Suberosin (BioDeep_00000229831)

 

Secondary id: BioDeep_00000227415

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)- (9CI)

化学式: C15H16O3 (244.1099)
中文名称: 软木花椒素
谱图信息: 最多检出来源 Viridiplantae(plant) 78.1%

分子结构信息

SMILES: CC(=CCC1=C(C=C2C(=C1)C=CC(=O)O2)OC)C
InChI: InChI=1S/C15H16O3/c1-10(2)4-5-11-8-12-6-7-15(16)18-14(12)9-13(11)17-3/h4,6-9H,5H2,1-3H3

描述信息

Suberosin is a member of the class of coumarins in which the coumarin ring is substituted at positions 6 and 7 by a 3-methylbut-2-en-1-yl group and a methoxy group, respectively. A natural product found in Citropsis articulata. It has a role as a plant metabolite and an anticoagulant. It is a member of coumarins and an aromatic ether. It is functionally related to a 7-demethylsuberosin.
Suberosin is a natural product found in Zanthoxylum ovalifolium, Prangos bucharica, and other organisms with data available.
A member of the class of coumarins in which the coumarin ring is substituted at positions 6 and 7 by a 3-methylbut-2-en-1-yl group and a methoxy group, respectively. A natural product found in Citropsis articulata.
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

同义名列表

22 个代谢物同义名

2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)- (9CI); 2H-1-Benzopyran-2-one, 7-methoxy-6-(3-methyl-2-butenyl)-; 7-Methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-2-one; 7-Methoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one; 7-Methoxy-6-(3-methyl-2-butenyl)-2H-chromen-2-one #; 7-methoxy-6-(3-methylbut-2-enyl)chromen-2-one; Coumarin, 7-methoxy-6-(3-methyl-2-butenyl)-; RSZDAYHEZSRVHS-UHFFFAOYSA-N; 7-methoxy-6-prenylcoumarin; MEGxp0_001424; NCI60_002737; ACon1_000574; Suberosin; Coumarin, 7-methoxy-6-(3-methyl-2-butenyl)- (8CI); 7-methoxy-6-(3-methylbut-2-enyl)-2-chromenone; 7-methoxy-6-(3-methylbut-2-enyl)coumarin; AIDS-011993; AIDS011993; NSC 31869; NSC31869; 581-31-7; Suberosin



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Saeed Tavakoli, Mohammad-Reza Delnavazi, Reza Hadjiaghaee, Saeedeh Jafari-Nodooshan, Farahnaz Khalighi-Sigaroodi, Maryam Akhbari, Abbas Hadjiakhoondi, Narguess Yassa. Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran. Natural product research. 2018 Nov; 32(22):2724-2728. doi: 10.1080/14786419.2017.1375915. [PMID: 28954543]
  • Marie Fomani, Emmanuel Ngeufa Happi, Achille Nouga Bisoue, Jean Claude Ndom, Alain François Kamdem Waffo, Norbert Sewald, Jean Duplex Wansi. Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco). Bioorganic & medicinal chemistry letters. 2016 Jan; 26(2):306-309. doi: 10.1016/j.bmcl.2015.12.028. [PMID: 26711890]
  • Fereshteh Golfakhrabadi, Mohammad Abdollahi, Mohammad Reza Shams Ardakani, Soodabeh Saeidnia, Tahmineh Akbarzadeh, Amir Nili Ahmadabadi, Azin Ebrahimi, Fatemeh Yousefbeyk, Alireza Hassanzadeh, Mahnaz Khanavi. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharmaceutical biology. 2014 Oct; 52(10):1335-40. doi: 10.3109/13880209.2014.892140. [PMID: 25017518]
  • Imran Ahmad, Jay Prakash Thakur, Debabrata Chanda, Dharmendra Saikia, Feroz Khan, Shivani Dixit, Amit Kumar, Rituraj Konwar, Arvind Singh Negi, Atul Gupta. Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents. Bioorganic & medicinal chemistry letters. 2013 Mar; 23(5):1322-5. doi: 10.1016/j.bmcl.2012.12.096. [PMID: 23369537]
  • Damien Lacroix, Soizic Prado, Dennis Kamoga, John Kasenene, Bernard Bodo. Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark. Journal of natural products. 2011 Oct; 74(10):2286-9. doi: 10.1021/np2004825. [PMID: 21985060]
  • Y-C Chen, W-J Tsai, M-H Wu, L-C Lin, Y-C Kuo. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-kappaB. British journal of pharmacology. 2007 Feb; 150(3):298-312. doi: 10.1038/sj.bjp.0706987. [PMID: 17179947]
  • C M Teng, H L Li, T S Wu, S C Huang, T F Huang. Antiplatelet actions of some coumarin compounds isolated from plant sources. Thrombosis research. 1992 Jun; 66(5):549-57. doi: 10.1016/0049-3848(92)90309-x. [PMID: 1523611]