Dieckol (BioDeep_00000307186)

Main id: BioDeep_00000178238

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Dieckol

化学式: C36H22O18 (742.0806112)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C=C(C=C1O)OC2=C(C=C(C3=C2OC4=C(C=C(C=C4O3)OC5=C(C=C(C=C5O)OC6=C(C=C(C7=C6OC8=C(C=C(C=C8O7)O)O)O)O)O)O)O)O)O
InChI: InChI=1S/C36H22O18/c37-12-1-13(38)3-15(2-12)49-31-22(44)10-25(47)34-35(31)54-30-21(43)8-17(9-27(30)52-34)48-28-19(41)6-16(7-20(28)42)50-32-23(45)11-24(46)33-36(32)53-29-18(40)4-14(39)5-26(29)51-33/h1-11,37-47H

描述信息

A phlorotannin isolated from a brown alga Ecklonia cava which exhibits antioxidant, hepatoprotective and anticoagulant activities.
Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions[1].
Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions[1].

同义名列表

1 个代谢物同义名

Dieckol



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Muhammad Irfan, Tae-Hyung Kwon, Hyuk-Woo Kwon, Man Hee Rhee. Pharmacological actions of dieckol on modulation of platelet functions and thrombus formation via integrin αIIbβ3 and cAMP signaling. Pharmacological research. 2022 Mar; 177(?):106088. doi: 10.1016/j.phrs.2022.106088. [PMID: 35038555]
  • Durairaj Karthick Rajan, Kannan Mohan, Shubing Zhang, Abirami Ramu Ganesan. Dieckol: a brown algal phlorotannin with biological potential. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111988. doi: 10.1016/j.biopha.2021.111988. [PMID: 34371307]
  • Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Seung Eon Oh, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun. Dieckol-Attenuated High-Fat Diet Induced Muscle Atrophy by Modulating Muscular Deposition of Lipid Droplets. Nutrients. 2021 Sep; 13(9):. doi: 10.3390/nu13093160. [PMID: 34579038]
  • Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun. Dieckol Decreases Caloric Intake and Attenuates Nonalcoholic Fatty Liver Disease and Hepatic Lymphatic Vessel Dysfunction in High-Fat-Diet-Fed Mice. Marine drugs. 2021 Aug; 19(9):. doi: 10.3390/md19090495. [PMID: 34564157]
  • Hyunjun Woo, Min-Kyung Kim, Sohyeon Park, Seung-Hee Han, Hyeon-Cheol Shin, Byeong-Gon Kim, Seung-Ha Oh, Myung-Whan Suh, Jun-Ho Lee, Moo-Kyun Park. Effect of Phlorofucofuroeckol A and Dieckol Extracted from Ecklonia cava on Noise-induced Hearing Loss in a Mouse Model. Marine drugs. 2021 Aug; 19(8):. doi: 10.3390/md19080443. [PMID: 34436282]
  • Seyeon Oh, Jinyoung Yang, Chulhyun Park, Kukhui Son, Kyunghee Byun. Dieckol Attenuated Glucocorticoid-Induced Muscle Atrophy by Decreasing NLRP3 Inflammasome and Pyroptosis. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158057. [PMID: 34360821]
  • Jin Hwang, Hye-Won Yang, Yu An Lu, Jun-Geon Je, Hyo-Geun Lee, K H N Fernando, You-Jin Jeon, BoMi Ryu. Phloroglucinol and dieckol isolated from Ecklonia cava suppress impaired diabetic angiogenesis; A study of in-vitro and in-vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111431. doi: 10.1016/j.biopha.2021.111431. [PMID: 33752058]
  • Myeongjoo Son, Seyeon Oh, Junwon Choi, Ji Tae Jang, Kuk Hui Son, Kyunghee Byun. Attenuating Effects of Dieckol on Hypertensive Nephropathy in Spontaneously Hypertensive Rats. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084230. [PMID: 33921823]
  • Su Hui Seong, Pradeep Paudel, Hyun Ah Jung, Jae Sue Choi. Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action. Marine drugs. 2019 Oct; 17(11):. doi: 10.3390/md17110600. [PMID: 31652867]
  • Velayutham Sadeeshkumar, Arul Duraikannu, Thiyagarajan Aishwarya, Prithi Jayaram, Samuthrapandian Ravichandran, Raghunathan Ganeshamurthy. Radioprotective efficacy of dieckol against gamma radiation-induced cellular damage in hepatocyte cells. Naunyn-Schmiedeberg's archives of pharmacology. 2019 08; 392(8):1031-1041. doi: 10.1007/s00210-019-01652-z. [PMID: 31028451]
  • Seonyoung Kim, Seok-Seong Kang, Soo-Im Choi, Gun-Hee Kim, Jee-Young Imm. Ecklonia cava Extract Containing Dieckol Suppresses RANKL-Induced Osteoclastogenesis via MAP Kinase/NF-κB Pathway Inhibition and Heme Oxygenase-1 Induction. Journal of microbiology and biotechnology. 2019 Jan; 29(1):11-20. doi: 10.4014/jmb.1810.10005. [PMID: 30518021]
  • Velayutham Sadeeshkumar, Arul Duraikannu, Samuthrapandian Ravichandran, Wilson Sylvester Fredrick, Ramar Sivaperumal, Paulrasu Kodisundaram. Protective effects of dieckol on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Dec; 84(?):1810-1819. doi: 10.1016/j.biopha.2016.10.091. [PMID: 27825803]
  • Sang Yoon Lee, Jihyun Lee, HyoJung Lee, Bonglee Kim, Jaehwan Lew, Namin Baek, Sung-Hoon Kim. MicroRNA134 Mediated Upregulation of JNK and Downregulation of NFkB Signalings Are Critically Involved in Dieckol Induced Antihepatic Fibrosis. Journal of agricultural and food chemistry. 2016 Jul; 64(27):5508-14. doi: 10.1021/acs.jafc.6b01945. [PMID: 27321552]
  • Hyeon-Son Choi, Hui-Jeon Jeon, Ok-Hwan Lee, Boo-Yong Lee. Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation. Molecular nutrition & food research. 2015 Aug; 59(8):1458-71. doi: 10.1002/mnfr.201500021. [PMID: 25944759]
  • Tae-Hyung Kwon, Yong-Xiang Wu, Jong-Shik Kim, Jung-Hee Woo, Kyu Tae Park, O Jun Kwon, Hyun-Ju Seo, Taewan Kim, Nyun-Ho Park. 6,6'-Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3-L1 cells. Journal of the science of food and agriculture. 2015 Jul; 95(9):1830-7. doi: 10.1002/jsfa.6881. [PMID: 25142414]
  • Seung-Hong Lee, You-Jin Jeon. Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. Food & function. 2015 Mar; 6(3):853-8. doi: 10.1039/c4fo00940a. [PMID: 25608849]
  • Min-Cheol Kang, Kil-Nam Kim, Sung-Myung Kang, Xiudong Yang, Eun-A Kim, Choon Bok Song, Jae-Woon Nah, Mi-Kyeong Jang, Jung-Suck Lee, Won-Kyo Jung, You-Jin Jeon. Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model. Environmental toxicology and pharmacology. 2013 Nov; 36(3):1217-26. doi: 10.1016/j.etap.2013.09.018. [PMID: 24189014]
  • Min-Cheol Kang, Seon Heui Cha, W A J P Wijesinghe, Sung-Myung Kang, Seung-Hong Lee, Eun-A Kim, Choon Bok Song, You-Jin Jeon. Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo. Food chemistry. 2013 Jun; 138(2-3):950-5. doi: 10.1016/j.foodchem.2012.11.005. [PMID: 23411200]
  • Min-Cheol Kang, Sung-Myung Kang, Ginnae Ahn, Kil-Nam Kim, Nalae Kang, Kalpa W Samarakoon, Myung-Cheol Oh, Jung-Suck Lee, You-Jin Jeon. Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse. Environmental toxicology and pharmacology. 2013 May; 35(3):517-23. doi: 10.1016/j.etap.2013.02.013. [PMID: 23528870]
  • Min-Cheol Kang, W A J P Wijesinghe, Seung-Hong Lee, Sung-Myung Kang, Seok-Chun Ko, Xiudong Yang, Nalae Kang, Byong-Tae Jeon, Jaell Kim, Dae-Ho Lee, You-Jin Jeon. Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):294-8. doi: 10.1016/j.fct.2012.12.012. [PMID: 23261675]
  • Min-Cheol Kang, Ginnae Ahn, Xiudong Yang, Kil-Nam Kim, Sung-Myung Kang, Seung-Hong Lee, Seok-Chun Ko, Ju-Young Ko, Daekyung Kim, Yong-Tae Kim, Youngheun Jee, Sun-Joo Park, You-Jin Jeon. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Jun; 50(6):1986-91. doi: 10.1016/j.fct.2012.03.078. [PMID: 22504843]
  • Eunjin Park, Ginnae Ahn, Jin-Suk Yun, Min Ju Kim, So Jin Bing, Dae Seung Kim, Jehee Lee, Nam Ho Lee, Jae Woo Park, Youngheun Jee. Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression. International journal of radiation biology. 2010 Oct; 86(10):848-59. doi: 10.3109/09553002.2010.487011. [PMID: 20883140]
  • Seung-Hong Lee, Ji-Sook Han, Soo-Jin Heo, Ji-Young Hwang, You-Jin Jeon. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicology in vitro : an international journal published in association with BIBRA. 2010 Mar; 24(2):375-81. doi: 10.1016/j.tiv.2009.11.002. [PMID: 19896528]
  • BoMi Ryu, Yong Li, Zhong-Ji Qian, Moon-Moo Kim, Se-Kwon Kim. Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease. Chemico-biological interactions. 2009 May; 179(2-3):192-201. doi: 10.1016/j.cbi.2009.01.006. [PMID: 19330880]
  • Na Young Yoon, Hyeung Rak Kim, Hae Young Chung, Jae Sue Choi. Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Archives of pharmacal research. 2008 Dec; 31(12):1564-71. doi: 10.1007/s12272-001-2152-8. [PMID: 19099225]