S-Propenylcysteine (BioDeep_00000395494)

Main id: BioDeep_00000871752

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2R)-2-amino-3-[(E)-prop-1-enyl]sulfanylpropanoic acid

化学式: C6H11NO2S (161.0510466)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC=CSCC(C(=O)O)N
InChI: InChI=1S/C6H11NO2S/c1-2-3-10-4-5(7)6(8)9/h2-3,5H,4,7H2,1H3,(H,8,9)/b3-2+/t5-/m0/s1

描述信息

S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway[2]. S-1-Propenyl-L-cysteine is orally active.
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model[1].

同义名列表

5 个代谢物同义名

(2R)-2-amino-3-[(E)-prop-1-enyl]sulfanylpropanoic acid; (E)-S-(Prop-1-en-1-yl)-L-cysteine; trans-(+)-S-1-Propenyl-L-cystein; S-1-Propenyl-L-cysteine; S-Propenylcysteine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hiroshi Nango, Masahiro Ohtani. S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts. PloS one. 2023; 18(4):e0284713. doi: 10.1371/journal.pone.0284713. [PMID: 37083725]
  • Satomi Miki, Jun-Ichiro Suzuki, Miyuki Takashima, Mari Ishida, Hiroki Kokubo, Masao Yoshizumi. S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling. Scientific reports. 2021 11; 11(1):22469. doi: 10.1038/s41598-021-01866-3. [PMID: 34789834]
  • Kayo Kunimura, Satomi Miki, Miyuki Takashima, Jun-Ichiro Suzuki. S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway. Cell communication and signaling : CCS. 2021 02; 19(1):17. doi: 10.1186/s12964-020-00692-w. [PMID: 33588881]
  • Toshiaki Matsutomo, Mitsuyasu Ushijima, Kayo Kunimura, Masahiro Ohtani. Metabolomic study reveals the acute hypotensive effect of S-1-propenylcysteine accompanied by alteration of the plasma histidine level in spontaneously hypertensive rats. Journal of pharmaceutical and biomedical analysis. 2019 May; 168(?):148-154. doi: 10.1016/j.jpba.2019.01.043. [PMID: 30807919]
  • Mitsuyasu Ushijima, Miyuki Takashima, Kayo Kunimura, Yukihiro Kodera, Naoaki Morihara, Koichi Tamura. Effects of S-1-propenylcysteine, a sulfur compound in aged garlic extract, on blood pressure and peripheral circulation in spontaneously hypertensive rats. The Journal of pharmacy and pharmacology. 2018 Apr; 70(4):559-565. doi: 10.1111/jphp.12865. [PMID: 29380376]
  • Yukihioro Kodera, Mitsuyasu Ushijima, Hirotaka Amano, Jun-Ichiro Suzuki, Toshiaki Matsutomo. Chemical and Biological Properties of S-1-Propenyl-l-Cysteine in Aged Garlic Extract. Molecules (Basel, Switzerland). 2017 Mar; 22(4):. doi: 10.3390/molecules22040570. [PMID: 28362335]