Wuweizisu A (BioDeep_00000230794)
Main id: BioDeep_00000000535
PANOMIX_OTCML-2023
代谢物信息卡片
(9S,10R)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.0^{2,7}]hexadeca-1(16),2,4,6,12,14-hexaene
化学式: C24H32O6 (416.2199)
中文名称: 五味子甲素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2=CC(=C(C(=C2C3=C(C(=C(C=C3CC1C)OC)OC)OC)OC)OC)OC
InChI: InChI=1S/C24H32O6/c1-13-9-15-11-17(25-3)21(27-5)23(29-7)19(15)20-16(10-14(13)2)12-18(26-4)22(28-6)24(20)30-8/h11-14H,9-10H2,1-8H3/t13-,14+
描述信息
Schizandrin A is a natural product found in Schisandra henryi, Schisandra rubriflora, and other organisms with data available.
See also: Schisandra chinensis fruit (part of).
Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
同义名列表
33 个代谢物同义名
(9S,10R)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.0^{2,7}]hexadeca-1(16),2,4,6,12,14-hexaene; (9R,10s)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaene; Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6R,7S,12aS)-; DIBENZO(A,C)CYCLOOCTENE, 5,6,7,8-TETRAHYDRO-1,2,3,10,11,12-HEXAMETHOXY-6,7-DIMETHYL-, (6R,7S,12AR)-; Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, stereoisomer; (6R,7S,12aR)-5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene; (6R,7S)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulene; Dibenzo(a,c)cyclooctene, 5,6,7,8-tetrahydro-6,7-dimethyl-1,2,3,10,11,12-hexamethoxy-; SCHISANDRIN A (DEOXYSCHISANDRIN) (CONSTITUENT OF NORTHERN SCHISANDRA) [DSC]; SCHISANDRIN A (DEOXYSCHISANDRIN) (CONSTITUENT OF NORTHERN SCHISANDRA); Schizandrin-A;Wuweizisu-A;Deoxyschizandrin; Schisandrin A, analytical standard; Schisandrin A, >=98\\% (HPLC); hexamethoxy(dimethyl)[?]; SCHIZANDRIN A [WHO-DD]; (-)-Dimethylgomisin J; (-)-Deoxyschisandrin; (+)-Deoxyschizandrin; (-)-Deoxyschizandrin; Di-O-methylgomisin J; Dimethylgomisin J; deoxyschisandrin; deoxyschizandrin; UNII-74XQL5DO3S; schizandrin A; schisandrin A; schisandrin-a; Wuweizisu A; 74XQL5DO3S; Schizandrin; Schizandrin-A; Wuweizisu-A; Deoxyschizandrin
数据库引用编号
11 个数据库交叉引用编号
- PubChem: 155256
- ChEMBL: CHEMBL253908
- MeSH: schizandrin A
- ChemIDplus: 0061281387
- chemspider: 136769
- CAS: 69176-53-0
- CAS: 61281-38-7
- medchemexpress: HY-N0693
- KEGG: C16951
- PubChem: 96023438
- KNApSAcK: 80818
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Di He, Xinyi Pei, Bo Liu, Jiajing Li, Juane Dong, Thomas Efferth, Pengda Ma. Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155361. doi:
10.1016/j.phymed.2024.155361. [PMID: 38552434] - Matthew E Poynter, Madeleine M Mank, Jennifer L Ather. Obesity-associated inflammatory macrophage polarization is inhibited by capsaicin and phytolignans.
American journal of physiology. Regulatory, integrative and comparative physiology.
2024 May; 326(5):R370-R382. doi:
10.1152/ajpregu.00161.2023. [PMID: 38436058] - Yifan Ding, Na Guo, Yuhan Jiang, Sihan Liu, Tongpei Zhou, Haoyun Bai, Yanni Lv, Shengli Han, Langchong He. Establishment of cluster of differentiation 20 immobilized cell membrane chromatography for the screening of active antitumor components in traditional Chinese medicine.
Journal of chromatography. A.
2024 Apr; 1721(?):464845. doi:
10.1016/j.chroma.2024.464845. [PMID: 38552371] - Yi Xiao, Hanlin Zhou, Yingwen Cui, Xinting Zhu, Sanhua Li, Changyan Yu, Nian Jiang, Liu Liu, Fang Liu. Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway.
International immunopharmacology.
2024 Jan; 128(?):111472. doi:
10.1016/j.intimp.2023.111472. [PMID: 38176342] - Linhai Zhu, Yanye Wang, Xuhua Huang, Xide Liu, Bo Ye, Yi He, Haojie Yu, Wang Lv, Luming Wang, Jian Hu. Schizandrin A induces non-small cell lung cancer apoptosis by suppressing the epidermal growth factor receptor activation.
Cancer medicine.
2024 Jan; 13(2):e6942. doi:
10.1002/cam4.6942. [PMID: 38376003] - Lu-Jie Lin, Ming-Xiao Zhang, Hua Li, Xue-Mei Lan, Xiao-Lu Wei, Cong Guo, Bin Yang. [Identification of Q-markers for Schisandrae Sphenantherae Fructus in treating drug-induced liver injury based on network pharmacology, fingerprint and quantitative analysis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Oct; 48(20):5460-5473. doi:
10.19540/j.cnki.cjcmm.20230627.201. [PMID: 38114139] - Zhu Bin, Y U Ning, Wang Lei, Tian Yue, W U Mingfen, Zhao Zhigang. Synergistic effect of schizandrin A and DNase I knockdown on high glucose induced beta cell apoptosis by decreasing intracellular calcium concentration.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 08; 43(4):661-666. doi:
10.19852/j.cnki.jtcm.2023.04.003. [PMID: 37454250] - Qin Qiu, Weizhen Zhang, Kangdi Liu, Fangfang Huang, Jiating Su, Liyan Deng, Jiake He, Qianwen Lin, Lianxiang Luo. Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response.
European journal of pharmacology.
2023 Jun; ?(?):175850. doi:
10.1016/j.ejphar.2023.175850. [PMID: 37329976] - Zhe Chen, Xuling Luo, Meiqing Liu, Jinyong Jiang, Yao Li, Zhen Huang, Lingzhi Wang, Jiangang Cao, Lu He, Shifang Huang, Haoliang Hu, Lanfang Li, Linxi Chen. Elabela-apelin-12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1-P2X7 signaling pathway.
Journal of cellular biochemistry.
2023 Mar; ?(?):. doi:
10.1002/jcb.30392. [PMID: 36855998] - Ming Gu, Yaru Feng, Yujun Chen, Shengjie Fan, Cheng Huang. Deoxyschizandrin ameliorates obesity and non-alcoholic fatty liver disease: Involvement of dual Farnesyl X receptor/G protein-coupled bile acid receptor 1 activation and leptin sensitization.
Phytotherapy research : PTR.
2023 Feb; ?(?):. doi:
10.1002/ptr.7770. [PMID: 36809683] - Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154273. doi:
10.1016/j.phymed.2022.154273. [PMID: 36044818] - Ke Fu, Honglin Zhou, Cheng Wang, Lihong Gong, Cheng Ma, Yafang Zhang, Yunxia Li. A review: Pharmacology and pharmacokinetics of Schisandrin A.
Phytotherapy research : PTR.
2022 Jun; 36(6):2375-2393. doi:
10.1002/ptr.7456. [PMID: 35384105] - Qi Wang, Li Liu, Huibo Guan, Yanyan Zhou, Quan Li. Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer's disease mice.
Pharmaceutical biology.
2021 Dec; 59(1):860-867. doi:
10.1080/13880209.2021.1941132. [PMID: 34214019] - Linhai Zhu, Ying Wang, Wang Lv, Xiao Wu, Hongxu Sheng, Cheng He, Jian Hu. Schizandrin A can inhibit non‑small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy.
International journal of molecular medicine.
2021 Dec; 48(6):. doi:
10.3892/ijmm.2021.5047. [PMID: 34643254] - Huachao Pu, Qian Qian, Fuli Wang, Minjie Gong, Xinguo Ge. Schizandrin A induces the apoptosis and suppresses the proliferation, invasion and migration of gastric cancer cells by activating endoplasmic reticulum stress.
Molecular medicine reports.
2021 Nov; 24(5):. doi:
10.3892/mmr.2021.12427. [PMID: 34498719] - Jialu Bao, Yan Zhang, Linchao Zhang, Xincheng Gong, Wanyu Shi, Liantao Liu, Xiaodan Wang. Therapeutic effect of Schisandrin A on avian colibacillosis through gut-liver axis.
Poultry science.
2021 Oct; 100(10):101371. doi:
10.1016/j.psj.2021.101371. [PMID: 34481217] - Fen Wei, Xiaoshuang He, Ke Xu, Sicen Wang. Stepwise frontal analysis coupled with cell membrane chromatography for affinity screening and characterization analysis of bioactive constituent from the mature fruits of schisandra chinensis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Dec; 1161(?):122443. doi:
10.1016/j.jchromb.2020.122443. [PMID: 33246280] - Shan-Shan Guo, Xue Pang, Yang Wang, Zhu-Feng Geng, Ju-Qin Cao, Jun-Yu Liang, Zhi-Wei Deng, Shu-Shan Du. Chemical constituents isolated from stems of Schisandra chinensis and their antifeedant activity against Tribolium castaneum.
Natural product research.
2020 Sep; 34(18):2595-2601. doi:
10.1080/14786419.2018.1547291. [PMID: 30623674] - Zhenyue Wang, Yongtao Liu, Xiaohui Ai, Liqiao Zhong, Gang Han, Jinlong Song, Qiuhong Yang, Jing Dong. Effects of 27 natural products on drug metabolism genes in channel catfish (Ictalurus punctatus) cell line.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Sep; 50(9):1043-1051. doi:
10.1080/00498254.2020.1737760. [PMID: 32118504] - Huiling Yan, Meng Guo. Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155.
IUBMB life.
2020 08; 72(8):1640-1648. doi:
10.1002/iub.2329. [PMID: 32623835] - MyeongHoon Yeon, Hojung Choi, Hee-Sook Jun. Preventive Effects of Schisandrin A, A Bioactive Component of Schisandra chinensis, on Dexamethasone-Induced Muscle Atrophy.
Nutrients.
2020 Apr; 12(5):. doi:
10.3390/nu12051255. [PMID: 32354126] - Murphy L Y Wan, Paul C Turner, Vanessa A Co, M F Wang, Khaled M A Amiri, Hani El-Nezami. Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation.
Scientific reports.
2019 12; 9(1):19173. doi:
10.1038/s41598-019-55821-4. [PMID: 31844123] - Yinghao Zhi, Yongxi Jin, Lulu Pan, Aiguo Zhang, Feiwen Liu. Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy.
Archives of pharmacal research.
2019 Nov; 42(11):1012-1020. doi:
10.1007/s12272-019-01186-1. [PMID: 31552591] - Yiwen Zhang, Xinyan Lv, Ran Liu, Mingyang Zhang, Haopeng Liu, Hao Gao, Qian Zhang, Huarong Xu, Qing Li, Kaishun Bi. An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling.
Journal of chromatography. A.
2019 Aug; 1598(?):122-131. doi:
10.1016/j.chroma.2019.03.056. [PMID: 31047662] - Jingjing Fan, Lu Chen, Xiaoqing Lu, Mengxue Li, Liqin Zhu. The Pharmacokinetic Prediction of Cyclosporin A after Coadministration with Wuzhi Capsule.
AAPS PharmSciTech.
2019 Jul; 20(6):247. doi:
10.1208/s12249-019-1444-6. [PMID: 31286321] - Bingsheng Yu, Dongdi Sheng, Qiumin Tan. Determination of Schisandrin A and Schisandrin B in Traditional Chinese Medicine Preparation Huganpian Tablet by RP-HPLC.
Chemical & pharmaceutical bulletin.
2019 Jul; 67(7):713-716. doi:
10.1248/cpb.c18-00968. [PMID: 31006725] - Mi Ji Jeong, Sang Ryong Kim, Un Ju Jung. Schizandrin A supplementation improves nonalcoholic fatty liver disease in mice fed a high-fat and high-cholesterol diet.
Nutrition research (New York, N.Y.).
2019 04; 64(?):64-71. doi:
10.1016/j.nutres.2019.01.001. [PMID: 30802724] - Mengying Wei, Yuanyuan Liu, Zifeng Pi, Shizhe Li, Mingxin Hu, Yang He, Kexin Yue, Tianshu Liu, Zhiqiang Liu, Fengrui Song, Zhongying Liu. Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS.
Molecules (Basel, Switzerland).
2019 Mar; 24(7):. doi:
10.3390/molecules24071203. [PMID: 30934777] - Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang Ueng. Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation.
Journal of food and drug analysis.
2019 01; 27(1):284-294. doi:
10.1016/j.jfda.2018.10.005. [PMID: 30648582] - Xiaodong Ma, Mengqi Hu, Hao Wang, Jiaming Li. Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance.
European journal of medicinal chemistry.
2018 Nov; 159(?):381-392. doi:
10.1016/j.ejmech.2018.09.061. [PMID: 30308411] - Xiaona Liu, Shifeng Wang, Zhisheng Wu, Zhaoyi Wang, Qiusheng Zheng, Defang Li. Deoxyschizandrin Loaded Liposomes on the Suppression Lipid Accumulation in 3T3-L1 Adipocytes.
Molecules (Basel, Switzerland).
2018 Aug; 23(9):. doi:
10.3390/molecules23092158. [PMID: 30150602] - James T Lyles, Paula Tyler, E Jane Bradbury, Kate Nelson, Carl F Brown, Stefanie T Pierce, Cassandra L Quave. Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandra spp.): Potential for Development as a New Dietary Supplement Ingredient.
Journal of dietary supplements.
2017 Nov; 14(6):640-652. doi:
10.1080/19390211.2017.1304483. [PMID: 28384001] - Xiangyu Su, Chanchan Gao, Fangfang Shi, Xiaoyao Feng, Lin Liu, Ding Qu, Cailian Wang. A microemulsion co-loaded with Schizandrin A-docetaxel enhances esophageal carcinoma treatment through overcoming multidrug resistance.
Drug delivery.
2017 Nov; 24(1):10-19. doi:
10.1080/10717544.2016.1225854. [PMID: 28155336] - Minyu Zhang, Hongwei Wu, Feifei Guo, Yangyang Yu, Junying Wei, Ya Geng, Shifeng Wang, Shiyou Li, Hongjun Yang. Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach.
Molecular bioSystems.
2017 Jul; 13(8):1469-1480. doi:
10.1039/c6mb00813e. [PMID: 28604846] - Jing-Jing Wu, Yun-Feng Cao, Liang Feng, Yu-Qi He, James Y Hong, Tong-Yi Dou, Ping Wang, Da-Cheng Hao, Guang-Bo Ge, Ling Yang. A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5.
Journal of medicinal chemistry.
2017 05; 60(9):3804-3813. doi:
10.1021/acs.jmedchem.7b00001. [PMID: 28441491] - Lian-lin Su, Xue Cheng, De Ji, Li-jun Wang, Xi-yan Ding, Tu-lin Lu, Chun-qin Mao, Ji Zhang. [Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 10; 51(10):1600-8. doi:
. [PMID: 29932608] - Jin-Hui Song, Li Cui, Li-Bin An, Wen-Tao Li, Zhong-Ze Fang, Yan-Yan Zhang, Pei-Pei Dong, Xue Wu, Li-Xuan Wang, Frank J Gonzalez, Xiao-Yu Sun, De-Wei Zhao. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.
Phytotherapy research : PTR.
2015 Oct; 29(10):1658-64. doi:
10.1002/ptr.5395. [PMID: 26084208] - Tao Yang, Shan Liu, Tian-Hui Zheng, Yan-Yan Tao, Cheng-Hai Liu. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
Journal of ethnopharmacology.
2015 May; 166(?):305-12. doi:
10.1016/j.jep.2015.03.024. [PMID: 25794805] - A Szopa, W Kisiel, H Ekiert, A Szewczyk. Isolation of three dibenzocyclooctadiene lignans from in vitro cultures of Schisandra chinensis (Turcz.) Baill.--the first report.
Die Pharmazie.
2015 May; 70(5):337-9. doi:
. [PMID: 26062304] - Yiming Jiang, Xiaomei Fan, Ying Wang, Huasen Tan, Pan Chen, Hang Zeng, Min Huang, Huichang Bi. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation.
Chemico-biological interactions.
2015 Apr; 231(?):83-9. doi:
10.1016/j.cbi.2015.02.022. [PMID: 25753323] - Lijia Xu, Nicole Grandi, Claudia Del Vecchio, Daniela Mandas, Angela Corona, Dario Piano, Francesca Esposito, Cristina Parolin, Enzo Tramontano. From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors.
Journal of microbiology (Seoul, Korea).
2015 Apr; 53(4):288-93. doi:
10.1007/s12275-015-4652-0. [PMID: 25740376] - Wei Hou, Wei Gao, Datao Wang, Qingxiu Liu, Siwen Zheng, Yingping Wang. The Protecting Effect of Deoxyschisandrin and Schisandrin B on HaCaT Cells against UVB-Induced Damage.
PloS one.
2015; 10(5):e0127177. doi:
10.1371/journal.pone.0127177. [PMID: 25978330] - Cheng-Xian Guo, Sheng Deng, Ji-Ye Yin, Zhao-Qian Liu, Wei Zhang, Hong-Hao Zhou. Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity.
Die Pharmazie.
2015 Jan; 70(1):29-32. doi:
. [PMID: 25975095] - Ou Wang, Qian Cheng, Jia Liu, Yong Wang, Liang Zhao, Feng Zhou, Baoping Ji. Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice.
Food & function.
2014 Nov; 5(11):3018-25. doi:
10.1039/c4fo00550c. [PMID: 25255087] - Ye Lu, Wen-Juan Wang, Yun-Zhen Song, Zhong-Qin Liang. The protective mechanism of schisandrin A in d-galactosamine-induced acute liver injury through activation of autophagy.
Pharmaceutical biology.
2014 Oct; 52(10):1302-7. doi:
10.3109/13880209.2014.890232. [PMID: 24992201] - Li-shi Zheng, Shu-shan Du, Qian Cai. [Study on chemical constituents from Schisandra chinensis stem].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2014 Oct; 37(10):1803-6. doi:
. [PMID: 25895389] - Cai-Ping Wang, Gui-Cai Li, Yun-Wei Shi, Xiao-Chuan Zhang, Jian-Long Li, Zhi-Wei Wang, Fei Ding, Xin-Miao Liang. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.
Journal of physiology and biochemistry.
2014 Sep; 70(3):735-47. doi:
10.1007/s13105-014-0342-3. [PMID: 24986222] - Xiaoyan Wu, Yuan Zhou, Fangzhou Yin, Guoliang Dai, Lin Li, Bin Xu, De Ji, Yong Sun, Chunqin Mao, Tulin Lu. Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis).
Biomedical chromatography : BMC.
2014 Aug; 28(8):1075-83. doi:
10.1002/bmc.3122. [PMID: 24474333] - L M Kong, S Y Xu, H H Hu, H Zhou, H D Jiang, L S Yu, S Zeng. Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model.
Die Pharmazie.
2014 May; 69(5):362-6. doi:
". [PMID: 24855828] - Minyan Liu, Shaohua Zhao, Zongquan Wang, Yufeng Wang, Ting Liu, Song Li, Cuicui Wang, Hongtao Wang, Pengfei Tu. Identification of metabolites of deoxyschizandrin in rats by UPLC-Q-TOF-MS/MS based on multiple mass defect filter data acquisition and multiple data processing techniques.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Feb; 949-950(?):115-26. doi:
10.1016/j.jchromb.2013.12.022. [PMID: 24487041] - Agnieszka Szopa, Halina Ekiert. Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).
Journal of biotechnology.
2013 Jun; 165(3-4):209-13. doi:
10.1016/j.jbiotec.2013.03.010. [PMID: 23562619] - Bao-Lian Wang, Jin-Ping Hu, Li Sheng, Hui Chen, Yan Li. Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract.
Yao xue xue bao = Acta pharmaceutica Sinica.
2013 May; 48(5):734-40. doi:
. [PMID: 23888698] - Hui Sun, Fangfang Wu, Aihua Zhang, Wenfeng Wei, Ying Han, Xijun Wang. Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS.
Journal of separation science.
2013 Feb; 36(3):485-91. doi:
10.1002/jssc.201200887. [PMID: 23303577] - Cong Liu, Yun-Feng Cao, Zhong-Ze Fang, Yan-Yan Zhang, Cui-Min Hu, Xiao-Yu Sun, Ting Huang, Jia Zeng, Xu-Ran Fan, Hong Mo. Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction.
Fitoterapia.
2012 Dec; 83(8):1415-9. doi:
10.1016/j.fitote.2012.08.004. [PMID: 23339253] - Di Hu, Changxia Li, Na Han, Lijing Miao, Dong Wang, Zhihui Liu, Hua Wang, Jun Yin. Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice.
Planta medica.
2012 Aug; 78(12):1332-6. doi:
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