Propoxyphene (BioDeep_00000397859)

Main id: BioDeep_00000001945

 


代谢物信息卡片


dextropropoxyphene

化学式: C22H29NO2 (339.2198174)
中文名称: 右旋达尔丰
谱图信息: 最多检出来源 Mus musculus(not specific) 50%

分子结构信息

SMILES: CCC(=O)OC(Cc(c2)cccc2)(c(c1)cccc1)C([H])(C)CN(C)C
InChI: InChI=1S/C22H29NO2/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19/h6-15,18H,5,16-17H2,1-4H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AC - Diphenylpropylamine derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3344

同义名列表

4 个代谢物同义名

dextropropoxyphene; Propoxyphene; Propoxyphene; Propoxyphene



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guillermo Alberto Keller, Cecilia Villa Etchegoyen, Nicolás Fernandez, Nancy Mónica Olivera, Patricia Noemí Quiroga, Roberto Alejandro Diez, Guillermo Di Girolamo. Dextrophropoxyphene effects on QTc-interval prolongation: Frequency and characteristics in relation to plasma levels. Journal of opioid management. 2018 Sep; 14(5):335-344. doi: 10.5055/jom.2018.0466. [PMID: 30387857]
  • Nicolás Fernández, Nancy Mónica Olivera, Guillermo Alberto Keller, Roberto Alberto Diez, Guillermo Di Girolamo, Patricia Noemí Quiroga. Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses. Rapid communications in mass spectrometry : RCM. 2017 Sep; 31(18):1519-1533. doi: 10.1002/rcm.7933. [PMID: 28686794]
  • James Price. A trend analysis of laboratory positive propoxyphene workplace urine drug screens before and after the product recall. Journal of addiction medicine. 2015 Mar; 9(2):136-8. doi: 10.1097/adm.0000000000000108. [PMID: 25622125]
  • Brandi Puet, Anne DePriest, Julie Knight, Rebecca Heltsley, David L Black, Yale H Caplan, Edward J Cone. Urine drug testing of chronic pain patients. V. Prevalence of propoxyphene following its withdrawal from the United States market. Journal of analytical toxicology. 2013 Jan; 37(1):1-4. doi: 10.1093/jat/bks083. [PMID: 23129731]
  • Yatan Pal Singh Balhara, Raka Jain. A urinalysis-based study of buprenorphine and non-prescription opioid use among patients on buprenorphine maintenance. Journal of pharmacology & pharmacotherapeutics. 2012 Jan; 3(1):15-9. doi: 10.4103/0976-500x.92496. [PMID: 22368411]
  • Yatan Pal Singh Balhara, Raka Jain. Urinalysis-based comparative evaluation of pattern of use of dextropropoxyphene and buprenorphine among opioid-dependent subjects. Journal of opioid management. 2012 Jan; 8(1):45-9. doi: . [PMID: 22479884]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
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  • Ophelia Q P Yin, Brian Tomlinson, Moses S S Chow. CYP3A5 but not CYP2D6 polymorphism contributes significantly to the variability in dextropropoxyphene disposition. Journal of clinical pharmacology. 2010 Oct; 50(10):1136-41. doi: 10.1177/0091270009359006. [PMID: 20133509]
  • Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications. Current neuropharmacology. 2010 Sep; 8(3):254-67. doi: 10.2174/157015910792246254. [PMID: 21358975]
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  • Bridgit Crews, Charles Mikel, Sergey Latyshev, Robert West, Amadeo Pesce. Unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2009 Sep; 33(7):379-83. doi: 10.1093/jat/33.7.379. [PMID: 19796508]
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  • Ophelia Q P Yin, Sherry S L Lam, Moses S S Chow. Simultaneous determination of paracetamol and dextropropoxyphene in human plasma by liquid chromatography/tandem mass spectrometry: application to clinical bioequivalence studies. Rapid communications in mass spectrometry : RCM. 2005; 19(6):767-74. doi: 10.1002/rcm.1850. [PMID: 15714600]
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  • A A Somogyi, A Menelaou, S V Fullston. CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Xenobiotica; the fate of foreign compounds in biological systems. 2004 Oct; 34(10):875-87. doi: 10.1080/00498250400008371. [PMID: 15764408]
  • Alphonse Poklis, Justin L Poklis, Lisa D Tarnai, Ronald C Backer. Evaluation of the Triage PPY on-site testing device for the detection of dextropropoxyphene in urine. Journal of analytical toxicology. 2004 Sep; 28(6):485-8. doi: 10.1093/jat/28.6.485. [PMID: 15516300]
  • Alphonse Poklis, Ronald Backer. Urine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches. Journal of analytical toxicology. 2004 Sep; 28(6):422-5. doi: 10.1093/jat/28.6.422. [PMID: 15516290]
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  • Hans-Ake Lakso, Ake Norström. Determination of dextropropoxyphene and nordextropropoxyphene in urine by liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Aug; 794(1):57-65. doi: 10.1016/s1570-0232(03)00397-0. [PMID: 12888198]
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  • George R Bailie, Curtis A Johnson. Safety of propoxyphene in dialysis patients. Seminars in dialysis. 2002 Sep; 15(5):375. doi: 10.1046/j.1525-139x.2002.t01-1-00911.x. [PMID: 12358644]
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  • S Schneider, R Wennig. Interference of diphenhydramine with the EMIT II immunoassay for propoxyphene. Journal of analytical toxicology. 1999 Nov; 23(7):637-8. doi: 10.1093/jat/23.7.637. [PMID: 10595854]
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  • F Mersch, M Yegles, R Wennig. Quantification of dextropropoxyphene and its metabolite by HPLC in hair of overdose cases. Forensic science international. 1997 Jan; 84(1-3):237-42. doi: 10.1016/s0379-0738(96)02067-1. [PMID: 9042729]
  • L Bergendal, A Friberg, A M Schaffrath, M Holmdahl, S Landahl. The clinical relevance of the interaction between carbamazepine and dextropropoxyphene in elderly patients in Gothenburg, Sweden. European journal of clinical pharmacology. 1997; 53(3-4):203-6. doi: 10.1007/s002280050363. [PMID: 9476032]
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