Gambogic_acid (BioDeep_00000230517)

Main id: BioDeep_00000407856

Secondary id: BioDeep_00000265106

PANOMIX_OTCML-2023


代谢物信息卡片


2-Butenoic acid, 2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, [1R-[1.alpha.,1(Z),3a.beta.,5.alpha.,11.beta.,14aS*]]-

化学式: C38H44O8 (628.3036)
中文名称: 藤黄酸, 异藤黄酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCCC1(C=CC2=C(C3=C(C(=C2O1)CC=C(C)C)OC45C6CC(C=C4C3=O)C(=O)C5(OC6(C)C)CC=C(C)C(=O)O)O)C)C
InChI: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13+

描述信息

beta-Guttiferin is a natural product found in Garcinia hanburyi with data available.
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

同义名列表

37 个代谢物同义名

(Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid; (E)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid; 2-BUTENOIC ACID, 2-METHYL-4-((1R,3AS,5S,11R,14AS)-3A,4,5,7-TETRAHYDRO-8-HYDROXY-3,3,11-TRIMETHYL-13-(3-METHYL-2-BUTEN-1-YL)-11-(4-METHYL-3-PENTEN-1-YL)-7,15-DIOXO-1,5-METHANO-1H,3H,11H-FURO(3,4-G)PYRANO(3,2-B)XANTHEN-1-YL)-, (2Z)-; (2Z)-2-METHYL-4-((1R,3AS,5S,11R,14AS)-3A,4,5,7-TETRAHYDRO-8-HYDROXY-3,3,11-TRIMETHYL-13-(3-METHYL-2-BUTEN-1-YL)-11-(4-METHYL-3-PENTEN-1-YL)-7,15-DIOXO-1,5-METHANO-1H,3H,11H-FURO(3,4-G)PYRANO(3,2-B)XANTHEN-1-YL)-2-BUTENOIC ACID; (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid; 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-; Gambogic acid, >=95\\% (HPLC), powder; GEZHEQNLKAOMCA-RRZNCOCZSA-N; alpha-Gambogic acid; GAMBOGIC ACID [MI]; (-)-Gambogic Acid; .beta.-Guttiferin; Beta-Guttiferrin; Isogambogic acid; UNII-8N585K83U2; |A-Guttilactone; beta-Guttiferin; R-gambogic acid; gambogoic acid; Cambogic acid; Guttatic acid; |A-Guttiferin; gambogic acid; Gambogic-acid; GAMBOGICACID; B-Guttiferin; gamboge acid; Guttic acid; 8N585K83U2; 2-Butenoic acid, 2-methyl-4-[3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, [1R-[1.alpha.,1(Z),3a.beta.,5.alpha.,11.beta.,14aS*]]-; (2E)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0^{2,15}.0^{2,19}.0^{4,13}.0^{6,11}]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid; (E)-4-[12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid; 1,5-Methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthene-1-crotonic acid, 3a,4,5,7-tetrahydro-8-hydroxy-.alpha.,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-, (Z)-; 2-Butenoic acid, 2-methyl-4-*3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-meth; GEZHEQNLKAOMCA-LPYMAVHISA-N; Epigambogic acid; Gambogic acid



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qianyu Zhang, Ying Zhang, Chen Wang, Huan Tang, Ang Ma, Peng Gao, Qiaoli Shi, Guohua Wang, Shengnan Shen, Junzhe Zhang, Fei Xia, Yinhua Zhu, Jigang Wang. Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155657. doi: 10.1016/j.phymed.2024.155657. [PMID: 38692076]
  • Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system. Free radical biology & medicine. 2024 Jun; 218(?):26-40. doi: 10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172]
  • Jiaojiao Li, Dandan Mi, Rujing Wang, Yuke Li, Mengnan Zhao, Sanjun Shi. A lava-inspired proteolytic enzyme therapy on cancer with a PEG-based hydrogel enhances tumor distribution and penetration of liposomes. Journal of nanobiotechnology. 2024 May; 22(1):216. doi: 10.1186/s12951-024-02468-7. [PMID: 38698399]
  • You Li, Wenqi Liao, Wei Huang, Fenglin Liu, Lin Ma, Xiaoping Qian. Mechanism of gambogic acid repressing invasion and metastasis of colorectal cancer by regulating macrophage polarization via tumor cell-derived extracellular vesicle-shuttled miR-21. Drug development research. 2024 Feb; 85(1):e22141. doi: 10.1002/ddr.22141. [PMID: 38349264]
  • Xu Wen, Dian Li, Peng Chen, Ming Tan, Hui Zhang, Yuting Liu, Jihua Ren, Shengtao Cheng. Gambogic acid inhibits HBx-mediated hepatitis B virus replication by targeting the DTX1-Notch signaling pathway. Virus research. 2024 Jan; 339(?):199273. doi: 10.1016/j.virusres.2023.199273. [PMID: 38029800]
  • Mengting Da, Su Li, Rui Yang, Zhen Jia, Yulian Ma, Fengxian Qi, Jiuda Zhao, Guoshuang Shen, Daozhen Chen. Therapeutic effect and metabolic fingerprinting of triple-negative breast cancer cells following exposure to a novel pH-responsive, gambogic acid-loaded micelle. Nanotechnology. 2023 Dec; 35(11):. doi: 10.1088/1361-6528/ad1448. [PMID: 38081078]
  • Ang Cai, Pengfei Xia, Xiaokang Zhou, Yao He, Jun Lv. MiR-1275 Targeting SPARC Promotes Gambogic Acid-Induced Inhibition of Gastric Cancer. Biochemical genetics. 2023 Apr; ?(?):. doi: 10.1007/s10528-023-10381-1. [PMID: 37118619]
  • Siyan Zhang, Xingyao Zhang, Dong Zhang, Liang Wei, Bin Xiong, Qi Meng, Shougang Jiang. Synergistic effect of docetaxel and gambogic acid on bone metastasis of lung cancer. Bulletin du cancer. 2023 Mar; ?(?):. doi: 10.1016/j.bulcan.2023.02.007. [PMID: 36890055]
  • Fengli Huang, Qun Zhang, Jie Xiao, Xin Zhang, Xingzhi Han, Xiao Shi, Jing Hu, Li Li, Xiaoping Qian. Cancer Cell Membrane-Coated Gambogic Acid Nanoparticles for Effective Anticancer Vaccination by Activating Dendritic Cells. International journal of nanomedicine. 2023; 18(?):2261-2273. doi: 10.2147/ijn.s408521. [PMID: 37159807]
  • Yuling Liu, Xin Nie, Yihan Wu, Longfei Lin, Qian Liao, Jingjing Li, Simon Ming-Yuen Lee, Hui Li, Jinming Zhang. Carrier-Free Gambogic Acid Dimer Self-Assembly Nanomedicines for Rheumatoid Arthritis Treatment. International journal of nanomedicine. 2023; 18(?):5457-5472. doi: 10.2147/ijn.s422096. [PMID: 37771407]
  • Song Lyu, Xue Zhang, Zhenzhen Tu, Haisheng Zhou, Xisong Ke, Yi Qu. GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer. Pharmacological research. 2022 08; 182(?):106279. doi: 10.1016/j.phrs.2022.106279. [PMID: 35659621]
  • Nutchanard Khunpatee, Kanit Bhukhai, Varanuj Chatsudthipong, Chaowalit Yuajit. Potential Application of Gambogic Acid for Retarding Renal Cyst Progression in Polycystic Kidney Disease. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123837. [PMID: 35744960]
  • Tao Ren, Xian-Yu Bai, Meng-Zhe Yang, Ning Xu, Xing-Zhe Guo, Liu-Jie Qin, Zhi-Lin Huang, Qiong-Yao Zhong, Yuan-Jiao Huang, Wen-Zhen Lin, Ai-Jun Jiao, Bei-Bei Zhang. Gambogic acid suppresses nasopharyngeal carcinoma via rewiring molecular network of cancer malignancy and immunosurveillance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113012. doi: 10.1016/j.biopha.2022.113012. [PMID: 35658246]
  • Feng Wang, Lei Dong, Simin Liang, Xixi Wei, Yongling Wang, Liansheng Chang, Kang Guo, Hongwei Wu, Yuqiao Chang, Yaling Yin, Lu Wang, Yu Shi, Fei Yan, Nana Li. Ultrasound-triggered drug delivery for glioma therapy through gambogic acid-loaded nanobubble-microbubble complexes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113042. doi: 10.1016/j.biopha.2022.113042. [PMID: 35658212]
  • Jianxin Liu, Shuhao Fan, Yinhong Xiang, Jiaojiao Xia, Hua Jin, Jun-Fa Xu, Fen Yang, Jiye Cai, Jiang Pi. Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy. Scanning. 2022; 2022(?):1422185. doi: 10.1155/2022/1422185. [PMID: 35937670]
  • Ding Zhang, Boqi Chen, Qingke Mu, Wei Wang, Kaili Liang, Liyan Wang, Qing Wang. Topical delivery of gambogic acid assisted by the combination of low-frequency ultrasound and chemical enhancers for chemotherapy of cutaneous melanoma. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Nov; 166(?):105975. doi: 10.1016/j.ejps.2021.105975. [PMID: 34391880]
  • Zhixin Zhang, Lili Liang, Gang Cao. Critical role of miR-26a-5p/Wnt5a signaling in gambogic acid-induced inhibition of gastric cancer. Journal of biochemical and molecular toxicology. 2021 Apr; 35(4):e22721. doi: 10.1002/jbt.22721. [PMID: 33533530]
  • Zhoujiang Chen, Guanghui Hong, Zhiyan Liu, Dayun Yang, Ranjith Kumar Kankala, Wenguo Wu. Synergistic antitumor efficacy of doxorubicin and gambogic acid-encapsulated albumin nanocomposites. Colloids and surfaces. B, Biointerfaces. 2020 Dec; 196(?):111286. doi: 10.1016/j.colsurfb.2020.111286. [PMID: 32768988]
  • Tongtong Wang, Jing Du, Dexia Kong, Guosheng Yang, Qihao Zhou, Fei You, Yan Lin, Ying Wang. Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells. Oncology reports. 2020 10; 44(4):1747-1757. doi: 10.3892/or.2020.7726. [PMID: 32945501]
  • Zhe Ma, Nan Li, Bing Zhang, YuYu Hui, Ying Zhang, Peng Lu, Jiaxin Pi, Zhidong Liu. Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality. Journal of nanobiotechnology. 2020 Sep; 18(1):123. doi: 10.1186/s12951-020-00681-8. [PMID: 32887626]
  • Elham Hatami, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu. Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics. Biochimica et biophysica acta. Reviews on cancer. 2020 08; 1874(1):188381. doi: 10.1016/j.bbcan.2020.188381. [PMID: 32492470]
  • Pei Wang, Fuquan Jiang, Biaoqi Chen, Hanxiao Tang, Xiaojiao Zeng, Duanhua Cai, Mingzhi Zhu, Ruimin Long, Dayun Yang, Ranjith Kumar Kankala, Shibin Wang, Yuangang Liu. Bioinspired red blood cell membrane-encapsulated biomimetic nanoconstructs for synergistic and efficacious chemo-photothermal therapy. Colloids and surfaces. B, Biointerfaces. 2020 May; 189(?):110842. doi: 10.1016/j.colsurfb.2020.110842. [PMID: 32058253]
  • Yuling Liu, Yingchong Chen, Longfei Lin, Hui Li. Gambogic Acid as a Candidate for Cancer Therapy: A Review. International journal of nanomedicine. 2020; 15(?):10385-10399. doi: 10.2147/ijn.s277645. [PMID: 33376327]
  • Chun-Yu Li, Qi Wang, Xiao-Min Wang, Guo-Xia Li, Shen Shen, Xiao-Lu Wei. Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways. European journal of pharmacology. 2019 Dec; 864(?):172719. doi: 10.1016/j.ejphar.2019.172719. [PMID: 31586634]
  • Zhi Xu, Shi-Jia Zhao, Yi Liu. 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships. European journal of medicinal chemistry. 2019 Dec; 183(?):111700. doi: 10.1016/j.ejmech.2019.111700. [PMID: 31546197]
  • Yonghui Wang, Yana Sui, Yinggang Tao. Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway. Molecular medicine reports. 2019 Nov; 20(5):4515-4522. doi: 10.3892/mmr.2019.10697. [PMID: 31545492]
  • Yilin Song, Yule Wang, Yan Zhu, Yu Cheng, Yidan Wang, Siyu Wang, Fengping Tan, Fan Lian, Nan Li. Biomodal Tumor-Targeted and Redox-Responsive Bi2 Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal Radiotherapy. Advanced healthcare materials. 2019 08; 8(16):e1900250. doi: 10.1002/adhm.201900250. [PMID: 31290616]
  • Zhenlong Yu, Yanan Jv, Lu Cai, Xiangge Tian, Xiaokui Huo, Chao Wang, Baojing Zhang, ChengPeng Sun, Jing Ning, Lei Feng, Houli Zhang, Xiaochi Ma. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90. Toxicology and applied pharmacology. 2019 05; 371(?):63-73. doi: 10.1016/j.taap.2019.03.028. [PMID: 30953615]
  • Li Wan, Qun Zhang, Sheng Wang, Yong Gao, Xiaofei Chen, Yang Zhao, Xiaoping Qian. Gambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis. Phytotherapy research : PTR. 2019 May; 33(5):1579-1591. doi: 10.1002/ptr.6350. [PMID: 31033039]
  • Yulin Ren, Esperanza J Carcache de Blanco, James R Fuchs, Djaja D Soejarto, Joanna E Burdette, Steven M Swanson, A Douglas Kinghorn. Potential Anticancer Agents Characterized from Selected Tropical Plants. Journal of natural products. 2019 03; 82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018. [PMID: 30830783]
  • Dereje Kebebe, Yumei Wu, Bing Zhang, Jian Yang, Yuanyuan Liu, Xinyue Li, Zhe Ma, Peng Lu, Zhidong Liu, Jiawei Li. Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer. International journal of nanomedicine. 2019; 14(?):6179-6195. doi: 10.2147/ijn.s202424. [PMID: 31447559]
  • Lili Liang, Zhixin Zhang, Xiaowei Qin, Ying Gao, Peng Zhao, Jing Liu, Weihui Zeng. Gambogic Acid Inhibits Melanoma through Regulation of miR-199a-3p/ZEB1 Signalling. Basic & clinical pharmacology & toxicology. 2018 Dec; 123(6):692-703. doi: 10.1111/bcpt.13090. [PMID: 29959879]
  • Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu. Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment. Drug delivery. 2018 Nov; 25(1):757-765. doi: 10.1080/10717544.2018.1446474. [PMID: 29528244]
  • Yan Zhang, Xinyi Tan, Tianyang Ren, Chao Jia, Zaixing Yang, Hong Sun. Folate-modified carboxymethyl-chitosan/polyethylenimine/bovine serum albumin based complexes for tumor site-specific drug delivery. Carbohydrate polymers. 2018 Oct; 198(?):76-85. doi: 10.1016/j.carbpol.2018.06.055. [PMID: 30093044]
  • Zhongcheng Ke, Lei Yang, Hao Wu, Zihao Li, Xiaobin Jia, Zhenghai Zhang. Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles. International journal of pharmaceutics. 2018 Jul; 545(1-2):306-317. doi: 10.1016/j.ijpharm.2018.04.016. [PMID: 29654896]
  • Wei-Lun Tang, Wei-Hsin Tang, Andras Szeitz, Jayesh Kulkarni, Pieter Cullis, Shyh-Dar Li. Systemic study of solvent-assisted active loading of gambogic acid into liposomes and its formulation optimization for improved delivery. Biomaterials. 2018 06; 166(?):13-26. doi: 10.1016/j.biomaterials.2018.03.004. [PMID: 29529479]
  • Qing Yue, Frank Stahl, Oliver Plettenburg, Andreas Kirschning, Athanasia Warnecke, Carsten Zeilinger. The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG. Biochemistry. 2018 05; 57(18):2601-2605. doi: 10.1021/acs.biochem.8b00155. [PMID: 29664615]
  • Sheng-Li Niu, Da-Hong Li, Xin-Yu Li, Yue-Tong Wang, Sheng-Ge Li, Jiao Bai, Yue-Hu Pei, Yong-Kui Jing, Zhan-Lin Li, Hui-Ming Hua. Bioassay- and Chemistry-Guided Isolation of Scalemic Caged Prenylxanthones from the Leaves of Garcinia bracteata. Journal of natural products. 2018 04; 81(4):749-757. doi: 10.1021/acs.jnatprod.7b00454. [PMID: 29565129]
  • Fan Yu, Fuguang Jiang, Xinhui Tang, Bochu Wang. N-octyl-N-arginine-chitosan micelles for gambogic acid intravenous delivery: characterization, cell uptake, pharmacokinetics, and biodistribution. Drug development and industrial pharmacy. 2018 Apr; 44(4):615-623. doi: 10.1080/03639045.2017.1405973. [PMID: 29188736]
  • Qing Lai Wang, Dong Zhen Yang, Cunxian Lv. Anti‑inflammatory effects of gambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway. Molecular medicine reports. 2018 03; 17(3):4791-4796. doi: 10.3892/mmr.2018.8389. [PMID: 29328461]
  • Yanan Kang, Lu Lu, Jinshuai Lan, Yue Ding, Jing Yang, Yong Zhang, Yuan Zhao, Tong Zhang, Rodney J Y Ho. Redox-responsive polymeric micelles formed by conjugating gambogic acid with bioreducible poly(amido amine)s for the co-delivery of docetaxel and MMP-9 shRNA. Acta biomaterialia. 2018 03; 68(?):137-153. doi: 10.1016/j.actbio.2017.12.028. [PMID: 29288085]
  • Zhen Zhang, Hanqing Qian, Jie Huang, Huizi Sha, Hang Zhang, Lixia Yu, Baorui Liu, Dong Hua, Xiaoping Qian. Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment. International journal of nanomedicine. 2018; 13(?):4961-4975. doi: 10.2147/ijn.s170148. [PMID: 30214200]
  • Dinghu Zhang, Zhengyun Zou, Wei Ren, Hanqing Qian, Qianfeng Cheng, Liulian Ji, Baorui Liu, Qin Liu. Gambogic acid-loaded PEG-PCL nanoparticles act as an effective antitumor agent against gastric cancer. Pharmaceutical development and technology. 2018 Jan; 23(1):33-40. doi: 10.1080/10837450.2017.1295068. [PMID: 29069711]
  • Shengpeng Wang, Min Shao, Zhangfeng Zhong, Anqi Wang, Jiliang Cao, Yucong Lu, Yitao Wang, Jinming Zhang. Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer. Drug delivery. 2017 Nov; 24(1):1791-1800. doi: 10.1080/10717544.2017.1406558. [PMID: 29172759]
  • Teng Zhao, Hong-Jian Wang, Wen-Wen Zhao, Yi-Ling Sun, Li-Kuan Hu. Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway. The Kaohsiung journal of medical sciences. 2017 Nov; 33(11):543-549. doi: 10.1016/j.kjms.2017.06.013. [PMID: 29050671]
  • Jingya Ruan, Chang Zheng, Yanxia Liu, Lu Qu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang. Chemical and Biological Research on Herbal Medicines Rich in Xanthones. Molecules (Basel, Switzerland). 2017 Oct; 22(10):. doi: 10.3390/molecules22101698. [PMID: 29019929]
  • Abhishek Shetty, Thejaswini Venkatesh, Padmanaban S Suresh, Rie Tsutsumi. Exploration of acute genotoxic effects and antigenotoxic potential of gambogic acid using Allium cepa assay. Plant physiology and biochemistry : PPB. 2017 Sep; 118(?):643-652. doi: 10.1016/j.plaphy.2017.08.005. [PMID: 28806720]
  • Yan Zhang, Zhijie Yang, Xinyi Tan, Xing Tang, Zaixing Yang. Development of a More Efficient Albumin-Based Delivery System for Gambogic Acid with Low Toxicity for Lung Cancer Therapy. AAPS PharmSciTech. 2017 Aug; 18(6):1987-1997. doi: 10.1208/s12249-016-0670-4. [PMID: 27933587]
  • Xuefei Yan, Ye Yang, Liqin He, Daiyin Peng, Dengke Yin. Gambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect. International journal of pharmaceutics. 2017 Apr; 522(1-2):110-118. doi: 10.1016/j.ijpharm.2017.02.051. [PMID: 28242375]
  • Zhen Zhang, Hanqing Qian, Mi Yang, Rutian Li, Jing Hu, Li Li, Lixia Yu, Baorui Liu, Xiaoping Qian. Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment. International journal of nanomedicine. 2017; 12(?):1593-1605. doi: 10.2147/ijn.s127256. [PMID: 28280328]
  • Yiqing Zhou, Weichao Li, Xixi Zhang, Haibing Zhang, Youli Xiao. Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics. Chemical communications (Cambridge, England). 2016 Nov; 52(97):14035-14038. doi: 10.1039/c6cc07581a. [PMID: 27853763]
  • Mohammad Ishaq, Rani Ojha, Kapil Sharma, Gaurav Sharma, Shrawan K Singh, Sekhar Majumdar. Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells. Biochimica et biophysica acta. 2016 11; 1863(11):2560-2573. doi: 10.1016/j.bbamcr.2016.07.001. [PMID: 27395830]
  • Yubei Qu, Guanghua Zhang, Yunxia Ji, Haibo Zhua, Changjun Lv, Wanglin Jiang. Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Apr; 23(4):350-8. doi: 10.1016/j.phymed.2016.01.011. [PMID: 27002405]
  • Fan Yu, Xinhui Tang. Novel Long-Circulating Liposomes Consisting of PEG Modified β-Sitosterol for Gambogic Acid Delivery. Journal of nanoscience and nanotechnology. 2016 Mar; 16(3):3115-21. doi: 10.1166/jnn.2016.12405. [PMID: 27455771]
  • Yang Wu, Laura N Cruz, Tadge Szestak, Gavin Laing, Gemma R Molyneux, Celia R S Garcia, Alister G Craig. An external sensing system in Plasmodium falciparum-infected erythrocytes. Malaria journal. 2016 Feb; 15(?):103. doi: 10.1186/s12936-016-1144-6. [PMID: 26893139]
  • Qingxi Yue, Lixing Feng, Biyin Cao, Miao Liu, Dongmei Zhang, Wanying Wu, Baohong Jiang, Min Yang, Xuan Liu, Dean Guo. Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid. Molecular & cellular proteomics : MCP. 2016 Jan; 15(1):26-44. doi: 10.1074/mcp.m115.053272. [PMID: 26499837]
  • Ying Xu, JinBao Liu, YingLi Wu, QingLong Guo, HanDong Sun, GuoQiang Chen. Natural products against hematological malignancies and identification of their targets. Science China. Life sciences. 2015 Dec; 58(12):1191-201. doi: 10.1007/s11427-015-4922-4. [PMID: 26566803]
  • Zhifen Zheng, Wanglu Ou, Xinshi Zhang, Yongzhi Li, Yujuan Li. UHPLC-MS method for determination of gambogic acid and application to bioavailability, pharmacokinetics, excretion and tissue distribution in rats. Biomedical chromatography : BMC. 2015 Oct; 29(10):1581-8. doi: 10.1002/bmc.3462. [PMID: 25828810]
  • Jinhao Chen, Min Zhou, Qian Zhang, Jingyan Xu, Jian Ouyang. Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro. Medical science monitor : international medical journal of experimental and clinical research. 2015 Jun; 21(?):1604-10. doi: 10.12659/msm.893004. [PMID: 26049398]
  • Xiangdong Hua, Chuang Liang, Lei Dong, Xiaotong Qu, Tong Zhao. Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS/MS. Biomedical chromatography : BMC. 2015 Apr; 29(4):545-51. doi: 10.1002/bmc.3311. [PMID: 25159917]
  • Aungkana Krajarng, Masaya Imoto, Etsu Tashiro, Takahiro Fujimaki, Satoko Shinjo, Ramida Watanapokasin. Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid. BMC complementary and alternative medicine. 2015 Feb; 15(?):26. doi: 10.1186/s12906-015-0544-4. [PMID: 25887496]
  • Dong Li, Xiao-Yi Song, Qing-Xi Yue, Ya-Jun Cui, Miao Liu, Li-Xing Feng, Wan-Ying Wu, Bao-Hong Jiang, Min Yang, Xiao-Bo Qu, Xuan Liu, De-An Guo. Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells. Chinese journal of natural medicines. 2015 Jan; 13(1):41-51. doi: 10.1016/s1875-5364(15)60005-x. [PMID: 25660287]
  • Miguel A González, Julie Clark, Michele Connelly, Fatima Rivas. Antimalarial activity of abietane ferruginol analogues possessing a phthalimide group. Bioorganic & medicinal chemistry letters. 2014 Nov; 24(22):5234-7. doi: 10.1016/j.bmcl.2014.09.061. [PMID: 25316317]
  • Dengke Yin, Ye Yang, Hanxu Cai, Fei Wang, Daiyin Peng, Liqing He. Gambogic acid-loaded electrosprayed particles for site-specific treatment of hepatocellular carcinoma. Molecular pharmaceutics. 2014 Nov; 11(11):4107-17. doi: 10.1021/mp500214a. [PMID: 25290462]
  • Lamya M Saeed, Meena Mahmood, Sebastian J Pyrek, Tariq Fahmi, Yang Xu, Thikra Mustafa, Zeid A Nima, Stacie M Bratton, Dan Casciano, Enkeleda Dervishi, Anna Radominska-Pandya, Alexandru S Biris. Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells. Journal of applied toxicology : JAT. 2014 Nov; 34(11):1188-99. doi: 10.1002/jat.3018. [PMID: 25220893]
  • Jiaolin Wen, Heying Pei, Xianhuo Wang, Caifeng Xie, Shucai Li, Li Huang, Neng Qiu, Wenwen Wang, Xia Cheng, Lijuan Chen. Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation. Journal of dermatological science. 2014 Jun; 74(3):242-50. doi: 10.1016/j.jdermsci.2014.03.001. [PMID: 24685902]
  • Fan Yu, Chenghua He, Ayman Y Waddad, Were L L Munyendo, Huixia Lv, Jianping Zhou, Qiang Zhang. N-octyl-N-arginine-chitosan (OACS) micelles for gambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion. Drug development and industrial pharmacy. 2014 Jun; 40(6):774-82. doi: 10.3109/03639045.2013.786723. [PMID: 23679668]
  • Dongzhu Duan, Baoxin Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge, Shoujiao Peng, Jianguo Fang. Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free radical biology & medicine. 2014 Apr; 69(?):15-25. doi: 10.1016/j.freeradbiomed.2013.12.027. [PMID: 24407164]
  • Haiyuan Zhang, Yunlong Lei, Ping Yuan, Lingjun Li, Chao Luo, Rui Gao, Jun Tian, Zuohua Feng, Edouard C Nice, Jun Sun. ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PloS one. 2014; 9(5):e96418. doi: 10.1371/journal.pone.0096418. [PMID: 24810758]
  • Jianxia Wang, Zhixiang Yuan. Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis. Cell biochemistry and biophysics. 2013 Sep; 67(1):199-206. doi: 10.1007/s12013-013-9534-7. [PMID: 23436279]
  • Parry Ngan Hon Lee, Wing Shing Ho. Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells. Oncology reports. 2013 May; 29(5):1744-50. doi: 10.3892/or.2013.2291. [PMID: 23426995]
  • Mariana Leão, Sara Gomes, José Pedraza-Chaverri, Neuza Machado, Emília Sousa, Madalena Pinto, Alberto Inga, Clara Pereira, Lucília Saraiva. Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach. Journal of natural products. 2013 Apr; 76(4):774-8. doi: 10.1021/np400049j. [PMID: 23540934]
  • Li-jing Yang, Yan Chen. New targets for the antitumor activity of gambogic acid in hematologic malignancies. Acta pharmacologica Sinica. 2013 Feb; 34(2):191-8. doi: 10.1038/aps.2012.163. [PMID: 23274413]
  • Zhen-Hai Zhang, Xiao-Pan Wang, Waddad Y Ayman, Were L L Munyendo, Hui-Xia Lv, Jian-Ping Zhou. Studies on lactoferrin nanoparticles of gambogic acid for oral delivery. Drug delivery. 2013 Feb; 20(2):86-93. doi: 10.3109/10717544.2013.766781. [PMID: 23495734]
  • Jing Geng, Shuyan Xiao, Zhonghui Zheng, Siyang Song, Lianru Zhang. Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2013 Feb; 62(2):165-72. doi: 10.1007/s00011-012-0563-2. [PMID: 23064679]
  • Peipei Xu, Jingyuan Li, Lixin Shi, Matthias Selke, Baoan Chen, Xuemei Wang. Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition. International journal of nanomedicine. 2013; 8(?):3729-36. doi: 10.2147/ijn.s51622. [PMID: 24109183]
  • Yihebali Chi, Xiao-kai Zhan, Hao Yu, Guang-ru Xie, Zhen-zhong Wang, Wei Xiao, Yong-gang Wang, Fu-xing Xiong, Jun-feng Hu, Lin Yang, Cheng-xu Cui, Jin-wan Wang. An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. Chinese medical journal. 2013; 126(9):1642-6. doi: ". [PMID: 23652044]
  • Emmanuelle Saugues, Anne-Laure Debaud, Fabrice Anizon, Nathalie Bonnefoy, Pascale Moreau. Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators. European journal of medicinal chemistry. 2012 Nov; 57(?):112-25. doi: 10.1016/j.ejmech.2012.09.012. [PMID: 23047228]
  • Yong Xu, Jian Ouyang, Qi-Guo Zhang, Min Zhou, Juan Li, Min-Min Chen, Yue-Yi Xu. [Gambogic acid induces apoptosis of Jurkat cell through the MAPK signal pathway]. Zhongguo shi yan xue ye xue za zhi. 2012 Jun; 20(3):587-91. doi: . [PMID: 22739161]
  • Zhengyun Zou, Li Xie, Jia Wei, Lixia Yu, Xiaoping Qian, Junhao Chen, Tingting Wang, Baorui Liu. Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines. BMC complementary and alternative medicine. 2012 Apr; 12(?):58. doi: 10.1186/1472-6882-12-58. [PMID: 22546220]
  • Natthinee Anantachoke, Patoomratana Tuchinda, Chutima Kuhakarn, Manat Pohmakotr, Vichai Reutrakul. Prenylated caged xanthones: chemistry and biology. Pharmaceutical biology. 2012 Jan; 50(1):78-91. doi: 10.3109/13880209.2011.636176. [PMID: 22196584]
  • Xiao-Liang Jiang, Yao Zhang, Chun-Li Luo, Xiao-Hou Wu. Targeting renal cell carcinoma with gambogic acid in combination with sunitinib in vitro and in vivo. Asian Pacific journal of cancer prevention : APJCP. 2012; 13(12):6463-8. doi: 10.7314/apjcp.2012.13.12.6463. [PMID: 23464475]
  • Chenglin Li, Na Lu, Qi Qi, Fanni Li, Yun Ling, Yan Chen, Yansu Qin, Zhiyu Li, Haiwei Zhang, Qidong You, Qinglong Guo. Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway. Biochemical pharmacology. 2011 Dec; 82(12):1873-83. doi: 10.1016/j.bcp.2011.09.013. [PMID: 21946083]
  • Sahdeo Prasad, Manoj K Pandey, Vivek R Yadav, Bharat B Aggarwal. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. Cancer prevention research (Philadelphia, Pa.). 2011 Jul; 4(7):1084-94. doi: 10.1158/1940-6207.capr-10-0340. [PMID: 21490133]
  • Jing Yang, Li Ding, Linlin Hu, Wenjuan Qian, Shaohong Jin, Xiaoping Sun, Zhenzhong Wang, Wei Xiao. Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition. Drug metabolism and disposition: the biological fate of chemicals. 2011 Apr; 39(4):617-26. doi: 10.1124/dmd.110.037044. [PMID: 21191083]
  • Yulin Ren, Chunhua Yuan, Hee-byung Chai, Yuanqing Ding, Xing-Cong Li, Daneel Ferreira, A Douglas Kinghorn. Absolute configuration of (-)-gambogic acid, an antitumor agent. Journal of natural products. 2011 Mar; 74(3):460-3. doi: 10.1021/np100422z. [PMID: 21067206]
  • Liming Cao, Huanming Liu, Dennis Shun-Chiu Lam, Gary Hin-Fai Yam, Chi-Pui Pang. In vitro screening for angiostatic potential of herbal chemicals. Investigative ophthalmology & visual science. 2010 Dec; 51(12):6658-64. doi: 10.1167/iovs.10-5524. [PMID: 20671276]
  • Oraphin Chantarasriwong, Ayse Batova, Warinthorn Chavasiri, Emmanuel A Theodorakis. Chemistry and biology of the caged Garcinia xanthones. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Sep; 16(33):9944-62. doi: 10.1002/chem.201000741. [PMID: 20648491]
  • Eriko Suzuki, Tracy R Daniels, Gustavo Helguera, Manuel L Penichet, Kazuo Umezawa, Benjamin Bonavida. Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis. International journal of oncology. 2010 May; 36(5):1299-307. doi: 10.3892/ijo_00000615. [PMID: 20372806]
  • Jing Yang, Li Ding, Shaohong Jin, Xiaoxue Liu, Wenyuan Liu, Zhenzhong Wang. Identification and quantitative determination of a major circulating metabolite of gambogic acid in human. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Mar; 878(7-8):659-66. doi: 10.1016/j.jchromb.2010.01.032. [PMID: 20149761]
  • Jing Yang, Li Ding, Linlin Hu, Shaohong Jin, Wenyuan Liu, Zhenzhong Wang, Wei Xiao, Qidong Yu, Qinglong Guo. Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma. European journal of mass spectrometry (Chichester, England). 2010; 16(5):605-17. doi: 10.1255/ejms.1095. [PMID: 20814086]
  • Qi-Guo Zhang, Cui-Ping Li, Jun-Hao Chen, -Jian Ouyang. [Apoptosis-inducing effect of gambogic acid on K562 cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. 2009 Dec; 17(6):1443-7. doi: . [PMID: 20030923]
  • Guowei Qu, Xian Zhu, Can Zhang, Qineng Ping. Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery. Drug delivery. 2009 Oct; 16(7):363-70. doi: 10.1080/10717540903075545. [PMID: 19575591]
  • Di He, Qin Xu, Ming Yan, Ping Zhang, Xiaojian Zhou, Zhiyuan Zhang, Wenhu Duan, Laiping Zhong, Dongxia Ye, Wantao Chen. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. BMC cancer. 2009 Sep; 9(?):343. doi: 10.1186/1471-2407-9-343. [PMID: 19778460]
  • Elena Zaks-Makhina, Hui Li, Anatoly Grishin, Vicenta Salvador-Recatala, Edwin S Levitan. Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid. The Journal of biological chemistry. 2009 Jun; 284(23):15432-8. doi: 10.1074/jbc.m901586200. [PMID: 19366693]
  • Hua Xie, Yu-xin Qin, Yun-long Zhou, Lin-jiang Tong, Li-ping Lin, Mei-yu Geng, Wen-hu Duan, Jian Ding. GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms. Acta pharmacologica Sinica. 2009 Mar; 30(3):346-54. doi: 10.1038/aps.2009.3. [PMID: 19262558]
  • Xiaoyuan Xu, Yeqiang Liu, Ling Wang, Jun He, Hongfeng Zhang, Xinxiang Chen, Yan Li, Jing Yang, Juan Tao. Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells. International journal of dermatology. 2009 Feb; 48(2):186-92. doi: 10.1111/j.1365-4632.2009.03946.x. [PMID: 19200201]
  • Si-Jia Tao, Shu-Hong Guan, Wei Wang, Zhi-Qiang Lu, Guang-Tong Chen, Na Sha, Qing-Xi Yue, Xuan Liu, De-An Guo. Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi. Journal of natural products. 2009 Jan; 72(1):117-24. doi: 10.1021/np800460b. [PMID: 19072548]
  • Quan-Bin Han, Hong-Xi Xu. Caged Garcinia xanthones: development since 1937. Current medicinal chemistry. 2009; 16(28):3775-96. doi: 10.2174/092986709789104993. [PMID: 19747141]