Phenazepam (BioDeep_00000272445)
Secondary id: BioDeep_00000605897
代谢物信息卡片
Phenazepam
化学式: C15H10BrClN2O (347.966498)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: O=C1CN=C(c2ccccc2Cl)c2cc(Br)ccc2N1
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M S Zastrozhin, A V Efimova, VYu Skryabin, V V Smirnov, A E Petukhov, E P Pankratenko, S A Pozdniakov, E V Kaverina, D A Klepikov, E A Grishina, K A Ryzhikova, I V Bure, E A Bryun, D A Sychev. Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder.
Psychopharmacology bulletin.
2021 11; 51(4):87-104. doi:
NULL. [PMID: 34887601] - Mikhail Sergeevich Zastrozhin, Valentin Yurievich Skryabin, Alexander Sergeevich Sorokin, Aleksey Evgenievich Petukhov, Valery Valerievich Smirnov, Ekaterina Petrovna Pankratenko, Elena Anatolievna Grishina, Kristina Anatolievna Ryzhikova, Aleksey Sergeevich Panov, Ludmila Mikhailovna Savchenko, Evgeny Alekseevich Bryun, Dmitry Alekseevich Sychev. CYP3A subfamily activity affects the equilibrium concentration of Phenazepam® in patients with anxiety disorders and comorbid alcohol use disorder.
Pharmacogenomics.
2020 05; 21(7):449-457. doi:
10.2217/pgs-2019-0071. [PMID: 32336193] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Liang Meng, Binling Zhu, Kefang Zheng, Shanlin Fu. Ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction for the determination of 4 designer benzodiazepines in urine samples by gas chromatography-triple quadrupole mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1053(?):9-15. doi:
10.1016/j.jchromb.2017.04.008. [PMID: 28399467] - Kathy T Vo, Xander M R van Wijk, Alan H B Wu, Kara L Lynch, Raymond Y Ho. Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse.
Clinical toxicology (Philadelphia, Pa.).
2017 Jan; 55(1):71-72. doi:
10.1080/15563650.2016.1240806. [PMID: 27736261] - Megan L Crichton, Catriona F Shenton, Gail Drummond, Lewis J Beer, L Nitin Seetohul, Peter D Maskell. Analysis of phenazepam and 3-hydroxyphenazepam in post-mortem fluids and tissues.
Drug testing and analysis.
2015 Oct; 7(10):926-36. doi:
10.1002/dta.1790. [PMID: 25847502] - Pirkko Kriikku, Lars Wilhelm, Janne Rintatalo, Jukka Hurme, Jan Kramer, Ilkka Ojanperä. Phenazepam abuse in Finland: findings from apprehended drivers, post-mortem cases and police confiscations.
Forensic science international.
2012 Jul; 220(1-3):111-7. doi:
10.1016/j.forsciint.2012.02.006. [PMID: 22391477] - R A F Couch, H Madhavaram. Phenazepam and cannabinomimetics sold as herbal highs in New Zealand.
Drug testing and analysis.
2012 Jun; 4(6):409-14. doi:
10.1002/dta.349. [PMID: 22924168] - Patrick B Kyle, Kathryn B Brown, Alyssa P Bailey, John L Stevenson. Reactivity of commercial benzodiazepine immunoassays to phenazepam.
Journal of analytical toxicology.
2012 Apr; 36(3):207-9. doi:
10.1093/jat/bks008. [PMID: 22417837] - N Yu Polomeyeva, R V Gurto, O S Bryushinina, V A Slepichev, A V Kaigorodtsev, V Yu Smirnov, N I Suslov, V V Udut. Anxiolytic and antidepressant effects of aqueous tincture of the aerial part of Myosotis arvensis.
Bulletin of experimental biology and medicine.
2011 Sep; 151(5):604-6. doi:
10.1007/s10517-011-1393-x. [PMID: 22462056] - Kristen Bailey, Lauren Richards-Waugh, David Clay, Myron Gebhardt, Hamada Mahmoud, James C Kraner. Fatality involving the ingestion of phenazepam and poppy seed tea.
Journal of analytical toxicology.
2010 Oct; 34(8):527-32. doi:
10.1093/jat/34.8.527. [PMID: 21819799] - O A Dorofeeva, S A Siuniakov, V P Zherdev, G B Kolyvanov, A A Litvin, G G Neznamov. [Therapeutic effect and pharmacokinetics of transdermal phenazepam preparation in patients with different anxiety disorders].
Eksperimental'naia i klinicheskaia farmakologiia.
2009 Mar; 72(2):6-10. doi:
NULL. [PMID: 19441719] - Tiina J Kauppila, Ville Arvola, Markus Haapala, Jaroslav Pól, Laura Aalberg, Ville Saarela, Sami Franssila, Tapio Kotiaho, Risto Kostiainen. Direct analysis of illicit drugs by desorption atmospheric pressure photoionization.
Rapid communications in mass spectrometry : RCM.
2008 Apr; 22(7):979-85. doi:
10.1002/rcm.3461. [PMID: 18320545] - V N Bekhterev, S N Gavrilova, I V Maslakov. [Application of extraction freezing for analysis of 1,4-benzodiazepines in urine].
Sudebno-meditsinskaia ekspertiza.
2007 Mar; 50(2):32-5. doi:
NULL. [PMID: 17520905] - M A Kutlubaev, R R Farkhutdinov, L R Akhmadeeva, A F Mufazalov. Free radical oxidation in rat brain during chronic stress and pharmacological regulation of this process.
Bulletin of experimental biology and medicine.
2005 Oct; 140(4):416-8. doi:
10.1007/s10517-005-0507-8. [PMID: 16671569] - Valentina Bashkatova, Victor Narkevich, Galina Vitskova, Anatoly Vanin. The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures.
Progress in neuro-psychopharmacology & biological psychiatry.
2003 May; 27(3):487-92. doi:
10.1016/s0278-5846(03)00037-x. [PMID: 12691785] - E M Molochkina, I B Ozerova. [The influence of pharmacologically active substances of different classes at ultra low doses on lipid peroxidation in brain cell membranes and activity of acetylcholinesterase in vivo and in vitro].
Radiatsionnaia biologiia, radioecologiia.
2003 May; 43(3):294-300. doi:
". [PMID: 12881982] - S A Menzikov, O V Menzikova. [Effect of naloxone on the activity of Cl(-)-activated Mg(2+)-ATPase from plasma membrane fraction of the common bream brain (Abramis brama L.) in the presence of GABAa-ergic substances].
Izvestiia Akademii nauk. Seriia biologicheskaia.
2003 Mar; ?(2):154-8. doi:
NULL. [PMID: 12712575] - V P Zherdev, T A Voronina, T L Garibova, G B Kolyvanov, A A Litvin, A K Sariev, V N Tokhmakhchi, A E Vasil'ev. [Pharmacokinetics and efficacy of phenazepam after transdermal and enteral administration in rats].
Eksperimental'naia i klinicheskaia farmakologiia.
2003 Jan; 66(1):50-3. doi:
NULL. [PMID: 12683082] - E M Molochkina, I B Ozerova, E B Burlakova. Phenazepam in therapeutic and ultralow doses in vitro modulates the content of lipid peroxidation products and acetylcholinesterase activity in membrane fraction from mouse brain.
Bulletin of experimental biology and medicine.
2003 Jan; 135 Suppl 7(?):42-4. doi:
10.1023/a:1024762209515. [PMID: 12949645] - N Ya Golovenko, V B Larionov, I A Kravchenko, N V Ovcharenko, A I Aleksandrova. Biokinetics of transdermal 3-hydroxyphenazepam.
Bulletin of experimental biology and medicine.
2002 Sep; 134(3):254-6. doi:
10.1023/a:1021503417490. [PMID: 12511995] - S A Menzikov, O V Menzikova. Effect of activators and blockers of ligand-regulated ion channels on the activity of the Cl-stimulated Mg2+-ATPase of the plasma membrane fraction from bream (Abramis brama L.) brain.
Biochemistry. Biokhimiia.
2002 Feb; 67(2):233-9. doi:
10.1023/a:1014422332601. [PMID: 11952420] - N Y Golovenko, I A Kravchenko, V G Zin'kovskii, S A Andronati, A I Aleksandrova, N V Ovcharenko, V B Larionov. Biokinetics of transdermal therapeutic medicinal form of phenazepam.
Bulletin of experimental biology and medicine.
2000 Dec; 130(12):1153-5. doi:
NULL. [PMID: 11276308] - T L Karaseva, M V Belikova, V I Pavlovskiĭ, K S Andronati, T A Kabanova. [In vitro effect of 1,2-dihydro-3H-1,4-benzodiazepine-2-one derivatives on the platelet aggregation and lipid peroxidation in rats].
Ukrainskii biokhimicheskii zhurnal (1978).
1998 Sep; 70(5):81-5. doi:
". [PMID: 10445265] - I I Baryshnikov. [Importance of toxicological studies in animals for elaboration of pathogenetic therapy of hydrazine intoxication].
Meditsina truda i promyshlennaia ekologiia.
1997; ?(6):22-5. doi:
". [PMID: 9273132] - E V Nikushkin, M M Bordiukov. [Antioxidative activity of drugs used in anticonvulsive therapy].
Biulleten' eksperimental'noi biologii i meditsiny.
1993 Mar; 115(3):254-6. doi:
. [PMID: 8054610] - A A Nikonorov, V P Tverdokhlib. [Comparative evaluation of the protective effect of sodium valproate, phenazepam and ionol in stress-induced liver damage in rats].
Fiziologicheskii zhurnal.
1991 May; 37(3):66-70. doi:
. [PMID: 1894054] - G D Kaipova, E B Burlakova, E M Molochkina, G G Neznamov, M V Poiurovskiĭ. [Changes in the antioxidative activity and phospholipid composition of the erythrocytes in neurosis patients as affected by fenazepam].
Biulleten' eksperimental'noi biologii i meditsiny.
1988 Feb; 105(2):171-3. doi:
". [PMID: 3349146] - A V Eremenko, N A Avdulov, E M Gankina, L D Smirnov, K M Diumaev. [Effect of subchronic administration of phenazepam and synthetic antioxidants on the functional status of synaptic membranes in the cerebral cortex of rats subjected to prolonged stress].
Biulleten' eksperimental'noi biologii i meditsiny.
1988 Jan; 105(1):38-40. doi:
. [PMID: 2892546] - V A Sozinov, S B Seredenin, N Ia Golovenko. [Biotransformation of the 14C-hydrogenated analog of phenazepam in inbred mice].
Biulleten' eksperimental'noi biologii i meditsiny.
1987 May; 103(5):581-3. doi:
NULL. [PMID: 3593933] - V P Zherdev, Iu A Aleksandrovskiĭ, G G Neznamov, G M Rudenko, E A Antokhin. [Correlations between the pharmacokinetic indices of the tranquilizer fenazepam in single and long-term administration to patients].
Farmakologiia i toksikologiia.
1987 Jan; 50(1):81-5. doi:
NULL. [PMID: 3556559] - A N Kudrin, V S Smolenskiĭ, V M Khusainov, A A Abinder, L L Luk'ianova. [Effect of tranquilizers on lipid peroxidation of biological membranes].
Farmakologiia i toksikologiia.
1987 Jan; 50(1):14-7. doi:
". [PMID: 3104081] - A K Otkalenko, A A Pentiuk, N K Barkov. [Mechanism of the anti-alcohol action of fenazepam].
Farmakologiia i toksikologiia.
1987 Jan; 50(1):104-7. doi:
". [PMID: 3556543] - S B Seredenin, Iu A Blednov. [Effect of fenazepam on the ACTH content of the blood plasma in inbred mice under stress exposure].
Biulleten' eksperimental'noi biologii i meditsiny.
1986 Dec; 102(12):724-6. doi:
NULL. [PMID: 3026513] - N Ia Golovenko, V A Sozinov, O P Rudenko. [Distribution of the 14C-hydrated analog of phenazepam in the organs and tissues of mice].
Biulleten' eksperimental'noi biologii i meditsiny.
1986 Mar; 101(3):327-9. doi:
NULL. [PMID: 2869800] - S B Seredinin, B A Badyshtov. [Study of the hereditary differences in the cyclic nucleotide content of the blood serum in mice after exposure to stress and administration of phenazepam].
Biulleten' eksperimental'noi biologii i meditsiny.
1985 Nov; 100(11):586-8. doi:
NULL. [PMID: 2865987] - G M Molodavkin, M V Poiurovskiĭ. [Effect of the antioxidant dibunol and its combination with phenazepam on the behavior of rats in a conflict situation].
Biulleten' eksperimental'noi biologii i meditsiny.
1985 Jul; 100(7):36-8. doi:
". [PMID: 4016240] - E M Molochkina, G D Kaipova, A A Papin, R N Korotkina, A A Karelin. [The role of changes in the antioxidative activity and phospholipid composition of the rat liver in the mechanism of phenazepam action on the liver and the protective effect of talamonal].
Voprosy meditsinskoi khimii.
1985 May; 31(3):17-21. doi:
. [PMID: 4024526] - L A Malikova, V A Arefolov. [Protective effect of phenazepam and sodium oxybutyrate on somatic manifestations in immobilization stress].
Biulleten' eksperimental'noi biologii i meditsiny.
1983 Dec; 96(12):60-2. doi:
". [PMID: 6140968] - V P Zherdev, A L Ekonomov. [Characteristics of fenazepam excretion in rats and mice].
Farmakologiia i toksikologiia.
1983 May; 46(3):32-7. doi:
NULL. [PMID: 6134636] - S B Seredenin, V G Zin'kovskiĭ, N Ia Golovenko, I V Rybina. [Genetic differences in the excretion of phenazepam-14C].
Voprosy meditsinskoi khimii.
1981 Nov; 27(6):788-90. doi:
NULL. [PMID: 6121421] - N Ia Golovenko, V G Zin'kovskiĭ, S B Seredenin, S A Andronati, L N Iakubovskaia. [Distribution of 14C-phenazepam and its metabolites in the liver, brain and blood plasma in single and prolonged administration to white rats].
Farmakologiia i toksikologiia.
1980 Mar; 43(2):144-8. doi:
NULL. [PMID: 6108232] - V G Zin'kovskiĭ, A V Bogatskiĭ, N Ia Golovenko, S B Seredenin, S A Andronati. [Kinetics of phenazepam-14C excretion from the body of white rats in the single and prolonged administration of the preparation].
Biulleten' eksperimental'noi biologii i meditsiny.
1979 Jun; 87(6):561-3. doi:
NULL. [PMID: 37940]