Timsaponin C (BioDeep_00000230686)

 

Secondary id: BioDeep_00000230687, BioDeep_00000330674, BioDeep_00000396808

PANOMIX_OTCML-2023


代谢物信息卡片


2-[4-[16-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-6-en-6-yl]-2-methylbutoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C45H74O18 (902.4874904000001)
中文名称: 知母皂苷BIII, 知母皂苷C, 知母皂苷B, 知母皂苷B3
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 36.67%

分子结构信息

SMILES: CC1=C(OC2C1C3(CCC4C(C3C2)CCC5C4(CCC(C5)OC6C(C(C(C(O6)CO)O)O)OC7C(C(C(C(O7)CO)O)O)O)C)C)CCC(C)COC8C(C(C(C(O8)CO)O)O)O
InChI: InChI=1S/C45H74O18/c1-19(18-57-41-38(55)35(52)32(49)28(15-46)60-41)5-8-26-20(2)31-27(59-26)14-25-23-7-6-21-13-22(9-11-44(21,3)24(23)10-12-45(25,31)4)58-43-40(37(54)34(51)30(17-48)62-43)63-42-39(56)36(53)33(50)29(16-47)61-42/h19,21-25,27-43,46-56H,5-18H2,1-4H3

描述信息

Anemarsaponin BIII is a natural product found in Asparagus officinalis with data available.
Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects[1][2][3].
Timosaponin B III is a major bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge, and exhibits anti-inflammatory, anti-platelet aggregative and anti-depressive effects[1][2][3].

同义名列表

11 个代谢物同义名

2-[4-[16-[4,5-Dihydroxy-6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-7,9,13-trimethyl-5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-6-en-6-yl]-2-methylbutoxy]-6-(hydroxymethyl)oxane-3,4,5-triol; 26-O-beta-D-glucopyranosyl-furost-20(22)-ene-3-beta,26-diol-3-O-beta-D-glucopyranosyl-(1-2)-beta-D-galactopyranoside; Pseudoprototimosaponin A III; Anemarsaponin BIII; Anemarsaponin BII; Anemarsaponin C; anemarsaponin B; Timosaponin C; Timsaponin C; TimosaponinC; Timosaponin B III



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang. The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro. Pharmaceutical biology. 2021 Dec; 59(1):1528-1532. doi: 10.1080/13880209.2021.1990355. [PMID: 34726569]
  • Mingwei Wang, Wei Jiang, Juan Zhou, Xiujuan Xue, Changlong Yin. Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes. Pharmaceutical biology. 2020 Dec; 58(1):1064-1069. doi: 10.1080/13880209.2020.1835996. [PMID: 33103940]
  • Bing-You Yang, Jing Zhang, Yan Liu, Hai-Xue Kuang. Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides. Molecules (Basel, Switzerland). 2016 Aug; 21(8):. doi: 10.3390/molecules21081075. [PMID: 27548119]
  • Guo-long Li, Jie Yang, Jin-ao Duan, Hong-bo Liu, Zhen-hua Zhu, Da-wei Qian, Zhi-shu Tang. [Quality Analysis and Evaluation of Anemarrhena asphodeloides Rhizome from Different Habitats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jun; 38(6):1148-52. doi: . [PMID: 26762052]
  • Ji-Yeon Kim, Ji-Sun Shin, Jong Hoon Ryu, Sun Yeou Kim, Young-Wuk Cho, Jung-Hye Choi, Kyung-Tae Lee. Anti-inflammatory effect of anemarsaponin B isolated from the rhizomes of Anemarrhena asphodeloides in LPS-induced RAW 264.7 macrophages is mediated by negative regulation of the nuclear factor-kappaB and p38 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Jul; 47(7):1610-7. doi: 10.1016/j.fct.2009.04.009. [PMID: 19375480]
  • Jin Kyung Oh, Seung Ye Hyun, Hye Rim Oh, Ji Wook Jung, Chan Park, Sun-Young Lee, Ji Ho Park, Sun Yeou Kim, Ki Hoon Kim, Young Kyun Kim, Jong Hoon Ryu. Effects of Anemarrhena asphodeloides on focal ischemic brain injury induced by middle cerebral artery occlusion in rats. Biological & pharmaceutical bulletin. 2007 Jan; 30(1):38-43. doi: 10.1248/bpb.30.38. [PMID: 17202656]