Transcop (BioDeep_00000398487)
Main id: BioDeep_00000001430
PANOMIX_OTCML-2023
代谢物信息卡片
Scopolamine hydrobromide
化学式: C17H21NO4 (303.1471)
中文名称: 东莨菪碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OCC(c(c4)cccc4)C(=O)OC(C2)CC(N(C)3)C(O1)C1C23
InChI: InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ban Chen, Shuangshuang Liu, Xican Li, Rongxin Cai, Chunhou Li, Yuchen Hu, Jiangtao Su, Tongxun Lei. Database-aided ultrahigh-performance liquid chromatography Q-Exactive-Orbitrap tandem mass spectrometry putatively identifies 16 unexpected compounds and three anticounterfeiting pharmacopoeia quality markers for Perillae Fructus.
Rapid communications in mass spectrometry : RCM.
2024 Jul; 38(13):e9762. doi:
10.1002/rcm.9762. [PMID: 38693787] - Yuqin Gou, Yanming Jing, Jiaxin Song, Mohammad Mahmoud Nagdy, Chao Peng, Lingjiang Zeng, Min Chen, Xiaozhong Lan, Zun Lai Lai Htun, Zhihua Liao, Yan Li. A novel bHLH gene responsive to low nitrogen positively regulates the biosynthesis of medicinal tropane alkaloids in Atropa belladonna.
International journal of biological macromolecules.
2024 May; 266(Pt 1):131012. doi:
10.1016/j.ijbiomac.2024.131012. [PMID: 38522709] - Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hsu. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis.
Environmental toxicology.
2024 May; 39(5):3198-3210. doi:
10.1002/tox.24175. [PMID: 38351887] - Reza Babanzadeh, Seyed Yaser Vafaei, Davood Ahmadi Moghadam, Alireza Komaki, Mojdeh Mohammadi. Quercetin-loaded nanoemulsions prevent Scopolamine-induced neurotoxicity in male rats.
Physiology & behavior.
2024 Apr; 277(?):114494. doi:
10.1016/j.physbeh.2024.114494. [PMID: 38360390] - Maria Lazarova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Diamara Uzunova, Petko Denev, Valya Vassileva, Krasimira Tasheva. Extracts of Sideritis scardica and Clinopodium vulgare Alleviate Cognitive Impairments in Scopolamine-Induced Rat Dementia.
International journal of molecular sciences.
2024 Feb; 25(3):. doi:
10.3390/ijms25031840. [PMID: 38339117] - Rui-Dan Hu, Wen-Li Zhu, Wei-Yao Lin, Yu-Hui Qiu, Guang-Liang Wu, Xiao-Ying Ding, Zhen-Kun Yang, Qian Feng, Rong-Rong Zhang, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang. Ethanol extract of Evodia lepta Merr. ameliorates cognitive impairment through inhibiting NLRP3 inflammasome in scopolamine-treated mice.
Aging.
2024 Jan; 16(?):. doi:
10.18632/aging.205486. [PMID: 38284892] - Haojie Ni, Muqiu Liu, Mindie Cao, Lingyu Zhang, Yijing Zhao, Lang Yi, Yanwu Li, Liang Liu, Peixun Wang, Qun Du, Hua Zhou, Yan Dong. Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 171(?):116190. doi:
10.1016/j.biopha.2024.116190. [PMID: 38278026] - Shuyao Ruan, Jiaqi Li, Hang Ruan, Qing Xia, Xiaolin Hou, Zhi Wang, Teng Guo, Chunyun Zhu, Nianping Feng, Yongtai Zhang. Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Jan; 366(?):712-731. doi:
10.1016/j.jconrel.2024.01.013. [PMID: 38219911] - Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang. Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids.
Journal of ethnopharmacology.
2024 Jan; 318(Pt A):116792. doi:
10.1016/j.jep.2023.116792. [PMID: 37356745] - Ismaheel Akinwale Adeniyi, Peace Oluwafolakemi Oregbesan, Adegboyega Adesanya, Mujeedat Adebukola Olubori, Gbenga Stanley Olayinka, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo. Olax subscorpioidea prevented scopolamine-induced memory impairment through the prevention of oxido-inflammatory damage and modulation of cholinergic transmission.
Journal of ethnopharmacology.
2024 Jan; 318(Pt B):116995. doi:
10.1016/j.jep.2023.116995. [PMID: 37541399] - Maria I Lazarova, Elina R Tsvetanova, Almira P Georgieva, Miroslava O Stefanova, Diamara N Uzunova, Petko N Denev, Krasimira N Tasheva. Marrubium vulgare Extract Improves Spatial Working Memory and Oxidative Stress Damage in Scopolamine-Treated Rats.
Journal of Alzheimer's disease : JAD.
2024; 99(s1):S157-S169. doi:
10.3233/jad-231011. [PMID: 38489175] - Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson. Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer's-like cognitive impairment in zebrafish and mice.
Pharmaceutical biology.
2023 Dec; 61(1):825-838. doi:
10.1080/13880209.2023.2209130. [PMID: 37212299] - Xiajing Xu, Yutong Song, Man Jiang, Meihan Liu, Xuanmeng Zhang, Dongmei Wang, Yingni Pan, Shumeng Ren, Xiaoqiu Liu. Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine-Induced AD Animals.
Molecular nutrition & food research.
2023 Nov; ?(?):e2200816. doi:
10.1002/mnfr.202200816. [PMID: 38018298] - Qiumei Zhang, Yujiao Li, Bei Fan, Fengzhong Wang, Zhi Li, Alberto Carlos Pires Dias, Xinmin Liu, Qiong Wang. Dendrobium nobile Lindl ameliorates learning and memory deficits in scopolamine-treated mice.
Journal of ethnopharmacology.
2023 Nov; 324(?):117416. doi:
10.1016/j.jep.2023.117416. [PMID: 37981114] - Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee. The Neuroprotective Effects of Dendropanax morbifera Water Extract on Scopolamine-Induced Memory Impairment in Mice.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216444. [PMID: 38003650] - Mahalingam Jeyakumar, Devasahayam Jaya Balan, Chandramohan Kiruthiga, Sakthivel Jafni, Kasi Pandima Devi. α-bisabolol β-d-fucopyranoside (ABFP) ameliorates scopolamine-induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio).
Journal of biochemical and molecular toxicology.
2023 Nov; ?(?):e23580. doi:
10.1002/jbt.23580. [PMID: 37961937] - Farimah Moazzam, Ashrafalsadat Hatamian-Zarmi, Bahman Ebrahimi Hosseinzadeh, Fariba Khodagholi, Meisam Rooki, Fatemehsadat Rashidi. Preparation and characterization of brain-targeted polymeric nanocarriers (Frankincense-PMBN-lactoferrin) and in-vivo evaluation on an Alzheimer's disease-like rat model induced by scopolamine.
Brain research.
2023 Oct; ?(?):148622. doi:
10.1016/j.brainres.2023.148622. [PMID: 37832760] - Rohit Malik, Sunishtha Kalra, Pooja, Govind Singh, Meenu, Vinod Gahlot, Anjali Kajal, Rimpy. Antioxidative and neuroprotective potential of Acorus calamus linn. and Cordia dichotoma G. Forst. In Alzheimer's type dementia in rodent.
Brain research.
2023 Oct; 1822(?):148616. doi:
10.1016/j.brainres.2023.148616. [PMID: 37793605] - Baile Ning, Zhifang Wang, Jiangshan He, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Fan Jiang, Wenbin Fu. The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex.
Brain research.
2023 Sep; 1822(?):148609. doi:
10.1016/j.brainres.2023.148609. [PMID: 37783259] - Fanying Deng, Fuxia Zhao, Wenhui Wang, Shiqi Liu, Yan Wang. Serum lipidomics reveal the mechanism of memory disorder improvement by Qifu decoction.
Analytical methods : advancing methods and applications.
2023 Sep; ?(?):. doi:
10.1039/d3ay00899a. [PMID: 37668283] - Hira Afshan, Humera Khatoon, Aisha Aziz, Mariam Arefa, Sheikh Abdul Khaliq, Nausheen Alam. Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5(Special)):1609-1618. doi:
". [PMID: 38008959] - Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng, Changhong Wang. Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice.
Journal of ethnopharmacology.
2023 Aug; 319(Pt 1):117106. doi:
10.1016/j.jep.2023.117106. [PMID: 37652198] - Xiajing Xu, Yong Ding, Meihan Liu, Xuanmeng Zhang, Dongmei Wang, Yingni Pan, Shumeng Ren, Xiaoqiu Liu. Neuroprotective mechanisms of defatted walnut powder against scopolamine-induced Alzheimer's disease in mice revealed through metabolomics and proteomics analyses.
Journal of ethnopharmacology.
2023 Aug; 319(Pt 1):117107. doi:
10.1016/j.jep.2023.117107. [PMID: 37652196] - Rafia Ferdous, Md Badrul Islam, Md Yusuf Al-Amin, Anik Kumar Dey, Md Omar Ali Mondal, Md Nurul Islam, Ahm Khurshid Alam, Aziz Abdur Rahman, Md Golam Sadik. Anticholinesterase and antioxidant activity of Drynaria quercifolia and its ameliorative effect in scopolamine-induced memory impairment in mice.
Journal of ethnopharmacology.
2023 Aug; ?(?):117095. doi:
10.1016/j.jep.2023.117095. [PMID: 37634747] - Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Roua A Alsubki, Kaynat Sajid, Sana Shoukat, Kotb A Attia, Sajid Fiaz, Shaukat Ali, Itoh Kimiko, Ghulam Muhammad Ali. Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer's disease mice model.
Molecular biology reports.
2023 Aug; ?(?):. doi:
10.1007/s11033-023-08674-0. [PMID: 37535247] - Lizeth M Zavala-Ocampo, Perla Y López-Camacho, Eva Aguirre-Hernández, René Cárdenas-Vázquez, Herlinda Bonilla-Jaime, Gustavo Basurto-Islas. Neuroprotective effects of Petiveria alliacea on scopolamine-induced learning and memory impairment mouse model.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116881. doi:
10.1016/j.jep.2023.116881. [PMID: 37460029] - Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain. Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis.
Pharmacology, biochemistry, and behavior.
2023 Jul; ?(?):173602. doi:
10.1016/j.pbb.2023.173602. [PMID: 37453560] - Umesh Chandra Dash, Sandeep Kumar Swain, Atala Bihari Jena, Jagnehswar Dandapat, Atish Kumar Sahoo. The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats.
Journal of ethnopharmacology.
2023 Jul; ?(?):116911. doi:
10.1016/j.jep.2023.116911. [PMID: 37451488] - Mater H Mahnashi, Muhammad Ashraf, Abdulaziz Hassan Alhasaniah, Hammad Ullah, Alam Zeb, Mehreen Ghufran, Shah Fahad, Muhammad Ayaz, Maria Daglia. Polyphenol-enriched Desmodium elegans DC. ameliorate scopolamine-induced amnesia in animal model of Alzheimer's disease: In Vitro, In Vivo and In Silico approaches.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jul; 165(?):115144. doi:
10.1016/j.biopha.2023.115144. [PMID: 37437376] - Rengasamy Balakrishnan, Yon-Suk Kim, Ga-Won Kim, Woo-Jung Kim, Sun-Mee Hong, Choong-Gon Kim, Dong-Kug Choi. Standardized extract of Glehnia Littoralis abrogates memory impairment and neuroinflammation by regulation of CREB/BDNF and NF-κB/MAPK signaling in scopolamine-induced amnesic mice model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jul; 165(?):115106. doi:
10.1016/j.biopha.2023.115106. [PMID: 37421783] - Ismail O Ishola, Taiwo Grace Olubodun-Obadun, Abisola Sekinat Akinwande, Olufunmilayo Olaide Adeyemi. Cajanus cajan (L) Millsp. seed extract ameliorates scopolamine-induced amnesia through increase in antioxidant defense mechanisms and cholinergic neurotransmission.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2023 Jun; 38(1):91-99. doi:
10.54548/njps.v38i1.13. [PMID: 38243363] - Rifat Jahan, Mohammad Yousaf, Hamayun Khan, Shahid Ali Shah, Abdul Aziz Khan, Nousheen Bibi, Fatima Javed, Musarrat Ijaz, Arif Ali, Dong-Qing Wei. Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2023 Jun; ?(?):. doi:
10.1007/s11481-023-10067-w. [PMID: 37261605] - Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine.
Applied microbiology and biotechnology.
2023 Apr; ?(?):. doi:
10.1007/s00253-023-12537-w. [PMID: 37099059] - Yuman Xie, Li Liu, Junzuo Zheng, Kun Shi, Wenqi Ai, Xuesong Zhang, Ping Wang, Zhou Lan, Lvyi Chen. Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins.
Journal of ethnopharmacology.
2023 Mar; 311(?):116400. doi:
10.1016/j.jep.2023.116400. [PMID: 37003402] - Seung-Eun Lee, Saetbyeol Park, Gwi Yeong Jang, Jeonghoon Lee, Minho Moon, Yun-Jeong Ji, Ji Wook Jung, Yunkwon Nam, Soo Jung Shin, Yunji Lee, Jehun Choi, Dong Hwi Kim. Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065765. [PMID: 36982837] - Fangyuan Zhang, Fei Qiu, Junlan Zeng, Zhichao Xu, Yueli Tang, Tengfei Zhao, Yuqin Gou, Fei Su, Shiyi Wang, Xiuli Sun, Zheyong Xue, Weixing Wang, Chunxian Yang, Lingjiang Zeng, Xiaozhong Lan, Min Chen, Junhui Zhou, Zhihua Liao. Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family.
Nature communications.
2023 Mar; 14(1):1446. doi:
10.1038/s41467-023-37133-4. [PMID: 36922496] - Maria I Lazarova, Lyubka P Tancheva, Krasimira N Tasheva, Petko N Denev, Diamara N Uzunova, Miroslava O Stefanova, Elina R Tsvetanova, Almira P Georgieva, Reni E Kalfin. Effects of Sideritis scardica Extract on Scopolamine-Induced Learning and Memory Impairment in Mice.
Journal of Alzheimer's disease : JAD.
2023 Mar; ?(?):. doi:
10.3233/jad-230017. [PMID: 36872784] - Khushboo Govind Faldu, Snehal Sanjay Patel, Jigna Samir Shah. Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model.
Metabolic brain disease.
2023 Feb; ?(?):. doi:
10.1007/s11011-023-01186-7. [PMID: 36809523] - Binod Timalsina, Md Nazmul Haque, Ho Jin Choi, Raju Dash, Il Soo Moon. Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model.
Phytotherapy research : PTR.
2023 Feb; ?(?):. doi:
10.1002/ptr.7777. [PMID: 36808768] - Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect.
Drug development and industrial pharmacy.
2023 Feb; 49(2):240-247. doi:
10.1080/03639045.2023.2201625. [PMID: 37032647] - Monique de Nijs, Colin Crews, Folke Dorgelo, Susan MacDonald, Patrick P J Mulder. Emerging Issues on Tropane Alkaloid Contamination of Food in Europe.
Toxins.
2023 Jan; 15(2):. doi:
10.3390/toxins15020098. [PMID: 36828413] - Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A Alananzeh, Mohd Nizam Mordi. Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.
Journal of ethnopharmacology.
2023 Jan; 300(?):115753. doi:
10.1016/j.jep.2022.115753. [PMID: 36162546] - Sakshi Tyagi, Ajit Kumar Thakur. Neuropharmacological Study on Capsaicin in Scopolamine-injected Mice.
Current Alzheimer research.
2023; 20(9):660-676. doi:
10.2174/0115672050286225231230130613. [PMID: 38213170] - Asmaa K Abdelghany, El-Shymaa El-Nahass, Marwa A Ibrahim, Akram M El-Kashlan, H H Emeash, Fatma Khalil. Neuroprotective role of medicinal plant extracts evaluated in a scopolamine-induced rat model of Alzheimer's disease.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2022 Dec; 27(8):773-783. doi:
10.1080/1354750x.2022.2112975. [PMID: 35950787] - Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao. Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway.
Metabolic brain disease.
2022 12; 37(8):2751-2762. doi:
10.1007/s11011-022-00980-z. [PMID: 35921056] - Rumyana Simeonova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova, Irini Doytchinova. Ex Vivo Antioxidant and Cholinesterase Inhibiting Effects of a Novel Galantamine-Curcumin Hybrid on Scopolamine-Induced Neurotoxicity in Mice.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314843. [PMID: 36499171] - Opeyemi B Ogunsuyi, Folorunsho B Omage, Omamuyovwi M Ijomone, Ganiyu Oboh, João B T Rocha. Effect of chlorogenic acid plus donepezil on critical neurocortical enzyme activities, inflammatory markers, and synaptophysin immunoreactivity in scopolamine-assaulted rats, supported by multiple ligand simultaneous docking.
Journal of food biochemistry.
2022 11; 46(11):e14312. doi:
10.1111/jfbc.14312. [PMID: 35791518] - Ayokunle O Ademosun, Temitope V Popoola, Ganiyu Oboh, Olamide W Fasakin. Parquetina nigrescens and Spondias mombin protects against neurochemical alterations in the scopolamine model of cognitive dysfunction.
Journal of food biochemistry.
2022 11; 46(11):e14213. doi:
10.1111/jfbc.14213. [PMID: 35475510] - Fatemeh Sadat Mousavizadeh, Nahid Sarlak, Mansour Ghorbanpour, Reza Ghafarzadegan. Rapid Detection and Determination of Scopolamine in the Leaf Extract of Black Henbane (Hyoscyamus niger L.) Plants Using a Novel Nanosensor.
Journal of AOAC International.
2022 Oct; 105(6):1730-1740. doi:
10.1093/jaoacint/qsac061. [PMID: 35951765] - Marwa M Saeed, Álvaro Fernández-Ochoa, Fatema R Saber, Rabab H Sayed, María de la Luz Cádiz-Gurrea, Amira K Elmotayam, Francisco Javier Leyva-Jiménez, Antonio Segura-Carretero, Rania I Nadeem. The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches.
Molecules (Basel, Switzerland).
2022 Oct; 27(20):. doi:
10.3390/molecules27207118. [PMID: 36296710] - Lorena González-Gómez, Sonia Morante-Zarcero, Jorge A M Pereira, José S Câmara, Isabel Sierra. Improved Analytical Approach for Determination of Tropane Alkaloids in Leafy Vegetables Based on µ-QuEChERS Combined with HPLC-MS/MS.
Toxins.
2022 Sep; 14(10):. doi:
10.3390/toxins14100650. [PMID: 36287919] - Varinder Singh, Kiranpreet Kaur, Sanimardeep Kaur, Richa Shri, Thakur Gurjeet Singh, Manjinder Singh. Trimethoxyflavones from Ocimum basilicum L. leaves improve long term memory in mice by modulating multiple pathways.
Journal of ethnopharmacology.
2022 Sep; 295(?):115438. doi:
10.1016/j.jep.2022.115438. [PMID: 35671863] - Ion Brinza, Mohamed A El Raey, Walaa El-Kashak, Omayma A Eldahshan, Lucian Hritcu. Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185901. [PMID: 36144637] - Muhammad Afzal, Sami I Alzarea, Khalid Saad Alharbi, Abdulaziz I Alzarea, Sattam Khulaif Alenezi, Mohammed Salem Alshammari, Ali H Alquraini, Imran Kazmi. Rosiridin Attenuates Scopolamine-Induced Cognitive Impairments in Rats via Inhibition of Oxidative and Nitrative Stress Leaded Caspase-3/9 and TNF-α Signaling Pathways.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185888. [PMID: 36144623] - Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi. Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits.
International journal of molecular sciences.
2022 Sep; 23(17):. doi:
10.3390/ijms23179923. [PMID: 36077321] - Parul Katiyar, Aaina Singh Rathore, Somesh Banerjee, Sandip Nathani, Walia Zahra, Surya Pratap Singh, Debabrata Sircar, Partha Roy. Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice.
Food & function.
2022 Aug; 13(16):8474-8488. doi:
10.1039/d2fo00423b. [PMID: 35861716] - Deniz Kantar, Alev Duygu Acun, Betül Danışman. Effects of thymoquinone on scopolamine-induced spatial and echoic memory changes through regulation of lipid peroxidation and cholinergic impairment.
Behavioural brain research.
2022 08; 431(?):113972. doi:
10.1016/j.bbr.2022.113972. [PMID: 35718231] - Ze-Xing Wang, Wen-Wen Lian, Jun He, Xiao-Li He, Yu-Ming Wang, Chen-Hao Pan, Mei Li, Wei-Ku Zhang, Lian-Qi Liu, Jie-Kun Xu. Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: Involvement of neurotransmitter and oxidative stress.
Journal of ethnopharmacology.
2022 Jul; 293(?):115252. doi:
10.1016/j.jep.2022.115252. [PMID: 35405255] - Marva Sandhu, Hafiz Muhammad Irfan, Shahid Ali Shah, Madiha Ahmed, Iffat Naz, Muhammad Akram, Humaira Fatima, Ayesha Shuja Farooq. Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144513. [PMID: 35889382] - Mi-Jin Kwon, Ju-Woon Lee, Kwan-Soo Kim, Hao Chen, Cheng-Bi Cui, Gye Won Lee, Young Ho Cho. The Influence of Tyrosol-Enriched Rhodiola sachalinensis Extracts Bioconverted by the Mycelium of Bovista plumbe on Scopolamine-Induced Cognitive, Behavioral, and Physiological Responses in Mice.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144455. [PMID: 35889329] - Qiaozhuo Zhang, Mengjiao Liang, Junlan Zeng, Chunxian Yang, Jianbo Qin, Wei Qiang, Xiaozhong Lan, Min Chen, Min Lin, Zhihua Liao. Engineering tropane alkaloid production and glyphosate resistance by overexpressing AbCaM1 and G2-EPSPS in Atropa belladonna.
Metabolic engineering.
2022 07; 72(?):237-246. doi:
10.1016/j.ymben.2022.03.014. [PMID: 35390492] - Łukasz Pecio, Solomiia Kozachok, Ion Brinza, Razvan Stefan Boiangiu, Lucian Hritcu, Cornelia Mircea, Ana Flavia Burlec, Oana Cioanca, Monica Hancianu, Olga Wronikowska-Denysiuk, Krystyna Skalicka-Woźniak, Wiesław Oleszek. Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123692. [PMID: 35744815] - Gui-Jiao Zhang, Dong Zheng, Huan Yu, Xiao-Ping Luo, Wei Wu. Ginkgo Biloba Extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage.
Current medical science.
2022 Jun; 42(3):474-482. doi:
10.1007/s11596-022-2582-8. [PMID: 35678907] - Ayokunle O Ademosun, Adeniyi A Adebayo, Temitope V Popoola, Ganiyu Oboh. Shaddock (Citrus maxima) peels extract restores cognitive function, cholinergic and purinergic enzyme systems in scopolamine-induced amnesic rats.
Drug and chemical toxicology.
2022 May; 45(3):1073-1080. doi:
10.1080/01480545.2020.1808668. [PMID: 32847424] - Ewelina Kowalczyk, Krzysztof Kwiatek. Scopolamine and atropine in feeds - determination with liquid chromatography mass spectrometry.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2022 May; 39(5):977-989. doi:
10.1080/19440049.2022.2037724. [PMID: 35302907] - Asli Aykac, Kerem Teralı, Dilek Özbeyli, Seren Ede, Ömercan Albayrak, Kemal Hüsnü Can Başer, Göksel Şener. A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats.
Metabolic brain disease.
2022 04; 37(4):1041-1055. doi:
10.1007/s11011-022-00933-6. [PMID: 35201555] - Bo-Yu Zhang, Xiao-Min Luo, Yi Ding, Bin Yang, Han-Yun Que, Rui Tan, Pu-Yang Gong, Jian Gu. [Mechanism of Tibetan medicine Ershiwuwei Shanhu Pills on scopolamine-induced learning and memory impairment in mice based on Keap1/Nrf2/HO-1 signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2082-2089. doi:
10.19540/j.cnki.cjcmm.20220207.701. [PMID: 35531724] - Ting Zhang, Min Jung Kim, Min Ju Kim, Xuangao Wu, Hye Jeong Yang, Heng Yuan, Shaokai Huang, Sun Myung Yoon, Keun-Nam Kim, Sunmin Park. Long-Term Effect of Porcine Brain Enzyme Hydrolysate Intake on Scopolamine-Induced Memory Impairment in Rats.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063361. [PMID: 35328781] - Tiantian Zhao, Saiyi Zhong, Jucai Xu, Wenjuan Jiao, Weifeng Liu, Lihua Huang, Yehui Zhang, Yousheng Zhang. PAYCS Alleviates Scopolamine-Induced Memory Deficits in Mice by Reducing Oxidative and Inflammatory Stress and Modulation of Gut Microbiota-Fecal Metabolites-Brain Neurotransmitter Axis.
Journal of agricultural and food chemistry.
2022 Mar; 70(9):2864-2875. doi:
10.1021/acs.jafc.1c06726. [PMID: 35174709] - Beenita Saikia, Lipika Buragohain, Chandana Choudhury Barua, Jadav Sarma, Sarojini Mahanta Tamuli, Dhruba Jyoti Kalita, Acheenta Gohain Barua, Iswar Chandra Barua, Ramakrishna Elancheran. Evaluation of anti-amnesic effect of Conyza bonariensis in rats.
Indian journal of pharmacology.
2022 Mar; 54(2):102-109. doi:
10.4103/ijp.ijp_201_19. [PMID: 35546461] - Sethuraman Sathya, Boovaragamoorthy Gowri Manogari, Kaliannan Thamaraiselvi, Sethuraman Vaidevi, Kandasamy Ruckmani, Kasi Pandima Devi. Phytol loaded PLGA nanoparticles ameliorate scopolamine-induced cognitive dysfunction by attenuating cholinesterase activity, oxidative stress and apoptosis in Wistar rat.
Nutritional neuroscience.
2022 Mar; 25(3):485-501. doi:
10.1080/1028415x.2020.1764290. [PMID: 32406811] - Iriny M Ayoub, Mina Y George, Esther T Menze, Maryhan Mahmoud, Mariam Botros, Mariam Essam, Israa Ashmawy, Pussey Shendi, Andrew Hany, Mohammed Galal, Mohamed Ayman, Rola M Labib. Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model.
Food & function.
2022 Feb; 13(4):2253-2268. doi:
10.1039/d1fo02988f. [PMID: 35137748] - Zeinab Hosseini, Fatemeh Mansouritorghabeh, Faezeh Sadat Hosseini Kakhki, Mahmoud Hosseini, Hassan Rakhshandeh, Azar Hosseini, Maede Hasanpour, Mehrdad Iranshahi, Arezoo Rajabian. Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase.
Metabolic brain disease.
2022 02; 37(2):473-488. doi:
10.1007/s11011-021-00898-y. [PMID: 34982352] - Smriti Tripathi, Papiya Mitra Mazumder. Comprehensive investigations for a potential natural prophylaxis-A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress.
Drug development research.
2022 02; 83(1):105-118. doi:
10.1002/ddr.21849. [PMID: 34184291] - Zhiqiang Lu, Xiaomeng Xu, Dongmei Li, Na Sun, Songyi Lin. Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism.
Journal of agricultural and food chemistry.
2022 Jan; 70(1):157-170. doi:
10.1021/acs.jafc.1c06475. [PMID: 34932331] - Yingcheng Deng, Wei Li, Lei Niu, Xianglin Luo, Jing Li, Yuan Zhang, Hong Liu, Jie He, Wei Wan. Amelioration of scopolamine-induced learning and memory impairment by the TRPV4 inhibitor HC067047 in ICR mice.
Neuroscience letters.
2022 01; 767(?):136209. doi:
10.1016/j.neulet.2021.136209. [PMID: 34480999] - Umesh Chandra Dash, Sandeep Kumar Swain, Satish Kanhar, Purusottam Banjare, Partha Pratim Roy, Jagneshwar Dandapat, Atish Kumar Sahoo. The modulatory role of prime identified compounds in Geophila repens in mitigating scopolamine-induced neurotoxicity in experimental rats of Alzheimer's disease via attenuation of cholinesterase, β-secretase, MAPt levels and inhibition of oxidative stress imparts inflammation.
Journal of ethnopharmacology.
2022 Jan; 282(?):114637. doi:
10.1016/j.jep.2021.114637. [PMID: 34534598] - Karline da Costa Rodrigues, Renata Leivas de Oliveira, Julia da Silva Chaves, Vanessa Macedo Esteves da Rocha, Beatriz Fuzinato Dos Santos, Mariana Gallio Fronza, Nelson Luís de Campos Domingues, Lucielli Savegnago, Ethel Antunes Wilhelm, Cristiane Luchese. A new arylsulfanyl-benzo-2,1,3-thiadiazoles derivative produces an anti-amnesic effect in mice by modulating acetylcholinesterase activity.
Chemico-biological interactions.
2022 Jan; 351(?):109736. doi:
10.1016/j.cbi.2021.109736. [PMID: 34740600] - Mahdieh Anoush, Nasrin Tayebi, Soroush Bijani, Mina Ebrahimi, Ali Reza Yazdinezhad, Mir-Jamal Hosseini. Thymus daenensis extract prevents scopolamine‑induced memory impairment through declining oxidative stress in rats.
Acta neurobiologiae experimentalis.
2022; 82(3):380-388. doi:
10.55782/ane-2022-036. [PMID: 36214720] - Seong Min Hong, Da Hye Yoon, Mi Kyeong Lee, Jae Kang Lee, Sun Yeou Kim. A Mixture of Ginkgo biloba L. Leaf and Hericium erinaceus (Bull.) Pers. Fruit Extract Attenuates Scopolamine-Induced Memory Impairments in Mice.
Oxidative medicine and cellular longevity.
2022; 2022(?):9973678. doi:
10.1155/2022/9973678. [PMID: 35126824] - Piaoxue Liu, Xun Zhou, Haoran Zhang, Rui Wang, Xiaolang Wu, Wenxuan Jian, Weirong Li, Dongsheng Yuan, Qi Wang, Wei Zhao. Danggui-Shaoyao-San Attenuates Cognitive Impairment via the Microbiota-Gut-Brain Axis With Regulation of Lipid Metabolism in Scopolamine-Induced Amnesia.
Frontiers in immunology.
2022; 13(?):796542. doi:
10.3389/fimmu.2022.796542. [PMID: 35664001] - Lyubka Tancheva, Maria Lazarova, Lyudmila Velkova, Alexander Dolashki, Diamara Uzunova, Borislav Minchev, Polina Petkova-Kirova, Yozljam Hassanova, Petja Gavrilova, Krasimira Tasheva, Teodora Taseva, Yordan Hodzhev, Atanas G Atanasov, Miroslava Stefanova, Albena Alexandrova, Elina Tzvetanova, Ventseslav Atanasov, Reni Kalfin, Pavlina Dolashka. Beneficial Effects of Snail Helix aspersa Extract in an Experimental Model of Alzheimer's Type Dementia.
Journal of Alzheimer's disease : JAD.
2022; 88(1):155-175. doi:
10.3233/jad-215693. [PMID: 35599481] - Ying Wang, Jun-Jie Zhang, Jin-Gang Hou, Xin Li, Wei Liu, Jing-Tian Zhang, Si-Wen Zheng, Feng-Yan Su, Wei Li. Protective Effect of Ginsenosides from Stems and Leaves of Panax ginseng against Scopolamine-Induced Memory Damage via Multiple Molecular Mechanisms.
The American journal of Chinese medicine.
2022; 50(4):1113-1131. doi:
10.1142/s0192415x22500458. [PMID: 35475974] - Shaza H Aly, Ahmed M Elissawy, Ahmed M Fayez, Omayma A Eldahshan, Mohamed A Elshanawany, Abdel Nasser B Singab. Neuroprotective effects of Sophora secundiflora, Sophora tomentosa leaves and formononetin on scopolamine-induced dementia.
Natural product research.
2021 Dec; 35(24):5848-5852. doi:
10.1080/14786419.2020.1795853. [PMID: 32696670] - Samuel Adetunji Onasanwo, Vanessa O Adamaigbo, Olusegun G Adebayo, Spiff E Eleazer. Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway.
Metabolic brain disease.
2021 12; 36(8):2445-2460. doi:
10.1007/s11011-021-00855-9. [PMID: 34669098] - Suk Kyung Shin, Jae-Myung Yoo, Fu Yi Li, Seong Yeon Baek, Mee Ree Kim. Mulberry fruit improves memory in scopolamine-treated mice: role of cholinergic function, antioxidant system, and TrkB/Akt signaling.
Nutritional neuroscience.
2021 Dec; 24(12):940-950. doi:
10.1080/1028415x.2019.1696613. [PMID: 31793392] - H V Sudeep, K Venkatakrishna, Amritharaj, K Gouthamchandra, B Reethi, P Naveen, H B Lingaraju, K Shyamprasad. A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins.
Journal of food biochemistry.
2021 12; 45(12):e13994. doi:
10.1111/jfbc.13994. [PMID: 34778972] - Samah M El Sohafy, Eman Shawky, Shaimaa M Sallam. Effect of ontogeny on the content of the hallucinogenic alkaloids atropine and scopolamine in the different organs of some Solanaceae plants.
Natural product research.
2021 Dec; 35(24):5894-5898. doi:
10.1080/14786419.2020.1800698. [PMID: 32748646] - Luminita Capatina, Edoardo Marco Napoli, Giuseppe Ruberto, Lucian Hritcu. Origanum vulgare ssp. hirtum (Lamiaceae) Essential Oil Prevents Behavioral and Oxidative Stress Changes in the Scopolamine Zebrafish Model.
Molecules (Basel, Switzerland).
2021 Nov; 26(23):. doi:
10.3390/molecules26237085. [PMID: 34885665] - Maryam Sajjadi, Ehsan Oskoueian, Ehsan Karimi, Mahdi Ebrahimi. Amygdalus spinosissima root extract enhanced scopolamine-induced learning and memory impairment in mice.
Metabolic brain disease.
2021 10; 36(7):1859-1869. doi:
10.1007/s11011-021-00768-7. [PMID: 34273042] - Dongli Li, Chuipu Cai, Yanfang Liao, Qihui Wu, Hanzhong Ke, Pengfei Guo, Qi Wang, Banghan Ding, Jiansong Fang, Shuhuan Fang. Systems pharmacology approach uncovers the therapeutic mechanism of medicarpin against scopolamine-induced memory loss.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153662. doi:
10.1016/j.phymed.2021.153662. [PMID: 34333326] - Małgorzata Gołąb, Martyna Przybyłowska, Petr Kubáň, Petra Itterheimová, Michał Woźniakiewicz. Development of CE-C4D Method for Determination Tropane Alkaloids.
Molecules (Basel, Switzerland).
2021 Sep; 26(19):. doi:
10.3390/molecules26195749. [PMID: 34641293] - Mamali Das, Devasahayam Jaya Balan, Pandima Devi Kasi. Mitigation of oxidative stress with dihydroactinidiolide, a natural product against scopolamine-induced amnesia in Swiss albino mice.
Neurotoxicology.
2021 09; 86(?):149-161. doi:
10.1016/j.neuro.2021.08.003. [PMID: 34371027] - Ho-Sub Park, Eun-Sang Hwang, Ga-Young Choi, Hyun-Bum Kim, Kyun-Seob Park, Jai-Yoon Sul, Yoonjin Hwang, Geun Wook Choi, Byung Il Kim, Hyunwoo Park, Sungho Maeng, Ji-Ho Park. Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment.
Physiology & behavior.
2021 09; 238(?):113467. doi:
10.1016/j.physbeh.2021.113467. [PMID: 34033847] - Yeojin Kim, Jihyun Kim, Meitong He, Ahyoung Lee, Eunju Cho. Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175192. [PMID: 34500626] - Ji-Hye Choi, Eun-Byeol Lee, Hwan-Hee Jang, Youn-Soo Cha, Yong-Soon Park, Sung-Hyen Lee. Allium hookeri Extracts Improve Scopolamine-Induced Cognitive Impairment via Activation of the Cholinergic System and Anti-Neuroinflammation in Mice.
Nutrients.
2021 Aug; 13(8):. doi:
10.3390/nu13082890. [PMID: 34445062] - Eunjin Sohn, Yu Jin Kim, Joo-Hwan Kim, Soo-Jin Jeong. Ficus erecta Thunb Leaves Alleviate Memory Loss Induced by Scopolamine in Mice via Regulation of Oxidative Stress and Cholinergic System.
Molecular neurobiology.
2021 Aug; 58(8):3665-3676. doi:
10.1007/s12035-021-02358-1. [PMID: 33797061] - Samar R Saleh, Asmaa M Masry, Doaa A Ghareeb, Al-Sayeda A Newairy, Eman Sheta, Adham M Maher. Trichoderma reesei fungal degradation boosted the potentiality of date pit extract in fighting scopolamine-induced neurotoxicity in male rats.
Scientific reports.
2021 07; 11(1):14872. doi:
10.1038/s41598-021-94058-y. [PMID: 34290261] - Bernardino Barceló, Isabel Gomila, Ana de-Castro-Ríos, Jon Perez-Barcena, Carmen Jimenez, Elena Lendoiro, Miguel Ángel Elorza. Diminished Consciousness in a Woman Following an Unsuspected Scopolamine Overdose.
Journal of analytical toxicology.
2021 Jul; 45(6):e7-e14. doi:
10.1093/jat/bkaa135. [PMID: 33025011]
