Fenticonazole nitrate (BioDeep_00000399025)

   

natural product


代谢物信息卡片


1-[2-(2,4-dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole;nitric acid

  化学式: C24H21Cl2N3O4S (517.063)
中文名称: 芬替康唑硝酸盐
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: C(OCC1=CC=C(C=C1)SC2=CC=CC=C2)(C3=CC=C(C=C3Cl)Cl)CN4(C=CN=C4).[N+]([O-])(=O)O
InChI: InChI=1S/C24H20Cl2N2OS.HNO3/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20


描述信息

D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

47 个代谢物同义名

Fenticonazole nitrate; UNII-8V4JGC8YRF; (+-)-1-(2,4-Dichloro-beta-((p-(phenylthio)benzyl)oxy)phenethyl)imidazole mononitrate; (+/-)-1-(2,4-DICHLORO-.BETA.-((P-(PHENYLTHIO)BENZYL)OXY)PHENETHYL)IMIDAZOLE MONONITRATE; (+/-)-1-(2,4-DICHLORO-BETA-((P-(PHENYLTHIO)BENZYL)OXY)PHENETHYL)IMIDAZOLE MONONITRATE; 1-(2-(2,4-dichlorophenyl)-2-((4-(phenylthio)benzyl)oxy)ethyl)-1H-imidazole nitrate; 1-(2-(2,4-Dichlorophenyl)-2-((4-(phenylthio)phenyl)methoxy)ethyl)-1H-imidazolium nitrate; 1-(2-(2,4-dichlorophenyl)-2-((4-phenylsulfanylphenyl)methoxy)ethyl)imidazole nitrate; 1-(2-(2,4-dichlorophenyl)-2-(4-(phenylthio)benzyloxy)ethyl)-1H-imidazole nitrate; 1-(2,4-dichloro-beta-((p-(phenylthio)benzyl)oxy)phenethyl)imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole nitrate; 1-[2-(2,4-dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole;nitric acid; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((4-(phenylthio)phenyl)methoxy)ethyl)-, (+-)-, mononitrate; 1H-IMIDAZOLE, 1-(2-(2,4-DICHLOROPHENYL)-2-((4-(PHENYLTHIO)PHENYL)METHOXY)ETHYL)-, (+/-)-, MONONITRATE; 8V4JGC8YRF; alpha-(2,4-Dichlorophenyl)-beta,N-imidazolylethyl-4-phenylthiobenzyl ether nitrate; Falvin; Fenizolan; fenticonazole; Fenticonazole (Nitrate); Fenticonazole (Nitrate) (Standard); fenticonazole mononitate; Fenticonazole mononitrate; FENTICONAZOLE MONONITRATE [MI]; FENTICONAZOLE NITRATE (EP MONOGRAPH); FENTICONAZOLE NITRATE (MART.); Fenticonazole nitrate (USAN); FENTICONAZOLE NITRATE [EP MONOGRAPH]; FENTICONAZOLE NITRATE [MART.]; Fenticonazole nitrate [USAN]; FENTICONAZOLE NITRATE [WHO-DD]; Fenticonazolnitrat; FJNRUWDGCVDXLU-UHFFFAOYSA-N; Gynoxin; Imidazole, 1-(2,4-dichloro-beta-(p-(phenylthio)benzyloxy)phenethyl)-, nitrate; Laurimic; Lomexin; Lomexin (TN); Lomexin Nitrate; Micofulvin; Nitric acid--1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole (1/1); rac-1-(2-(2,4-dichlorophenyl)-2-((4-(phenylsulfanyl)benzyl)oxy)ethyl)-1H-imidazole nitrate; rac-1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]-1H-imidazole nitrate; Rec 15-1476; REC 15/1476; REC-15/1476; Terlomexin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Rafael Campos, Samara F Bittencourt, Julio Alejandro Rojas-Moscoso, Lorenzo Pissinatti, Lu Shi Chen, Marcovan Porto, Ronilson Agnaldo Moreno, Gustavo D Mendes, Gilberto De Nucci. The rabbit vagina as an in vivo model for vaginal fenticonazole permeability and toxicity. Journal of pharmacological and toxicological methods. 2018 Nov; 94(Pt 1):14-18. doi: 10.1016/j.vascn.2018.04.001. [PMID: 29630936]
  • Zhenbin Feng, Qiaogen Zou, Xiaoheng Tan, Wenjun Che, Zunjian Zhang. Determination of fenticonazole enantiomers by LC-ESI-MS/MS and its application to pharmacokinetic studies in female rats. Arzneimittel-Forschung. 2011; 61(10):587-93. doi: 10.1055/s-0031-1300557. [PMID: 22164967]
  • K S Han, Y G Kim, J W Lee, M G Lee. Blood partition and protein binding of a new reversible proton pump inhibitor, YH1885. Biopharmaceutics & drug disposition. 1998 Sep; 19(6):413-5. doi: 10.1002/(sici)1099-081x(199809)19:6<413::aid-bdd128>3.0.co;2-g. [PMID: 9737823]
  • W Speed, J M Long, R J Simmonds, T A Enos. The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method. Rapid communications in mass spectrometry : RCM. 1995; 9(14):1452-6. doi: 10.1002/rcm.1290091424. [PMID: 8534893]
  • A Novelli, E Periti, G B Massi, R Masi, T Mazzei, P Periti. Systemic absorption of 3H-fenticonazole after vaginal administration of 1 gram in patients. Journal of chemotherapy (Florence, Italy). 1991 Feb; 3(1):23-7. doi: 10.1080/1120009x.1991.11739058. [PMID: 2019858]
  • M Veronese, M Salvaterra, D Barzaghi. Fenticonazole, a new imidazole derivative with antibacterial and antifungal activity. In vitro study. Arzneimittel-Forschung. 1981; 31(12):2133-7. doi: NULL. [PMID: 7199313]