Ursamine (BioDeep_00000230025)
Secondary id: BioDeep_00000016743, BioDeep_00000231026
PANOMIX_OTCML-2023
代谢物信息卡片
[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3E,5R,6S,14aR,14bR)-
化学式: C18H25NO6 (351.168179)
中文名称: 光萼野百合碱, 光萼野百合碱(标准品)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC=C1CC(C(C(=O)OCC2=CCN3C2C(CC3)OC1=O)(CO)O)C
InChI: InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3+/t11-,14-,15-,18-/m1/s1
描述信息
LSM-2938 is a macrolide.
Usaramine is a natural product found in Senecio malacitanus, Senecio ceratophylloides, and other organisms with data available.
D000970 - Antineoplastic Agents
Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50\\% of biofilm formation without killing the bacteria[1].
Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50\% of biofilm formation without killing the bacteria[1].
同义名列表
18 个代谢物同义名
[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3E,5R,6S,14aR,14bR)-; (5R,6S,9a1R,14aR,E)-3-Ethylidene-6-hydroxy-6-(hydroxymethyl)-5-methyl-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione; (1R,4E,6R,7S,17R)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione; Senecionan-11,16-dione, 12,18-dihydroxy-, (15E)-; (15E)-12,18-Dihydroxysenecionan-11,16-dione; retrorsine hydrochloride; retrorsine, (15E)-isomer; USARAMINE;MUCRONATINE; (15E)-Retrorsine; trans-Retrorsine; (+)-Ursamine; Mucronatine; SMP1_000259; retrorsine; Usaramine; 1ST170859; Ursamine; Usaramin
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:92743
- ChEBI: CHEBI:9912
- PubChem: 5281756
- ChEMBL: CHEMBL520570
- MeSH: retrorsine
- ChemIDplus: 0015503874
- chemspider: 13076866
- CAS: 15503-87-4
- medchemexpress: HY-N6931
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 猪屎豆: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yongguo Dai, Qi Guo, Kequan Xu, Zheng Gong, Shuaikai Qiu, Xiaoxiang Sun, Jie Liu, Yuxi Wang, Zhixin Yang, Hui Wang, Yu Guo. Lactational retrorsine exposure changes maternal milk components and disturbs metabolism homeostasis of offspring rats.
The Science of the total environment.
2023 Jun; ?(?):164929. doi:
10.1016/j.scitotenv.2023.164929. [PMID: 37329908] - Weiwei Li, Ting Cheng, Tingting Jiang, Mengyue Zhou, Bowen Gong, Guode Zhao, Jing Li, Rong Tan, Xiaojing Yang, Kandarp Joshi, Ying Peng, Maosheng Cheng, Ting Liu, Dan Ohtan Wang, Jiang Zheng. Hepatic RNA adduction derived from metabolic activation of retrorsine in vitro and in vivo.
Chemico-biological interactions.
2022 Sep; 365(?):110047. doi:
10.1016/j.cbi.2022.110047. [PMID: 35917946] - Lin Zhu, Junyi Xue, Yisheng He, Qingsu Xia, Peter P Fu, Ge Lin. Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid.
Toxins.
2022 05; 14(6):. doi:
10.3390/toxins14060377. [PMID: 35737038] - Feifei Lin, Yan Ma, Anni Pan, Yang Ye, Jia Liu. Quantification of Usaramine and its N-Oxide Metabolite in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry.
Journal of analytical toxicology.
2022 May; 46(5):512-518. doi:
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Biomedical chromatography : BMC.
2022 Feb; 36(2):e5270. doi:
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Archives of toxicology.
2022 02; 96(2):639-651. doi:
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Molecular nutrition & food research.
2022 01; 66(2):e2100800. doi:
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Archives of toxicology.
2021 10; 95(10):3191-3204. doi:
10.1007/s00204-021-03129-6. [PMID: 34390356] - Li Guo, Li Zhang, Haiman Xu, Pei Yu, Zhigang Wang, Danyi Lu, Min Chen, Baojian Wu. Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Sep; 51(9):1019-1028. doi:
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Current drug metabolism.
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Phytochemistry.
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Research in veterinary science.
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Toxicology.
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Cell transplantation.
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The Journal of surgical research.
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Hepato-gastroenterology.
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Transplantation.
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