Escitalopram (BioDeep_00000405814)
Main id: BioDeep_00000017867
PANOMIX_OTCML-2023
代谢物信息卡片
Escitalopram
化学式: C20H21FN2O (324.1638)
中文名称: 艾司西酞普兰
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
InChI: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AB - Selective serotonin reuptake inhibitors
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression[1][2].
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:36791
- KEGGdrug: D07913
- PubChem: 146570
- DrugBank: DB01175
- ChEMBL: CHEMBL1508
- MeSH: Escitalopram
- CAS: 128196-01-0
- MoNA: FiehnHILIC001920
- MoNA: FiehnHILIC000338
- RefMet: Escitalopram
- medchemexpress: HY-14258
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yue Ma, Jiakai He, Xinyu Lu, Jifei Sun, Chunlei Guo, Yi Luo, Shanshan Gao, Yong Liu, Zhangjin Zhang, Peijing Rong, Jiliang Fang. Transcutaneous electrical cranial-auricular acupoint stimulation versus escitalopram for modulating the brain activity in mild to moderate major depressive disorder: An fMRI study.
Neuroscience letters.
2023 09; 814(?):137414. doi:
10.1016/j.neulet.2023.137414. [PMID: 37544579] - Yannan Li, Junnan Li, Lixuan Yang, Feifei Ren, Kaiqiang Dong, Zhonghui Zhao, Wenzhe Duan, Wei Wei, Rongjuan Guo. Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Sep; 121(?):155083. doi:
10.1016/j.phymed.2023.155083. [PMID: 37722244] - Aaron L Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J Knox, Anand K Muthusamy, Jonathan S Marvin, Charlene H Kim, Stephen N Grant, David P Walton, Bruce N Cohen, Rebekkah Hammar, Loren Looger, Per Artursson, Dennis A Dougherty, Henry A Lester. Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2023 03; 43(13):2222-2241. doi:
10.1523/jneurosci.1519-22.2022. [PMID: 36868853] - Zhang-Jin Zhang, Shui-Yan Zhang, Xin-Jing Yang, Zong-Shi Qin, Feng-Quan Xu, Gui-Xing Jin, Xiao-Bing Hou, Yong Liu, Ji-Fu Cai, Hai-Bing Xiao, Yat Kwan Wong, Yu Zheng, Lei Shi, Jin-Niu Zhang, Yuan-Yuan Zhao, Xue Xiao, Liu-Lu Zhang, Yue Jiao, Yu Wang, Jia-Kai He, Guo-Bing Chen, Pei-Jing Rong. Transcutaneous electrical cranial-auricular acupoint stimulation versus escitalopram for mild-to-moderate depression: An assessor-blinded, randomized, non-inferiority trial.
Psychiatry and clinical neurosciences.
2023 Mar; 77(3):168-177. doi:
10.1111/pcn.13512. [PMID: 36445151] - Leonardo Wensing Fischer, Talita Biude Mendes, Joana Noguères Simas, Marina Nunes, Samara Urban de Oliva, Sandra Maria Miraglia. Effects of escitalopram treatment and chronic mild stress induced from peripuberty on spermatic parameters of adult rats.
Andrology.
2023 01; 11(1):177-195. doi:
10.1111/andr.13333. [PMID: 36334023] - Zhanhua Hu, Jiali Li, Aixiang Xiao, Juntao Zheng, Shaoxing Guan, Jianxiong Guo, Min Huang. Development and validation of UHPLC-MS/MS method for simultaneous quantification of escitalopram and its major metabolites in human plasma and its application in depressed patients.
Journal of pharmaceutical and biomedical analysis.
2022 Aug; 217(?):114810. doi:
10.1016/j.jpba.2022.114810. [PMID: 35550493] - M S Zastrozhin, VYu Skryabin, F Rwere, A E Petukhov, E P Pankratenko, S A Pozdniakov, V A Ivanchenko, V V Noskov, I A Zaytsev, N V Vinokurova, D S Horyaev, R V Vlasovskih, E A Bryun, D A Sychev. Influence of CYP2C19*17 Genetic Polymorphism on the Steady-State Concentration of Escitalopram in Patients with Recurrent Depressive Disorder.
Psychopharmacology bulletin.
2022 06; 52(3):8-19. doi:
NULL. [PMID: 35815173] - Magdalene M Assimon, Patrick H Pun, Sana M Al-Khatib, M Alan Brookhart, Bradley N Gaynes, Wolfgang C Winkelmayer, Jennifer E Flythe. Proton pump inhibitors may enhance the risk of citalopram- and escitalopram-associated sudden cardiac death among patients receiving hemodialysis.
Pharmacoepidemiology and drug safety.
2022 06; 31(6):670-679. doi:
10.1002/pds.5428. [PMID: 35285107] - Rachel G Zsido, Eóin N Molloy, Elena Cesnaite, Gergana Zheleva, Nathalie Beinhölzl, Ulrike Scharrer, Fabian A Piecha, Ralf Regenthal, Arno Villringer, Vadim V Nikulin, Julia Sacher. One-week escitalopram intake alters the excitation-inhibition balance in the healthy female brain.
Human brain mapping.
2022 04; 43(6):1868-1881. doi:
10.1002/hbm.25760. [PMID: 35064716] - Anna M Becker, Friederike Holze, Tanja Grandinetti, Aaron Klaiber, Vanja E Toedtli, Karolina E Kolaczynska, Urs Duthaler, Nimmy Varghese, Anne Eckert, Edna Grünblatt, Matthias E Liechti. Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects.
Clinical pharmacology and therapeutics.
2022 04; 111(4):886-895. doi:
10.1002/cpt.2487. [PMID: 34743319] - Helena M Abelaira, Thayse Rosa, Airam B de Moura, Natalia M Andrade, Nicoly S Martinello, Larissa R Maciel, Maria Eduarda M Botelho, Laura A Borba, Beatriz C Chede, Camila O Arent, Larissa Joaquim, Sandra Bonfante, Lucinéia G Danielski, Talita Tuon, Fabricia Petronilho, João Quevedo, Gislaine Z Réus. Combination of electroconvulsive stimulation with ketamine or escitalopram protects the brain against inflammation and oxidative stress induced by maternal deprivation and is critical for associated behaviors in male and female rats.
Molecular neurobiology.
2022 Mar; 59(3):1452-1475. doi:
10.1007/s12035-021-02718-x. [PMID: 34994953] - Johané Gericke, Makhotso Lekhooa, Stephan F Steyn, Alvaro M Viljoen, Brian H Harvey. An acute dose-ranging evaluation of the antidepressant properties of Sceletium tortuosum (Zembrin®) versus escitalopram in the Flinders Sensitive Line rat.
Journal of ethnopharmacology.
2022 Feb; 284(?):114550. doi:
10.1016/j.jep.2021.114550. [PMID: 34454055] - Marta Lopes Lima, Maiara Amaral, Samanta Etel Treiger Borborema, Andre Gustavo Tempone. Evaluation of antileishmanial potential of the antidepressant escitalopram in Leishmania infantum.
Journal of pharmaceutical and biomedical analysis.
2022 Feb; 209(?):114469. doi:
10.1016/j.jpba.2021.114469. [PMID: 34838348] - Weiwei Xue, Tingting Fu, Shengzhe Deng, Fengyuan Yang, Jingyi Yang, Feng Zhu. Molecular Mechanism for the Allosteric Inhibition of the Human Serotonin Transporter by Antidepressant Escitalopram.
ACS chemical neuroscience.
2022 02; 13(3):340-351. doi:
10.1021/acschemneuro.1c00694. [PMID: 35041375] - Jian Yang, Jingjing Zhou, Jia Zhou, Haixia Wang, Zuoli Sun, Xuequan Zhu, Yi He, Albert H C Wong, Fang Liu, Gang Wang. Serum amyloid P component level is associated with clinical response to escitalopram treatment in patients with major depressive disorder.
Journal of psychiatric research.
2022 02; 146(?):172-178. doi:
10.1016/j.jpsychires.2021.12.051. [PMID: 34995992] - Mohsen Khosravi. Candidate Psychotropics against SARS - CoV - 2: A Narrative Review.
Pharmacopsychiatry.
2022 Jan; 55(1):16-23. doi:
10.1055/a-1551-3756. [PMID: 34399430] - Chih-Wei Hsu, Wei-Ting Tseng, Liang-Jen Wang, Yao-Hsu Yang, Hung-Yu Kao, Pao-Yen Lin. Comparative effectiveness of antidepressants on geriatric depression: Real-world evidence from a population-based study.
Journal of affective disorders.
2022 01; 296(?):609-615. doi:
10.1016/j.jad.2021.10.009. [PMID: 34655698] - Yi-Ru Lin, Jin-Yi Wang, Ya-Ru Ji, Zi-Han Lin. [Curative effect of the combined therapy of warm acupuncture at back-shu points of five zang organs and western medicine on depression of yang deficiency pattern and its attenuating effect].
Zhen ci yan jiu = Acupuncture research.
2021 Nov; 46(11):953-7. doi:
10.13702/j.1000-0607.201127. [PMID: 34865333] - Olof R Hjorth, Andreas Frick, Malin Gingnell, Johanna M Hoppe, Vanda Faria, Sara Hultberg, Iman Alaie, Kristoffer N T Månsson, Jörgen Rosén, Margareta Reis, Kurt Wahlstedt, My Jonasson, Mark Lubberink, Gunnar Antoni, Mats Fredrikson, Tomas Furmark. Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial.
Translational psychiatry.
2021 11; 11(1):559. doi:
10.1038/s41398-021-01682-3. [PMID: 34732695] - Giuseppe Bersani, Francesca Pacitti, Angela Iannitelli, Eleonora Caroti, Adele Quartini, Dionysios Xenos, Michela Marconi, Valentina Cuoco, Benedetta Bigio, Nicole P Bowles, Filippo Weisz, Flaminia Fanelli, Valentina D Di Lallo, Ilaria Belluomo, Ferdinando Nicoletti, Carla Nasca. Inverse correlation between plasma 2-arachidonoylglycerol levels and subjective severity of depression.
Human psychopharmacology.
2021 07; 36(4):e2779. doi:
10.1002/hup.2779. [PMID: 33559925] - Anna Colombo, Francesca Giordano, Federica Giorgetti, Ilaria Di Bernardo, Monica F Bosi, Alberto Varinelli, Rita Cafaro, Paola Pileri, Irene Cetin, Emilio Clementi, Caterina A Viganò, Bernardo Dell'Osso. Correlation between pharmacokinetics and pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Selective Serotonin and Noradrenaline Reuptake Inhibitors and maternal and neonatal outcomes: Results from a naturalistic study in patients with affective disorders.
Human psychopharmacology.
2021 05; 36(3):e2772. doi:
10.1002/hup.2772. [PMID: 33253437] - Humaira Anser, Shahlla Imam, Humera Khatoon, Sana Sarfaraz, Wajiha Iffat, Sakina Fatima, Sumaira Ishaq, Fozia Israr, Rabia Munawwar, Saba Zubair. Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models.
Pakistan journal of pharmaceutical sciences.
2021 May; 34(3(Special)):1261-1269. doi:
". [PMID: 34602398] - Giampaolo Perna, Silvia Daccò, Alessandra Alciati, Francesco Cuniberti, Domenico De Berardis, Daniela Caldirola. Childhood maltreatment history for guiding personalized antidepressant choice in major depressive disorder: Preliminary results from a systematic review.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 04; 107(?):110208. doi:
10.1016/j.pnpbp.2020.110208. [PMID: 33338557] - Anja Dvojkovic, Matea Nikolac Perkovic, Marina Sagud, Gordana Nedic Erjavec, Alma Mihaljevic Peles, Dubravka Svob Strac, Bjanka Vuksan Cusa, Lucija Tudor, Zorana Kusevic, Marcela Konjevod, Maja Zivkovic, Sasa Jevtovic, Nela Pivac. Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 03; 105(?):110016. doi:
10.1016/j.pnpbp.2020.110016. [PMID: 32534176] - Nageswari Yarravarapu, Laura Geffert, Christopher K Surratt, Michael Cascio, David J Lapinsky. Clickable photoaffinity ligands for the human serotonin transporter based on the selective serotonin reuptake inhibitor (S)-citalopram.
Bioorganic & medicinal chemistry letters.
2018 11; 28(21):3431-3435. doi:
10.1016/j.bmcl.2018.09.029. [PMID: 30266542] - Sid Topiol, Benny Bang-Andersen, Connie Sanchez, Per Plenge, Claus J Loland, Karsten Juhl, Krestian Larsen, Peter Bregnedal, Klaus P Bøgesø. X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Bioorganic & medicinal chemistry letters.
2017 02; 27(3):470-478. doi:
10.1016/j.bmcl.2016.12.037. [PMID: 28041833] - Jonathan A Coleman, Evan M Green, Eric Gouaux. X-ray structures and mechanism of the human serotonin transporter.
Nature.
2016 Apr; 532(7599):334-9. doi:
10.1038/nature17629. [PMID: 27049939] - Vivek Kumar, Nageswari Yarravarapu, David J Lapinsky, Danielle Perley, Bruce Felts, Michael J Tomlinson, Roxanne A Vaughan, L Keith Henry, John R Lever, Amy Hauck Newman. Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.
Journal of medicinal chemistry.
2015 Jul; 58(14):5609-19. doi:
10.1021/acs.jmedchem.5b00682. [PMID: 26153715] - Connie Sanchez, Elin H Reines, Stuart A Montgomery. A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?.
International clinical psychopharmacology.
2014 Jul; 29(4):185-96. doi:
10.1097/yic.0000000000000023. [PMID: 24424469] - Ashwini K Banala, Peng Zhang, Per Plenge, George Cyriac, Theresa Kopajtic, Jonathan L Katz, Claus Juul Loland, Amy Hauck Newman. Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.
Journal of medicinal chemistry.
2013 Dec; 56(23):9709-24. doi:
10.1021/jm4014136. [PMID: 24237160] - Swapnil Marghade, Prashant B Musmade, Sudheer Moorkoth. High-performance liquid chromatographic assay for ziprasidone in plasma samples: application to pharmacokinetic studies in rats.
Journal of chromatographic science.
2012 Nov; 50(10):902-8. doi:
10.1093/chromsci/bms088. [PMID: 22677485] - Christian Ineichen, Hannes Sigrist, Simona Spinelli, Klaus-Peter Lesch, Eva Sautter, Erich Seifritz, Christopher R Pryce. Establishing a probabilistic reversal learning test in mice: evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin.
Neuropharmacology.
2012 Nov; 63(6):1012-21. doi:
10.1016/j.neuropharm.2012.07.025. [PMID: 22824190] - Rupert Lanzenberger, Georg S Kranz, Daniela Haeusler, Elena Akimova, Markus Savli, Andreas Hahn, Markus Mitterhauser, Christoph Spindelegger, Cecile Philippe, Martin Fink, Wolfgang Wadsak, Georgios Karanikas, Siegfried Kasper. Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas.
NeuroImage.
2012 Nov; 63(2):874-81. doi:
10.1016/j.neuroimage.2012.07.023. [PMID: 22828162] - Thomas I F H Cremers, Gunnar Flik, Corry Hofland, Robert E Stratford. Microdialysis evaluation of clozapine and N-desmethylclozapine pharmacokinetics in rat brain.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Oct; 40(10):1909-16. doi:
10.1124/dmd.112.045682. [PMID: 22736307] - Evi V Nagler, Angela C Webster, Raymond Vanholder, Carmine Zoccali. Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Oct; 27(10):3736-45. doi:
10.1093/ndt/gfs295. [PMID: 22859791] - Yi Xiang, Liping Zhou, Zhenyu Qian, Kelong Peng, Dongyan Li, Xiaomei Chen, Hongliang Jiang, Heng Zheng. Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Sep; 26(9):1083-8. doi:
10.1002/bmc.1751. [PMID: 22120786] - Roberto Lozano-Ortiz, Reyes Marin-Lacasa, Asuncion Pascual-Garcia, Maria J Santacruz-Abion, Francisca Sebastian-Perez, Beatriz Orea-Ramón. Therapeutic monitoring of escitalopram by dexamethasone suppression test.
Actas espanolas de psiquiatria.
2012 Sep; 40(5):275-80. doi:
NULL. [PMID: 23076610] - Ravid Doron, Dafna Lotan, Anat Rak-Rabl, Adi Raskin-Ramot, Karen Lavi, Moshe Rehavi. Anxiolytic effects of a novel herbal treatment in mice models of anxiety.
Life sciences.
2012 Jun; 90(25-26):995-1000. doi:
10.1016/j.lfs.2012.05.014. [PMID: 22683433] - Katarzyna Socała, Dorota Nieoczym, Elżbieta Wyska, Ewa Poleszak, Piotr Wlaź. Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice.
Journal of neural transmission (Vienna, Austria : 1996).
2012 Jun; 119(6):645-52. doi:
10.1007/s00702-011-0756-9. [PMID: 22215207] - J M Warwick, P D Carey, N Cassimjee, C Lochner, S Hemmings, H Moolman-Smook, E Beetge, P Dupont, D J Stein. Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram.
Metabolic brain disease.
2012 Jun; 27(2):151-8. doi:
10.1007/s11011-012-9280-3. [PMID: 22350963] - Ulla Benedichte Knorr. The effect of selective serotonin reuptake inhibitors in healthy first-degree relatives of patients with major depressive disorder - an experimental medicine blinded controlled trial.
Danish medical journal.
2012 Apr; 59(4):B4426. doi:
NULL. [PMID: 22459724] - Huailing Zhong, Connie Sánchez, Marc G Caron. Consideration of allosterism and interacting proteins in the physiological functions of the serotonin transporter.
Biochemical pharmacology.
2012 Feb; 83(4):435-42. doi:
10.1016/j.bcp.2011.09.020. [PMID: 21983034] - Edoardo Spina, Gianluca Trifirò, Filippo Caraci. Clinically significant drug interactions with newer antidepressants.
CNS drugs.
2012 Jan; 26(1):39-67. doi:
10.2165/11594710-000000000-00000. [PMID: 22171584] - Huailing Zhong, Nasser Haddjeri, Connie Sánchez. Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action.
Psychopharmacology.
2012 Jan; 219(1):1-13. doi:
10.1007/s00213-011-2463-5. [PMID: 21901317] - Jingqiu Chen, Daniel Korostyshevsky, Sean Lee, Ethan O Perlstein. Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy.
PloS one.
2012; 7(4):e34024. doi:
10.1371/journal.pone.0034024. [PMID: 22529904] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - Laura Gedge, Ashley Beaudoin, Lauren Lazowski, Regina du Toit, Ruzica Jokic, Roumen Milev. Effects of electroconvulsive therapy and repetitive transcranial magnetic stimulation on serum brain-derived neurotrophic factor levels in patients with depression.
Frontiers in psychiatry.
2012; 3(?):12. doi:
10.3389/fpsyt.2012.00012. [PMID: 22375129] - Po-Hsin Tsai, Hsi-Chung Chen, Shih-Cheng Liao, Mei-Chih Meg Tseng, Ming-Been Lee. Recurrent escitalopram-induced hyponatremia in an elderly woman with dementia with Lewy bodies.
General hospital psychiatry.
2012 Jan; 34(1):101.e5-7. doi:
10.1016/j.genhosppsych.2011.06.007. [PMID: 21831444] - M Colotto, F Vinci, N Vo Hong, O Raimo, A Castello, A Carnovale, A Paciaroni, P Coletta. [Effect of treatment with selective serotonin reuptake inhibitors on lipid profile: state of the art].
La Clinica terapeutica.
2012; 163(1):e41-5. doi:
NULL. [PMID: 22362243] - Guilherme A Behr, José C F Moreira, Benicio N Frey. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder.
Oxidative medicine and cellular longevity.
2012; 2012(?):609421. doi:
10.1155/2012/609421. [PMID: 22693652] - Stefan Unterecker, Jürgen Deckert, Bruno Pfuhlmann. No influence of body weight on serum levels of antidepressants.
Therapeutic drug monitoring.
2011 Dec; 33(6):730-4. doi:
10.1097/ftd.0b013e318237b0fa. [PMID: 22105590] - Netta Shoenfeld, Dana Bodnik, Oded Rosenberg, Moshe Kotler, Pinhas Dannon. [Six-month follow-up study of drug treatment for cannabis addiction: comparison study of four drugs].
Harefuah.
2011 Dec; 150(12):888-92, 937. doi:
NULL. [PMID: 22352278] - Thierno Madjou Bah, Mohamed Benderdour, Sévan Kaloustian, Ramy Karam, Guy Rousseau, Roger Godbout. Escitalopram reduces circulating pro-inflammatory cytokines and improves depressive behavior without affecting sleep in a rat model of post-cardiac infarct depression.
Behavioural brain research.
2011 Nov; 225(1):243-51. doi:
10.1016/j.bbr.2011.07.039. [PMID: 21824496] - Wendy S Biggs, Robin H Demuth. Premenstrual syndrome and premenstrual dysphoric disorder.
American family physician.
2011 Oct; 84(8):918-24. doi:
NULL. [PMID: 22010771] - Charles V Vorhees, LaRonda R Morford, Devon L Graham, Matthew R Skelton, Michael T Williams. Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug.
Behavioral and brain functions : BBF.
2011 Oct; 7(?):41. doi:
10.1186/1744-9081-7-41. [PMID: 21974752] - Michael Bennett, Gerry Fitzpatrick, Maria Donnelly. Rhabdomyolysis associated with polydipsia induced hyponatraemia.
BMJ case reports.
2011 Oct; 2011(?):. doi:
10.1136/bcr.08.2011.4659. [PMID: 22679167] - Jana Strohmaier, Stefan Wüst, Rudolf Uher, Neven Henigsberg, Ole Mors, Joanna Hauser, Daniel Souery, Astrid Zobel, Mojca Z Dernovsek, Fabian Streit, Christine Schmäl, Dejan Kozel, Anna Placentino, Anne Farmer, Peter McGuffin, Katherine J Aitchison, Marcella Rietschel. Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2011 Oct; 12(7):528-38. doi:
10.3109/15622975.2011.559270. [PMID: 21388237] - Catherine F Capello, Chase H Bourke, James C Ritchie, Zachary N Stowe, D Jeffrey Newport, Amanda Nemeroff, Michael J Owens. Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk.
The Journal of pharmacology and experimental therapeutics.
2011 Oct; 339(1):275-85. doi:
10.1124/jpet.111.183855. [PMID: 21775476] - Hasan Aydin, Nilgun Mutlu, Naz Berfu Gunel Akbas. Treatment of a major depression episode suppresses markers of bone turnover in premenopausal women.
Journal of psychiatric research.
2011 Oct; 45(10):1316-20. doi:
10.1016/j.jpsychires.2011.04.005. [PMID: 21531430] - A Salomone, D Di Corcia, E Gerace, M Vincenti. A fatal case of simultaneous ingestion of mirtazapine, escitalopram, and valproic acid.
Journal of analytical toxicology.
2011 Sep; 35(7):519-23. doi:
10.1093/anatox/35.7.519. [PMID: 21871163] - Owen M Wolkowitz, Jessica Wolf, Wendy Shelly, Rebecca Rosser, Heather M Burke, George K Lerner, Victor I Reus, J Craig Nelson, Elissa S Epel, Synthia H Mellon. Serum BDNF levels before treatment predict SSRI response in depression.
Progress in neuro-psychopharmacology & biological psychiatry.
2011 Aug; 35(7):1623-30. doi:
10.1016/j.pnpbp.2011.06.013. [PMID: 21749907] - Filippo Caraci, Rosalia Crupi, Filippo Drago, Edoardo Spina. Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract.
Current drug metabolism.
2011 Jul; 12(6):570-7. doi:
10.2174/138920011795713706. [PMID: 21395523] - Y-E Jung, T-Y Jun, K-S Kim, W-M Bahk. Hyponatremia associated with selective serotonin reuptake inhibitors, mirtazapine, and venlafaxine in Korean patients with major depressive disorder.
International journal of clinical pharmacology and therapeutics.
2011 Jul; 49(7):437-43. doi:
10.5414/cp201500. [PMID: 21726494] - Choong Hyun Lee, Joon Ha Park, Ki-Yeon Yoo, Jung Hoon Choi, In Koo Hwang, Pan Dong Ryu, Do-Hoon Kim, Young-Guen Kwon, Young-Myeong Kim, Moo-Ho Won. Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress.
Experimental neurology.
2011 Jun; 229(2):450-9. doi:
10.1016/j.expneurol.2011.03.015. [PMID: 21458451] - Benny Bang-Andersen, Thomas Ruhland, Morten Jørgensen, Garrick Smith, Kristen Frederiksen, Klaus Gjervig Jensen, Huailing Zhong, Søren Møller Nielsen, Sandra Hogg, Arne Mørk, Tine Bryan Stensbøl. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Journal of medicinal chemistry.
2011 May; 54(9):3206-21. doi:
10.1021/jm101459g. [PMID: 21486038] - Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell. Effects of early life trauma are dependent on genetic predisposition: a rat study.
Behavioral and brain functions : BBF.
2011 May; 7(?):11. doi:
10.1186/1744-9081-7-11. [PMID: 21548935] - Rajendra A Morey, Ahmad R Hariri, Andrea L Gold, Michael A Hauser, Heidi J Munger, Florin Dolcos, Gregory McCarthy. Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder.
BMC psychiatry.
2011 May; 11(?):76. doi:
10.1186/1471-244x-11-76. [PMID: 21545724] - Eric J Lenze, Rose C Mantella, Peichang Shi, Alison M Goate, Petra Nowotny, Meryl A Butters, Carmen Andreescu, Paul A Thompson, Bruce L Rollman. Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2011 May; 19(5):482-90. doi:
10.1097/jgp.0b013e3181ec806c. [PMID: 20808146] - Valentina Durastanti, Alessandra Lugaresi, Placido Bramanti, Mariapia Amato, Paolo Bellantonio, Giovanna De Luca, Orietta Picconi, Roberta Fantozzi, Laura Locatelli, Annalisa Solda', Edoardo Sessa, Rocco Totaro, Silvia Marino, Valentina Zipoli, Marino Zorzon, Enrico Millefiorini. Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients.
Journal of translational medicine.
2011 Apr; 9(?):42. doi:
10.1186/1479-5876-9-42. [PMID: 21501517] - Lee Wei Lim, Arjan Blokland, Marlies van Duinen, Veerle Visser-Vandewalle, Sonny Tan, Rinske Vlamings, Mark Janssen, Ali Jahanshahi, Mujzgan Aziz-Mohammadi, Harry W M Steinbusch, Koen Schruers, Yasin Temel. Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats.
Behavioural brain research.
2011 Apr; 218(2):301-7. doi:
10.1016/j.bbr.2010.12.026. [PMID: 21185871] - R Keers, R Uher, P Huezo-Diaz, R Smith, S Jaffee, M Rietschel, N Henigsberg, D Kozel, O Mors, W Maier, A Zobel, J Hauser, D Souery, A Placentino, E R Larsen, M Dmitrzak-Weglarz, B Gupta, F Hoda, I Craig, P McGuffin, A E Farmer, K J Aitchison. Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project.
The pharmacogenomics journal.
2011 Apr; 11(2):138-45. doi:
10.1038/tpj.2010.14. [PMID: 20212518] - Ashraf H Ahmed, Michele Calvird, Richard D Gordon, Paul J Taylor, Gregory Ward, Eduardo Pimenta, Ross Young, Michael Stowasser. Effects of two selective serotonin reuptake inhibitor antidepressants, sertraline and escitalopram, on aldosterone/renin ratio in normotensive depressed male patients.
The Journal of clinical endocrinology and metabolism.
2011 Apr; 96(4):1039-45. doi:
10.1210/jc.2010-2603. [PMID: 21289246] - Chadi Albert Calarge, Del D Miller. Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents.
Journal of child and adolescent psychopharmacology.
2011 Apr; 21(2):163-9. doi:
10.1089/cap.2010.0038. [PMID: 21486167] - Leea H Muhonen, Jari Lahti, Hannu Alho, Jouko Lönnqvist, Jari Haukka, Sirkku T Saarikoski. Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence.
Psychiatry research.
2011 Mar; 186(1):53-7. doi:
10.1016/j.psychres.2010.07.039. [PMID: 20800901] - Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.
Basic & clinical pharmacology & toxicology.
2011 Jan; 108(1):46-54. doi:
10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390] - Y Ji, S Hebbring, H Zhu, G D Jenkins, J Biernacka, K Snyder, M Drews, O Fiehn, Z Zeng, D Schaid, D A Mrazek, R Kaddurah-Daouk, R M Weinshilboum. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics.
Clinical pharmacology and therapeutics.
2011 Jan; 89(1):97-104. doi:
10.1038/clpt.2010.250. [PMID: 21107318] - Ulla Knorr, Maj Vinberg, Allan Hansen, Marianne Klose, Ulla Feldt-Rasmussen, Linda Hilsted, Jørgen Hasselstrøm, Ulrik Gether, Per Winkel, Christian Gluud, Jørn Wetterslev, Lars Vedel Kessing. Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial.
PloS one.
2011; 6(6):e21224. doi:
10.1371/journal.pone.0021224. [PMID: 21738622] - Rima Kaddurah-Daouk, Rebecca A Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M Watkins, Miles Trupp, Ronald M Krauss. Enteric microbiome metabolites correlate with response to simvastatin treatment.
PloS one.
2011; 6(10):e25482. doi:
10.1371/journal.pone.0025482. [PMID: 22022402] - Bun-Hee Lee, Yong-Ku Kim. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment.
Psychiatry investigation.
2010 Dec; 7(4):231-5. doi:
10.4306/pi.2010.7.4.231. [PMID: 21253405] - Eric J Lenze, Alison M Goate, Petra Nowotny, David Dixon, Peichang Shi, Robert R Bies, Francis K Lotrich, Bruce L Rollman, M Katherine Shear, Paul A Thompson, Carmen Andreescu, Bruce G Pollock. Relation of serotonin transporter genetic variation to efficacy of escitalopram for generalized anxiety disorder in older adults.
Journal of clinical psychopharmacology.
2010 Dec; 30(6):672-7. doi:
10.1097/jcp.0b013e3181fc2bef. [PMID: 21105279] - William Berger, Akhil Mehra, Maryann Lenoci, Thomas J Metzler, Christian Otte, Gary Tarasovsky, Synthia H Mellon, Owen M Wolkowitz, Charles R Marmar, Thomas C Neylan. Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Oct; 34(7):1279-84. doi:
10.1016/j.pnpbp.2010.07.008. [PMID: 20643177] - Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newman. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.
Journal of medicinal chemistry.
2010 Aug; 53(16):6112-21. doi:
10.1021/jm1005034. [PMID: 20672825] - Lucia Carboni, Serena Becchi, Chiara Piubelli, Alessandra Mallei, Roberto Giambelli, Maria Razzoli, Aleksander A Mathé, Maurizio Popoli, Enrico Domenici. Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Aug; 34(6):1037-48. doi:
10.1016/j.pnpbp.2010.05.019. [PMID: 20580919] - G D Mendes, T Babadopulos, F R Bau, L S Chen, G De Nucci. Comparative bioavailability of two escitalopram formulations in healthy human volunteers.
International journal of clinical pharmacology and therapeutics.
2010 Aug; 48(8):554-62. doi:
10.5414/cpp48554. [PMID: 20650049] - Elsmarieke van de Giessen, Jan Booij. The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men.
European journal of nuclear medicine and molecular imaging.
2010 Aug; 37(8):1507-11. doi:
10.1007/s00259-010-1424-2. [PMID: 20309682] - D W Boulton, A H Balch, K Royzman, C G Patel, R M Berman, S Mallikaarjun, R A Reeves. The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder.
Journal of psychopharmacology (Oxford, England).
2010 Apr; 24(4):537-46. doi:
10.1177/0269881108096522. [PMID: 18832427] - Sanjay Dubé, Mary Anne Dellva, Marcia Jones, William Kielbasa, Robert Padich, Amitabh Saha, Prasad Rao. A study of the effects of LY2216684, a selective norepinephrine reuptake inhibitor, in the treatment of major depression.
Journal of psychiatric research.
2010 Apr; 44(6):356-63. doi:
10.1016/j.jpsychires.2009.09.013. [PMID: 19909980] - Christian Otte, Kim Hinkelmann, Steffen Moritz, Alexander Yassouridis, Holger Jahn, Klaus Wiedemann, Michael Kellner. Modulation of the mineralocorticoid receptor as add-on treatment in depression: a randomized, double-blind, placebo-controlled proof-of-concept study.
Journal of psychiatric research.
2010 Apr; 44(6):339-46. doi:
10.1016/j.jpsychires.2009.10.006. [PMID: 19909979] - Ming-Hsien Tsai, Keh-Ming Lin, Mei-Chun Hsiao, Winston W Shen, Mong-Liang Lu, Hwa-Sheng Tang, Chun-Kai Fang, Chi-Shin Wu, Shao-Chun Lu, Shu Chih Liu, Chun-Yu Chen, Yu-Li Liu. Genetic polymorphisms of cytochrome P450 enzymes influence metabolism of the antidepressant escitalopram and treatment response.
Pharmacogenomics.
2010 Apr; 11(4):537-46. doi:
10.2217/pgs.09.168. [PMID: 20350136] - Lanqiu Zhang, Mark M Rasenick. Chronic treatment with escitalopram but not R-citalopram translocates Galpha(s) from lipid raft domains and potentiates adenylyl cyclase: a 5-hydroxytryptamine transporter-independent action of this antidepressant compound.
The Journal of pharmacology and experimental therapeutics.
2010 Mar; 332(3):977-84. doi:
10.1124/jpet.109.162644. [PMID: 19996298] - Thomas Owley, Camille W Brune, Jeff Salt, Laura Walton, Steve Guter, Nelson Ayuyao, Robert D Gibbons, Bennett L Leventhal, Edwin H Cook. A pharmacogenetic study of escitalopram in autism spectrum disorders.
Autism research : official journal of the International Society for Autism Research.
2010 Feb; 3(1):1-7. doi:
10.1002/aur.109. [PMID: 20020537] - Annamaria Cattaneo, Luisella Bocchio-Chiavetto, Roberta Zanardini, Elena Milanesi, Anna Placentino, Massimo Gennarelli. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment.
The international journal of neuropsychopharmacology.
2010 Feb; 13(1):103-8. doi:
10.1017/s1461145709990812. [PMID: 19835669] - Shriram M Pathak, Prashant B Musmade, Krishnamurthy M Bhat, Nayanabhirama Udupa. Validated HPLC method for quantitative determination of talinolol in rat plasma and application to a preclinical pharmacokinetic study.
Bioanalysis.
2010 Jan; 2(1):95-104. doi:
10.4155/bio.09.162. [PMID: 21083123] - Yuyan Jin, Bruce G Pollock, Ellen Frank, Giovanni B Cassano, Paola Rucci, Daniel J Müller, James L Kennedy, Rocco Nicola Forgione, Margaret Kirshner, Gail Kepple, Andrea Fagiolini, David J Kupfer, Robert R Bies. Effect of age, weight, and CYP2C19 genotype on escitalopram exposure.
Journal of clinical pharmacology.
2010 Jan; 50(1):62-72. doi:
10.1177/0091270009337946. [PMID: 19841156] - Dan Zhou, Hong Jin, Huan-Bing Lin, Xue-Mei Yang, Yu-Fang Cheng, Feng-Jun Deng, Jiang-Ping Xu. Antidepressant effect of the extracts from Fructus Akebiae.
Pharmacology, biochemistry, and behavior.
2010 Jan; 94(3):488-95. doi:
10.1016/j.pbb.2009.11.003. [PMID: 19931301] - David A Mrazek. Psychiatric pharmacogenomic testing in clinical practice.
Dialogues in clinical neuroscience.
2010; 12(1):69-76. doi:
NULL. [PMID: 20373668] - Han Rong, Gaohua Wang, Tiebang Liu, Huiling Wang, Qirong Wan, Senghong Weng. Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor.
International journal of molecular sciences.
2010; 11(12):5310-22. doi:
10.3390/ijms11125310. [PMID: 21614209] - George S Alexopoulos, Christopher F Murphy, Faith M Gunning-Dixon, Charles E Glatt, Vassilios Latoussakis, Robert E Kelly, Dora Kanellopoulos, Sibel Klimstra, Kelvin O Lim, Robert C Young, Matthew J Hoptman. Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression.
Journal of affective disorders.
2009 Dec; 119(1-3):132-41. doi:
10.1016/j.jad.2009.03.004. [PMID: 19375170] - L Noehr-Jensen, S T Zwisler, F Larsen, S H Sindrup, P Damkier, K Brosen. Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain.
Clinical pharmacology and therapeutics.
2009 Dec; 86(6):626-33. doi:
10.1038/clpt.2009.154. [PMID: 19710642]
