Poricoic (BioDeep_00000231005)

 

Secondary id: BioDeep_00000230353, BioDeep_00000264966, BioDeep_00000859536

PANOMIX_OTCML-2023


代谢物信息卡片


(2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,6,7,8,9b-octahydro-1H-cyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid

化学式: C31H46O5 (498.3345066)
中文名称: 茯苓新酸 A, 茯苓新酸A, 茯苓酸A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 70.83%

分子结构信息

SMILES: C=C(CC[C@@H](C(=O)O)[C@H]1[C@H](O)C[C@@]2(C)C3=CC[C@@H](C(=C)C)[C@](C)(CCC(=O)O)C3=CC[C@]12C)C(C)C
InChI: InChI=1S/C31H46O5/c1-18(2)20(5)9-10-21(28(35)36)27-25(32)17-31(8)24-12-11-22(19(3)4)29(6,15-14-26(33)34)23(24)13-16-30(27,31)7/h12-13,18,21-22,25,27,32H,3,5,9-11,14-17H2,1-2,4,6-8H3,(H,33,34)(H,35,36)/t21-,22+,25-,27+,29+,30-,31+/m1/s1

描述信息

Poricoic acid A is a tricyclic triterpenoid isolated from Poria cocos. It has a role as a fungal metabolite. It is a tricyclic triterpenoid, a dicarboxylic acid and a secondary alcohol.
Poricoic acid A is a natural product found in Phellodendron amurense and Wolfiporia cocos with data available.
A tricyclic triterpenoid isolated from Poria cocos.
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity[1]. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis[2].
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity[1]. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis[2].

同义名列表

11 个代谢物同义名

(2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,6,7,8,9b-octahydro-1H-cyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,7,8-hexahydrocyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid; (2R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-carboxyethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-1,2,3,4,7,8-hexahydrocyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylene-heptanoic acid; (2R,3R,3aR,6S,7S,9bR)-3-[(1R)-1-Carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-1H-benz[e]indene-6-propanoic acid; (R)-2-[(2R,3R,3aR,6S,7S,9bR)-6-(2-Carboxy-ethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-2,3,3a,4,6,7,8,9b-octahydro-1H-benz[e]inden-3-yl]-6-methyl-5-methylene-heptanoic acid; 16.alpha.-Hydroxy-3,7,9(11),24(24(sup 1))-tetraene-3,21-dioic acid; Poricoic acid A(F); Poricoic acid A; PoricoicacidA; NCI60_039753; Poricoic



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuwen Wu, Haohua Deng, Jiazhong Sun, Jun Tang, Xin Li, Yancheng Xu. Poricoic acid A induces mitophagy to ameliorate podocyte injury in diabetic kidney disease via downregulating FUNDC1. Journal of biochemical and molecular toxicology. 2023 Sep; ?(?):e23503. doi: 10.1002/jbt.23503. [PMID: 37706594]
  • Zhi-Heng Shu, Cai-Lian Fan, Hong-Yan Wei, Zi-Ting Li, Hisayoshi Norimoto, Xi-Yang Tang, Zhi-Hong Yao, Xin-Sheng Yao, Yi Dai. An integrated strategy by absorbed component characterization, pharmacokinetics, and activity evaluation for identification of potential nephroprotective substances in Zhu-Ling decoction. Journal of separation science. 2023 Sep; 46(17):e2300331. doi: 10.1002/jssc.202300331. [PMID: 37438987]
  • Dan-Qian Chen, Yan-Ni Wang, Nosratola D Vaziri, Lin Chen, He-He Hu, Ying-Yong Zhao. Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153232. doi: 10.1016/j.phymed.2020.153232. [PMID: 32460034]
  • Ya-Long Feng, Gang Cao, Dan-Qian Chen, Nosratola D Vaziri, Lin Chen, Jun Zhang, Ming Wang, Yan Guo, Ying-Yong Zhao. Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease. Cellular and molecular life sciences : CMLS. 2019 Dec; 76(24):4961-4978. doi: 10.1007/s00018-019-03155-9. [PMID: 31147751]
  • Dan-Qian Chen, Ya-Long Feng, Lin Chen, Jing-Ru Liu, Ming Wang, Nosratola D Vaziri, Ying-Yong Zhao. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Free radical biology & medicine. 2019 04; 134(?):484-497. doi: 10.1016/j.freeradbiomed.2019.01.046. [PMID: 30716432]
  • Ming Wang, Dan-Qian Chen, Lin Chen, Gang Cao, Hui Zhao, Dan Liu, Nosratola D Vaziri, Yan Guo, Ying-Yong Zhao. Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis. British journal of pharmacology. 2018 07; 175(13):2689-2708. doi: 10.1111/bph.14333. [PMID: 29679507]
  • Motohiko Ukiya, Toshihiro Akihisa, Harukuni Tokuda, Masaya Hirano, Manabu Oshikubo, Yoshitoshi Nobukuni, Yumiko Kimura, Takaaki Tai, Seizo Kondo, Hoyoku Nishino. Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos. Journal of natural products. 2002 Apr; 65(4):462-5. doi: 10.1021/np0103721. [PMID: 11975480]
  • T Akihisa, J Ogihara, J Kato, K Yasukawa, M Ukiya, S Yamanouchi, K Oishi. Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase. Lipids. 2001 May; 36(5):507-12. doi: 10.1007/s11745-001-0750-4. [PMID: 11432464]