asarone (BioDeep_00000230827)

Main id: BioDeep_00000000098

Secondary id: BioDeep_00000008089, BioDeep_00000861156

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


beta-Asarone; 1,2,4-Trimethoxy-5-[(Z)-prop-1-enyl]benzene; ?-Asarone

化学式: C12H16O3 (208.1099386)
中文名称: β-细辛醚, 顺式2,4,5-三甲氧基-1-丙烯基苯, β-细辛脑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C/c1cc(OC)c(OC)cc1OC
InChI: InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3

描述信息

A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.
Asarone is a phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus. It has a role as a plant metabolite. It is a phenylpropanoid, a member of methoxybenzenes and an alkenylbenzene.
beta-Asarone is a natural product found in Asarum hypogynum, Carpesium abrotanoides, and other organisms with data available.
See also: Acorus calamus root (part of).
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D009676 - Noxae > D002273 - Carcinogens
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents
The cis-isomer of asarone.
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease[1].
Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties of immunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease[1].

同义名列表

53 个代谢物同义名

asarone; beta-Asarone; 1,2,4-Trimethoxy-5-[(Z)-prop-1-enyl]benzene; ?-Asarone; (z)-1 pound not2 pound not4-trimethoxy-5-(1-propenyl)benzene; beta-Asarone, primary pharmaceutical reference standard; 1,2,4-Trimethoxy-5-((z)-1-propenyl)benzene, ?-asarone; benzene, 1,2,4-trimethoxy-5-(1E)-1-propen-1-yl-; 1,2,4-trimethoxy-5-((1Z)-prop-1-en-1-yl)benzene; 1,2,4-trimethoxy-5-[(1Z)-prop-1-en-1-yl]benzene; BENZENE, 1,2,4-TRIMETHOXY-5-(1Z)-1-PROPEN-1-YL-; benzene, 1,2,4-trimethoxy-5-(1-propenyl)-, (E)-; benzene, 1,2,4-trimethoxy-5-(1-propenyl)-, (Z)-; Benzene, 1,2,4-trimethoxy-5-(1Z)-1-propenyl-; cis-2,4,5-Trimethoxy-1-propenylbenzene, 70\\%; 3-06-00-06440 (Beilstein Handbook Reference); 1,2,4-Trimethoxy-5-[(1Z)-1-propenyl]benzene; 1,2,4-trimethoxy-5-[(Z)-prop-1-enyl]benzene; BENZENE, 1,2,4-TRIMETHOXY-5-PROPENYL-, (Z)-; 1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene; (Z)-1,2,4-Trimethoxy-5-(1-propenyl)benzene; (Z)-1-(2,4,5-Trimethoxyphenyl)-1-propene; cis-2,4,5-Trimethoxy-1-propenylbenzene; cis-1-Propenyl-2,4,5-trimethoxybenzene; 1,2,4-trimethoxy-5-propenylbenzene, z-; (Z)-5-Propenyl-1,2,4-trimethoxybenzene; 2,4,5-trimethoxypropen-1-ylbenzene; cis-2,4,5-trimethoxyphenylpropene; .BETA.-ASARONE, CIS-; asarone, (Z)-isomer; asarone, (E)-isomer; (Z)-.beta.-Asarone; beta-ASARONE, CIS-; cis-.beta.-Asarone; cis-beta-asarone; UNII-IGA3MH6IUW; cis-isoelemicin; .beta.-Asarone; cis-isoasarone; alpha-asarone; gamma-asarone; trans-asarone; beta-Asarone; I(2)-Asarone; beta-asaron; (E)-asarone; cis-Asarone; (Z)-asarone; Cis-Asaron; isoasarone; IGA3MH6IUW; β-Asarone; AI3-36897; beta-Asarone; beta-Asarone



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bhani Kongkham, P Duraivadivel, P Hariprasad. Acorus calamus L. rhizome extract and its bioactive fraction exhibits antibacterial effect by modulating membrane permeability and fatty acid composition. Journal of ethnopharmacology. 2024 Sep; 331(?):118323. doi: 10.1016/j.jep.2024.118323. [PMID: 38729535]
  • Zhifang Wang, Jingpei Zhou, Bin Zhang, Zhanqiong Xu, Haoyu Wang, Quan Sun, Nanbu Wang. Inhibitory effects of β-asarone on lncRNA BACE1-mediated induction of autophagy in a model of Alzheimer's disease. Behavioural brain research. 2024 Apr; 463(?):114896. doi: 10.1016/j.bbr.2024.114896. [PMID: 38316166]
  • Zhenqiu Ning, Xiaoqin Zhong, Yanan Wu, Yu Wang, Dafeng Hu, Kai Wang, Minzhen Deng. β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155215. doi: 10.1016/j.phymed.2023.155215. [PMID: 38039902]
  • Xiao Zhao, Lixue Sun, Jing Wang, Xiaolu Xu, Shuting Ni, Mei Liu, Kaili Hu. Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy. International journal of pharmaceutics. 2023 Sep; 644(?):123351. doi: 10.1016/j.ijpharm.2023.123351. [PMID: 37640088]
  • Saihong Zhao, Pingping Zhang, Yonghuan Yan, Weifang Xu, Jiacheng Li, Lei Wang, Ning Wang, Yingying Huang. Network pharmacology-based prediction and validation of the active ingredients and potential mechanisms of the Huangxiong formula for treating ischemic stroke. Journal of ethnopharmacology. 2023 Aug; 312(?):116507. doi: 10.1016/j.jep.2023.116507. [PMID: 37080367]
  • Yuman Xie, Li Liu, Junzuo Zheng, Kun Shi, Wenqi Ai, Xuesong Zhang, Ping Wang, Zhou Lan, Lvyi Chen. Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins. Journal of ethnopharmacology. 2023 Mar; 311(?):116400. doi: 10.1016/j.jep.2023.116400. [PMID: 37003402]
  • Xirui He, Xufei Chen, Yan Yang, Yujie Liu, Yulu Xie. Acorus calamus var. angustatus Besser: Insight into current research on ethnopharmacological use, phytochemistry, pharmacology, toxicology, and pharmacokinetics. Phytochemistry. 2023 Mar; ?(?):113626. doi: 10.1016/j.phytochem.2023.113626. [PMID: 36871902]
  • Lu Yan, Chu-Han Liu, Li Xu, Yi-Yun Qian, Ping-Ping Song, Min Wei, Bao-Lin Liu. Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction. CNS neuroscience & therapeutics. 2023 Mar; 29(3):941-956. doi: 10.1111/cns.14030. [PMID: 36575869]
  • Xiaofeng Gao, Rui Li, Lijun Luo, Can Liao, Huiyuan Yang, Shengjun Mao. Alpha-Asarone Ameliorates Neurological Dysfunction of Subarachnoid Hemorrhagic Rats in Both Acute and Recovery Phases via Regulating the CaMKII-Dependent Pathways. Translational stroke research. 2023 Feb; ?(?):. doi: 10.1007/s12975-023-01139-3. [PMID: 36781743]
  • Ismail Ware, Katrin Franke, Mthandazo Dube, Hesham Ali El Enshasy, Ludger A Wessjohann. Characterization and Bioactive Potential of Secondary Metabolites Isolated from Piper sarmentosum Roxb. International journal of molecular sciences. 2023 Jan; 24(2):. doi: 10.3390/ijms24021328. [PMID: 36674844]
  • Haoyun Bai, Zhuoyin Xue, Wen Zhang, Chaohua Feng, Zhenqi Zhou, Shiling Hu, Yongjing Zhang, Qiaohong Qin, Yuanyuan Wu, Xiuzhen Sun, Yuhan Zhou, Nan Wang. α-Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2-STAT3 pathway. BioFactors (Oxford, England). 2023 Jan; 49(1):140-152. doi: 10.1002/biof.1879. [PMID: 35861676]
  • Di Zhang, Xin Li, Bei Jing, Zhenni Chen, Huimei Shi, Yachun Zheng, Shiquan Chang, Jianxin Sun, Guoping Zhao. α-Asarone attenuates chronic sciatica by inhibiting peripheral sensitization and promoting neural repair. Phytotherapy research : PTR. 2023 Jan; 37(1):151-162. doi: 10.1002/ptr.7603. [PMID: 36070878]
  • Paweł Szczeblewski, Mateusz Wróblewski, Julia Borzyszkowska-Bukowska, Tetiana Bairamova, Justyna Górska, Tomasz Laskowski, Anna Samulewicz, Michał Kosno, Łukasz Sobiech, Justyna Teresa Polit, Wirginia Kukula-Koch. The role of centrifugal partition chromatography in the removal of β-asarone from Acorus calamus essential oil. Scientific reports. 2022 12; 12(1):22217. doi: 10.1038/s41598-022-26726-6. [PMID: 36564541]
  • Li-Jing Du, Xin-Ning Zhang, Sha-Sha Li, Yuan-Fang Sun, Hui-Zi Jin, Shi-Kai Yan, Chuan-Gang Han. Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression. Metabolic brain disease. 2022 12; 37(8):2903-2914. doi: 10.1007/s11011-022-01067-5. [PMID: 36070047]
  • Hyojin Kim, Jin Young Maeng, Dan Bi Lee, Kyung Hyun Kim, Mi Sook Chung. Antiviral Activities of Asarones and Rhizomes of Acorus gramineus on Murine Norovirus. Viruses. 2022 10; 14(10):. doi: 10.3390/v14102228. [PMID: 36298783]
  • Kirubakaran Nithya, Sreeramulu Bhuvaragavan, Kannan Sruthi, Mani Meenakumari, Sathappan Shanthi, Sundaram Janarthanan. Purification, characterization and larvicidal activity of a potent bioactive compound asarone from leaves of Acorus calamus against the culician larval mosquitoes. Parasitology international. 2022 Oct; 90(?):102620. doi: 10.1016/j.parint.2022.102620. [PMID: 35792323]
  • Xiaofeng Gao, Rui Li, Lijun Luo, Di Zhang, Qi Liu, Jian Zhang, Shengjun Mao. Alpha-asarone ameliorates neurological deterioration of intracerebral hemorrhagic rats by alleviating secondary brain injury via anti-excitotoxicity pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Oct; 105(?):154363. doi: 10.1016/j.phymed.2022.154363. [PMID: 35926378]
  • Ran Wang, Yong Fang, Wunan Che, Qinghe Zhang, Jinda Wang, Chen Luo. The Toxicity, Sublethal Effects, and Biochemical Mechanism of β-Asarone, a Potential Plant-Derived Insecticide, against Bemisia tabaci. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810462. [PMID: 36142377]
  • Jian Zhang, Keman Mu, Peng Yang, Xinqian Feng, Di Zhang, Xiangyu Fan, Qiantao Wang, Shengjun Mao. Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives. Bioorganic chemistry. 2021 10; 115(?):105179. doi: 10.1016/j.bioorg.2021.105179. [PMID: 34332232]
  • Kun Zhang, Qi Liu, Lijun Luo, Xinqian Feng, Qinrui Hu, Xiangyu Fan, Shengjun Mao. Neuroprotective Effect of Alpha-asarone on the Rats Model of Cerebral Ischemia-Reperfusion Stroke via Ameliorating Glial Activation and Autophagy. Neuroscience. 2021 10; 473(?):130-141. doi: 10.1016/j.neuroscience.2021.08.006. [PMID: 34416342]
  • Jian Zou, Shuai Zhang, Huan Zhao, Yong-Heng Wang, Zheng-Qun Zhou, Guo-Dong Chen, Dan Hu, Ning Li, Xin-Sheng Yao, Hao Gao. Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875. Chinese journal of natural medicines. 2021 Sep; 19(9):700-705. doi: 10.1016/s1875-5364(21)60088-2. [PMID: 34561082]
  • Thomas Uebel, Lena Hermes, Sabrina Haupenthal, Lena Müller, Melanie Esselen. α-Asarone, β-asarone, and γ-asarone: Current status of toxicological evaluation. Journal of applied toxicology : JAT. 2021 08; 41(8):1166-1179. doi: 10.1002/jat.4112. [PMID: 33236787]
  • Min Yi, Dongsheng Wang, Yanyi Chen, Xia Xu, Xingping Dai. β-Asarone suppresses TNF-α expression through DNA methylation and c-Jun-mediated transcription modulation in scratch-injured neuronal cells. Journal of biochemical and molecular toxicology. 2021 Jul; 35(7):e22798. doi: 10.1002/jbt.22798. [PMID: 33969572]
  • Heng Zhu, Iftikhar Ali, Hidayat Hussain, Manzoor Hussain, Xing-Bao Wang, Xiangyun Song, Ge Luo, Zhenfang Zhang, Zhigang Wang, Daijie Wang. Extraction and purification of cis/trans asarone from Acorus tatarinowii Schott: Accelerated solvent extraction and silver ion coordination high-speed counter-current chromatography. Journal of chromatography. A. 2021 Apr; 1643(?):462080. doi: 10.1016/j.chroma.2021.462080. [PMID: 33799073]
  • Lili Zeng, Di Zhang, Qi Liu, Jian Zhang, Keman Mu, Xiaofeng Gao, Kun Zhang, Hui Li, Qiantao Wang, Yongxiang Zheng, Shengjun Mao. Alpha-asarone Improves Cognitive Function of APP/PS1 Mice and Reducing Aβ42, P-tau and Neuroinflammation, and Promoting Neuron Survival in the Hippocampus. Neuroscience. 2021 03; 458(?):141-152. doi: 10.1016/j.neuroscience.2020.12.026. [PMID: 33412244]
  • Xueliang Xu, Xiang Li, Zirong Liu, Fenshan Wang, Linjuan Fan, Caiyun Wu, Yingjuan Yao. Knockdown of CYP301B1 and CYP6AX1v2 increases the susceptibility of the brown planthopper to beta-asarone, a potential plant-derived insecticide. International journal of biological macromolecules. 2021 Feb; 171(?):150-157. doi: 10.1016/j.ijbiomac.2020.12.217. [PMID: 33418039]
  • Masashi Mikami, Ohba Takuya, Yuta Yoshino, Shinsuke Nakamura, Kenichi Ito, Hiroyuki Kojima, Tatsuji Takahashi, Arunasiri Iddamalgoda, Shintaro Inoue, Masamitsu Shimazawa, Hideaki Hara. Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin. Bioscience, biotechnology, and biochemistry. 2021 Feb; 85(3):493-501. doi: 10.1093/bbb/zbaa071. [PMID: 33589895]
  • Lena Hermes, Janis Römermann, Benedikt Cramer, Melanie Esselen. Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS. Journal of agricultural and food chemistry. 2021 Jan; 69(2):776-782. doi: 10.1021/acs.jafc.0c05513. [PMID: 33410326]
  • Nanbu Wang, Haoyu Wang, Qi Pan, Jian Kang, Ziwen Liang, Ronghua Zhang. The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer's Disease. Oxidative medicine and cellular longevity. 2021; 2021(?):7158444. doi: 10.1155/2021/7158444. [PMID: 34887998]
  • Prakash Ramalingam, Palanivel Ganesan, D S Prabakaran, Pardeep K Gupta, Sriramakamal Jonnalagadda, Karthivashan Govindarajan, Revuri Vishnu, Kalaiselvi Sivalingam, Srushti Sodha, Dong-Kug Choi, Young Tag Ko. Lipid Nanoparticles Improve the Uptake of α-Asarone Into the Brain Parenchyma: Formulation, Characterization, In Vivo Pharmacokinetics, and Brain Delivery. AAPS PharmSciTech. 2020 Nov; 21(8):299. doi: 10.1208/s12249-020-01832-8. [PMID: 33140227]
  • Yufeng Han, Nanbu Wang, Jian Kang, Yongqi Fang. β-Asarone improves learning and memory in Aβ1-42-induced Alzheimer's disease rats by regulating PINK1-Parkin-mediated mitophagy. Metabolic brain disease. 2020 10; 35(7):1109-1117. doi: 10.1007/s11011-020-00587-2. [PMID: 32556928]
  • Aline Aparecida Saldanha, Letícia Vieira, Flávio Martins de Oliveira, Débora de Oliveira Lopes, Rosy Iara Maciel de Azambuja Ribeiro, Ralph Gruppi Thomé, Hélio Batista Dos Santos, Denise Brentan Silva, Carlos Alexandre Carollo, João Máximo de Siqueira, Adriana Cristina Soares. Anti-inflammatory and central and peripheral anti-nociceptive activities of α-asarone through the inhibition of TNF-α production, leukocyte recruitment and iNOS expression, and participation of the adenosinergic and opioidergic systems. Inflammopharmacology. 2020 Aug; 28(4):1039-1052. doi: 10.1007/s10787-019-00679-1. [PMID: 31865494]
  • Lena Hermes, Sabrina Haupenthal, Thomas Uebel, Melanie Esselen. DNA double strand break repair as cellular response to genotoxic asarone isomers considering phase I metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Aug; 142(?):111484. doi: 10.1016/j.fct.2020.111484. [PMID: 32526244]
  • Xinxin Hei, Miao Xie, Jingqian Xu, Jinjin Li, Tao Liu. β-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway. Neurochemical research. 2020 Aug; 45(8):1953-1961. doi: 10.1007/s11064-020-03060-9. [PMID: 32623664]
  • Bin Xiao, Xiaobo Huang, Qian Wang, Yanchuan Wu. Beta-Asarone Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammatory Response and NLRP3 Inflammasome Mediated Pyroptosis. Biological & pharmaceutical bulletin. 2020 Jul; 43(7):1046-1051. doi: 10.1248/bpb.b19-00926. [PMID: 32321872]
  • Yu Chen, Xiaofeng Gao, Qi Liu, Lili Zeng, Kun Zhang, Keman Mu, Di Zhang, Huixi Zou, Nan Wu, Jierui Ou, Qiantao Wang, Shengjun Mao. Alpha-asarone improves cognitive function of aged rats by alleviating neuronal excitotoxicity via GABAA receptors. Neuropharmacology. 2020 01; 162(?):107843. doi: 10.1016/j.neuropharm.2019.107843. [PMID: 31704273]
  • Xueliang Xu, Xiang Li, Fenshan Wang, Kehong Han, Zirong Liu, Linjuan Fan, Hongxia Hua, Wanlun Cai, Yingjuan Yao. Candidate detoxification-related genes in brown planthopper, Nilaparvata lugens, in response to β-asarone based on transcriptomic analysis. Ecotoxicology and environmental safety. 2019 Dec; 185(?):109735. doi: 10.1016/j.ecoenv.2019.109735. [PMID: 31586846]
  • Jae Eun Lee, Nayeon Kim, Ji Yun Yeo, Dae-Gun Seo, Sunggun Kim, Jae-Sun Lee, Kwang Woo Hwang, So-Young Park. Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves against Beta-Amyloid Aggregation and Nitric Oxide Production. Molecules (Basel, Switzerland). 2019 Nov; 24(23):. doi: 10.3390/molecules24234297. [PMID: 31775356]
  • Thitaree Yooboon, Kazumu Kuramitsu, Vasakorn Bullangpoti, Yooichi Kainoh, Seiichi Furukawa. Cytotoxic effects of β-asarone on Sf9 insect cells. Archives of insect biochemistry and physiology. 2019 Sep; 102(1):e21596. doi: 10.1002/arch.21596. [PMID: 31270854]
  • Fatimah Alqadeeri, Yaya Rukayadi, Faridah Abbas, Khozirah Shaari. Antibacterial and Antispore Activities of Isolated Compounds from Piper cubeba L. Molecules (Basel, Switzerland). 2019 Aug; 24(17):. doi: 10.3390/molecules24173095. [PMID: 31454974]
  • Kelly Y C Lam, Qi-Yun Wu, Wei-Hui Hu, Ping Yao, Huai-You Wang, Tina T X Dong, Karl W K Tsim. Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes. Neuroscience letters. 2019 08; 707(?):134308. doi: 10.1016/j.neulet.2019.134308. [PMID: 31153972]
  • Ying Sun, Yajun Bai, Min Zeng, Xufei Chen, Jing Xie, Bin Li, Xirui He, Yujun Bai, Pu Jia, Xue Meng, Jing Liang, Shixiang Wang, Tai-Ping Fan, Biao Wu, Xiaohui Zheng. Pharmacokinetics and tissue distribution evaluation of α-asaronol and its main metabolite in rats by HPLC method. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):349-356. doi: 10.1016/j.jpba.2019.05.004. [PMID: 31085397]
  • Nwe Haymar Lynn, Thein Zaw Linn, Cui Yanmei, Yuuki Shimozu, Shoko Taniguchi, Tsutomu Hatano. 1H Quantitative NMR analyses of β-asarone and related compounds for quality control of Acorus rhizome herbal drugs in terms of the effects of their constituents on in vitro acetylcholine esterase activity. Bioscience, biotechnology, and biochemistry. 2019 May; 83(5):892-900. doi: 10.1080/09168451.2019.1569493. [PMID: 30696362]
  • Tao-Li Wang, Chen-Sheng Ouyang, Li-Zhu Lin. β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Oct; 106(?):821-830. doi: 10.1016/j.biopha.2018.07.009. [PMID: 29990876]
  • Prakash Ramalingam, Palanivel Ganesan, Dong-Kug Choi, Young Tag Ko. Development of a selective and sensitive LC-MS/MS method for the quantification of α-asarone in mouse plasma and its application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2018 Mar; 151(?):284-290. doi: 10.1016/j.jpba.2018.01.024. [PMID: 29413976]
  • Qiong Yang, Zhipeng Deng, Fang Zhang, Peilu Sun, Jun Li, Wanjin Zheng. Development of an LC-MS/MS method for quantification of two isomeric phenylpropenes and the application to pharmacokinetic studies in rats. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4115. [PMID: 29027249]
  • Xue-Mei Bai, Tie Liu, De-Long Liu, Yong-Ju Wei. Simultaneous determination of α-asarone and β-asarone in Acorus tatarinowii using excitation-emission matrix fluorescence coupled with chemometrics methods. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Feb; 191(?):195-202. doi: 10.1016/j.saa.2017.10.011. [PMID: 29032344]
  • Brijesh Sutariya, Madhusudan Saraf. α-asarone reduce proteinuria by restoring antioxidant enzymes activities and regulating necrosis factor κB signaling pathway in doxorubicin-induced nephrotic syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Feb; 98(?):318-324. doi: 10.1016/j.biopha.2017.12.051. [PMID: 29274588]
  • Linmei Pan, Jing Zhou, Feng Ju, Huaxu Zhu. Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification. Drug delivery and translational research. 2018 02; 8(1):83-96. doi: 10.1007/s13346-017-0438-8. [PMID: 29134552]
  • Beata Olas, Magdalena Bryś. Is it safe to use Acorus calamus as a source of promising bioactive compounds in prevention and treatment of cardiovascular diseases?. Chemico-biological interactions. 2018 Feb; 281(?):32-36. doi: 10.1016/j.cbi.2017.12.026. [PMID: 29273563]
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