Muzolimine (BioDeep_00000181151)

   

human metabolite blood metabolite


代谢物信息卡片


2-[1-(3,4-dichlorophenyl)ethyl]-5-iminopyrazolidin-3-one

  化学式: C11H11Cl2N3O (271.0279)
中文名称: 氯唑啉胺
  谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N
InChI: InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)


描述信息

C - Cardiovascular system > C03 - Diuretics > C03C - High-ceiling diuretics > C03CD - Pyrazolone derivatives
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics

同义名列表

7 个代谢物同义名

2-[1-(3,4-dichlorophenyl)ethyl]-5-iminopyrazolidin-3-one; 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one; g 2821, Bay; 2821, Bay g; Bay g 2821; Muzolimine; edrul



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • E Schlatter. Effect of various diuretics on membrane voltage of macula densa cells. Whole-cell patch-clamp experiments. Pflugers Archiv : European journal of physiology. 1993 Apr; 423(1-2):74-7. doi: 10.1007/bf00374963. [PMID: 8387670]
  • B Silke. Central hemodynamic effects of diuretic therapy in chronic heart failure. Cardiovascular drugs and therapy. 1993 Jan; 7 Suppl 1(?):45-53. doi: 10.1007/bf00877957. [PMID: 8435376]
  • F H Noormohamed, A F Lant. Muzolimine: renal site of action and interaction with probenecid in humans. Clinical pharmacology and therapeutics. 1991 Nov; 50(5 Pt 1):564-72. doi: 10.1038/clpt.1991.182. [PMID: 1934869]
  • M Grima, B Michel, M Barthelmebs, D Stephan, J L Imbs. The effects of muzolimine and urine from muzolimine-treated rats on Na+K+Cl- cotransport in Madin-Darby canine kidney cells. European journal of pharmacology. 1991 Sep; 202(2):137-42. doi: 10.1016/0014-2999(91)90287-z. [PMID: 1802742]
  • B Pohlmann-Eden, P Berlit, E A Maibach, N Gretz. Muzolimine-induced severe neuromyeloencephalopathy: report of seven cases. Acta neurologica Scandinavica. 1991 Jan; 83(1):41-4. doi: 10.1111/j.1600-0404.1991.tb03956.x. [PMID: 1849334]
  • M Grima, B Michel, M Barthelmebs, J L Imbs. [Mechanism of action of the diuretic effect of muzolimine]. Archives des maladies du coeur et des vaisseaux. 1990 Jul; 83(8):1205-8. doi: NULL. [PMID: 2124457]
  • B Pohlmann-Eden, P Berlit, A Holle, H Kaschel, N Gretz. [Neuromyeloencephalopathy caused by high-dose muzolimine medication in patients with renal failure]. Fortschritte der Neurologie-Psychiatrie. 1990 Mar; 58(3):87-97. doi: 10.1055/s-2007-1001173. [PMID: 2159946]
  • M A Osman, L K Dunning, V P Bhavnagri, L K Cheng. Determination of muzolimine in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1989 Nov; 496(2):478-84. doi: 10.1016/s0378-4347(00)82598-0. [PMID: 2613850]
  • H Schiffl. Platelet cytosolic free calcium concentration in hypertension associated with early stage kidney disease. Klinische Wochenschrift. 1989 Jul; 67(13):676-81. doi: 10.1007/bf01718029. [PMID: 2755032]
  • A M Gaiter, P E Nebiolo, M C Torazza, P Gabella, E Bottacchi, S Alloatti. [Nephrotoxicity caused by high-dose muzolimine. A multicenter study]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 1988 Oct; 40(4):309-12. doi: NULL. [PMID: 3075097]
  • G Planelles, B Meilhac, T Anagnostopoulos. Effects of muzolimine on the late distal tubule of necturus kidney. The Journal of pharmacology and experimental therapeutics. 1988 Sep; 246(3):1152-7. doi: NULL. [PMID: 3418514]
  • J Stríbrná, V Prát, V Lánská, M Englis. [Circadian rhythm in Na+ and K+ excretion during a change in muzolimine dosage and administration intervals in renal insufficiency]. Casopis lekaru ceskych. 1988 May; 127(21):648-50. doi: NULL. [PMID: 3396048]
  • F Tartagni, P Ortolani, D Degli Esposti, V Cervi, B Magnani. [Effects of sequentially administered or combined muzolimine and furosemide on water and solute excretion: quantitative and qualitative aspects]. Recenti progressi in medicina. 1987 Nov; 78(11):496-9. doi: NULL. [PMID: 3324236]
  • B Pohlmann-Eden, P Berlit, J Bangert, N Gretz. [Neuromyelopathy caused by treatment with muzolimine]. Deutsche medizinische Wochenschrift (1946). 1987 Jul; 112(31-32):1238. doi: NULL. [PMID: 3608851]
  • H Toutain, B Olier, J P Fillastre, J P Morin. Influence of muzolimine, a new diuretic, on experimental gentamicin nephrotoxicity. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1987; 2(6):520-5. doi: 10.1093/oxfordjournals.ndt.a091593. [PMID: 3126452]
  • F Galletti, P Strazzullo, R Gagliardi, M Cirillo, A Siani, R Iacone, M Mancini. Metabolic effects of long-term therapy with muzolimine and chlorthalidone in hypertension. European journal of clinical pharmacology. 1987; 33(5):515-7. doi: 10.1007/bf00544246. [PMID: 3428346]
  • P Bernardi, L Bastagli, M Cavazza, C Minelli, C Ventura, F Fontana, A Danieli, G Bartolini, V Tommasi, M Orlandi. Clinical trial with muzolimine in healthy and hypertensive subjects: new vistas on the drug action. International journal of clinical pharmacology research. 1987; 7(6):455-61. doi: NULL. [PMID: 3126155]
  • T Hannedouche, J P Morin, A Leroy, J P Fillastre, W Ritter. [Influence of muzolimine on the pharmacokinetics of gentamycin in subjects with normal renal function]. Therapie. 1986 Nov; 41(6):421-4. doi: NULL. [PMID: 3810537]
  • G Licata, R Scaglione, G Parrinello, G B Rini, N Asta. [Clinical and hemodynamic effects of medium-term treatment with muzolimine in subjects with essential arterial hypertension]. Giornale italiano di cardiologia. 1986 Jul; 16(7):583-5. doi: NULL. [PMID: 3781147]
  • H Toutain, B Olier, J P Fillastre, J P Morin. [Can gentamicin nephrotoxicity in rats be modified by chronic administration of muzolimine?]. Pathologie-biologie. 1986 Jun; 34(5 Pt 2):582-6. doi: NULL. [PMID: 3534747]
  • A Dal Canton, D Russo, R Gallo, G Ardillo, S Trevico, B Cianciaruso, V E Andreucci. Diuretic therapy in uremic patients. Kidney international. Supplement. 1985 Dec; 17(?):S154-6. doi: NULL. [PMID: 3867786]
  • S Dalla Volta, R Scognamiglio, M D Sorbio, G Fasoli, I Maragno. Effect of muzolimine in aortic insufficiency with different levels of left ventricular function. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):13-8. doi: NULL. [PMID: 4002787]
  • W Ritter, W Wingender, M Hanisch, U Lietz. Food and muzolimine interaction. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):145-8. doi: NULL. [PMID: 4002790]
  • G Amabile, A Serradimigni. Treatment of mild to moderate essential hypertension with muzolimine. Two years of follow-up. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):48-51. doi: NULL. [PMID: 4002804]
  • G Pagano, V Dal Molin, C Bozzo, Q Carta. Interference on metabolism induced by muzolimine and chlorthalidone in type II hypertensive diabetics. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):80-3. doi: NULL. [PMID: 3890395]
  • W Ritter, M Hanisch, P W Lücker, F Venitz, B Hey, N Baykal. Pharmacokinetics of muzolimine after oral administration with and without aluminium hydroxide in healthy volunteers. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):149-51. doi: NULL. [PMID: 4002791]
  • L Storstein, H Bjørnstad, P Mølstad. Pharmacokinetics and pharmacodynamics of muzolimine in chronic heart failure. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):34-6. doi: NULL. [PMID: 4002802]
  • L A Ferrara, P Strazzullo, A Scillitani, M Mancini, R Gagliardi. Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients. European journal of clinical pharmacology. 1985; 28(3):241-4. doi: 10.1007/bf00543316. [PMID: 4007027]
  • R Faedda, A Satta, G F Branca, B Contu, E Bartoli. Demonstration of action of muzolimine on the serosal side of Henle's loop cells. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):166-70. doi: NULL. [PMID: 4002794]
  • J M Davis, T Takabatake, K Thurau, D A Häberle. The effect of muzolimine on the tubuloglomerular feedback mechanism in the rat kidney. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):161-5. doi: NULL. [PMID: 4002793]
  • B Garthoff. Beneficial effect of muzolimine in postischemic acute renal failure in rats. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):171-4. doi: NULL. [PMID: 4002795]
  • J Mann, W Ritter, N Heckmann, F Sörgel, E Ritz. Pharmacokinetics of muzolimine after acute and chronic dosing in hypertensive patients with mild renal insufficiency. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):77-9. doi: NULL. [PMID: 4002808]
  • G Bandiani, E Camaiora, M A Nicolini, U Perotta. Muzolimine in patients on chronic hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):84-7. doi: NULL. [PMID: 4002809]
  • P Stratta, M Dogliani, G Squiccimarro, L Colla, A Vercellone. Muzolimine in chronic renal failure: a study in 16 patients. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):125-8. doi: NULL. [PMID: 4002786]
  • G Orsoni, A Di Felice, M Hadjigavriel, M Biavati, V Bonomini. Short-term, high-dose muzolimine treatment in patients with chronic renal failure and acute fluid retention. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):121-4. doi: . [PMID: 4002785]
  • T H Steele, L Challoner-Hue. Muzolimine modification of renal vasoconstriction. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):186-8. doi: NULL. [PMID: 2408394]
  • H Kahles, G Ertl, G Riegger, G Liebau, K Kochsiek. Muzolimine therapy in patients with congestive heart failure in comparison with furosemide pretreatment. Effect on digoxin plasma concentration. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):24-6. doi: NULL. [PMID: 4002799]
  • V E Andreucci, A Dal Canton, D Russo, P Veniero, O Oliva, E Cofelice, G Romano. Is the antihypertensive effect of muzolimine due to volume depletion?. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):43-7. doi: NULL. [PMID: 3890393]
  • M Bernardi, R De Palma, F Trevisani, C Santini, D Servadei, G Gasbarrini. Comparative pharmacodynamics of furosemide and muzolimine in cirrhosis. Study on renal sodium and potassium handling and renin-aldosterone axis. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):129-34. doi: NULL. [PMID: 3890391]
  • P Fiegel, A Röckel, M Hanisch, W Ritter, S Abdelhamid, D Walb. Effects of haemodialysis on the pharmacokinetics of muzolimine. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):100-2. doi: NULL. [PMID: 4002781]
  • NULL. New trends in diuretic therapy. 3rd International Edrul Symposium. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):1-193. doi: NULL. [PMID: 4002780]
  • F Mastrangelo, S Rizzelli, C Corlianò, L Alfonso, V De Blasi, M Aprile, A M Montinaro, M Napoli. Muzolimine in advanced chronic renal failure. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):109-14. doi: NULL. [PMID: 4002783]
  • P Morachiello, U Coli, S Landini, A Fracasso, F Righetto, F Scanferla, G Bazzato. Step-dose of muzolimine at different stages of chronic renal failure: comparison with furosemide. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):115-20. doi: NULL. [PMID: 4002784]
  • P W Lücker, J Venitz, B Hey, N Baykal, M Hanisch, W Ritter. Pharmacodynamic and pharmacokinetic correlation of muzolimine with and without aluminium hydroxide. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):141-4. doi: NULL. [PMID: 4002789]
  • M Salerno, M Di Salvo, R Furnari, F Vaccaro, S Licciardi, S Finocchiaro. Comparison of muzolimine and furosemide in heart failure. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):32-3. doi: NULL. [PMID: 4002801]
  • A Baumelou, E Singlas, W Ritter, H Merdjan, H Martre, R Brouard, C Chickh-Touami, R Patte. Diuretic effect and pharmacokinetic data observed at different stages of chronic renal failure with 240 mg of muzolimine. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):88-91. doi: NULL. [PMID: 4002810]
  • P Bouletreau, J Meunier, J C Kérihuel, W Ritter. Clinical study of muzolimine in acute renal failure, pharmacodynamics and pharmacokinetics. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):96-9. doi: NULL. [PMID: 4002812]
  • R Kirsten, K H Molz, I Tzonev, K Nelson. Clinical evaluation of muzolimine and indapamide during treatment for essential hypertension. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):66-72. doi: ". [PMID: 4002807]
  • W P Leary, A J Reyes, K van der Byl. The effects of single doses of muzolimine upon urinary solute and fluid excretion. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):135-40. doi: NULL. [PMID: 4002788]
  • L Calò, S Cantaro, A Piccoli, A Vianello, A Borsatti, R Bardini, A Antonello. Interactions between muzolimine, PgE2 and the renin-angiotensin-aldosterone system. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):157-60. doi: NULL. [PMID: 3859104]
  • G Riechers, M Futerova, M Hanisch, W Ritter, K Kühn. Effects of muzolimine and of a combination of hydrochlorothiazide/triamterene in healthy subjects and in nephrotic patients. Zeitschrift fur Kardiologie. 1985; 74 Suppl 2(?):103-8. doi: NULL. [PMID: 4002782]
  • D T Lowenthal, D Dickerman. The use of diuretics in varying degrees of renal impairment: an overview. Clinical and experimental hypertension. Part A, Theory and practice. 1983; 5(2):297-307. doi: 10.3109/10641968309048828. [PMID: 6403264]
  • H Schiffl, P Weidmann, R Mordasini, K Boehringer, W Riesen, C Bachmann. Serum lipoproteins in patients with mild renal disease treated with the diuretic muzolimine. Klinische Wochenschrift. 1982 Dec; 60(23):1449-53. doi: 10.1007/bf01720992. [PMID: 7154618]
  • R C Hanson, J B White, A W Gomoll. Acute and chronic diuretic-induced alterations in urinary sodium and calcium excretion in the conscious rat. Mineral and electrolyte metabolism. 1982 Dec; 8(6):314-24. doi: NULL. [PMID: 7167137]
  • B Garthoff, K Hoffmann, G Luckhaus, K Thurau. Adequate substitution with electrolytes in toxicological testing of 'loop' diuretics in the dog. Toxicology and applied pharmacology. 1982 Sep; 65(2):191-202. doi: 10.1016/0041-008x(82)90001-1. [PMID: 7179280]
  • H Schiffl, P Weidmann, C Beretta-Piccoli, C Cottier, A J Seiler, W H Ziegler. Antihypertensive mechanism of the diuretic muzolimine in mild renal failure. Roles of sodium and cardiovascular norepinephrine responsiveness. European journal of clinical pharmacology. 1982; 23(3):215-20. doi: 10.1007/bf00547556. [PMID: 6756933]
  • A Dal Canton, D Russo, R Gallo, G Conte, V E Andreucci. Muzolimine: a new high-ceiling diuretic suitable for patients with advanced renal disease. British medical journal (Clinical research ed.). 1981 Feb; 282(6264):595-8. doi: 10.1136/bmj.282.6264.595. [PMID: 6781585]
  • R Kinne, E Kinne-Saffran, B Koenig, E Bayerdoerffer, J Eveloff. Control mechanisms in active chloride transport. Scandinavian audiology. Supplementum. 1981; 14 Suppl(?):17-24. doi: NULL. [PMID: 6276964]
  • P Schmidt, D Loew, J Dycka, H Kopsa, P Balcke, J Zazgornik, E Deutsch. Comparison of the effects of muzolimine and furosemide in patients with end-stage renal failure on chronic dialysis. European journal of clinical pharmacology. 1981; 20(1):23-6. doi: 10.1007/bf00554662. [PMID: 7308268]
  • D Loew, J Dýcka, T Pfleiderer, W Ritter. [Pharmacodynamic and pharmacokinetic studies of muzolimine in patients with hepatogeneous ascites (author's transl)]. Zeitschrift fur Gastroenterologie. 1980 Oct; 18(10):537-42. doi: NULL. [PMID: 7456563]
  • O Brørs, P Fauchald, E Lind, S Jacobsen. Pharmacokinetics and saluretic effect of muzolimine in severe cardiac failure. Current medical research and opinion. 1980; 6(6):431-6. doi: 10.1185/03007998009109463. [PMID: 7363644]
  • E Schnurr, H Küppers. Changes of electrolyte excretion, renin activity, angiotensin-II and aldosterone concentrations during administration of 3-amino-1-(3,4-dichloro-a-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821). International journal of clinical pharmacology and biopharmacy. 1979 Nov; 17(11):453-6. doi: NULL. [PMID: 511420]