Pharmakon1600-01300027 (BioDeep_00000272160)
Secondary id: BioDeep_00000617172
natural product Chemicals and Drugs
代谢物信息卡片
Pesticide4_Ivermectin_C48H74O14_22,23-dihydroavermectin B1
化学式: C48H74O14 (874.5078304)
中文名称: 伊维菌素
谱图信息:
最多检出来源 Escherichia coli(natural_products) 14.29%
分子结构信息
SMILES: CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30?,31?,33+,34-,35-,36+,37+,38-,39-,40+,41-,42?,43+,44-,45+,47+,48+/m0/s1
描述信息
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CF - Avermectines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents
D010575 - Pesticides > D007306 - Insecticides
COVID info from clinicaltrials, clinicaltrial
D016573 - Agrochemicals
D - Dermatologicals
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import[1][2][3][4]. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[5].
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:91732
- PubChem: 45114068
- PubChem: 4330618
- MeSH: Ivermectin
- CAS: 70288-86-7
- CAS: 70288-86-7, 71827-03-7
- MoNA: CCMSLIB00001058390
- MoNA: CCMSLIB00001058661
- MoNA: CCMSLIB00001058666
- MoNA: CCMSLIB00001058893
- MoNA: CCMSLIB00001059021
- MoNA: CCMSLIB00000078110
- PMhub: MS000003449
- medchemexpress: HY-15310
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dezheng Guo, Ying Wang, Zhongyu Li, Da-Xia Zhang, Chen Wang, Hongfang Wang, Zhenguo Liu, Feng Liu, Xingqi Guo, Ningxin Wang, Baohua Xu, Zheng Gao. Effects of abamectin nanocapsules on bees through host physiology, immune function, and gut microbiome.
The Science of the total environment.
2024 Jun; 930(?):172738. doi:
10.1016/j.scitotenv.2024.172738. [PMID: 38670362] - Xu Shi, Tong Xu, Meichen Gao, Yanju Bi, Jiaqi Wang, Yilin Yin, Shiwen Xu. Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome/ROS/ferroptosis pathway.
Water research.
2024 Jun; 257(?):121660. doi:
10.1016/j.watres.2024.121660. [PMID: 38688190] - Magdalena Jankowska, Izabela Hrynko, Ewa Rutkowska, Bożena Łozowicka. Dissipation, processing factors and dietary risk assessment of the bioinsecticide abamectin in herbal plants belonging to Lamiaceae family from open field to herbal tea infusion.
Chemosphere.
2024 Jun; 358(?):142159. doi:
10.1016/j.chemosphere.2024.142159. [PMID: 38679175] - Jiaqing Li, Donglin Li, Zhaoyang Zhang, Chang Yu, Dan Sun, Ziyao Mo, Jiayin Wang, Mmby Mohamed, Hong You, Hu Wan, Jianhong Li, Shun He. Smart and Sustainable Crop Protection: Design and Evaluation of a Novel α-Amylase-Responsive Nanopesticide for Effective Pest Control.
Journal of agricultural and food chemistry.
2024 May; 72(21):12146-12155. doi:
10.1021/acs.jafc.4c00980. [PMID: 38747516] - Yingjian Ma, Meng Yu, Zhe Sun, Shouhe Pan, Yinmin Wang, Fengyu Li, Xinyu Guo, Rui Zhao, Yong Xu, Xuemin Wu. Biomass-Based, Dual Enzyme-Responsive Nanopesticides: Eco-friendly and Efficient Control of Pine Wood Nematode Disease.
ACS nano.
2024 May; 18(21):13781-13793. doi:
10.1021/acsnano.4c02031. [PMID: 38752333] - Shihao Gu, Mei Liu, Renle Xu, Xu Han, Yuhang Lou, Yue Kong, Yanqing Gao, Shibin Shang, Zhanqian Song, Jie Song, Jian Li. Ecofriendly Controlled-Release Insecticide Carrier: pH-/Temperature-Responsive Rosin-Derived Hydrogels for Avermectin Delivery against Mythimna separata (Walker).
Langmuir : the ACS journal of surfaces and colloids.
2024 May; 40(21):10992-11010. doi:
10.1021/acs.langmuir.4c00383. [PMID: 38743441] - Swaraj Kumar Babu, Dibya Ranjan Sahoo, Prajna Parimita Mohanta, Pradeep Kumar Naik. Exploring the antifilarial potential of an important medicinal plant Typhonium trilobatum (L. Schoot): Isolation, characterization, and structural elucidation of bioactive compounds against Brugia malayi.
Journal of ethnopharmacology.
2024 May; 326(?):117858. doi:
10.1016/j.jep.2024.117858. [PMID: 38346526] - Yuan Shi, Xinglu Pan, Xiaohu Wu, Jun Xu, Wensheng Xiang, Yongquan Zheng, Fengshou Dong, Xiangjing Wang. Uptake and Biotransformation of Guvermectin in Three Crops after In Vivo and In Vitro Exposure.
Journal of agricultural and food chemistry.
2024 May; 72(19):10842-10852. doi:
10.1021/acs.jafc.4c01320. [PMID: 38708761] - Fatma S Abou-Elnour, Salma E El-Habashy, Marwa M Essawy, Ossama Y Abdallah. Codelivery of ivermectin and methyl dihydrojasmonate in nanostructured lipid carrier for synergistic antileukemia therapy.
International journal of pharmaceutics.
2024 May; 656(?):124086. doi:
10.1016/j.ijpharm.2024.124086. [PMID: 38580074] - Yuqi Huang, Zhaohui Chen, Jianqiang Lan, Lei Zhang, Huaqing Chen, Linlong Jiang, Hongxiao Yu, Nannan Liu, Chenghong Liao, Qian Han. MDR49 coding for both P-glycoprotein and TMOF transporter functions in ivermectin resistance, trypsin activity inhibition, and fertility in the yellow fever mosquito, Aedes aegypti.
Pesticide biochemistry and physiology.
2024 May; 201(?):105899. doi:
10.1016/j.pestbp.2024.105899. [PMID: 38685208] - Xiquan Ding, Fei Gao, Long Chen, Zhanghua Zeng, Xiang Zhao, Yan Wang, Haixin Cui, Bo Cui. Size-dependent Effect on Foliar Utilization and Biocontrol Efficacy of Emamectin Benzoate Delivery Systems.
ACS applied materials & interfaces.
2024 May; 16(17):22558-22570. doi:
10.1021/acsami.4c02936. [PMID: 38637157] - Hossam El Din H Abdelhafez, Amr A Abdallah, Reda K Abdel-Razik, Nadia A Hamed, Ahmed Elshatory, Walaa Awad, Abdel Azeim A Khalaf, Aya M Mekkawy. Sex comparison of oxidative stress, mitochondrial dysfunction, and apoptosis triggers induced by single-dose Abamectin in albino rats.
Pesticide biochemistry and physiology.
2024 May; 201(?):105903. doi:
10.1016/j.pestbp.2024.105903. [PMID: 38685225] - Manman Zhang, Lei Li, Cheng Li, Aifang Ma, Junzhou Li, Chenyu Yang, Xujun Chen, Peng Cao, Shanshan Li, Yanyan Zhang, Zhiguang Yuchi, Xiangge Du, Chongxi Liu, Xiangjing Wang, Xiaodan Wang, Wensheng Xiang. Natural product guvermectin inhibits guanosine 5'-monophosphate synthetase and confers broad-spectrum antibacterial activity.
International journal of biological macromolecules.
2024 May; 267(Pt 2):131510. doi:
10.1016/j.ijbiomac.2024.131510. [PMID: 38608989] - Juan Tang, Qinghe Zhang, Cheng Qu, Qi Su, Chen Luo, Ran Wang. Knockdown of one cytochrome P450 gene CYP6DW4 increases the susceptibility of Bemisia tabaci to dimpropyridaz, a novel pyridazine pyrazolecarboxamide insecticide.
Pesticide biochemistry and physiology.
2024 May; 201(?):105888. doi:
10.1016/j.pestbp.2024.105888. [PMID: 38685219] - Ke Ding, Hailong Tian, Lei Li, Zhihan Wang, Shanshan Liu, Ning Ding, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer.
Journal of nanobiotechnology.
2024 Apr; 22(1):202. doi:
10.1186/s12951-024-02416-5. [PMID: 38658952] - Ralston B Goldfarb, Matthew J Atala Pleshinger, David F Yan, Drew J Adams. Lipid-Restricted Culture Media Reveal Unexpected Cancer Cell Sensitivities.
ACS chemical biology.
2024 Apr; 19(4):896-907. doi:
10.1021/acschembio.3c00699. [PMID: 38506663] - Samantha W Karanu, Inusa J Ajene, Elijah K Lelmen, Maureen A Ong'onge, Komivi S Akutse, Fathiya M Khamis. Biochemistry and transcriptomic analyses of Phthorimaea absoluta (Lepidoptera: Gelechiidae) response to insecticides.
Scientific reports.
2024 04; 14(1):7931. doi:
10.1038/s41598-024-58413-z. [PMID: 38575641] - Ahmed Rahib, Mustafa M Karhib, Hoda M Nasr, Raghda A El-Sayed, Mohamed M Abdel-Daim, Ali B Jebur, Fatma M El-Demerdash. Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats.
Tissue & cell.
2024 Apr; 87(?):102321. doi:
10.1016/j.tice.2024.102321. [PMID: 38350206] - Yu-Cheng Wang, Ya-Wen Chang, Wei-Rong Gong, Jie Hu, Yu-Zhou Du. The development of abamectin resistance in Liriomyza trifolii and its contribution to thermotolerance.
Pest management science.
2024 Apr; 80(4):2053-2060. doi:
10.1002/ps.7944. [PMID: 38131224] - Harish Kumar Shah, Vaishnavi Srinivasan, Shakila Venkatesan, Vijayakumar Balakrishnan, Sadanandane Candasamy, Nisha Mathew, Ashwani Kumar, Vijesh Sreedhar Kuttiatt. Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control.
Scientific reports.
2024 03; 14(1):5628. doi:
10.1038/s41598-024-56053-x. [PMID: 38454095] - Katie E Crawford, Shannon M Hedtke, Stephen R Doyle, Annette C Kuesel, Samuel Armoo, Mike Y Osei-Atweneboana, Warwick N Grant. Genome-based tools for onchocerciasis elimination: utility of the mitochondrial genome for delineating Onchocerca volvulus transmission zones.
International journal for parasitology.
2024 Mar; 54(3-4):171-183. doi:
10.1016/j.ijpara.2023.11.002. [PMID: 37993016] - Yue Xin, Xueqing Li, Kaixin Ping, Yannan Xiang, Mengxin Li, Xing Li, Haitao Yang, Jingquan Dong. Pesticide avermectin-induced hepatotoxicity and growth inhibition in carp: Ameliorative capacity and potential mechanisms of quercetin as a dietary additive.
Aquatic toxicology (Amsterdam, Netherlands).
2024 Mar; 268(?):106859. doi:
10.1016/j.aquatox.2024.106859. [PMID: 38342007] - Shi-Die Jiang, Lei Wang, Lin Wang, Jun Sun, Jin-Jun Wang, Dan-Dan Wei. Mitochondrial coding genes mediate insecticide tolerance in the oriental fruit fly, Bactrocera dorsalis (Hendel).
Pesticide biochemistry and physiology.
2024 Feb; 199(?):105763. doi:
10.1016/j.pestbp.2023.105763. [PMID: 38458663] - Lin Liang, Jianyi Li, Long Jin, Kunpeng Yan, Yiou Pan, Qingli Shang. Identification of inducible CYP3 and CYP4 genes associated with abamectin tolerance in the fat body and Malpighian tubules of Spodoptera litura.
Pesticide biochemistry and physiology.
2024 Jan; 198(?):105751. doi:
10.1016/j.pestbp.2023.105751. [PMID: 38225094] - Faruk Dube, Nicolas Delhomme, Frida Martin, Andrea Hinas, Magnus Åbrink, Staffan Svärd, Eva Tydén. Gene co-expression network analysis reveal core responsive genes in Parascaris univalens tissues following ivermectin exposure.
PloS one.
2024; 19(2):e0298039. doi:
10.1371/journal.pone.0298039. [PMID: 38359071] - Yevhen Kustovskiy, Pavel Karpov, Yaroslav Blume, Alla Yemets. Ivermectin affects Arabidopsis thaliana microtubules through predicted binding site of β-tubulin.
Plant physiology and biochemistry : PPB.
2024 Jan; 206(?):108296. doi:
10.1016/j.plaphy.2023.108296. [PMID: 38141401] - Tarık Balkan, Adem Yağcı, Kenan Kara. Dissipation behaviors of deltamethrin, emamectin benzoate and hexythiazox in grape under field conditions.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2024; 59(3):123-129. doi:
10.1080/03601234.2024.2308487. [PMID: 38287657] - Yakup Yildirim, Ali Küçük, Mehmet Kale, Sibel Hasircioğlu, Kamil Atli, Hasbi Sait Saltik. Evaluating the Efficiency of Various Treatment Methods in Cattle Cutaneous Papillomatosis.
Veterinaria italiana.
2023 Dec; 59(4):. doi:
10.12834/vetit.3138.21450.2. [PMID: 38756023] - Ying Sun, Changxiong Hu, Guohua Chen, Xingxing Li, Jihuan Liu, Zhengwei Xu, Yang Zhou, Daohui Wu, Xiaoming Zhang. Insecticide-mediated changes in the population and toxicity of the thrips species, Frankliniella occidentalis (Pergande) and Thrips flavus (Schrank) (Thysanoptera: Thripidae).
Journal of economic entomology.
2023 Dec; ?(?):. doi:
10.1093/jee/toad226. [PMID: 38142234] - Kang Wang, Jia-Qing Li, Shun He, Jun Lu, Dan Wang, Jie-Xin Wang, Jian-Feng Chen. Redox/Near-Infrared Dual-Responsive Hollow Mesoporous Organosilica Nanoparticles for Pesticide Smart Delivery.
Langmuir : the ACS journal of surfaces and colloids.
2023 12; 39(50):18466-18475. doi:
10.1021/acs.langmuir.3c02752. [PMID: 38054693] - Zeinab R Hassan, Samar El-Sayed, Kareman M Zekry, Samah Gouda Ahmed, Asmaa Hassan Abd-Elhamid, Doaa E A Salama, Azza Kamal Taha, Nihal A Mahmoud, Shaymaa Fathy Mohammed, Mona M Amin, Rasha Elsayed Mohamed, Ayat M S Eraque, Shimaa A Mohamed, Ranya M Abdelgalil, Shimaa Attia Atta, Nermeen Talaat Fahmy, Mohamed S Badr. Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis.
Parasitology research.
2023 Dec; 123(1):57. doi:
10.1007/s00436-023-08077-x. [PMID: 38105357] - Behdad Seyyedabadi, Shabnam Babataheri, Ismail Laher, Hamid Soraya. Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats.
Metabolic brain disease.
2023 12; 38(8):2807-2815. doi:
10.1007/s11011-023-01290-8. [PMID: 37755672] - L Laber, C Eichberg, A Zimmerbeutel, R-A Düring, T W Donath. Effects of macrocyclic lactone anthelmintics on seed germination of temperate grassland species.
Plant biology (Stuttgart, Germany).
2023 Dec; 25(7):1046-1057. doi:
10.1111/plb.13577. [PMID: 37703534] - Celeste E Wheeler, Christine Vandervoort, John C Wise. Trunk injection to control Xylosandrus germanus (Coleoptera: Curculionidae) in topworked apple trees.
Journal of economic entomology.
2023 Nov; ?(?):. doi:
10.1093/jee/toad217. [PMID: 38011810] - Juan C Durán-Álvarez, Blanca Prado, Rodolfo Zanella, Mario Rodríguez, Suhaila Díaz. Wastewater surveillance of pharmaceuticals during the COVID-19 pandemic in Mexico City and the Mezquital Valley: A comprehensive environmental risk assessment.
The Science of the total environment.
2023 Nov; 900(?):165886. doi:
10.1016/j.scitotenv.2023.165886. [PMID: 37524191] - Mahmoud Shafeik Sharaf, Ahmad Ali Othman, Amira Elsayed Abdel-Ghaffar, Dareen Mohamed Ali, Mohamed Mahmoud Eid. Crusted scabies in a rabbit model: a severe skin disease or more?.
Parasites & vectors.
2023 Nov; 16(1):413. doi:
10.1186/s13071-023-05995-8. [PMID: 37964301] - Lihong Zhang, Chengwang Sheng, Chaowen Chen, Jian Luo, Zhengyan Wu, Haiqun Cao. Ecofriendly polysaccharide-based alginate/pluronic F127 semi-IPN hydrogel with magnetic collectability for precise release of pesticides and sustained pest control.
International journal of biological macromolecules.
2023 Nov; 251(?):126175. doi:
10.1016/j.ijbiomac.2023.126175. [PMID: 37558040] - Xun-Yan Liu, Ke Li, Deng Pan, Wei Dou, Guo-Rui Yuan, Jin-Jun Wang. Cross-resistance, inheritance and biochemical mechanism of abamectin resistance in a field-derived strain of the citrus red mite, Panonychus citri (Acari: Tetranychidae).
Pest management science.
2023 Oct; ?(?):. doi:
10.1002/ps.7855. [PMID: 37889506] - Yang Shi, Li He, Wenbing Ding, Hong Huang, Hualiang He, Jin Xue, Qiao Gao, Zhixiang Zhang, Youzhi Li, Lin Qiu. Function analysis of CYP321A9 from Spodoptera frugiperda (Lepidoptera: Noctuidae) associated with emamectin benzoate, and a novel insecticide, cyproflanilide detoxification.
Journal of economic entomology.
2023 10; 116(5):1812-1819. doi:
10.1093/jee/toad168. [PMID: 37651729] - Nicolò Di Sora, Luca Rossini, Mario Contarini, Giovanni Mastrandrea, Stefano Speranza. Toumeyella parvicornis versus endotherapic abamectin: three techniques, 1 year after.
Pest management science.
2023 Oct; 79(10):3676-3680. doi:
10.1002/ps.7547. [PMID: 37183578] - Muhammad Usman Ali Khan, Tasleem Akhtar, Nadia Naseem, Usman Aftab, Safdar Hussain, Muhammad Shahzad. Evaluation of therapeutic potential of ivermectin against complete Freund's adjuvant-induced arthritis in rats: Involvement of inflammatory mediators.
Fundamental & clinical pharmacology.
2023 Oct; 37(5):971-982. doi:
10.1111/fcp.12902. [PMID: 37085956] - Busra Aslan Akyol, Cengiz Gokbulut. The effect of intravenous lipid emulsion (ILE) on the pharmacokinetic/toxicokinetic dispositions of ivermectin and carprofen in rabbits.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Sep; ?(?):. doi:
10.1007/s00210-023-02738-5. [PMID: 37768375] - Xiaoli Cao, Jiaping Wei, Huichen Ge, Daojie Guan, Hai Li, Hainan Zhang, Yang Zheng, Kun Qian, Jianjun Wang. Involvement of Glutamate Cysteine Ligase Genes in Tolerance to Emamectin Benzoate in Spodoptera frugiperda and Their Putative Regulatory Mechanisms.
Journal of agricultural and food chemistry.
2023 Sep; 71(37):13717-13728. doi:
10.1021/acs.jafc.3c04392. [PMID: 37691233] - Mingmei Wu, Yan Zhang, Tian Tian, Dandan Xu, Qingjun Wu, Wen Xie, Youjun Zhang, Neil Crickmore, Zhaojiang Guo, Shaoli Wang. Assessment of the role of an ABCC transporter TuMRP1 in the toxicity of abamectin to Tetranychus urticae.
Pesticide biochemistry and physiology.
2023 Sep; 195(?):105543. doi:
10.1016/j.pestbp.2023.105543. [PMID: 37666614] - Borris Rosnay Galani Tietcheu, Theodore Betrosse, Rene Bilingwe Ayiseh, Emmanuel Issa Yuunoeoene, Emmanuel Mfotie Njoya, Francis Nveikoueng, Nicolas Yanou Njintang, Dieudonne Ndjonka. In Vitro Filaricidal Properties of Hydro-Methanolic Extracts of Powdery Fractions of Khaya senegalensis (Meliaceae) on Onchocerca ochengi.
Acta parasitologica.
2023 Jun; ?(?):. doi:
10.1007/s11686-023-00686-x. [PMID: 37336863] - Jinjing Xiao, Yuanhui Liu, Siyuan Jiang, Han Wang, Yuying Liu, Fengxiang Lin, Tianhe Liu, Ke Fang, Min Liao, Yanhong Shi, Haiqun Cao. Incorporating Bioaccessibility into Inhalation Exposure Assessment of Emamectin Benzoate from Field Spraying.
Environmental science & technology.
2023 05; 57(21):7978-7988. doi:
10.1021/acs.est.3c02241. [PMID: 37162498] - JeongWoo Kang, HyunYoung Chae, Md Akil Hossain. Poultry red mite eradication potential of ivermectin and allicin combination treatment.
Veterinary medicine and science.
2023 05; 9(3):1292-1296. doi:
10.1002/vms3.1136. [PMID: 37018122] - Xianheng Ouyang, Qingbin Fan, Anliang Chen, Junhao Huang. Effects of trunk injection with emamectin benzoate on arthropod diversity.
Pest management science.
2023 Mar; 79(3):935-946. doi:
10.1002/ps.7264. [PMID: 36309931] - Ning Zhao, Li Zhu, Meichen Liu, Liangheng He, Hanhong Xu, Jinliang Jia. Enzyme-Responsive Lignin Nanocarriers for Triggered Delivery of Abamectin to Control Plant Root-Knot Nematodes (Meloidogyne incognita).
Journal of agricultural and food chemistry.
2023 Mar; 71(8):3790-3799. doi:
10.1021/acs.jafc.2c07466. [PMID: 36800495] - Xiang Wang, Jian Wang, Ping Zhang, Cheng Zhang, Weiguo Wang, Mengqi Wu, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang. Cytotoxicity and Autophagy Induced by Ivermectin via AMPK/mTOR Signaling Pathway in RAW264.7 Cells.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052201. [PMID: 36903447] - Ming Zhao, Zhenhai Chen, Li Hao, Huayao Chen, Xinhua Zhou, Hongjun Zhou. CMC based microcapsules for smart delivery of pesticides with reduced risks to the environment.
Carbohydrate polymers.
2023 Jan; 300(?):120260. doi:
10.1016/j.carbpol.2022.120260. [PMID: 36372488] - Gaurav Kumar, Shweta Pasi, Chander Prakash Yadav, Jaspreet Kaur, Amit Sharma. Potential of ivermectin as an active ingredient of the attractive toxic sugar baits against the Indian malaria vectors Anopheles culicifacies and Anopheles stephensi.
Pest management science.
2023 Jan; 79(1):474-480. doi:
10.1002/ps.7217. [PMID: 36176013] - Faruk Dube, Andrea Hinas, Nicolas Delhomme, Magnus Åbrink, Staffan Svärd, Eva Tydén. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain.
PloS one.
2023; 18(5):e0285262. doi:
10.1371/journal.pone.0285262. [PMID: 37141255] - Jennifer J Ebel, Kristi Gannon, Mara Kraenzlin. The use of intralipid emulsion therapy to treat status epilepticus in a guinea pig (Cavia porcellus) secondary to severe ivermectin toxicity.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2023 Jan; 33(1):107-111. doi:
10.1111/vec.13254. [PMID: 36082409] - Simona Nardoni, Francesca Mancianti. Essential Oils against Sarcoptes scabiei.
Molecules (Basel, Switzerland).
2022 Dec; 27(24):. doi:
10.3390/molecules27249067. [PMID: 36558200] - Chao Wang, Xinan Li, Decai Jin, Peipan Gong, Qiuchi Li, Yunhui Zhang, Xiangrui Li, Ye Deng, Tomislav Cernava, Xun Zhu. Implications of environmentally shaped microbial communities for insecticide resistance in Sitobion miscanthi.
Environmental research.
2022 12; 215(Pt 2):114409. doi:
10.1016/j.envres.2022.114409. [PMID: 36152886] - Maria A González-Morales, Andrea E Thomson, Olivia A Petritz, Rocio Crespo, Ahmed Haija, Richard G Santangelo, Coby Schal. Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms.
Parasites & vectors.
2022 Nov; 15(1):431. doi:
10.1186/s13071-022-05555-6. [PMID: 36397113] - César García-Hernández, Rolando Rojo-Rubio, Pedro Mendoza-de Gives, Manasés González-Cortazar, Alejandro Zamilpa, Jaime Mondragón-Ancelmo, Abel Villa-Mancera, Jaime Olivares-Pérez, Daniel Tapia-Maruri, Agustín Olmedo-Juárez. In vitro and in vivo anthelmintic properties of Caesalpinia coriaria fruits against Haemonchus contortus.
Experimental parasitology.
2022 Nov; 242(?):108401. doi:
10.1016/j.exppara.2022.108401. [PMID: 36209935] - Molly K Stott, Martha S Phillips, Sophia Sheikh. Intravenous lipid emulsion for ivermectin toxicity in an eight-year-old male.
Clinical toxicology (Philadelphia, Pa.).
2022 11; 60(11):1287-1288. doi:
10.1080/15563650.2022.2134023. [PMID: 36264048] - Qiuhui Wang, Haocheng Wang, Yingxin Zhang, Jing Chen, Archana Upadhyay, Biswajit Bhowmick, Jiayu Hang, Shaoying Wu, Chenghong Liao, Qian Han. Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti.
Pest management science.
2022 Oct; 78(10):4173-4182. doi:
10.1002/ps.7035. [PMID: 35690922] - Liyin Shi, Weiyao Yan, Li Sun, Chaoqun Hou, Nuo Wei, Zhiyang Chen, Jianguo Feng. Preparation and characterization of emamectin benzoate nanocapsules based on the dual role of polydopamine.
Pest management science.
2022 Oct; 78(10):4407-4416. doi:
10.1002/ps.7061. [PMID: 35767285] - Paula Berna da Silva Medeiros, Tiago Manuel Fernandes Mendes, Vera Lucia Garcia, Rosimeire Nunes De Oliveira, Leticia Bastos Duart, Silmara Marques Allegretti. The effect of Spondias mombin L. against Strongyloides venezuelensis: An in vitro approach.
Acta tropica.
2022 Oct; 234(?):106617. doi:
10.1016/j.actatropica.2022.106617. [PMID: 35914566] - Lais Alonso, Miriam Leandro Dorta, Antonio Alonso. Ivermectin and curcumin cause plasma membrane rigidity in Leishmania amazonensis due to oxidative stress.
Biochimica et biophysica acta. Biomembranes.
2022 09; 1864(9):183977. doi:
10.1016/j.bbamem.2022.183977. [PMID: 35654148] - Danielle DeMel, Molly Gleeson, Karen Schachterle, Amanda Thomer. Successful treatment of ivermectin overdose in a bearded dragon (Pogona vitticeps) using gastric lavage and intravenous lipid emulsion.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2022 Sep; 32(5):680-684. doi:
10.1111/vec.13218. [PMID: 35708909] - Manal Bin Qabbus, Katey S Hunt, Joshua Dynka, Craig D Woodworth, Shantanu Sur, Damien S K Samways. Ivermectin-induced cell death of cervical cancer cells in vitro a consequence of precipitate formation in culture media.
Toxicology and applied pharmacology.
2022 Aug; 449(?):116073. doi:
10.1016/j.taap.2022.116073. [PMID: 35605787] - Fernando Calahorro, Mark Chapman, Katarzyna Dudkiewicz, Lindy Holden-Dye, Vincent O'Connor. PharmacoGenetic targeting of a C. elegans essential neuron provides an in vivo screening for novel modulators of nematode ion channel function.
Pesticide biochemistry and physiology.
2022 Aug; 186(?):105152. doi:
10.1016/j.pestbp.2022.105152. [PMID: 35973757] - Aleksandra Barac, Michele Bartoletti, Ozlem Azap, Linda Bussini, Onder Ergonul, Robert Krause, José Ramón Paño-Pardo, Nicholas R Power, Jesús Rodríguez-Baño, Marcella Sibani, Balint Gergely Szabo, Sotirios Tsiodras, Paul E Verweij, Alejandro Martín Quirós, Ines Zollner-Schwetz. Inappropriate use of ivermectin during the COVID-19 pandemic: primum non nocere!.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2022 07; 28(7):908-910. doi:
10.1016/j.cmi.2022.03.022. [PMID: 35337977] - M Mauger, G Kelly, C H Annandale, I D Robertson, F K Waichigo, J W Aleri. Anthelmintic resistance of gastrointestinal nematodes in dairy calves within a pasture-based production system of south West Western Australia.
Australian veterinary journal.
2022 Jul; 100(7):283-291. doi:
10.1111/avj.13162. [PMID: 35383394] - Ran Wang, Yong Fang, Wunan Che, Qinghe Zhang, Jinda Wang, Chen Luo. Metabolic Resistance in Abamectin-Resistant Bemisia tabaci Mediterranean from Northern China.
Toxins.
2022 06; 14(7):. doi:
10.3390/toxins14070424. [PMID: 35878162] - Maria Popp, Stefanie Reis, Selina Schießer, Renate Ilona Hausinger, Miriam Stegemann, Maria-Inti Metzendorf, Peter Kranke, Patrick Meybohm, Nicole Skoetz, Stephanie Weibel. Ivermectin for preventing and treating COVID-19.
The Cochrane database of systematic reviews.
2022 06; 6(?):CD015017. doi:
10.1002/14651858.cd015017.pub3. [PMID: 35726131] - Kunlakanya Jitobaom, Chompunuch Boonarkart, Suwimon Manopwisedjaroen, Nuntaya Punyadee, Suparerk Borwornpinyo, Arunee Thitithanyanont, Panisadee Avirutnan, Prasert Auewarakul. Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations.
BMC pharmacology & toxicology.
2022 06; 23(1):41. doi:
10.1186/s40360-022-00580-8. [PMID: 35717393] - NULL. COVID-19 update: NIH recommends against ivermectin.
The Medical letter on drugs and therapeutics.
2022 06; 64(1652):95-96. doi:
NULL. [PMID: 35657909] - Arman Shafiee, Mohammad Mobin Teymouri Athar, Omid Kohandel Gargari, Kyana Jafarabady, Sepehr Siahvoshi, Sayed-Hamidreza Mozhgani. Ivermectin under scrutiny: a systematic review and meta-analysis of efficacy and possible sources of controversies in COVID-19 patients.
Virology journal.
2022 Jun; 19(1):102. doi:
10.1186/s12985-022-01829-8. [PMID: 35698151] - Samilla Alves Sobral, Carolina Magri Ferraz, Rômulo Inácio Lopes Souza, Luanderson Mendes Queiroz, Natália Reinó, Otavio Luiz Fidelis Junior, Fernando Luiz Tobias, José Antônio Lima Correia, Jackson Victor Araújo, Vinicius Ribeiro Longo Vilela, Filippe Elias Freitas Soares, Fabio Ribeiro Braga. Association between Duddingtonia flagrans, dimethylsulfoxide and ivermectin for the control of Rhabditis spp. in cattle.
Tropical animal health and production.
2022 Jun; 54(4):198. doi:
10.1007/s11250-022-03197-5. [PMID: 35666291] - Martin K Nielsen, Brooke A Littman, Sierra W Orzech, Nichol E Ripley. Equine strongylids: Ivermectin efficacy and fecal egg shedding patterns.
Parasitology research.
2022 Jun; 121(6):1691-1697. doi:
10.1007/s00436-022-07509-4. [PMID: 35384503] - Laoise R Griffin, Emily Katherine Pender, Mary Elizabeth Laing, Trevor Markham. Unexpected consequences of SARS-CoV-2 pandemic: scabies infestation.
Clinical and experimental dermatology.
2022 06; 47(6):1196-1197. doi:
10.1111/ced.15151. [PMID: 35191083] - Luis Ignacio Garegnani, Eva Madrid, Nicolás Meza. Misleading clinical evidence and systematic reviews on ivermectin for COVID-19.
BMJ evidence-based medicine.
2022 06; 27(3):156-158. doi:
10.1136/bmjebm-2021-111678. [PMID: 33888547] - Qingbo Xu, Jinming Li, Wenxiu Guo, Juncheng Xiang, Liqi Zhou, Jianjun Zhang. High Value Utilization of an Avermectin Fermentation Byproduct: Novel B2a Derivatives as Pesticide Candidates.
Journal of agricultural and food chemistry.
2022 Jun; 70(21):6377-6384. doi:
10.1021/acs.jafc.2c01035. [PMID: 35584200] - Maria Popp, Peter Kranke, Patrick Meybohm, Maria-Inti Metzendorf, Nicole Skoetz, Miriam S Stegemann, Stephanie Weibel. Evidence on the efficacy of ivermectin for COVID-19: another story of apples and oranges.
BMJ evidence-based medicine.
2022 06; 27(3):187-188. doi:
10.1136/bmjebm-2021-111791. [PMID: 34417268] - Maria Sophia Unterköfler, Iris Eipeldauer, Sophie Merz, Nikola Pantchev, Josef Hermann, René Brunthaler, Walter Basso, Barbara Hinney. Strongyloides stercoralis infection in dogs in Austria: two case reports.
Parasites & vectors.
2022 May; 15(1):168. doi:
10.1186/s13071-022-05270-2. [PMID: 35570317] - Doaa F El Sherif, Nagat H Soliman, Khalid S Alshallash, Nevin Ahmed, Mervat A R Ibrahim, Kholoud A Al-Shammery, Areej A Al-Khalaf. The Binary Mixtures of Lambda-Cyhalothrin, Chlorfenapyr, and Abamectin, against the House Fly Larvae, Musca domestica L.
Molecules (Basel, Switzerland).
2022 May; 27(10):. doi:
10.3390/molecules27103084. [PMID: 35630573] - Ahmed H Albariqi, Yuncheng Wang, Rachel Yoon Kyung Chang, Diana H Quan, Xiaonan Wang, Stefanie Kalfas, John Drago, Warwick J Britton, Hak-Kim Chan. Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment.
International journal of pharmaceutics.
2022 May; 619(?):121688. doi:
10.1016/j.ijpharm.2022.121688. [PMID: 35314278] - Jinpeng Zheng, Caihong Lu, Yaning Ding, Jinbang Zhang, Fangyun Tan, Jingzhou Liu, Guobao Yang, Yuli Wang, Zhiping Li, Meiyan Yang, Yang Yang, Wei Gong, Chunsheng Gao. Red blood cell-hitchhiking mediated pulmonary delivery of ivermectin: Effects of nanoparticle properties.
International journal of pharmaceutics.
2022 May; 619(?):121719. doi:
10.1016/j.ijpharm.2022.121719. [PMID: 35390488] - Waresi Tuersong, Caixian Zhou, Simin Wu, Peixi Qin, Chunqun Wang, Wenda Di, Lu Liu, Hui Liu, Min Hu. Comparative analysis on transcriptomics of ivermectin resistant and susceptible strains of Haemonchus contortus.
Parasites & vectors.
2022 May; 15(1):159. doi:
10.1186/s13071-022-05274-y. [PMID: 35524281] - Gilmar Reis, Eduardo A S M Silva, Daniela C M Silva, Lehana Thabane, Aline C Milagres, Thiago S Ferreira, Castilho V Q Dos Santos, Vitoria H S Campos, Ana M R Nogueira, Ana P F G de Almeida, Eduardo D Callegari, Adhemar D F Neto, Leonardo C M Savassi, Maria I C Simplicio, Luciene B Ribeiro, Rosemary Oliveira, Ofir Harari, Jamie I Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Christina M Guo, Karen Rowland-Yeo, Gordon H Guyatt, David R Boulware, Craig R Rayner, Edward J Mills. Effect of Early Treatment with Ivermectin among Patients with Covid-19.
The New England journal of medicine.
2022 05; 386(18):1721-1731. doi:
10.1056/nejmoa2115869. [PMID: 35353979] - Karen Cardwell, Eamon O Murchu, Paula Byrne, Natasha Broderick, Kieran A Walsh, Sinéad M O'Neill, Susan M Smith, Patricia Harrington, Máirín Ryan, Michelle O'Neill. Pharmacological interventions to prevent Covid-19 disease: A rapid review.
Reviews in medical virology.
2022 05; 32(3):e2299. doi:
10.1002/rmv.2299. [PMID: 34582072] - Andreea Molnar, Stephanie Lau, Maja Berges, Raymond B Masa, Joshua J Solano, Scott M Alter, Lisa M Clayton, Richard D Shih, David L DeMets, Dennis G Maki, Charles H Hennekens. Ivermectin in COVID-19: The Case for a Moratorium on Prescriptions.
Therapeutic innovation & regulatory science.
2022 05; 56(3):382-385. doi:
10.1007/s43441-022-00378-0. [PMID: 35147927] - Satish Kumar Sharma, Pankaj Bhatt, Syed Mohammed Basheeruddin Asdaq, Mohammed Kanan Alshammari, Abeer Alanazi, Naif Saleh Alrasheedi, Bader Abdullah Alrashdi, Saad Saleh Alyami, Bshayer Hamdan Alhazmi, Perwaiz Alam, Prerna Sharma, Ritu Tomar, Mandeep K Arora, Mohd Imran. Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review.
Journal of infection and public health.
2022 May; 15(5):566-572. doi:
10.1016/j.jiph.2022.03.014. [PMID: 35462191] - Dora Buonfrate, Eliana Rulli, Zeno Bisoffi. Reply to: Viral load reduction and high-dose ivermectin in early treatment: a reappraisal.
International journal of antimicrobial agents.
2022 05; 59(5):106576. doi:
10.1016/j.ijantimicag.2022.106576. [PMID: 35322791] - Mei Nee Chiu, Maitry Bhardwaj, Sangeeta Pilkhwal Sah. Safety profile of COVID-19 drugs in a real clinical setting.
European journal of clinical pharmacology.
2022 May; 78(5):733-753. doi:
10.1007/s00228-021-03270-2. [PMID: 35088108] - Simone Tedeschi, Luigi Ventura. Viral Load Reduction and High-Dose Ivermectin in Early Treatment: A Reappraisal.
International journal of antimicrobial agents.
2022 05; 59(5):106575. doi:
10.1016/j.ijantimicag.2022.106575. [PMID: 35322790] - Daniel Echeverría-Esnal, Santiago Grau. Ivermectin: a pathway out of the pandemic or another dead end?.
Expert review of anti-infective therapy.
2022 05; 20(5):645-647. doi:
10.1080/14787210.2022.2012154. [PMID: 34894986] - Changcheng An, Jianxia Cui, Qin Yu, Bingna Huang, Ningjun Li, Jiajun Jiang, Yue Shen, Chong Wang, Shenshan Zhan, Xiang Zhao, Xingye Li, Changjiao Sun, Bo Cui, Chunxin Wang, Fei Gao, Zhanghua Zeng, Haixin Cui, Runxiang Zhang, Yan Wang. Polylactic acid nanoparticles for co-delivery of dinotefuran and avermectin against pear tree pests with improved effective period and enhanced bioactivity.
International journal of biological macromolecules.
2022 May; 206(?):633-641. doi:
10.1016/j.ijbiomac.2022.02.182. [PMID: 35247422] - Titouan Launay, Isabelle Bardoulat, Magali Lemaitre, Thierry Blanchon, Laurence Fardet. Effects of the COVID-19 pandemic on head lice and scabies infestation dynamics: a population-based study in France.
Clinical and experimental dermatology.
2022 May; 47(5):867-872. doi:
10.1111/ced.15054. [PMID: 34888912] - Kelly Johnson-Arbor. Ivermectin: a mini-review.
Clinical toxicology (Philadelphia, Pa.).
2022 May; 60(5):571-575. doi:
10.1080/15563650.2022.2043338. [PMID: 35225114] - Andrew Hill, Manya Mirchandani, Leah Ellis, Victoria Pilkington. Ivermectin for the prevention of COVID-19: addressing potential bias and medical fraud.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1413-1416. doi:
10.1093/jac/dkac052. [PMID: 35190831] - Daojie Guan, Xuemei Yang, Heng Jiang, Nan Zhang, Zhaolu Wu, Chengyun Jiang, Qinwen Shen, Kun Qian, Jianjun Wang, Xiangkun Meng. Identification and Validation of ATP-Binding Cassette Transporters Involved in the Detoxification of Abamectin in Rice Stem Borer, Chilo suppressalis.
Journal of agricultural and food chemistry.
2022 Apr; 70(15):4611-4619. doi:
10.1021/acs.jafc.2c00414. [PMID: 35410476] - Gideon Meyerowitz-Katz, Sarah Wieten, María de Jesús Medina Arellano, Gavin Yamey. Unethical studies of ivermectin for covid-19.
BMJ (Clinical research ed.).
2022 04; 377(?):o917. doi:
10.1136/bmj.o917. [PMID: 35422425] - Amira F Gad. Emamectin benzoate as a potential molluscicide against white garden snail, Theba pisana in association with biochemical defects.
Pest management science.
2022 Apr; 78(4):1657-1664. doi:
10.1002/ps.6785. [PMID: 34989113]