Cucurbitacin B (BioDeep_00000350955)

Main id: BioDeep_00000000391

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


acetic acid [(E,5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-3,11-diketo-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-4-keto-1,1-dimethyl-hex-2-enyl] ester

化学式: C32H46O8 (558.3193)
中文名称: 葫芦素B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2(C)[C@@H]3CC=C4[C@@H](C[C@@H](C(=O)C4(C)C)O)[C@]3(C)C(=O)C[C@]12C)O)O
InChI: InChI=1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1

描述信息

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity[1][2][3][4][5].

同义名列表

24 个代谢物同义名

acetic acid [(E,5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-3,11-diketo-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-4-keto-1,1-dimethyl-hex-2-enyl] ester; acetic acid [(5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-3,11-diketo-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-4-keto-1,1-dimethyl-hex-2-enyl] ester; acetic acid [(E,5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxohex-2-enyl] ester; acetic acid [(5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxohex-2-enyl] ester; [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxo-hept-3-en-2-yl] ethanoate; [(E,5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate; [(6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxo-hept-3-en-2-yl] ethanoate; [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; [(5R)-5-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate; [(6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, [2.beta.,.gamma.,.beta.,10.alpha.,16.alpha.]-; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2.beta.,9.beta.,10.alpha.,16.alpha.,23E)-; 19-nor-9.beta.,10.alpha.-Lanosta-5,23-diene-3,11,22-trione, 9-methyl-2.beta.,16.alpha.,20,25-tetrahydroxy-, 25-acetate; Datiscn Principle B; Datisca principle B; Cucurbitacine (B); Cucurbitacin B; LMST01010104; NCI60_004184; NSC144154; 6199-67-3; NSC49451; C08794; Cucurbitacin B



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

169 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 19 AKT1, ANXA5, BCL2, BCL2L1, BIRC5, CASP3, CCNB1, CCND1, CDKN1A, CIP2A, EGFR, JAK2, MTOR, MYC, PIK3CA, PTGS2, PTK2, STAT3, VEGFA
Peripheral membrane protein 5 ANXA5, JAK2, MTOR, PTGS2, PTK2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, EGFR, MTOR, PTGS2
Mitochondrion membrane 1 BCL2L1
Nucleus 14 AKT1, BCL2, BIRC5, CASP3, CCNB1, CCND1, CDKN1A, EGFR, JAK2, MTOR, MYC, PTK2, STAT3, VEGFA
cytosol 15 AKT1, ANXA5, BCL2, BCL2L1, BIRC5, CASP3, CCNB1, CCND1, CDKN1A, CIP2A, JAK2, MTOR, PIK3CA, PTK2, STAT3
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 4 BCL2L1, CCNB1, CCND1, PTK2
nucleoplasm 10 AKT1, BIRC5, CASP3, CCNB1, CCND1, CDKN1A, JAK2, MTOR, MYC, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 AKT1, EGFR, ITGAM, PTK2
Cytoplasmic side 3 BCL2L1, MTOR, PTK2
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
cell cortex 2 AKT1, PTK2
cell junction 1 EGFR
cell surface 3 EGFR, ITGAM, VEGFA
glutamatergic synapse 4 AKT1, CASP3, EGFR, JAK2
Golgi apparatus 1 VEGFA
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 CASP3
postsynapse 2 AKT1, JAK2
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 BCL2L1
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 8 AKT1, CIP2A, EGFR, ITGAM, JAK2, PIK3CA, PTK2, STAT3
synaptic vesicle membrane 1 BCL2L1
Membrane 10 AKT1, ANXA5, BCL2, CCNB1, EGFR, ITGAM, JAK2, MTOR, MYC, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 2 JAK2, PTGS2
extracellular exosome 2 ANXA5, ITGAM
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, BCL2L1, PTGS2, VEGFA
extracellular space 3 EGFR, ITGAM, VEGFA
perinuclear region of cytoplasm 4 CDKN1A, EGFR, PIK3CA, PTK2
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, BCL2L1
protein-containing complex 7 AKT1, BCL2, BIRC5, CDKN1A, EGFR, MYC, PTGS2
intracellular membrane-bounded organelle 1 PTK2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, ITGAM
Secreted 1 VEGFA
extracellular region 2 ANXA5, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 2 BCL2L1, CCNB1
anchoring junction 1 PTK2
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, PTK2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 4 BCL2, BCL2L1, CCND1, EGFR
external side of plasma membrane 2 ANXA5, ITGAM
Secreted, extracellular space, extracellular matrix 1 VEGFA
dendritic spine 1 PTK2
microtubule cytoskeleton 2 AKT1, BIRC5
nucleolus 2 CDKN1A, MYC
midbody 1 BIRC5
cell-cell junction 1 AKT1
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 PTK2
Membrane raft 3 EGFR, ITGAM, JAK2
pore complex 1 BCL2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 4 ANXA5, EGFR, JAK2, PTK2
microtubule 1 BIRC5
spindle 2 AKT1, BIRC5
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, PTK2
chromatin 2 MYC, STAT3
cell projection 1 PTK2
Chromosome 2 BIRC5, CIP2A
cytoskeleton 2 JAK2, PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
centriole 1 BIRC5
Nucleus, nucleolus 1 MYC
spindle pole 1 CCNB1
nuclear chromosome 1 BIRC5
Cytoplasm, cell cortex 1 PTK2
nuclear envelope 2 MTOR, MYC
Endomembrane system 2 JAK2, MTOR
endosome lumen 1 JAK2
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Nucleus, nucleoplasm 1 MYC
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 1 JAK2
myelin sheath 1 BCL2
stress fiber 1 PTK2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 1 ITGAM
endoplasmic reticulum lumen 1 PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
kinetochore 1 BIRC5
RNA polymerase II transcription repressor complex 1 MYC
chromosome, centromeric region 1 BIRC5
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
chromosome passenger complex 1 BIRC5
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
cytoplasmic microtubule 1 BIRC5
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
death-inducing signaling complex 1 CASP3
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
integrin complex 1 ITGAM
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
integrin alphaM-beta2 complex 1 ITGAM
cyclin B1-CDK1 complex 1 CCNB1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
nucleoplasmic reticulum 1 MYC


文献列表

  • Carina Stein, Johanna Voigts, Lisa Niederreiter, Stefanie Kowarschik, Roman Huber, Volker M Lüth. Antiproliferative and immunomodulative potential of Citrullus colocynthis and its bioactive compounds in human lymphocytes and lung cells. Journal of ethnopharmacology. 2024 Jun; 328(?):118053. doi: 10.1016/j.jep.2024.118053. [PMID: 38499257]
  • Hong Wu, Tianjun Ma, Mei He, Wenkai Xie, Xueyan Wang, Liuping Lu, Hui Wang, Ying Cui. Cucurbitacin B modulates M2 macrophage differentiation and attenuates osteosarcoma progression via PI3K/AKT pathway. Phytotherapy research : PTR. 2024 May; 38(5):2215-2233. doi: 10.1002/ptr.8146. [PMID: 38411031]
  • Qi-Zhang Li, Yu-Ying Chen, Qiu-Ping Liu, Zhi-Hui Feng, Lei Zhang, Hong Zhang. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155177. doi: 10.1016/j.phymed.2023.155177. [PMID: 38412667]
  • Shu Dai, Rui Wu, Ke Fu, Yanzhi Li, Chenghao Yao, Yanfang Liu, Fang Zhang, Shenglin Zhang, Yiling Guo, Yuxin Yao, Yunxia Li. Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification. Journal of ethnopharmacology. 2024 Mar; 322(?):117584. doi: 10.1016/j.jep.2023.117584. [PMID: 38104874]
  • Filiz Bakar-Ates, Erva Ozkan. Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Nov; ?(?):105732. doi: 10.1016/j.tiv.2023.105732. [PMID: 37956772]
  • Sandipan Jana, Srijon Gayen, Barun Dasgupta, Seha Singha, Jayashree Mondal, Amit Kar, Abhimanyu Nepal, Suparna Ghosh, Rajan Rajabalaya, Sheba R David, Ashok Kumar Balaraman, Asis Bala, Pulok K Mukerjee, Pallab Kanti Haldar. Investigation on anti-diabetic efficacy of a Cucurbitaceae food plant from the North-East region of India: Exploring the molecular mechanism through modulation of oxidative stress and glycosylated hemoglobin (HbA1c). Endocrine, metabolic & immune disorders drug targets. 2023 Sep; ?(?):. doi: 10.2174/1871530323666230907115818. [PMID: 37691221]
  • Ahmed A Ishola, Kayode E Adewole, Joseph O Adebayo, Elizabeth A Balogun. Potentials of Terpenoids as Inhibitors of Multiple Plasmodium falciparum Protein Drug Targets. Acta parasitologica. 2023 Aug; ?(?):. doi: 10.1007/s11686-023-00711-z. [PMID: 37603126]
  • Guizhou Hu, Wenya Liu, Liyan Li. Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra-high-performance liquid chromatography-tandem mass spectrometry. Journal of separation science. 2023 Jun; ?(?):e2300019. doi: 10.1002/jssc.202300019. [PMID: 37269211]
  • Qi Wang, Xiaohui Li, Chen Zhang, Ning Yue, Simeng Li, Xueying Chen, Fen Jin, Hua Shao, Jing Wang. Discovery and Identification of the Key Contributor to the Bitter Taste in Oriental Melon after Forchlorfenuron Application. Journal of agricultural and food chemistry. 2023 Apr; 71(16):6415-6423. doi: 10.1021/acs.jafc.3c00380. [PMID: 37039537]
  • Shu Dai, Cheng Wang, XingTao Zhao, Cheng Ma, Ke Fu, Yanfang Liu, Cheng Peng, Yunxia Li. Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics. Pharmacological research. 2023 01; 187(?):106587. doi: 10.1016/j.phrs.2022.106587. [PMID: 36460279]
  • Haoyue Zhang, Bei Zhao, HuiZhen Wei, Hairong Zeng, Dongya Sheng, Yang Zhang. Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer. Journal of ethnopharmacology. 2022 Apr; 287(?):114915. doi: 10.1016/j.jep.2021.114915. [PMID: 34954267]
  • Zhiyong Liu, Manish Kumar, Atul Kabra. Cucurbitacin B exerts neuroprotection in a murine Alzheimer's disease model by modulating oxidative stress, inflammation, and neurotransmitter levels. Frontiers in bioscience (Landmark edition). 2022 02; 27(2):71. doi: 10.31083/j.fbl2702071. [PMID: 35227014]
  • Tingting Chen, Bingxiang Ma, Shi Lu, Lupeng Zeng, Huaying Wang, Wanhua Shi, Linying Zhou, Yaokun Xia, Xi Zhang, Jing Zhang, Jinghua Chen. Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy. International journal of nanomedicine. 2022; 17(?):3583-3599. doi: 10.2147/ijn.s362244. [PMID: 35974872]
  • Pornpatsorn Lertphadungkit, Xue Qiao, Supaart Sirikantaramas, Veena Satitpatipan, Min Ye, Somnuk Bunsupa. De novo transcriptome analysis and identification of candidate genes associated with triterpenoid biosynthesis in Trichosanthes cucumerina L. Plant cell reports. 2021 Oct; 40(10):1845-1858. doi: 10.1007/s00299-021-02748-8. [PMID: 34228189]
  • Miwako Toyofuku, Daiki Fujinaga, Kazue Inaba, Tomoki Funahashi, Yuuta Fujikawa, Hideshi Inoue, Hiroshi Kataoka, Ryusuke Niwa, Hajime Ono. The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster. Journal of insect physiology. 2021 10; 134(?):104294. doi: 10.1016/j.jinsphys.2021.104294. [PMID: 34389412]
  • Renyikun Yuan, Wentong Zhao, Qin-Qin Wang, Jia He, Shan Han, Hongwei Gao, Yulin Feng, Shilin Yang. Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis. Pharmacological research. 2021 08; 170(?):105748. doi: 10.1016/j.phrs.2021.105748. [PMID: 34217831]
  • Xiaoli Wang, Yudi Bai, Xue Yan, Jin Li, Bingxue Lin, Linzhi Dai, Cheng Xu, Hua Li, Dong Li, Tai Yang, Tao Zhang. Cucurbitacin B exhibits antitumor effects on CD133+ HepG2 liver cancer stem cells by inhibiting JAK2/STAT3 signaling pathway. Anti-cancer drugs. 2021 06; 32(5):548-557. doi: 10.1097/cad.0000000000001062. [PMID: 33675610]
  • Shuai Huang, Bihui Cao, Jinling Zhang, Yunfei Feng, Lu Wang, Xiaopei Chen, Hang Su, Shengrong Liao, Jinggong Liu, Jun Yan, Baoxia Liang. Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential. Cell death & disease. 2021 03; 12(3):237. doi: 10.1038/s41419-021-03516-y. [PMID: 33664249]
  • Xiaoli Wang, Hua Li, Dong Li, Yudi Bai, Yao Zhang, Xue Yan, Jin Li, Ri Zhao, Jiahui Liu, Wei Liu, Maolin Shi, Cheng Xu, Tai Yang, Tao Zhang. Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation. FEBS open bio. 2021 01; 11(1):133-145. doi: 10.1002/2211-5463.13035. [PMID: 33176070]
  • Xianjing Zhang, Huihui Li, Wenqiong Wang, Tong Chen, Lijiang Xuan. Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives. Journal of natural products. 2020 12; 83(12):3536-3544. doi: 10.1021/acs.jnatprod.0c00364. [PMID: 33269591]
  • Li Yang, Qinfang Ao, Qingmei Zhong, Wen Li, Wenhong Li. SIRT1/IGFBPrP1/TGF β1 axis involved in cucurbitacin B ameliorating concanavalin A-induced mice liver fibrosis. Basic & clinical pharmacology & toxicology. 2020 Nov; 127(5):371-379. doi: 10.1111/bcpt.13446. [PMID: 32452080]
  • Qi Tian, Jianbo Guo, Qi Zhang, Liang Fang, Chao Liu, Hui Xu. Development and Evaluation of Cucurbitacin B Microemulsion: the Effect of Oil Phase and Aqueous Phase on Drug Percutaneous Absorption Based on ATR-FTIR Spectroscopy and Molecular Modeling. AAPS PharmSciTech. 2020 Sep; 21(7):258. doi: 10.1208/s12249-020-01797-8. [PMID: 32895882]
  • Fei Luo, Qi Li, Lei Yu, Chengyang Wang, Hongyan Qi. High concentrations of CPPU promotes cucurbitacin B accumulation in melon (Cucumis melo var. makuwa Makino) fruit by inducing transcription factor CmBt. Plant physiology and biochemistry : PPB. 2020 Sep; 154(?):770-781. doi: 10.1016/j.plaphy.2020.05.033. [PMID: 32827970]
  • Filiz Bakar-Ates, Erva Ozkan, Ceyda Tuba Sengel-Turk. Encapsulation of cucurbitacin B into lipid polymer hybrid nanocarriers induced apoptosis of MDAMB231 cells through PARP cleavage. International journal of pharmaceutics. 2020 Aug; 586(?):119565. doi: 10.1016/j.ijpharm.2020.119565. [PMID: 32592898]
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