Diospyrin (BioDeep_00000270198)

Main id: BioDeep_00000021535

 

PANOMIX_OTCML-2023


代谢物信息卡片


3,4,5,7,3,4,5-Heptahydroxyflavan 3-O-glucopyranoside

化学式: C21H24O13 (484.1217)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=C(O)C(O)=C(O)C=3)C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C(O)C=2C(O)=C1
InChI: InChI=1S/C21H24O13/c22-5-12-15(28)17(30)18(31)21(33-12)34-20-16(29)13-8(24)3-7(23)4-11(13)32-19(20)6-1-9(25)14(27)10(26)2-6/h1-4,12,15-31H,5H2/t12-,15-,16?,17+,18-,19?,20?,21+/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Diospyrin; 3,4,5,7,3,4,5-Heptahydroxyflavan 3-O-glucopyranoside



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Premysl Landa, Zsofia Kutil, Veronika Temml, Anna Vuorinen, Jan Malik, Marcela Dvorakova, Petr Marsik, Ladislav Kokoska, Marie Pribylova, Daniela Schuster, Tomas Vanek. Redox and non-redox mechanism of in vitro cyclooxygenase inhibition by natural quinones. Planta medica. 2012 Mar; 78(4):326-33. doi: 10.1055/s-0031-1280430. [PMID: 22174077]
  • Xiaoning Wang, Eman Habib, Francisco León, Mohamed M Radwan, Nurhayat Tabanca, Jiangtao Gao, David E Wedge, Stephen J Cutler. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chemistry & biodiversity. 2011 Dec; 8(12):2331-40. doi: 10.1002/cbdv.201000310. [PMID: 22162171]
  • Banasri Hazra, Subhalakshmi Ghosh, Amit Kumar, B N Pandey. The prospective role of plant products in radiotherapy of cancer: a current overview. Frontiers in pharmacology. 2011; 2(?):94. doi: 10.3389/fphar.2011.00094. [PMID: 22291649]
  • Sunil Sagar, Mandeep Kaur, Kenneth P Minneman, Vladimir B Bajic. Anti-cancer activities of diospyrin, its derivatives and analogues. European journal of medicinal chemistry. 2010 Sep; 45(9):3519-30. doi: 10.1016/j.ejmech.2010.06.021. [PMID: 20615584]
  • Supriya Baikar, Nutan Malpathak. Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. Pharmacognosy reviews. 2010 Jan; 4(7):12-26. doi: 10.4103/0973-7847.65320. [PMID: 22228937]
  • Piyali Mukherjee, Sutapa Biswas Majee, Subhalakshmi Ghosh, Banasri Hazra. Apoptosis-like death in Leishmania donovani promastigotes induced by diospyrin and its ethanolamine derivative. International journal of antimicrobial agents. 2009 Dec; 34(6):596-601. doi: 10.1016/j.ijantimicag.2009.08.007. [PMID: 19783125]
  • Binod Kumar, Amit Kumar, B N Pandey, K P Mishra, Banasri Hazra. Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. Molecular and cellular biochemistry. 2009 Jan; 320(1-2):185-95. doi: 10.1007/s11010-008-9920-4. [PMID: 18836818]
  • Madhushree Das Sarma, Rina Ghosh, Amarendra Patra, Rajdeep Chowdhury, Keya Chaudhuri, Banasri Hazra. Novel glycoconjugates of diospyrin, a quinonoid plant product: synthesis and evaluation of cytotoxicity against human malignant melanoma (A375) and laryngeal carcinoma (Hep2). Organic & biomolecular chemistry. 2007 Oct; 5(19):3115-25. doi: 10.1039/b707851j. [PMID: 17878970]
  • Binod Kumar, Jayashree Joshi, Amit Kumar, Badri N Pandey, Banasri Hazra, Kaushala P Mishra. Radiosensitization by diospyrin diethylether in MCF-7 breast carcinoma cell line. Molecular and cellular biochemistry. 2007 Oct; 304(1-2):287-96. doi: 10.1007/s11010-007-9511-9. [PMID: 17534696]
  • Madhushree Das Sarma, Rina Ghosh, Amarendra Patra, Banasri Hazra. Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid. Bioorganic & medicinal chemistry. 2007 Jun; 15(11):3672-7. doi: 10.1016/j.bmc.2007.03.050. [PMID: 17400463]
  • B Hazra, M Das Sarma, B Kumar, S Basu, K Das, B N Pandey, K P Mishra. Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells in vitro and in vivo. Chemotherapy. 2007; 53(3):173-6. doi: 10.1159/000100514. [PMID: 17347562]
  • S Ganapaty, P Steve Thomas, Gloria Karagianis, Peter G Waterman, Reto Brun. Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis. Phytochemistry. 2006 Sep; 67(17):1950-6. doi: 10.1016/j.phytochem.2006.05.039. [PMID: 16890968]
  • Syamasri Gupta, S P Moulik, Banasri Hazra, Rekha Ghosh, S K Sanyal, S Datta. New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound. Drug delivery. 2006 May; 13(3):193-9. doi: 10.1080/10717540500455983. [PMID: 16556571]
  • B Hazra, B Kumar, S Biswas, B N Pandey, K P Mishra. Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation. Toxicology letters. 2005 Jun; 157(2):109-17. doi: 10.1016/j.toxlet.2005.01.016. [PMID: 15836998]
  • Banasri Hazra, Madhushree Das Sarma, Utpal Sanyal. Separation methods of quinonoid constituents of plants used in Oriental traditional medicines. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Dec; 812(1-2):259-75. doi: 10.1016/j.jchromb.2004.08.007. [PMID: 15556503]
  • Seru Ganapaty, Pannakal Steve Thomas, Serge Fotso, Hartmut Laatsch. Antitermitic quinones from Diospyros sylvatica. Phytochemistry. 2004 May; 65(9):1265-71. doi: 10.1016/j.phytochem.2004.03.011. [PMID: 15184011]
  • Utpal Sanyal, Saswati Bhattacharyya, Amarendra Patra, Banasri Hazra. Liquid chromatographic separation of derivatives of diospyrin, a bioactive bisnaphthoquinonoid plant-product, and analogous naphthyl compounds. Journal of chromatography. A. 2003 Oct; 1017(1-2):225-32. doi: 10.1016/j.chroma.2003.08.008. [PMID: 14584707]
  • N Lall, M Das Sarma, B Hazra, J J M Meyer. Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro. The Journal of antimicrobial chemotherapy. 2003 Feb; 51(2):435-8. doi: 10.1093/jac/dkg068. [PMID: 12562718]
  • Sutapa Chakrabarty, Madhumita Roy, Banasri Hazra, R K Bhattacharya. Induction of apoptosis in human cancer cell lines by diospyrin, a plant-derived bisnaphthoquinonoid, and its synthetic derivatives. Cancer letters. 2002 Dec; 188(1-2):85-93. doi: 10.1016/s0304-3835(02)00494-9. [PMID: 12406552]
  • Banasri Hazra, Rajes Sarkar, Saswati Bhattacharyya, Prabir K Ghosh, Gautam Chel, Biswanath Dinda. Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro. Phytotherapy research : PTR. 2002 Mar; 16(2):133-7. doi: 10.1002/ptr.867. [PMID: 11933114]
  • N Lall, J J Meyer. Inhibition of drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis. Journal of ethnopharmacology. 2001 Dec; 78(2-3):213-6. doi: 10.1016/s0378-8741(01)00356-7. [PMID: 11694367]