Bulleyaconi (BioDeep_00000230792)

 

Secondary id: BioDeep_00000230516

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


[11-ethyl-5-hydroxy-6,16,18-trimethoxy-4-(4-methoxybenzoyl)-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-8-yl] acetate

化学式: C35H49NO9 (627.3407144)
中文名称: 草乌甲素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 31.67%

分子结构信息

SMILES: CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6(CC4C5C6C(=O)C7=CC=C(C=C7)OC)O)OC)OC(=O)C)OC)OC)COC
InChI: InChI=1S/C35H49NO9/c1-8-36-17-32(18-40-3)14-13-23(42-5)35-22-15-33(39)24(43-6)16-34(45-19(2)37,27(31(35)36)29(44-7)30(32)35)25(22)26(33)28(38)20-9-11-21(41-4)12-10-20/h9-12,22-27,29-31,39H,8,13-18H2,1-7H3

描述信息

Bulleyaconitine a is a diterpene alkaloid. It is functionally related to an aconitane.
Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

同义名列表

6 个代谢物同义名

[11-ethyl-5-hydroxy-6,16,18-trimethoxy-4-(4-methoxybenzoyl)-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-8-yl] acetate; 20-Ethyl-13-hydroxy-1,6,16-trimethoxy-14-(4-methoxybenzoyl)-4-(methoxymethyl)aconitan-8-yl acetate; Bulleyaconi-cine-A; bulleyaconitine-A; bulleyaconitine A; Bulleyaconi



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Y Jin, C H Qin, B L Duan, Y Q Huang, K Ma. [Clinical efficacy of bulleyaconitine A combined with gabapentin on postherpetic neuralgia]. Zhonghua yi xue za zhi. 2021 Nov; 101(43):3575-3580. doi: 10.3760/cma.j.cn112137-20210817-01867. [PMID: 34808751]
  • Liping Liu, Shuyun Wang, Haiyan Xing, Yuemei Sun, Juan Ding, Ning He. Bulleyaconitine A inhibits the lung inflammation and airway remodeling through restoring Th1/Th2 balance in asthmatic model mice. Bioscience, biotechnology, and biochemistry. 2020 Jul; 84(7):1409-1417. doi: 10.1080/09168451.2020.1752140. [PMID: 32290781]
  • Xiaodong Zhan, Wenqi Zhang, Tian Sun, Yuling Feng, Yilong Xi, Yuxin Jiang, Xiaoniu Tang. Bulleyaconitine A Effectively Relieves Allergic Lung Inflammation in a Murine Asthmatic Model. Medical science monitor : international medical journal of experimental and clinical research. 2019 Mar; 25(?):1656-1662. doi: 10.12659/msm.915427. [PMID: 30828084]
  • Mei Yuan, Xiao-Xia Ma, Shu-De Yang, Zhi-Hong Zhou, Zhu-Ya Yang. [Chemical constituents of Aconitum bulleyanum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jun; 36(6):938-40. doi: ". [PMID: 24380280]
  • H R Xu, G X Ji, Q Wang, X N Li, Y J Gong, Y Zhang, W Li, T Shen. Dose-dependent pharmacokinetics of bulleyaconitine A in rats. Die Pharmazie. 2013 Mar; 68(3):170-2. doi: NULL. [PMID: 23556333]
  • Qi Wang, Bo Tan, Yijuan Gong, Guoxia Ji, Yun Zhang, Ping Yang, Wei Li, Teng Shen. Determination of bulleyaconitine A in plasma by a sensitive LC-MS/MS method and its application to an oral pharmacokinetic study in rats. Journal of pharmaceutical and biomedical analysis. 2012 Dec; 71(?):202-6. doi: 10.1016/j.jpba.2012.08.016. [PMID: 22980319]
  • Xin Xiong, Suodi Zhai, Zhongqiang Yao. Sensitive quantification of bulleyaconitine A in human serum by liquid chromatography-tandem mass spectrometry. Bioscience, biotechnology, and biochemistry. 2009 Jul; 73(7):1572-7. doi: 10.1271/bbb.90064. [PMID: 19584546]
  • Chi-Fei Wang, Peter Gerner, Sho-Ya Wang, Ging Kuo Wang. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007 Jul; 107(1):82-90. doi: 10.1097/01.anes.0000267502.18605.ad. [PMID: 17585219]
  • Wei-Yu Weng, Hui-Nan Xu, Jian-Ming Huang, Guo-Quan Wang, Teng Shen, Jian-Fang Zhang. A pharmacokinetic study of intramuscular administration of bulleyaconitine A in healthy volunteers. Biological & pharmaceutical bulletin. 2005 Apr; 28(4):747-9. doi: 10.1248/bpb.28.747. [PMID: 15802823]
  • Weiyu Weng, Huinan Xu, Jianming Huang, Guoquan Wang, Teng Shen, Jianfang Zhang. Determination of bulleyaconitine A in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Feb; 816(1-2):315-20. doi: 10.1016/j.jchromb.2004.11.051. [PMID: 15664364]