Gypenoside (BioDeep_00000230797)

Main id: BioDeep_00000230732

 

PANOMIX_OTCML-2023


代谢物信息卡片


3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al

化学式: C52H86O21 (1046.5661306)
中文名称: 绞股蓝皂苷 XLIX, 绞股蓝皂苷XLIX
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(COC2OC3CCC4(C5CCC6C(CCC6(C5(CCC4C3(C)C)C)C)C(CCC=C(C)C)(COC7C(C(C(C(O7)CO)O)O)O)O)C=O)O)OC8C(C(C(CO8)O)O)O)O)O)O
InChI: InChI=1S/C52H86O21/c1-24(2)9-8-15-52(65,23-68-45-40(63)38(61)36(59)30(19-53)70-45)27-12-16-49(6)26(27)10-11-32-50(49,7)17-13-31-48(4,5)33(14-18-51(31,32)22-54)71-47-43(73-46-41(64)37(60)34(57)25(3)69-46)42(29(56)21-67-47)72-44-39(62)35(58)28(55)20-66-44/h9,22,25-47,53,55-65H,8,10-21,23H2,1-7H3/t25-,26+,27-,28+,29-,30+,31-,32-,33-,34-,35-,36+,37+,38-,39+,40+,41+,42-,43+,44-,45+,46-,47-,49+,50+,51+,52+/m0/s1

描述信息

Gypenoside XLIX is a natural product found in Gynostemma pentaphyllum with data available.
Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells[1].
Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells[1].
Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells[1].

同义名列表

5 个代谢物同义名

3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al; Gypenoside-XLIX; Gypenoside XLIX; GypenosideXLIX; Gypenoside



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mengyuan Zhou, Yu Cao, Shaocheng Xie, Yannan Xiang, Mengxin Li, Haitao Yang, Zibo Dong. Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways. International immunopharmacology. 2024 Apr; 131(?):111872. doi: 10.1016/j.intimp.2024.111872. [PMID: 38503011]
  • Baoshi Xu, Rongrong Yang, Jingchao Qiang, Xuhui Xu, Mengyuan Zhou, Xiaomeng Ji, Yingzhi Lu, Zibo Dong. Gypenoside XLIX attenuates sepsis-induced splenic injury through inhibiting inflammation and oxidative stress. International immunopharmacology. 2024 Jan; 127(?):111420. doi: 10.1016/j.intimp.2023.111420. [PMID: 38142642]
  • Gang Li, Peng-Xin Lu, Hai-Zhen Liang, Wei Zheng, Xiao-Juan Chen, Jie Zhang, Juan Song, Guang Yang, Ya-Xi Wang, Tao Zhang, Bao-Lin Guo, Bai-Ping Ma. An effective and high-throughput sample preparation method involving demalonylation followed by an ultrahigh-performance liquid chromatography-charged aerosol detector for analyzing gypenoside XLIX and gypenoside A in Gynostemma longipes. Journal of pharmaceutical and biomedical analysis. 2023 Jun; 230(?):115393. doi: 10.1016/j.jpba.2023.115393. [PMID: 37062206]
  • Huanxi Zhao, Wenbo Jiao, Yang Xiu, Kailu Zhou, Peng Zhong, Nan Wang, Shanshan Yu. Enzymatic Biotransformation of Gypenoside XLIX into Gylongiposide I and Their Antiviral Roles against Enterovirus 71 In Vitro. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27134094. [PMID: 35807341]
  • Qixia Liu, Xiaohui Chen, Min Kan, Jing Yang, Qian Gong, Rui Jin, Yulong Dai, Juan Jin, Hongmei Zang. Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism. European journal of pharmacology. 2021 Nov; 910(?):174501. doi: 10.1016/j.ejphar.2021.174501. [PMID: 34529980]
  • Qin Yang, Hong-Mei Zang, Tian Xing, Shao-Fei Zhang, Chao Li, Yao Zhang, Yu-Hang Dong, Xiao-Wei Hu, Ju-Tao Yu, Jia-Gen Wen, Juan Jin, Jun Li, Ren Zhao, Tao-Tao Ma, Xiao-Ming Meng. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153541. doi: 10.1016/j.phymed.2021.153541. [PMID: 33773190]
  • Sheng-long Ma, Feng-xia Wang, Xue Yang, Shan-ning Wan, Xi-ying Wei. [Diversity of Endogeny Eumycetes in Gynostemma pentaphyllum and Its Correlation with Gypenoside XLIX]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Mar; 38(3):476-80. doi: ". [PMID: 26495645]
  • Tom Hsun-Wei Huang, Van Hoan Tran, Basil D Roufogalis, Yuhao Li. Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. European journal of pharmacology. 2007 Jun; 565(1-3):158-65. doi: 10.1016/j.ejphar.2007.03.013. [PMID: 17434475]
  • Tom Hsun-Wei Huang, Van Hoan Tran, Basil D Roufogalis, Yuhao Li. Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology and applied pharmacology. 2007 Jan; 218(1):30-6. doi: 10.1016/j.taap.2006.10.013. [PMID: 17141290]
  • A H Vagnucci. Analysis of circadian periodicity of plasma cortisol in normal man and in Cushing's syndrome. The American journal of physiology. 1979 May; 236(5):R268-81. doi: 10.1152/ajpregu.1979.236.5.r268. [PMID: 443406]
  • R L Chang, N Zampaglione, C Lin. Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas. Drug metabolism and disposition: the biological fate of chemicals. 1975 Nov; 3(6):487-93. doi: NULL. [PMID: 1223]