Panaxadiol (BioDeep_00000230282)
Secondary id: BioDeep_00000024328
PANOMIX_OTCML-2023 Antitumor activity
代谢物信息卡片
化学式: C30H52O3 (460.3916242)
中文名称: 人参萜二醇, 人参二醇, 20（R）-人参二醇
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 15.38%
分子结构信息
SMILES: C1C[C@]2(C)[C@@]3([H])C[C@@H](O)[C@]4([H])[C@@]([H])([C@]5(CCCC(C)(C)O5)C)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])C(C)(C)[C@H]1O
InChI: InChI=1S/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3/t19-,20+,21-,22+,23-,24-,27-,28+,29+,30+/m0/s1
描述信息
Panaxadiol is a triterpenoid saponin.
Panaxadiol is a natural product found in Panax ginseng with data available.
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].
同义名列表
11 个代谢物同义名
(3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol; Dammarane-3,12-diol, 20,25-epoxy-, (3beta,12beta,20R)-; (3beta,12beta,20R)-20,25-Epoxydammarane-3,12-diol; 20R,25-Epoxydammarane-3bet3,12beta-diol; panaxadiol, (3beta,12beta)-isomer; 20(R)-Panaxadiol; UNII-F84BLM3L74; F84BLM3L74; Panaxadiol; 88K; 20(R)-Panaxadiol
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:192043
- PubChem: 73498
- ChEMBL: CHEMBL491655
- LipidMAPS: LMPR0106080019
- MeSH: panaxadiol
- ChemIDplus: 0019666763
- CAS: 19666-76-3
- medchemexpress: HY-N0596
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ai Mi, Qinxue Hu, Ying Liu, Yanna Zhao, Fenglin Shen, Jinjian Lan, Keren Lv, Bolin Wang, Ruilan Gao, Xiaoling Yu. Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced NAFLD mice.
Food & function.
2024 Jan; 15(2):794-808. doi:
10.1039/d3fo03572g. [PMID: 38131276] - Jianshu Feng, Fanghui Cheng, Yuqian Lv, Zhiyi Yu, Ming Zhang, Li Chen, Mingzhu Xu, Fengying Guan. Effects of (20 R)-Panaxadiol on NAFLD using non‑targeted metabolomics in stool.
Journal of pharmaceutical and biomedical analysis.
2023 Jul; 234(?):115555. doi:
10.1016/j.jpba.2023.115555. [PMID: 37473506] - Jiuwei Li, Lu Wang, Xiaodan Yu, Yong Guan, Xue Wang. Panaxadiol targeting IL2 inducible T cell kinase promotes T cell immunity in radiotherapy.
Anti-cancer drugs.
2023 07; 34(6):705-714. doi:
10.1097/cad.0000000000001448. [PMID: 36730497] - Yuqian Lv, Yining Zhang, Jianshu Feng, Tianyu Zhao, Jingtong Zhao, Yue Ge, Xuehan Yang, Hao Han, Ming Zhang, Li Chen, Mingzhu Xu, Fengying Guan. (20R)-Panaxadiol as a Natural Active Component with Anti-Obesity Effects on ob/ob Mice via Modulating the Gut Microbiota.
Molecules (Basel, Switzerland).
2022 Apr; 27(8):. doi:
10.3390/molecules27082502. [PMID: 35458705] - Jing Ying Wang, Yue Xing, Ming Yue Li, Zhi Hong Zhang, Hong Lan Jin, Juan Ma, Jung Joon Lee, Yi Zhong, Hong Xiang Zuo, Xuejun Jin. Panaxadiol inhibits IL-1β secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages.
Journal of ethnopharmacology.
2022 Jan; 283(?):114715. doi:
10.1016/j.jep.2021.114715. [PMID: 34648898] - He Zhang, Yuyao Zhang, Xiaolei Tang, Wenjie Su, Chunhui Yang, Daian Pan, Daqing Zhao, Bin Qi, Xiangyan Li. Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway.
BioMed research international.
2022; 2022(?):8265898. doi:
10.1155/2022/8265898. [PMID: 36177062] - Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway.
European journal of pharmacology.
2020 Sep; 882(?):173272. doi:
10.1016/j.ejphar.2020.173272. [PMID: 32535096] - Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators.
Bioorganic & medicinal chemistry letters.
2020 09; 30(17):127364. doi:
10.1016/j.bmcl.2020.127364. [PMID: 32738969] - Shuyun Zhu, Zhenjia Zheng, Hongwei Peng, Jing Sun, Xian-En Zhao, Huwei Liu. Quadruplex stable isotope derivatization strategy for the determination of panaxadiol and panaxatriol in foodstuffs and medicinal materials using ultra high performance liquid chromatography tandem mass spectrometry.
Journal of chromatography. A.
2020 Apr; 1616(?):460794. doi:
10.1016/j.chroma.2019.460794. [PMID: 31870574] - Ziyi Wang, Meng Ding, Zhe Lin, Cuiwei He, Yuqing Zhao. Esterified Derivatives of Panaxadiol and Their Inhibitory Effect on HL-60, THP-1, and PC-3 Cell Lines.
Chemistry & biodiversity.
2019 Aug; 16(8):e1900188. doi:
10.1002/cbdv.201900188. [PMID: 31298488] - Xicai Liang, Yingjia Yao, Ying Lin, Liang Kong, Honghe Xiao, Yue Shi, Jingxian Yang. Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells.
Life sciences.
2019 Mar; 221(?):35-46. doi:
10.1016/j.lfs.2019.02.012. [PMID: 30735733] - Yumeng Zhang, Weihui Yuan, Xude Wang, Hongyu Zhang, Yuanyuan Sun, Xiaoshu Zhang, Yuqing Zhao. Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
MedChemComm.
2018 Nov; 9(11):1910-1919. doi:
10.1039/c8md00387d. [PMID: 30568759] - Jingcheng Wang, Yuanlong Hou, Zhiying Jia, Xie Xie, Jiajian Liu, Yani Kang, Xin Wang, Xiaoyan Wang, Wei Jia. Metabonomics Approach To Comparing the Antistress Effects of Four Panax ginseng Components in Rats.
Journal of proteome research.
2018 02; 17(2):813-821. doi:
10.1021/acs.jproteome.7b00559. [PMID: 29302971] - Jinqiang Zhu, Yubin Liang, Shaoqian Yue, Guanwei Fan, Han Zhang, Meng Zhang. Combination of Panaxadiol and Panaxatriol Type Saponins and Ophioponins From Shenmai Formula Attenuates Lipopolysaccharide-induced Inflammatory Injury in Cardiac Microvascular Endothelial Cells by Blocking NF-kappa B Pathway.
Journal of cardiovascular pharmacology.
2017 Mar; 69(3):140-146. doi:
10.1097/fjc.0000000000000450. [PMID: 28266999] - Tanya Biswas, Alok Kalra, A K Mathur, R K Lal, Manju Singh, Archana Mathur. Elicitors' influenced differential ginsenoside production and exudation into medium with concurrent Rg3/Rh2 panaxadiol induction in Panax quinquefolius cell suspensions.
Applied microbiology and biotechnology.
2016 Jun; 100(11):4909-22. doi:
10.1007/s00253-015-7264-z. [PMID: 26795963] - Yan Chen, Yanwei Du, Yang Li, Xiaoqin Wang, Pin Gao, Guang Yang, Yuan Fang, Yan Meng, Xuejian Zhao. Panaxadiol Saponin and Dexamethasone Improve Renal Function in Lipopolysaccharide-Induced Mouse Model of Acute Kidney Injury.
PloS one.
2015; 10(7):e0134653. doi:
10.1371/journal.pone.0134653. [PMID: 26230340] - Zhi-Ying Jia, Xie Xie, Xiao-Yan Wang, Wei Jia. [Comparative study of main components of ginseng on immune function of rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Sep; 39(17):3363-6. doi:
NULL. [PMID: 25522629] - Shuang Jiang, Dayong Ren, Jianrui Li, Guangxin Yuan, Hongyu Li, Guangyu Xu, Xiao Han, Peige Du, Liping An. Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus.
Fitoterapia.
2014 Jun; 95(?):58-64. doi:
10.1016/j.fitote.2014.02.017. [PMID: 24613802] - Cai Xiaojun, Xu Yuping, Pan Yu, Ren Yiping, Xiang Zheng. An UFLC-MS/MS method for quantification of panaxadiol in rat plasma and its application to a pharmacokinetic study.
Planta medica.
2013 Sep; 79(14):1324-8. doi:
10.1055/s-0033-1350675. [PMID: 23925904] - Guang-Jian Du, Chong-Zhi Wang, Zhi-Yu Zhang, Xiao-Dong Wen, Jacqueline Somogyi, Tyler Calway, Tong-Chuan He, Wei Du, Chun-Su Yuan. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells.
The Journal of pharmacy and pharmacology.
2012 May; 64(5):727-34. doi:
10.1111/j.2042-7158.2012.01463.x. [PMID: 22471369] - Tian Wang, Qingguo Meng, Jiangfeng Zhang, Yi Bi, Naicai Jiang. Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.
Fitoterapia.
2010 Oct; 81(7):783-7. doi:
10.1016/j.fitote.2010.04.005. [PMID: 20398743] - Tae-Hoon Kim, Sun-Mee Lee. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Jun; 48(6):1516-20. doi:
10.1016/j.fct.2010.03.018. [PMID: 20353807] - Miguel Rodriguez, Guang-Jian Du, Chong-Zhi Wang, Chun-Su Yuan. Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin.
The American journal of Chinese medicine.
2010; 38(6):1233-5. doi:
10.1142/s0192415x10008597. [PMID: 21061473] - Gui-Lun Fang, Rui-Lan Gao, Xiao-Jie Lin, Jin-Mei Jin. [Effects of Ginseng panaxadiol saponin on proliferation and differentiation of human bone marrow CD34+ cells].
Zhongguo shi yan xue ye xue za zhi.
2007 Aug; 15(4):776-9. doi:
". [PMID: 17708802] - Chun-Hong Zhang, Lian-Xue Zhang, Xiang-Gao Li, Yu-Gang Gao, Ya-Jing Liu. [Primary research on anti-tumor activity of panaxadiol fatty acid esters].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2006 Nov; 29(11):1200-3. doi:
". [PMID: 17228662] - Yang-ping Niu, Xu-dai Qian, Wen-xi Wang. [Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 Feb; 24(2):127-9, 132. doi:
". [PMID: 15015445] - Y H Liu, Y F Liu, X X Guo. Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.
Acta pharmacologica Sinica.
2001 Dec; 22(12):1071-7. doi:
. [PMID: 11749802] - M S Chang, S G Lee, H M Rho. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng.
Phytotherapy research : PTR.
1999 Dec; 13(8):641-4. doi:
10.1002/(sici)1099-1573(199912)13:8<641::aid-ptr527>3.0.co;2-z. [PMID: 10594930] - Y Jia, B Zhao, Q Liu, Y Liu. [Determination of panaxadiol and panaxatriol in shihu yeguang pills].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
1995 Dec; 20(12):732-5, 763. doi:
". [PMID: 8703336] - Z F Wang, J S Xiao, S Z Yan, Z B Wan. Protective effects of panaxadiol saponins on cardiac functions in burned rats.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1995 Jul; 16(4):345-8. doi:
". [PMID: 7668107] - Q Chi, J Guo, Q Dang. [Thin layer chromatography and extractive technology of Panax japonicum C.A. Mey. var. major (Burk.) C. Y. Wu et K. M. Feng growing in Qingba Mountain Area].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
1992 Aug; 17(8):478-80, 511. doi:
". [PMID: 1482533] - R P Wilson, P L Fowlkes. Activity of glutamine synthetase in channel catfish tissues determined by an improved tissue assay method.
Comparative biochemistry and physiology. B, Comparative biochemistry.
1976; 54(3):365-8. doi:
10.1016/0305-0491(76)90258-3. [PMID: 6197] - J P Radó, J Takó, T Szabó, C Bános. Diuretic and antidiuretic effects of furosemide before and during the early period of pitressin therapy in diabetes insipidus.
Endokrinologie.
1969; 54(1):26-35. doi:
NULL. [PMID: 5358572]