Salvianolic (BioDeep_00000230793)

 

Secondary id: BioDeep_00000242052, BioDeep_00000395813

PANOMIX_OTCML-2023


代谢物信息卡片


BENZENEPROPANOIC ACID, .ALPHA.-(((2E)-3-(2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4-BENZOFURANYL)-1-OXO-2-PROPEN-1-YL)OXY)-3,4-DIHYDROXY-, (.ALPHA.R)-

化学式: C26H20O10 (492.105642)
中文名称: 丹酚酸 C, 丹酚酸C
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.69%

分子结构信息

SMILES: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C3C=C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)O)O
InChI: InChI=1S/C26H20O10/c27-17-5-1-13(9-20(17)30)10-23(26(33)34)35-24(32)8-4-14-2-7-19(29)25-16(14)12-22(36-25)15-3-6-18(28)21(31)11-15/h1-9,11-12,23,27-31H,10H2,(H,33,34)/b8-4+/t23-/m1/s1

描述信息

Salvianolic acid C is a member of benzofurans.
Salvianolic acid C is a natural product found in Salvia miltiorrhiza, Origanum vulgare, and other organisms with data available.
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.

同义名列表

13 个代谢物同义名

BENZENEPROPANOIC ACID, .ALPHA.-(((2E)-3-(2-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4-BENZOFURANYL)-1-OXO-2-PROPEN-1-YL)OXY)-3,4-DIHYDROXY-, (.ALPHA.R)-; benzenepropanoic acid, alpha-(((2E)-3-(2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl)-1-oxo-2-propen-1-yl)oxy)-3,4-dihydroxy-, (alphaR)-; Benzenepropanoic acid, alpha-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (alphaR)-; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl]oxypropanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-benzofuran-4-yl]prop-2-enoyl]oxy-propanoic acid; (R,E)-3-(3,4-Dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoic acid; (R,E)-3-(3,4-Dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoicacid; Salvianolic-acid-C; Salvianolic acid C; Salvianolicacid C; UNII-I16H9Z53ZL; Salvianolic; I16H9Z53ZL



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ming Wu, Junyan Lin, Di Huang, Chaoyang Ye, Dongping Chen. Salvianolic Acid C Inhibits the Epithelial-Mesenchymal Transition and Ameliorates Renal Tubulointerstitial Fibrosis. Frontiers in bioscience (Landmark edition). 2023 06; 28(6):121. doi: 10.31083/j.fbl2806121. [PMID: 37395021]
  • Shiling Hu, Jue Wang, Yongjing Zhang, Haoyun Bai, Cheng Wang, Nan Wang, Langchong He. Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2. Journal of medical virology. 2021 05; 93(5):3143-3151. doi: 10.1002/jmv.26874. [PMID: 33580518]
  • Chan Yang, Xiaoyan Pan, Xinfeng Xu, Chen Cheng, Yuan Huang, Lin Li, Shibo Jiang, Wei Xu, Gengfu Xiao, Shuwen Liu. Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein. Signal transduction and targeted therapy. 2020 10; 5(1):220. doi: 10.1038/s41392-020-00325-1. [PMID: 33024075]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • Yan Duan, Wei An, Hongmei Wu, Yunxia Wu. Salvianolic Acid C Attenuates LPS-Induced Inflammation and Apoptosis in Human Periodontal Ligament Stem Cells via Toll-Like Receptors 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Dec; 25(?):9499-9508. doi: 10.12659/msm.918940. [PMID: 31831723]
  • Hongjin Tang, Dongsheng Zhao. Investigation of the interaction between salvianolic acid C and xanthine oxidase: Insights from experimental studies merging with molecular docking methods. Bioorganic chemistry. 2019 07; 88(?):102981. doi: 10.1016/j.bioorg.2019.102981. [PMID: 31085372]
  • Jia Fu, Yanni Lv, Qianqian Jia, Yuanyuan Lin, Shengli Han. Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors. Talanta. 2019 Jan; 192(?):248-254. doi: 10.1016/j.talanta.2018.09.053. [PMID: 30348386]
  • Chien-Ta Wu, Jeng-Shyan Deng, Wen-Chin Huang, Po-Chou Shieh, Mei-Ing Chung, Guan-Jhong Huang. Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Oxidative medicine and cellular longevity. 2019; 2019(?):9056845. doi: 10.1155/2019/9056845. [PMID: 31214283]
  • Pradeep Paudel, Su Hui Seong, Yajuan Zhou, Chan Hum Park, Takako Yokozawa, Hyun Ah Jung, Jae Sue Choi. Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3β Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23112919. [PMID: 30413117]
  • Junke Song, Wen Zhang, Jinhua Wang, Haiguang Yang, Xiaoyue Zhao, Qimeng Zhou, Haigang Wang, Li Li, Guanhua Du. Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro. International immunopharmacology. 2018 Oct; 63(?):299-310. doi: 10.1016/j.intimp.2018.08.004. [PMID: 30142530]
  • Mei-Juan Xu, Li-Feng Jiang, Ting Wu, Ji-Hong Chu, Yi-Dan Wei, Ji-Ye Aa, Guang-Ji Wang, Hai-Ping Hao, Wen-Zheng Ju, Ping Li. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chemico-biological interactions. 2018 Jun; 289(?):15-22. doi: 10.1016/j.cbi.2018.04.011. [PMID: 29689254]
  • Xiuqing Li, Xin Zhai, Zhiheng Shu, Ruifang Dong, Qianliang Ming, Luping Qin, Chengjian Zheng. Phoma glomerata D14: An Endophytic Fungus from Salvia miltiorrhiza That Produces Salvianolic Acid C. Current microbiology. 2016 Jul; 73(1):31-7. doi: 10.1007/s00284-016-1023-y. [PMID: 26979309]
  • Junke Song, Wen Zhang, Jialin Sun, Xue Zhang, Xiaona Xu, Li Zhang, Zhangying Feng, Guanhua Du. Determination of salvianolic acid C in rat plasma using liquid chromatography-mass spectrometry and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2016 Mar; 30(3):376-83. doi: 10.1002/bmc.3558. [PMID: 26173992]
  • Jun Li, Tong Gu, Xu Fu, Renjie Zhao. Effect of salvianolic acid A and C compatibility on inflammatory cytokines in rats with unilateral ureteral obstruction. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2015 Oct; 35(5):564-70. doi: 10.1016/s0254-6272(15)30140-0. [PMID: 26591687]
  • Gabriela López-Frías, Alejandro A Camacho-Dávila, David Chávez-Flores, Gerardo Zaragoza-Galán, Víctor H Ramos-Sánchez. Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants. Molecules (Basel, Switzerland). 2015 May; 20(5):8654-65. doi: 10.3390/molecules20058654. [PMID: 26007172]
  • Meijuan Xu, Haiping Hao, Lifeng Jiang, Fang Long, Yidan Wei, Hui Ji, Bingting Sun, Ying Peng, Guangji Wang, Wenzheng Ju, Ping Li. In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Apr; 22(4):444-51. doi: 10.1016/j.phymed.2015.02.001. [PMID: 25925966]
  • Yanmei Zhang, Feng Li, Mingxia Li, Jingwu Kang. Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2015 Apr; 1388(?):267-73. doi: 10.1016/j.chroma.2015.02.033. [PMID: 25725958]
  • Shih-Hung Lin, Kao-Jean Huang, Ching-Feng Weng, David Shiuan. Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening. Drug design, development and therapy. 2015; 9(?):3313-24. doi: 10.2147/dddt.s84641. [PMID: 26170618]