Cholylglycine (BioDeep_00000229687)
Main id: BioDeep_00000000126
human metabolite PANOMIX_OTCML-2023 Bile acids Antitumor activity BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
N-(3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholan-24-oyl)-glycine
化学式: C26H43NO6 (465.30902180000004)
中文名称: 甘氨胆酸, 甘氨胆酸水合物, 甘胆酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C([H])(C4(C)1)CCC1([H])C(C(O)3)(C(CC(O)4)([H])C(C)(C([H])2C3)CCC(C2)O)[H])C)CC(=O)NCC(O)=O
InChI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:17687
- KEGG: C01921
- PubChem: 10140
- HMDB: HMDB00138
- ChEMBL: CHEMBL411070
- LipidMAPS: LMST05030001
- MeSH: Glycocholic Acid
- CAS: 475-31-0
- MoNA: MT000026
- PubChem: 5027
- KNApSAcK: C00030410
- PDB-CCD: GCH
- 3DMET: B04823
- NIKKAJI: J12.411G
- medchemexpress: HY-N1423
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-420
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-969
- KNApSAcK: 17687
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hamid Alghurabi, Huda Jassim Muhammad, Tatsuaki Tagami, Koki Ogawa, Tetsuya Ozeki. Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid.
International journal of pharmaceutics.
2023 Dec; 648(?):123597. doi:
10.1016/j.ijpharm.2023.123597. [PMID: 37952559] - Yu Tang, Zhu Han, Han Zhang, Li Che, Genjie Liao, Jun Peng, Yu Lin, Yi Wang. Characterization of Calculus bovis by principal component analysis assisted qHNMR profiling to distinguish nefarious frauds.
Journal of pharmaceutical and biomedical analysis.
2023 Mar; 228(?):115320. doi:
10.1016/j.jpba.2023.115320. [PMID: 36871364] - Shibin Yao, Shengjie Ren, Chunfang Cai, Xiamin Cao, Ye Shi, Ping Wu, Yuantu Ye. Glycocholic acid supplementation improved growth performance and alleviated tissue damage in the liver and intestine in Pelteobagrus fulvidraco fed a high-pectin diet.
Fish physiology and biochemistry.
2022 Dec; ?(?):. doi:
10.1007/s10695-022-01148-3. [PMID: 36454392] - Xiaolu Zhou, Yaling Li, Ren Mu, Chuanming Wang, Yuyan Song, Caibi Zhou, Xin Mei. Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet.
The British journal of nutrition.
2022 Oct; ?(?):1-9. doi:
10.1017/s0007114522003166. [PMID: 36210537] - Jian Wu, Yanping Xu, Yubao Cui, Mariza Bortolanza, Minjie Wang, Bin Jiang, Meina Yan, Wei Liang, Yiwen Yao, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Dawei Wang, Hongcui Cao, Lanjuan Li. Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Journal of medical virology.
2022 06; 94(6):2714-2726. doi:
10.1002/jmv.27669. [PMID: 35199373] - Feiyang Deng, You Han Bae. Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3.
International journal of pharmaceutics.
2022 Apr; 617(?):121589. doi:
10.1016/j.ijpharm.2022.121589. [PMID: 35176336] - Hongxue Liu, Haidong Wang, Muling Zhang. Deep Learning Algorithm-Based Magnetic Resonance Imaging Feature-Guided Serum Bile Acid Profile and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy.
Computational and mathematical methods in medicine.
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Scientific reports.
2021 09; 11(1):17788. doi:
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Analytical and bioanalytical chemistry.
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Plant foods for human nutrition (Dordrecht, Netherlands).
2011 Nov; 66(4):370-5. doi:
10.1007/s11130-011-0253-1. [PMID: 21901402] - Xiaoqiang Xiang, Juha Vakkilainen, Janne T Backman, Pertti J Neuvonen, Mikko Niemi. No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid.
European journal of clinical pharmacology.
2011 Nov; 67(11):1159-67. doi:
10.1007/s00228-011-1070-z. [PMID: 21655991] - Dong-Ho Oh, Kyeung-Hwa Chun, Sang-Ok Jeon, Jeong-Won Kang, Sangkil Lee. Enhanced transbuccal salmon calcitonin (sCT) delivery: effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Oct; 79(2):357-63. doi:
10.1016/j.ejpb.2011.05.010. [PMID: 21683790] - Silvia Petersen, Frank Steiniger, Dagmar Fischer, Alfred Fahr, Heike Bunjes. The physical state of lipid nanoparticles influences their effect on in vitro cell viability.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Sep; 79(1):150-61. doi:
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Molecular & cellular proteomics : MCP.
2011 Jul; 10(7):M110.004945. doi:
10.1074/mcp.m110.004945. [PMID: 21518826] - Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, William J Zavadoski, Mark P Molloy, John D Baker, Max Kuhn, Over Cabrera, Judith L Treadway. Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
BMC genomics.
2011 Jun; 12(?):281. doi:
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Journal of proteome research.
2011 May; 10(5):2625-32. doi:
10.1021/pr200173q. [PMID: 21456628] - Jiang-shan Lian, Wei Liu, Shao-rui Hao, Yong-zheng Guo, Hai-jun Huang, De-ying Chen, Qing Xie, Xiao-ping Pan, Wei Xu, Wen-xia Yuan, Lan-juan Li, Jian-rong Huang. A serum metabonomic study on the difference between alcohol- and HBV-induced liver cirrhosis by ultraperformance liquid chromatography coupled to mass spectrometry plus quadrupole time-of-flight mass spectrometry.
Chinese medical journal.
2011 May; 124(9):1367-73. doi:
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Zhonghua fu chan ke za zhi.
2011 May; 46(5):333-7. doi:
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Biological chemistry.
2011 Apr; 392(6):539-46. doi:
10.1515/bc.2011.050. [PMID: 21521075] - Satish C Kalhan, Lining Guo, John Edmison, Srinivasan Dasarathy, Arthur J McCullough, Richard W Hanson, Mike Milburn. Plasma metabolomic profile in nonalcoholic fatty liver disease.
Metabolism: clinical and experimental.
2011 Mar; 60(3):404-13. doi:
10.1016/j.metabol.2010.03.006. [PMID: 20423748] - Jauricque Ursulla Kongo-Dia-Moukala, Hui Zhang, Pierre Claver Irakoze. In vitro binding capacity of bile acids by defatted corn protein hydrolysate.
International journal of molecular sciences.
2011 Feb; 12(2):1066-80. doi:
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Journal of chromatography. A.
2011 Jan; 1218(1):107-17. doi:
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PloS one.
2011; 6(10):e25482. doi:
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PloS one.
2011; 6(7):e22094. doi:
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JPEN. Journal of parenteral and enteral nutrition.
2010 Sep; 34(5):538-41. doi:
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Die Pharmazie.
2010 Jul; 65(7):457-60. doi:
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Langmuir : the ACS journal of surfaces and colloids.
2010 Apr; 26(7):4687-92. doi:
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PLoS computational biology.
2010 Feb; 6(2):e1000692. doi:
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Methods in molecular biology (Clifton, N.J.).
2010; 606(?):11-20. doi:
10.1007/978-1-60761-447-0_2. [PMID: 20013386] - Ellen Hildebrandt, David J McGee. Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent.
BMC microbiology.
2009 Dec; 9(?):258. doi:
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Hepatology research : the official journal of the Japan Society of Hepatology.
2009 Nov; 39(11):1144-9. doi:
10.1111/j.1872-034x.2009.00557.x. [PMID: 19619254] - Jing Fang, Wen-Li Gou, Qi-Ling Li. [Effect of integrative Chinese and Western medicine in treating pregnant women with intrahepatic cholestasis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2009 Oct; 29(10):869-71. doi:
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World journal of gastroenterology.
2009 Jul; 15(25):3134-41. doi:
10.3748/wjg.15.3134. [PMID: 19575493] - Tyler F Daniels, Karen M Killinger, Jennifer J Michal, Raymond W Wright, Zhihua Jiang. Lipoproteins, cholesterol homeostasis and cardiac health.
International journal of biological sciences.
2009 Jun; 5(5):474-88. doi:
10.7150/ijbs.5.474. [PMID: 19584955] - Do Kyung Lee, Seok Jang, Eun Hye Baek, Mi Jin Kim, Kyung Soon Lee, Hea Soon Shin, Myung Jun Chung, Jin Eung Kim, Kang Oh Lee, Nam Joo Ha. Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content.
Lipids in health and disease.
2009 Jun; 8(?):21. doi:
10.1186/1476-511x-8-21. [PMID: 19515264] - Yoshifumi Murata, Youko Kodama, Daijirou Hirai, Kyouko Kofuji, Susumu Kawashima. Properties of an oral preparation containing a chitosan salt.
Molecules (Basel, Switzerland).
2009 Feb; 14(2):755-62. doi:
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American journal of physiology. Endocrinology and metabolism.
2009 Feb; 296(2):E384-93. doi:
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Journal of lipid research.
2008 Dec; 49(12):2690-5. doi:
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International journal of pharmaceutics.
2008 Nov; 364(1):27-35. doi:
10.1016/j.ijpharm.2008.07.030. [PMID: 18760341] - Jiarong Chen, Tomohiro Terada, Ken Ogasawara, Toshiya Katsura, Ken-ichi Inui. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F247-52. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2008 Jun; 69(2):426-35. doi:
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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2008 May; 39(3):430-3. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Mar; 36(3):582-8. doi:
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Molecular systems biology.
2008; 4(?):157. doi:
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Cancer biotherapy & radiopharmaceuticals.
2007 Dec; 22(6):762-71. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Sep; 293(3):R1400-9. doi:
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Hepatology (Baltimore, Md.).
2007 Jul; 46(1):188-99. doi:
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Journal of molecular biology.
2007 Jun; 369(2):439-50. doi:
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Biochemical pharmacology.
2007 Feb; 73(3):394-404. doi:
10.1016/j.bcp.2006.10.014. [PMID: 17134679] - François-Pierre J Martin, Marc-Emmanuel Dumas, Yulan Wang, Cristina Legido-Quigley, Ivan K S Yap, Huiru Tang, Séverine Zirah, Gerard M Murphy, Olivier Cloarec, John C Lindon, Norbert Sprenger, Laurent B Fay, Sunil Kochhar, Peter van Bladeren, Elaine Holmes, Jeremy K Nicholson. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology.
2007; 3(?):112. doi:
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American journal of cardiovascular drugs : drugs, devices, and other interventions.
2007; 7(6):453-65. doi:
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