Palmatine (BioDeep_00000395780)
Main id: BioDeep_00000230896
PANOMIX_OTCML-2023
代谢物信息卡片
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
化学式: C21H22ClNO4 (387.1237282000001)
中文名称: 盐酸掌叶防己碱, 氯化巴马亭, 盐酸巴马亭, 盐酸巴马汀, 棕榈碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
InChI: /p-1
描述信息
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].
同义名列表
31 个代谢物同义名
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride; dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydroxide (1:1); 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride; 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride; dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride (1:1); Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride; Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, chloride; 3,4,10,11-TETRAMETHOXY-7,8-DIHYDRO-6??-AZATETRAPHEN-6-YLIUM CHLORIDE; berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, chloride; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium Chloride; berbinium, 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxy-, iodide; Palmatine chloride, >=98\\% (HPLC); o,o-dimethyldemethyleneberberine; Palmatine Hydrochloride,(S); PALMATINE CHLORIDE [USP-RS]; PALMATINE CHLORIDE [WHO-DD]; palmatine hydrochloride; palmatinium hydroxide; Palmatine (chloride); palmitine hydroxide; palmatine hydroxide; Palmatine chloride; palmatine sulfate; palmatine iodide; palmatine cation; UNII-ZJ6W8881Z8; palmatine ion; berbericinine; Fibrauretin; ZJ6W8881Z8; Palmatine
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 73442
- MeSH: palmatine
- ChemIDplus: 0010605024
- CAS: 10605-02-4
- medchemexpress: HY-N0110
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wanli Ji, Yan Huo, Yifan Zhang, Xiaojing Qian, Yi Ren, Cheng Hu, Jiaqi Zhang. Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.
International immunopharmacology.
2024 May; 132(?):111968. doi:
10.1016/j.intimp.2024.111968. [PMID: 38579565] - Shaoling Lin, Shengxi Zhang, Angyu Zhan, Jiaojiao Feng, Qianqian Yang, Tongjun Li, Zijian Liu, Quqian Mo, Hui Fan, Keke Wang, Lexun Wang. Palmatine alleviates cardiac fibrosis by inhibiting fibroblast activation through the STAT3 pathway.
European journal of pharmacology.
2024 Mar; 967(?):176395. doi:
10.1016/j.ejphar.2024.176395. [PMID: 38350592] - Yubin Xu, Bixin Shen, Xusheng Pan, Chang Liu, Yingyue Wang, Xiaowei Chen, Ting Wang, Guirong Chen, Jing Chen. Palmatine ameliorated lipopolysaccharide-induced sepsis-associated encephalopathy mice by regulating the microbiota-gut-brain axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155307. doi:
10.1016/j.phymed.2023.155307. [PMID: 38181529] - Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Chen. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells.
Biological & pharmaceutical bulletin.
2024; 47(4):827-839. doi:
10.1248/bpb.b23-00758. [PMID: 38599826] - Jianning Zeng, Hongyan Pei, Hong Wu, Weijia Chen, Rui Du, Zhongmei He. Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.
Journal of biochemical and molecular toxicology.
2023 Oct; ?(?):e23544. doi:
10.1002/jbt.23544. [PMID: 37815058] - Jinghua Qin, Zhuo Luo, Qianyi Wang, Chaoling Tang, Mingwei Meng, Zheng Huang, Bingjian Guo, Ying He, Linlin Feng, Yunyuan Nong, Lijun Deng, Dan Zhu, Hongwei Guo, Yonghong Liang, Zhiheng Su. Integrating metabonomics and metagenomics sequencing to study the anti-liver fibrosis effects of palmatine in Corydalis saxicola Bunting.
Journal of ethnopharmacology.
2023 May; 315(?):116666. doi:
10.1016/j.jep.2023.116666. [PMID: 37211189] - Gaoxiang Ai, Ronglei Huang, Jianhui Xie, Linjiang Zhong, Xiaoyan Wu, Zehui Qin, Ziren Su, Jiannan Chen, Xiaobo Yang, Yaoxing Dou. Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.
Journal of ethnopharmacology.
2023 Jan; 301(?):115775. doi:
10.1016/j.jep.2022.115775. [PMID: 36198377] - Xin Zhao, Pingyuan Ge, Shaohua Lei, Siqi Guo, Peng Zhou, Li Zhao, Yiyu Qi, Xiaotong Wei, Weizhen Wu, Ningjing Wang, Rui Guo, Nianyun Yang, Qingqing Xiao, Qichun Zhang, Huaxu Zhu. An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer's Disease with Berberine and Palmatine.
Drug design, development and therapy.
2023; 17(?):2401-2420. doi:
10.2147/dddt.s417465. [PMID: 37609432] - Guo-Shuai Lin, Mao-Mao Zhao, Qi-Chao Fu, Shu-Yi Zhao, Tao-Tao Ba, Hong-Xia Yu. Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease.
Drug development research.
2022 11; 83(7):1613-1622. doi:
10.1002/ddr.21981. [PMID: 35976121] - Lei Wang, Min Li, Cuiping Zhu, Aiping Qin, Jinchun Wang, Xianni Wei. The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice.
Neurochemical research.
2022 Oct; 47(10):3178-3191. doi:
10.1007/s11064-022-03672-3. [PMID: 35917005] - Juanjuan Cheng, Xingdong Ma, Haitao Zhang, Xiaoyan Wu, Minhua Li, Gaoxiang Ai, Ruoting Zhan, Jianhui Xie, Ziren Su, Xiaoqi Huang. 8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113335. doi:
10.1016/j.biopha.2022.113335. [PMID: 35779424] - Tianyun Fan, Yangyang Cheng, Wei Wei, Qingxuan Zeng, Xixi Guo, Zhihao Guo, Yinghong Li, Liping Zhao, Yulong Shi, Xintong Zhang, Jiandong Jiang, Yanxiang Wang, Weijia Kong, Danqing Song. Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation.
Journal of medicinal chemistry.
2022 05; 65(10):7399-7413. doi:
10.1021/acs.jmedchem.2c00592. [PMID: 35549263] - Juan-Juan Cheng, Xing-Dong Ma, Gao-Xiang Ai, Qiu-Xia Yu, Xiao-Ying Chen, Fang Yan, Yu-Cui Li, Jian-Hui Xie, Zi-Ren Su, Qing-Feng Xie. Palmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways.
Drug design, development and therapy.
2022; 16(?):2119-2132. doi:
10.2147/dddt.s356307. [PMID: 35812134] - Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng. Biological Response Profiling Reveals the Functional Differences of Main Alkaloids in Rhizoma Coptidis.
Molecules (Basel, Switzerland).
2021 Dec; 26(23):. doi:
10.3390/molecules26237389. [PMID: 34885971] - Ting Liu, Ruiyun Li, Nan Zhang, Yue Cui, Yunli Zhao, Zhiguo Yu. Screening of differential components of Gegenqinlian decoction and their comparative pharmacokinetics in normal and pyrexia rats using UHPLC-FT-ICR-MS and UHPLC-MS/MS.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5186. doi:
10.1002/bmc.5186. [PMID: 34075601] - Aneta Grabarska, Paula Wróblewska-Łuczka, Wirginia Kukula-Koch, Jarogniew J Łuszczki, Eleftherios Kalpoutzakis, Grzegorz Adamczuk, Alexios Leandros Skaltsounis, Andrzej Stepulak. Palmatine, a Bioactive Protoberberine Alkaloid Isolated from Berberis cretica, Inhibits the Growth of Human Estrogen Receptor-Positive Breast Cancer Cells and Acts Synergistically and Additively with Doxorubicin.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206253. [PMID: 34684834] - Yang Song, Kefei Wang, Xiaoyi Wei, Tongyuan Wei, Tianhao Xiao, Minjie Wei. Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 203(?):114226. doi:
10.1016/j.jpba.2021.114226. [PMID: 34182412] - Mehdi Khaksari, Samira Esmaili, Reyhane Abedloo, Hossein Khastar. Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats.
Archives of physiology and biochemistry.
2021 Jun; 127(3):273-278. doi:
10.1080/13813455.2019.1633354. [PMID: 31241354] - Qingxuan Zeng, Hongbin Deng, Yinghong Li, Tianyun Fan, Yang Liu, Sheng Tang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang, Danqing Song. Berberine Directly Targets the NEK7 Protein to Block the NEK7-NLRP3 Interaction and Exert Anti-inflammatory Activity.
Journal of medicinal chemistry.
2021 01; 64(1):768-781. doi:
10.1021/acs.jmedchem.0c01743. [PMID: 33440945] - Patrick N Okechukwu, Sophia O Ekeuku, Hor K Chan, Kalpana Eluri, Gabriele R A Froemming. Palmatine Inhibits Up-Regulation of GRP78 and CALR Protein in an STZ-Induced Diabetic Rat Model.
Current pharmaceutical biotechnology.
2021; 22(2):288-298. doi:
10.2174/1389201021666200730124208. [PMID: 32744968] - Nada H Aljarba, Huma Ali, Saad Alkahtani. Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice.
Drug design, development and therapy.
2021; 15(?):4043-4052. doi:
10.2147/dddt.s322769. [PMID: 34588765] - Weizhang Jia, Qina Su, Qiong Cheng, Qiong Peng, Aimin Qiao, Xiongming Luo, Jing Zhang, Ying Wang. Neuroprotective Effects of Palmatine via the Enhancement of Antioxidant Defense and Small Heat Shock Protein Expression in Aβ-Transgenic Caenorhabditis elegans.
Oxidative medicine and cellular longevity.
2021; 2021(?):9966223. doi:
10.1155/2021/9966223. [PMID: 34567416] - Yayuan Ning, Fei Xu, Rui Xin, Fang Yao. Palmatine regulates bile acid cycle metabolism and maintains intestinal flora balance to maintain stable intestinal barrier.
Life sciences.
2020 Dec; 262(?):118405. doi:
10.1016/j.lfs.2020.118405. [PMID: 32926925] - Cheng Tao, Sheng-Quan Hu, Jian Chen, Yuan-Ji Chen, Ke-Huan Sun, Guo-Zhen Cui, Min Ma, Zheng-Zhi Wu. Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine.
Neurochemistry international.
2020 10; 139(?):104807. doi:
10.1016/j.neuint.2020.104807. [PMID: 32711021] - Xusheng Tian, Yukun Zhang, Han Li, Yunfeng Li, Ning Wang, Wei Zhang, Boyan Ma. Palmatine ameliorates high fat diet induced impaired glucose tolerance.
Biological research.
2020 Sep; 53(1):39. doi:
10.1186/s40659-020-00308-0. [PMID: 32928312] - Xing Chen, Ruilin Wang, Chunmei Bao, Jianzhong Zhang, Juling Zhang, Ruisheng Li, Shihua Wu, Jianxian Wen, Tao Yang, Shizhang Wei, Haotian Li, Ying Wei, Sichen Ren, Yanling Zhao. Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR.
European journal of pharmacology.
2020 Sep; 882(?):173267. doi:
10.1016/j.ejphar.2020.173267. [PMID: 32569674] - Soane Kaline Morais Chaves, Muhammad Inam Afzal, Muhammad Torequl Islam, Aneela Hameed, Ana Maria Oliveira Ferreira Da Mata, Lidiane Da Silva Araújo, Shinawar Waseem Ali, Hercília Maria Lins Rolim, Maria das Graças Freire De Medeiros, Emmanoel Vilaca Costa, Bahare Salehi, Natália Martins, Atta Muhammad Arif, Muhammad Imran, Javad Sharifi-Rad, Ana Amélia de Carvalho Melo-Cavalcante, Chistiane Mendes Feitosa. Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jun; 66(4):54-59. doi:
. [PMID: 32583771] - Kinga Gawel, Wirginia Kukula-Koch, Dorota Nieoczym, Katarzyna Stepnik, Wietske van der Ent, Nancy Saana Banono, Dominik Tarabasz, Waldemar A Turski, Camila V Esguerra. The Influence of Palmatine Isolated from Berberis sibiricaRadix on Pentylenetetrazole-Induced Seizures in Zebrafish.
Cells.
2020 05; 9(5):. doi:
10.3390/cells9051233. [PMID: 32429356] - L He, L Liu, S Guan, X Zheng, H Ge, C Yin, Y Shen, M Tan, C Wang, Y Gao, W Xiong. Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve.
The British journal of oral & maxillofacial surgery.
2020 05; 58(4):443-450. doi:
10.1016/j.bjoms.2020.01.031. [PMID: 32139146] - Xiaojiang Liu, Yaru Zhang, Siqi Wu, Minmin Xu, Youfeng Shen, Min Yu, Jinhua Fan, Sijia Wei, Chaohang Xu, Lu Huang, Han Zhao, Xuegang Li, Xiaoli Ye. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Biochemical pharmacology.
2020 05; 175(?):113933. doi:
10.1016/j.bcp.2020.113933. [PMID: 32224138] - Juanjuan Liu, Qianqian Li, Changzhong Wang, Jing Shao, Tianming Wang, Daqiang Wu, Kelong Ma, Guiming Yan, Dengke Yin. Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in Candida albicans and Candida auris.
Biofouling.
2020 03; 36(3):319-331. doi:
10.1080/08927014.2020.1759559. [PMID: 32410461] - Yaohui Gao, Ziwei Hu, Jiamin Wu, Zan Ning, Jingyi Jian, Ting Zhao, Xiaochen Liang, Xingjie Yang, Zi Yang, Qinyu Zhao, Jianping Wang, Zhigang Wang, Nicoleta Elena Dina, Ana Maria Raluca Gherman, Zhengjin Jiang, Haibo Zhou. Size-tunable Au@Ag nanoparticles for colorimetric and SERS dual-mode sensing of palmatine in traditional Chinese medicine.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):123-133. doi:
10.1016/j.jpba.2019.05.045. [PMID: 31163346] - Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine.
Pesticide biochemistry and physiology.
2019 Sep; 159(?):51-58. doi:
10.1016/j.pestbp.2019.05.015. [PMID: 31400784] - Jiaying Long, Jiawen Song, Li Zhong, Yanmei Liao, Luona Liu, Xiaofang Li. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics.
Biochimie.
2019 Jul; 162(?):176-184. doi:
10.1016/j.biochi.2019.04.008. [PMID: 31051209] - Okiemute Rosa Johnson-Ajinwo, Alan Richardson, Wen-Wu Li. Palmatine from Unexplored Rutidea parviflora Showed Cytotoxicity and Induction of Apoptosis in Human Ovarian Cancer Cells.
Toxins.
2019 04; 11(4):. doi:
10.3390/toxins11040237. [PMID: 31027283] - Shizuka Kamimura, Masakazu Nishihara, Yuko Osumi, Hironori Shiota. [Simultaneous Quantitative Analysis of Berberine and Other Alkaloids in Powdered Phellodendron Bark].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2019; 139(11):1471-1478. doi:
10.1248/yakushi.19-00097. [PMID: 31685744] - Xiao-Jun Zhang, Zhong-Wen Yuan, Chang Qu, Xiu-Ting Yu, Tao Huang, Ping Vicky Chen, Zi-Ren Su, Yao-Xing Dou, Jia-Zhen Wu, Hui-Fang Zeng, Ying Xie, Jian-Nan Chen. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.
Pharmacological research.
2018 11; 137(?):34-46. doi:
10.1016/j.phrs.2018.09.010. [PMID: 30243842] - Jiaojiao Yu, Qiuyan Liu, Xiaoyu Lu, Xiaonan Li, Ning Li, Baolin Liu, Fang Huang, Zhixia Qiu. Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats.
Phytotherapy research : PTR.
2018 Sep; 32(9):1818-1827. doi:
10.1002/ptr.6117. [PMID: 29806105] - Xinyu Zhao, Yan Wang, Lu Zheng, Chengpeng Sun, Chao Wang, Haijian Cong, Ting Xiang, Lin Zhang, Houli Zhang, Sa Deng, Baojing Zhang, Bin Wu, Xiaokui Huo. Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
Natural product research.
2018 Sep; 32(17):2031-2036. doi:
10.1080/14786419.2017.1365075. [PMID: 28871816] - Lvhuan Wang, Yumei Zhao, Yanyan Zhang, Tingting Zhang, Jeroen Kool, Govert W Somsen, Qiqin Wang, Zhengjin Jiang. Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry.
Journal of chromatography. A.
2018 Aug; 1563(?):135-143. doi:
10.1016/j.chroma.2018.05.069. [PMID: 29866504] - Tian-Jin Wu, Jun Lu, Hui Ni, Ping Li, Yan Jiang, Hui-Jun Li. Construction of an optimized method for quality evaluation and species discrimination of Coptidis Rhizoma by ion-pair high performance liquid chromatography combined with response surface methodology.
Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):152-157. doi:
10.1016/j.jpba.2018.02.019. [PMID: 29494887] - Xiaoling Gu, Yang Jin, Fang Dong, Yueqing Cai, Zhengyi You, Junhui You, Liying Zhang, Shuhu Du. Toward rapid analysis, forecast and discovery of bioactive compounds from herbs by jointly using thin layer chromatography and ratiometric surface-enhanced Raman spectroscopy technique.
Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):9-15. doi:
10.1016/j.jpba.2018.02.016. [PMID: 29459236] - Padmapriya Kumar, Ritu Barthwal. Structural and biophysical insight into dual site binding of the protoberberine alkaloid palmatine to parallel G-quadruplex DNA using NMR, fluorescence and Circular Dichroism spectroscopy.
Biochimie.
2018 Apr; 147(?):153-169. doi:
10.1016/j.biochi.2018.02.002. [PMID: 29458089] - Yubin Xu, Song Guo, Guirong Chen, Mingbo Zhang, Xu Zhang, Deqiang Dou. Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
Immunopharmacology and immunotoxicology.
2017 Dec; 39(6):364-370. doi:
10.1080/08923973.2017.1380661. [PMID: 28975862] - Yonggang Yuan, Wanzhong Peng, Yongxing Liu, Zesheng Xu. Palmatine attenuates isoproterenol-induced pathological hypertrophy via selectively inhibiting HDAC2 in rats.
International journal of immunopathology and pharmacology.
2017 Dec; 30(4):406-412. doi:
10.1177/0394632017742225. [PMID: 29164959] - Xuelin Zhou, Haotian Li, Zhilong Shi, Sijia Gao, Shizhang Wei, Kun Li, Jiabo Wang, Jianyu Li, Ruilin Wang, Man Gong, Yanling Zhao, Xiaohe Xiao. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1.
Scientific reports.
2017 Nov; 7(1):15549. doi:
10.1038/s41598-017-15733-7. [PMID: 29138445] - Jinglong Wang, Dandan Zheng, Yingzi Wang, Chao Zhang, Xiumei Sun. Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Aug; 1059(?):35-42. doi:
10.1016/j.jchromb.2017.05.019. [PMID: 28570935] - Balamurugan Thirumalraj, Subbiramaniyan Kubendhiran, Shen-Ming Chen, Kuan-Yu Lin. Highly sensitive electrochemical detection of palmatine using a biocompatible multiwalled carbon nanotube/poly-l-lysine composite.
Journal of colloid and interface science.
2017 Jul; 498(?):144-152. doi:
10.1016/j.jcis.2017.03.045. [PMID: 28324720] - Jing-Yu Zheng, Guo-Feng Li, Zhong-Mei He, Hong-Yan Zhu, Yan Zhao, Yu-Gang Gao, He Yang, Lian-Xue Zhang. [Pharmacokinetics and oral bioavailability of palmatine and jatrorrhizine in Huangteng in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Jul; 42(14):2773-2778. doi:
10.19540/j.cnki.cjcmm.20170523.002. [PMID: 29098836] - Byeong-Hoon Lee, Kiramage Chathuranga, Md Bashir Uddin, Prasanna Weeratunga, Myun Soo Kim, Won-Kyung Cho, Hong Ik Kim, Jin Yeul Ma, Jong-Soo Lee. Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state.
Journal of microbiology (Seoul, Korea).
2017 Jun; 55(6):488-498. doi:
10.1007/s12275-017-7088-x. [PMID: 28551874] - Guirong Chen, Yubin Xu, Jing Jing, Brianna Mackie, Xinchuan Zheng, Xu Zhang, Jing Wang, Xuetao Li. The anti-sepsis activity of the components of Huanglian Jiedu Decoction with high lipid A-binding affinity.
International immunopharmacology.
2017 May; 46(?):87-96. doi:
10.1016/j.intimp.2017.02.025. [PMID: 28278436] - Chhavarath Dary, Sok-Siya Bun, Gaëtan Herbette, Fathi Mabrouki, Hot Bun, Sothea Kim, Florian Jabbour, Sovanmoly Hul, Béatrice Baghdikian, Evelyne Ollivier. Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD.
Natural product research.
2017 Apr; 31(7):802-809. doi:
10.1080/14786419.2016.1247077. [PMID: 27976592] - Kun Wang, Liwei Chai, Liqin Ding, Feng Qiu. Identification of metabolites of palmatine in rats after oral administration using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2017 Mar; 31(6):523-537. doi:
10.1002/rcm.7819. [PMID: 28044413] - Lianrong Yang, Xin Meng, Xiaojin Yu, Haixue Kuang. Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats.
Journal of pharmaceutical and biomedical analysis.
2017 Feb; 134(?):43-52. doi:
10.1016/j.jpba.2016.11.021. [PMID: 27875787] - Ling Wang, Xue Wang, Su-Li Zhang, Xiao-Ming Zhu, Yan-Qi Liu, Zi-Jing Song, Wen-Juan Du, Jun Ji, Cheng-Long Cui, Xin He, Chun-Feng Zhang, Chang-Run Guo, Chong-Zhi Wang, Chun-Su Yuan. Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats.
Journal of natural medicines.
2017 Jan; 71(1):257-264. doi:
10.1007/s11418-016-1057-2. [PMID: 27858308] - Jiang-Tao Zhou, Cai-Lan Li, Li-Hua Tan, Yi-Fei Xu, Yu-Hong Liu, Zhi-Zhun Mo, Yao-Xing Dou, Rui Su, Zi-Ren Su, Ping Huang, Jian-Hui Xie. Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism.
PloS one.
2017; 12(1):e0168944. doi:
10.1371/journal.pone.0168944. [PMID: 28045966] - Juntao Yin, Cuiyu Xiang, Guangxiu Lu. Cationic lipid emulsions as potential bioadhesive carriers for ophthalmic delivery of palmatine.
Journal of microencapsulation.
2016 Dec; 33(8):718-724. doi:
10.1080/02652048.2016.1248512. [PMID: 27733080] - Maciej Grzybek, Wirginia Kukula-Koch, Aneta Strachecka, Aleksandra Jaworska, Andrew M Phiri, Jerzy Paleolog, Krzysztof Tomczuk. Evaluation of Anthelmintic Activity and Composition of Pumpkin (Cucurbita pepo L.) Seed Extracts-In Vitro and in Vivo Studies.
International journal of molecular sciences.
2016 Sep; 17(9):. doi:
10.3390/ijms17091456. [PMID: 27598135] - Juan Wu, Qicai Xiao, Na Zhang, Changhu Xue, Albert Wingnang Leung, Hongwei Zhang, Chuanshan Xu, Qing-Juan Tang. Photodynamic action of palmatine hydrochloride on colon adenocarcinoma HT-29 cells.
Photodiagnosis and photodynamic therapy.
2016 Sep; 15(?):53-8. doi:
10.1016/j.pdpdt.2016.05.005. [PMID: 27181460] - Juan Wu, Qicai Xiao, Na Zhang, Changhu Xue, Albert Wingnang Leung, Hongwei Zhang, Qing-Juan Tang, Chuanshan Xu. Palmatine hydrochloride mediated photodynamic inactivation of breast cancer MCF-7 cells: Effectiveness and mechanism of action.
Photodiagnosis and photodynamic therapy.
2016 Sep; 15(?):133-8. doi:
10.1016/j.pdpdt.2016.07.006. [PMID: 27444887] - Qian Rong, Min Xu, Qi Dong, Yuli Zhang, Yinglun Li, Gang Ye, Ling Zhao. In vitro and in vivo bactericidal activity of Tinospora sagittata (Oliv.) Gagnep. var. craveniana (S.Y.Hu) Lo and its main effective component, palmatine, against porcine Helicobacter pylori.
BMC complementary and alternative medicine.
2016 Aug; 16(1):331. doi:
10.1186/s12906-016-1310-y. [PMID: 27576439] - Wei-Kun Ma, Hui Li, Cui-Lan Dong, Xin He, Chang-Run Guo, Chun-Feng Zhang, Chun-Hao Yu, Chong-Zhi Wang, Chun-Su Yuan. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines.
Molecular medicine reports.
2016 Jul; 14(1):491-8. doi:
10.3892/mmr.2016.5285. [PMID: 27175745] - Yan Li, Xiu-Mei Lv, Ya-Li Lin, Jia-Qi Mo, Gang Fan, Xian-Rong Lai, Yi Zhang. [Study on quality standard of Berberidis Cortex].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Feb; 41(4):592-596. doi:
10.4268/cjcmm20160407. [PMID: 28871677] - Liping Li, Siyuan Sun, Yayun Weng, Feifeng Song, Sisi Zhou, Mengru Bai, Hui Zhou, Su Zeng, Huidi Jiang. Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Xenobiotica; the fate of foreign compounds in biological systems.
2016; 46(2):175-83. doi:
10.3109/00498254.2015.1056283. [PMID: 26134304] - Wenhua Qiao, Lu Wang, Baoxian Ye, Gaiping Li, Jianjun Li. Electrochemical behavior of palmatine and its sensitive determination based on an electrochemically reduced L-methionine functionalized graphene oxide modified electrode.
The Analyst.
2015 Dec; 140(23):7974-83. doi:
10.1039/c5an01770j. [PMID: 26517817] - Heather G Hambright, Izhar Singh Batth, Jianping Xie, Rita Ghosh, Addanki Pratap Kumar. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role for rpS6/NFκB/FLIP.
Molecular carcinogenesis.
2015 Oct; 54(10):1227-34. doi:
10.1002/mc.22192. [PMID: 25043857] - Wenguang Wang, Xiaoli Ma, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang. A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case.
Journal of chromatography. A.
2015 Sep; 1412(?):100-11. doi:
10.1016/j.chroma.2015.08.015. [PMID: 26298606] - Raphael N Alolga, Yong Fan, Gang Zhang, Jin Li, Yi-Jing Zhao, Jimmy Lelu Kakila, Yan Chen, Ping Li, Lian-Wen Qi. Pharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers.
Scientific reports.
2015 Aug; 5(?):12961. doi:
10.1038/srep12961. [PMID: 26268432] - Zhu-yan Huang, Bei-bei Pan, Chun-yan Huang, Yi-lu Ye, Dan-dan Liu, Yue-ping Yu, Qi Zhang. [Screening of Active Fractions from Huanglian Jiedu Decoction against Primary Neuron Injury after Oxygen-Glucose Deprivation].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Aug; 35(8):981-7. doi:
. [PMID: 26485915] - Chen-Wen Xiao, Quan-An Ji, Qiang Wei, Yan Liu, Guo-Lian Bao. Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism.
BMC complementary and alternative medicine.
2015 Jun; 15(?):177. doi:
10.1186/s12906-015-0680-x. [PMID: 26054937] - Jiawei Meng, Wenpeng Zhang, Tao Bao, Zilin Chen. Novel molecularly imprinted magnetic nanoparticles for the selective extraction of protoberberine alkaloids in herbs and rat plasma.
Journal of separation science.
2015 Jun; 38(12):2117-25. doi:
10.1002/jssc.201500264. [PMID: 25832420] - Na Ning, Kai He, Yanzhi Wang, Zongyao Zou, Hao Wu, Xuegang Li, Xiaoli Ye. Hypolipidemic Effect and Mechanism of Palmatine from Coptis chinensis in Hamsters Fed High-Fat diet.
Phytotherapy research : PTR.
2015 May; 29(5):668-73. doi:
10.1002/ptr.5295. [PMID: 25586479] - Chang-Seob Seo, Ohn Soon Kim, Jung-Hoon Kim, Hyeun-Kyoo Shin. Simultaneous quantification and antiatherosclerosis effect of the traditional Korean medicine, Hwangryunhaedok-tang.
BMC complementary and alternative medicine.
2015 Apr; 15(?):108. doi:
10.1186/s12906-015-0632-5. [PMID: 25880755] - Ying Chen, Yuejie Li, Yajie Wang, Qing Yang, Yu Dong, Xiaogang Weng, Xiaoxin Zhu, Yiwei Wang, Zipeng Gong, Ruijie Zhang. Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method.
European journal of drug metabolism and pharmacokinetics.
2015 Mar; 40(1):67-74. doi:
10.1007/s13318-014-0181-1. [PMID: 24577954] - Xu Jing, Bing Bai, Chenxuan Zhang, Wenying Wu, Liming Du, Hailong Liu, Guojun Yao. Rapid and sensitive determination of clenbuterol in porcine muscle and swine urine using a fluorescent probe.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt B(?):714-8. doi:
10.1016/j.saa.2014.09.086. [PMID: 25315870] - Yan Li, Chang-Feng Li, Li-Ming Du, Jian-Xia Feng, Hai-Long Liu, Yun-Long Fu. A competitive strategy based on cucurbit[7]uril supramolecular interaction for simple and sensitive detection of dibucaine.
Talanta.
2015 Jan; 132(?):653-7. doi:
10.1016/j.talanta.2014.09.005. [PMID: 25476359] - Shinghung Mak, Wilson W K Luk, Wei Cui, Shengquan Hu, Karl W K Tsim, Yifan Han. Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs.
Journal of molecular neuroscience : MN.
2014 Jul; 53(3):511-6. doi:
10.1007/s12031-014-0288-5. [PMID: 24793543] - Kejun Tan, Jiayu Li, Huachun Li, Yingying Wang, Rui Yuan. A highly sensitive dual-readout assay based on poly(A) and gold nanoparticles for palmatine hydrochloride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Mar; 122(?):198-203. doi:
10.1016/j.saa.2013.11.075. [PMID: 24316533] - Dinesh Dhingra, Arun Bhankher. Behavioral and biochemical evidences for antidepressant-like activity of palmatine in mice subjected to chronic unpredictable mild stress.
Pharmacological reports : PR.
2014 Feb; 66(1):1-9. doi:
10.1016/j.pharep.2013.06.001. [PMID: 24905299] - Zhao-Tang Ma, Xiu-Wei Yang, Ying Zhang, Jian-Xun Liu. Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
Journal of Asian natural products research.
2014; 16(5):483-96. doi:
10.1080/10286020.2014.913577. [PMID: 24797560] - Qing-Feng Liu, Xiao-Jin Shi, Zhong-Dong Li, Ming-kang Zhong, Zheng Jiao, Bin Wang. Pharmacokinetic comparisons of berberine and palmatine in normal and metabolic syndrome rats.
Journal of ethnopharmacology.
2014; 151(1):287-91. doi:
10.1016/j.jep.2013.10.031. [PMID: 24269776] - Antonina V Pustovidko, Tatiana I Rokitskaya, Inna I Severina, Ruben A Simonyan, Tatiana A Trendeleva, Konstantin G Lyamzaev, Yuri N Antonenko, Anton G Rogov, Renata A Zvyagilskaya, Vladimir P Skulachev, Boris V Chernyak. Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria.
Mitochondrion.
2013 Sep; 13(5):520-5. doi:
10.1016/j.mito.2012.09.006. [PMID: 23026390] - Si Chen, Liqing Wan, Letha Couch, Haixia Lin, Yan Li, Vasily N Dobrovolsky, Nan Mei, Lei Guo. Mechanism study of goldenseal-associated DNA damage.
Toxicology letters.
2013 Jul; 221(1):64-72. doi:
10.1016/j.toxlet.2013.05.641. [PMID: 23747414] - Huaxu Zhu, Zhilei Qian, Feng He, Mengzhu Liu, Linmei Pan, Qichun Zhang, Yuping Tang. Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Jul; 20(10):767-74. doi:
10.1016/j.phymed.2012.11.012. [PMID: 23628154] - Suqin Han, Bei Wei, Fang Hao. Flow-injection post-chemiluminescence method for the determination of palmatine.
Applied spectroscopy.
2013 Jul; 67(7):747-51. doi:
10.1366/12-06841. [PMID: 23816126] - M K Sangeetha, C D Mohana Priya, Hannah R Vasanthi. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Feb; 20(3-4):246-8. doi:
10.1016/j.phymed.2012.11.006. [PMID: 23290487] - Wei Men, Ying Chen, Qing Yang, Yu-Jie Li, Zi-Peng Gong, Xiao-Gang Weng, Ya-Jie Wang, Rui-Jie Zhang, Xiao-Xin Zhu. [Study on metabolism of Coptis chinensis alkaloids from different compatibility of Wuji Wan in human intestinal flora].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Feb; 38(3):417-21. doi:
NULL. [PMID: 23668021] - Jun Yi, Xiaoli Ye, Dezhen Wang, Kai He, Yong Yang, Xujing Liu, Xuegang Li. Safety evaluation of main alkaloids from Rhizoma Coptidis.
Journal of ethnopharmacology.
2013 Jan; 145(1):303-10. doi:
10.1016/j.jep.2012.10.062. [PMID: 23159469] - Huma Ali, Savita Dixit. Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine.
TheScientificWorldJournal.
2013; 2013(?):376216. doi:
10.1155/2013/376216. [PMID: 24379740] - Asma Yasmeen Khan, Maidul Hossain, Gopinatha Suresh Kumar. Binding of plant alkaloids berberine and palmatine to serum albumins: a thermodynamic investigation.
Molecular biology reports.
2013 Jan; 40(1):553-66. doi:
10.1007/s11033-012-2092-z. [PMID: 23065224] - De-Lan Yang, Wen-Li Mei, Yan-Bo Zeng, Zhi-Kai Guo, Dai-Jing Wei, Shou-Bai Liu, Qing-Huang Wang, Hao-Fu Dai. A new antibacterial denitroaristolochic acid from the tubers of Stephania succifera.
Journal of Asian natural products research.
2013; 15(3):315-8. doi:
10.1080/10286020.2012.762641. [PMID: 23418880] - Rui An, Hua Zhang, Yi-Zhu Zhang, Ran-Chi Xu, Xin-Hong Wang. [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ].
Yao xue xue bao = Acta pharmaceutica Sinica.
2012 Dec; 47(12):1696-702. doi:
". [PMID: 23460978] - Gang Fan, Meng Ying Zhang, Xiang Dong Zhou, Xian Rong Lai, Qing Hong Yue, Ce Tang, Wei Zao Luo, Yi Zhang. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.
Analytica chimica acta.
2012 Oct; 747(?):76-83. doi:
10.1016/j.aca.2012.08.038. [PMID: 22986138] - Yu-Li Zhang, Qin-Wan Huang, Jin Wang, Juan Su, Xiao-Fang Li. [Classification study of Coptis chinensis based on quantitative physical property characteristics of appearance and internal quality evaluation].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Oct; 37(20):3047-51. doi:
10.4268/cjcmm20122010. [PMID: 23311151] - B V Chernyak, Y N Antonenko, E R Galimov, L V Domnina, V B Dugina, R A Zvyagilskaya, O Yu Ivanova, D S Izyumov, K G Lyamzaev, A V Pustovidko, T I Rokitskaya, A G Rogov, I I Severina, R A Simonyan, M V Skulachev, V N Tashlitsky, E V Titova, T A Trendeleva, G S Shagieva. Novel mitochondria-targeted compounds composed of natural constituents: conjugates of plant alkaloids berberine and palmatine with plastoquinone.
Biochemistry. Biokhimiia.
2012 Sep; 77(9):983-95. doi:
10.1134/s0006297912090040. [PMID: 23157257] - Mayurkumar B Patel, Shrihari Mishra. Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase.
Phytotherapy research : PTR.
2012 Sep; 26(9):1342-7. doi:
10.1002/ptr.3721. [PMID: 22294283] - Lihong Liu, Zilin Chen. Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.
Analytica chimica acta.
2012 Aug; 737(?):99-104. doi:
10.1016/j.aca.2012.05.054. [PMID: 22769040] - Jin Ah Ryuk, Ming Shan Zheng, Mi Young Lee, Chang Seob Seo, Ying Li, Seung Ho Lee, Dong Cheul Moon, Hye Won Lee, Je-Hyun Lee, Ju Young Park, Jong Keun Son, Byoung Seob Ko. Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids.
Archives of pharmacal research.
2012 Jun; 35(6):1045-54. doi:
10.1007/s12272-012-0612-y. [PMID: 22870814] - Yu Ou-Yang, Xiao-Ling Li, Hong Wang, Min Fang, Yan-Jun Hu. Determination of the specific interaction between palmatine and bovine serum albumin.
Molecular biology reports.
2012 May; 39(5):5495-501. doi:
10.1007/s11033-011-1352-7. [PMID: 22187343]