PMID: 3379930] - A Georgotas, R E McCue, E Friedman, T B Cooper. A placebo-controlled comparison of the effect of nortriptyline and phenelzine on orthostatic hypotension in elderly depressed patients.
Journal of clinical psychopharmacology.
1987 Dec; 7(6):413-6. doi:
. [PMID: 3323263] - R N Gupta, M Steiner, M Lew. Determination of unconjugated 3-methoxy-4-hydroxyphenylglycol by liquid chromatography for monitoring inhibition of monoamine oxidase activity in plasma.
Clinical chemistry.
1987 Nov; 33(11):2078-80. doi:
10.1093/clinchem/33.11.2078. [PMID: 3677382] - T S Rao, G B Baker, R T Coutts, J M Yeung, G J McIntosh, G A Torok-Both. Analysis of the antidepressant phenelzine in brain tissue and urine using electron-capture gas chromatography.
Journal of pharmacological methods.
1987 Jul; 17(4):297-304. doi:
10.1016/0160-5402(87)90043-x. [PMID: 3613602] - A Georgotas, R E McCue, E Friedman, T B Cooper. Electrocardiographic effects of nortriptyline, phenelzine, and placebo under optimal treatment conditions.
The American journal of psychiatry.
1987 Jun; 144(6):798-801. doi:
10.1176/ajp.144.6.798. [PMID: 3592003] - I Modai, H Rinsky, G Cygielman. The DST as a predictor of acute response to treatment with ECT, chlorimipramine, amitriptyline, and phenelzine.
The Journal of clinical psychiatry.
1986 Mar; 47(3):139-40. doi:
. [PMID: 3949722] - I Modai, Y Beigel, G Cygielman. Urinary amine metabolite excretion in a patient with adrenergic hyperactivity state: reaction to phenelzine withdrawal and combined treatment.
The Journal of clinical psychiatry.
1986 Feb; 47(2):92-3. doi:
. [PMID: 2418010] - F X Breheny, G J Dobb, G M Clarke. Phenelzine poisoning.
Anaesthesia.
1986 Jan; 41(1):53-6. doi:
10.1111/j.1365-2044.1986.tb12704.x. [PMID: 2868672] - R B Resnick, E Resnick. Psychological issues in the treatment of cocaine abuse.
NIDA research monograph.
1986; 67(?):290-4. doi:
NULL. [PMID: 3092080] - D S Robinson, T B Cooper, S P Jindal, J Corcella, T Lutz. Metabolism and pharmacokinetics of phenelzine: lack of evidence for acetylation pathway in humans.
Journal of clinical psychopharmacology.
1985 Dec; 5(6):333-7. doi:
10.1097/00004714-198512000-00005. [PMID: 4066998] - R N Gupta, M Steiner. Liquid chromatographic determination of inhibition of monoamine oxidase activity in platelet rich plasma of depressed patients treated with phenelzine.
Clinica chimica acta; international journal of clinical chemistry.
1985 Oct; 152(1-2):63-9. doi:
10.1016/0009-8981(85)90176-7. [PMID: 4053406] - L E Dyck, D A Durden, A A Boulton. Formation of beta-phenylethylamine from the antidepressant, beta-phenylethylhydrazine.
Biochemical pharmacology.
1985 Jun; 34(11):1925-9. doi:
10.1016/0006-2952(85)90310-7. [PMID: 4004908] - D W Clark. Genetically determined variability in acetylation and oxidation. Therapeutic implications.
Drugs.
1985 Apr; 29(4):342-75. doi:
10.2165/00003495-198529040-00003. [PMID: 2859977] - C H Linden, B H Rumack, C Strehlke. Monoamine oxidase inhibitor overdose.
Annals of emergency medicine.
1984 Dec; 13(12):1137-44. doi:
10.1016/s0196-0644(84)80339-x. [PMID: 6391305] - A L Ask, I Fagervall, M Jonze, D Kelder, R Nygren, S B Ross. Effects of acute and repeated administration of amiflamine on monoamine oxidase inhibition in the rat.
Biochemical pharmacology.
1984 Sep; 33(18):2839-47. doi:
10.1016/0006-2952(84)90205-3. [PMID: 6477643] - R G Demers, P H McDonagh, R J Moore. Pyridoxine deficiency with phenelzine.
Southern medical journal.
1984 May; 77(5):641-2. doi:
10.1097/00007611-198405000-00026. [PMID: 6719168] - T J Danielson, G Torok-Both, R T Coutts. Effects of chronic phenelzine in the rat: altered tissue weights and metabolism of 14C-phenelzine.
Progress in neuro-psychopharmacology & biological psychiatry.
1984; 8(4-6):677-82. doi:
10.1016/0278-5846(84)90036-8. [PMID: 6531439] - C A Heller, P A Friedman. Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy.
The American journal of medicine.
1983 Nov; 75(5):887-8. doi:
10.1016/0002-9343(83)90422-9. [PMID: 6638055] - D S Robinson, G A Johnson, A Nies, J Corcella, T B Cooper, D Albright, D Howard. Plasma levels of catecholamines and dihydroxyphenylglycol during antidepressant drug treatment.
Journal of clinical psychopharmacology.
1983 Oct; 3(5):282-7. doi:
NULL. [PMID: 6355207]