5α-Androstane-3β,17β-diol (BioDeep_00000405286)

Main id: BioDeep_00000637501

 

Volatile Flavor Compounds


代谢物信息卡片


5alpha-Androstane-3beta,17beta-diol

化学式: C19H32O2 (292.24021719999996)
中文名称: 5α-雄烷二醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC(CC1CCC3C2CCC4(C3CCC4O)C)O
InChI: InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12-,13-,14-,15-,16-,17-,18-,19-/m0/s1

描述信息

An androstane-3,17-diol that is 5alpha-androstane substituted by beta-hydroxy groups at positions 3 and 17. It is a metabolite of dihydrotestosterone.

同义名列表

4 个代谢物同义名

5alpha-Androstane-3beta,17beta-diol; 5alpha-Androstan-3beta,17beta-diol; 5α-Androstane-3β,17β-diol; 5alpha-Androstan-3beta,17beta-diol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Magdalena M Przybycien-Szymanska, Roberta A Gillespie, Toni R Pak. 17β-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence. PloS one. 2012; 7(2):e32263. doi: 10.1371/journal.pone.0032263. [PMID: 22384198]
  • Saswati Mahapatra, R Jeffrey Karnes, Michael W Holmes, Charles Y F Young, John C Cheville, Manish Kohli, Eric W Klee, Donald J Tindall, Krishna Vanaja Donkena. Novel molecular targets of Azadirachta indica associated with inhibition of tumor growth in prostate cancer. The AAPS journal. 2011 Sep; 13(3):365-77. doi: 10.1208/s12248-011-9279-4. [PMID: 21560017]
  • Hanna Pettersson, Johan Lundqvist, Maria Norlin. Effects of CYP7B1-mediated catalysis on estrogen receptor activation. Biochimica et biophysica acta. 2010 Sep; 1801(9):1090-7. doi: 10.1016/j.bbalip.2010.05.011. [PMID: 20553962]
  • K M McNamara, D T Harwood, U Simanainen, K A Walters, M Jimenez, D J Handelsman. Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry. The Journal of steroid biochemistry and molecular biology. 2010 Aug; 121(3-5):611-8. doi: 10.1016/j.jsbmb.2010.02.001. [PMID: 20144714]
  • Hanna Pettersson, Lisa Holmberg, Magnus Axelson, Maria Norlin. CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling. The FEBS journal. 2008 Apr; 275(8):1778-89. doi: 10.1111/j.1742-4658.2008.06336.x. [PMID: 18331353]
  • Wanjin Tang, Maria Norlin. Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells. Biochemical and biophysical research communications. 2006 Jun; 344(2):540-6. doi: 10.1016/j.bbrc.2006.03.175. [PMID: 16630558]
  • Cornelia Schmutzler, Inka Hamann, Peter J Hofmann, Gabor Kovacs, Luise Stemmler, Birgit Mentrup, Lutz Schomburg, Petra Ambrugger, Annette Grüters, Dana Seidlova-Wuttke, Hubertus Jarry, Wolfgang Wuttke, Josef Köhrle. Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney. Toxicology. 2004 Dec; 205(1-2):95-102. doi: 10.1016/j.tox.2004.06.041. [PMID: 15458794]
  • M Szécsi, I Tóth, J Gardi, T Nyári, J Julesz. HPLC-RIA analysis of steroid hormone profile in a virilizing stromal tumor of the ovary. Journal of biochemical and biophysical methods. 2004 Oct; 61(1-2):47-56. doi: 10.1016/j.jbbm.2004.04.008. [PMID: 15560921]
  • D S Reddy. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol. Neuroscience. 2004; 129(1):195-207. doi: 10.1016/j.neuroscience.2004.08.002. [PMID: 15489042]
  • K Rose, A Allan, S Gauldie, G Stapleton, L Dobbie, K Dott, C Martin, L Wang, E Hedlund, J R Seckl, J A Gustafsson, R Lathe. Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation. The Journal of biological chemistry. 2001 Jun; 276(26):23937-44. doi: 10.1074/jbc.m011564200. [PMID: 11290741]