Hypolide (BioDeep_00000229928)

Main id: BioDeep_00000407579

 

PANOMIX_OTCML-2023


代谢物信息卡片


Phenanthro(1,2-c)furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR-trans)-

化学式: C20H24O3 (312.1725354)
中文名称: 雷酚内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=C(C2=C(C=C1)C3(CCC4=C(C3CC2)COC4=O)C)O
InChI: InChI=1S/C20H24O3/c1-11(2)12-4-6-16-14(18(12)21)5-7-17-15-10-23-19(22)13(15)8-9-20(16,17)3/h4,6,11,17,21H,5,7-10H2,1-3H3/t17-,20+/m0/s1

描述信息

(3bR,9bS)-6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one is an oxo steroid.
Triptophenolide is a natural product found in Tripterygium regelii, Tripterygium hypoglaucum, and other organisms with data available.
Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value: Target: In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1]. In vivo:
Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value: Target: In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1]. In vivo:

同义名列表

22 个代谢物同义名

Phenanthro(1,2-c)furan-1(3H)-one, 3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-, (3bR-trans)-; Phenanthro[1,2-c]furan-1(3H)-one,3b,4,5,9b,10,11-hexahydro-6-hydroxy-9b-methyl-7-(1-methylethyl)-,(3bR,9bS)-; (3bR,9bS)-6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one; (3bR,9bS)-6-hydroxy-9b-methyl-7-propan-2-yl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e][2]benzofuran-1-one; 6-Hydroxy-9b-methyl-7-(propan-2-yl)-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one; 6-hydroxy-7-isopropyl-9b-methyl-3,3b,4,5,10,11-hexahydronaphtho[2,1-e]isobenzofuran-1-one; Hypolide;(+)-Triptophenolide; (+)-Triptophenolide; (-)-triptophenolide; Spectrum4_001660; Spectrum2_001618; Spectrum3_001928; Spectrum5_000539; Triptophenolide; tryptophenolide; DivK1c_006662; KBio2_002202; KBio2_004770; KBio1_001606; KBio2_007338; KBio3_002756; Hypolide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • QinWei Huang, ChunMei Tan, Cheng Zheng, Hong Meng, ZhengNan Wang, Guo-Qiang Lin, WenTing Zhang, BiLian Chen, Qing-Li He. DCTPP1, a reliable Q-biomarker for comprehensive evaluation of the quality of tripterygium glycoside tablets based on chemical references. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 119(?):154972. doi: 10.1016/j.phymed.2023.154972. [PMID: 37531903]
  • Baowei Ma, Xihong Liu, Yun Lu, Xiaochi Ma, Xiaoyi Wu, Xing Wang, Meirong Jia, Ping Su, Yuru Tong, Hongyu Guan, Zhouqian Jiang, Jie Gao, Luqi Huang, Wei Gao. A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f. Phytochemistry. 2019 Oct; 166(?):112062. doi: 10.1016/j.phytochem.2019.112062. [PMID: 31299395]
  • Tuanjie Wang, Fei Shen, Shulan Su, Yongliang Bai, Sheng Guo, Hui Yan, Tao Ji, Yanyan Wang, Dawei Qian, Jin-Ao Duan. Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods. BMC complementary and alternative medicine. 2016 Nov; 16(1):476. doi: 10.1186/s12906-016-1453-x. [PMID: 27881165]
  • Chang Gao, Di Wang, Yan Zhang, Xiao-Xiao Huang, Shao-Jiang Song. Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation. Bioorganic & medicinal chemistry letters. 2016 06; 26(12):2942-2946. doi: 10.1016/j.bmcl.2016.04.026. [PMID: 27133593]
  • Zhenzhen Liu, Ronghua Zhao, Zhongmei Zou. [Chemical constituents from root bark of Tripterygium hypoglaucum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Sep; 36(18):2503-6. doi: . [PMID: 22256754]
  • Ming-xing Liu, Jing Dong, Ya-jiang Yang, Xiang-liang Yang, Hui-bi Xu. [Progress in research on triptolide]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Feb; 30(3):170-4. doi: ". [PMID: 15719629]
  • D F Yu, B H Hu, G P Chen, C X Yang, J Yang, J Y Xu, L Z Li. [Structure revision of triptophenolide]. Yao xue xue bao = Acta pharmaceutica Sinica. 1990; 25(12):929-31. doi: NULL. [PMID: 2104474]