Sparfloxacin (BioDeep_00000398987)
Main id: BioDeep_00000001822
natural product
代谢物信息卡片
Sparfloxacin
化学式: C19H22F2N4O3 (392.1659886)
中文名称: 司帕沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CN(CC(N1)C)C2=C(C(=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)N)F
InChI: InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:9212
- KEGG: C07662
- KEGGdrug: D00590
- PubChem: 60464
- DrugBank: DB01208
- ChEMBL: CHEMBL850
- CAS: 111542-93-9
- CAS: 110871-86-8
- MoNA: CCMSLIB00000081722
- MoNA: CCMSLIB00000081723
- MoNA: CCMSLIB00000078327
- MoNA: CCMSLIB00000078326
- PubChem: 9864
- NIKKAJI: J324.247A
- RefMet: Sparfloxacin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wen Li, Yilin Song, Xiaoyang Liang, Yue Zhou, Min Xu, Qiang Lu, Xinxing Wang, Nan Li. Mutual-reinforcing sonodynamic therapy against Rheumatoid Arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme.
Biomaterials.
2021 09; 276(?):121063. doi:
10.1016/j.biomaterials.2021.121063. [PMID: 34391020] - Dinesh M Morkhade, Vishwanath S Nande, Umesh V Barabde, Arun T Patil, Siddheshwar B Joshi. Design and evaluation of dental films of PEGylated rosin derivatives containing sparfloxacin for periodontitis.
Drug development and industrial pharmacy.
2018 Jun; 44(6):914-922. doi:
10.1080/03639045.2017.1421660. [PMID: 29277118] - Eleftherios Kouris, Stavros Kalogiannis, Franc Perdih, Iztok Turel, George Psomas. Cobalt(II) complexes of sparfloxacin: Characterization, structure, antimicrobial activity and interaction with DNA and albumins.
Journal of inorganic biochemistry.
2016 10; 163(?):18-27. doi:
10.1016/j.jinorgbio.2016.07.022. [PMID: 27501348] - Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Cardiovascular toxicology.
2016 Apr; 16(2):138-46. doi:
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International journal of pharmaceutics.
2015 Nov; 495(2):761-70. doi:
10.1016/j.ijpharm.2015.09.037. [PMID: 26392242] - André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
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PloS one.
2013; 8(4):e60556. doi:
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Pakistan journal of pharmaceutical sciences.
2012 Oct; 25(4):823-9. doi:
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European journal of medicinal chemistry.
2012 Sep; 55(?):67-73. doi:
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British journal of pharmacology.
2012 Jul; 166(5):1694-707. doi:
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2012; 29(3):383-91. doi:
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2011 Dec; 17(6):821-4. doi:
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2011 Oct; 40(37):9461-73. doi:
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Journal of inorganic biochemistry.
2011 Oct; 105(10):1273-85. doi:
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2011 Mar; 26(2):112-7. doi:
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PLoS neglected tropical diseases.
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2011; 6(?):547-55. doi:
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Basic & clinical pharmacology & toxicology.
2010 Aug; 107(2):643-9. doi:
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2010 May; 54(5):1855-63. doi:
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Journal of inorganic biochemistry.
2010 Apr; 104(4):455-66. doi:
10.1016/j.jinorgbio.2009.12.019. [PMID: 20106531] - Himanshu Gupta, Mohammed Aqil, Roop K Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal. Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery.
Nanomedicine : nanotechnology, biology, and medicine.
2010 Apr; 6(2):324-33. doi:
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2009 Aug; 52(15):4844-52. doi:
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Biological & pharmaceutical bulletin.
2009 Jun; 32(6):1095-100. doi:
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Indian journal of pharmacology.
2009 Jun; 41(3):106-9. doi:
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Bioorganic & medicinal chemistry.
2009 Mar; 17(6):2512-23. doi:
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Drug metabolism and pharmacokinetics.
2009; 24(2):167-74. doi:
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Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2008 Feb; 7(2):240-9. doi:
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Antimicrobial agents and chemotherapy.
2007 Feb; 51(2):576-82. doi:
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Pharmacological research.
2006 Aug; 54(2):111-7. doi:
10.1016/j.phrs.2006.03.004. [PMID: 16701999] - Hea-Young Cho, Sun-Ae Park, Yong-Bok Lee. Improvement and validation of an HPLC method for examining the effects of the MDR1 gene polymorphism on sparfloxacin pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 834(1-2):84-92. doi:
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Journal of pharmacological sciences.
2006 Jan; 100(1):88-92. doi:
10.1254/jphs.scj05008x. [PMID: 16404129] - Hiroyuki Sasabe, Yukio Kato, Takashi Suzuki, Minoru Itose, Gohachiro Miyamoto, Yuichi Sugiyama. Carrier-mediated uptake of grepafloxacin, a fluoroquinolone antibiotic, by the isolated rat lung cells.
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2005 Dec; 20(6):491-5. doi:
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European journal of pharmacology.
2004 Oct; 501(1-3):151-9. doi:
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The British journal of dermatology.
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